-
1
-
-
19744368302
-
Cancer of the ovary
-
Cannistra S.A. Cancer of the ovary. New Engl. J. Med. 351 (2004) 2519-2529
-
(2004)
New Engl. J. Med.
, vol.351
, pp. 2519-2529
-
-
Cannistra, S.A.1
-
2
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267 (1995) 1456-1462
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
3
-
-
0842281645
-
Cell death: critical control points
-
Daniel N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Daniel, N.N.1
Korsmeyer, S.J.2
-
4
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
28544443984
-
Promoting apoptosis as a strategy for cancer drug discovery
-
Fesik S.W. Promoting apoptosis as a strategy for cancer drug discovery. Nat. Rev. Cancer 5 (2005) 876-885
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 876-885
-
-
Fesik, S.W.1
-
6
-
-
0036598992
-
Targeting death and decoy receptors of the tumor-necrosis factor superfamily
-
Ashkenazi A. Targeting death and decoy receptors of the tumor-necrosis factor superfamily. Nat. Rev. Cancer 2 (2002) 420-430
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
7
-
-
17744396145
-
Death to the dad guys: targeting cancer via Apo2L/TRAIL
-
Bouralexis S., Findley D.M., and Evdokiou A. Death to the dad guys: targeting cancer via Apo2L/TRAIL. Apoptosis 10 (2005) 35-51
-
(2005)
Apoptosis
, vol.10
, pp. 35-51
-
-
Bouralexis, S.1
Findley, D.M.2
Evdokiou, A.3
-
8
-
-
16644372319
-
Following a TRAIL: update on a ligand and its five receptors
-
Kimberley F.C., and Screaton G.R. Following a TRAIL: update on a ligand and its five receptors. Cell Res. 14 (2004) 359-372
-
(2004)
Cell Res.
, vol.14
, pp. 359-372
-
-
Kimberley, F.C.1
Screaton, G.R.2
-
9
-
-
21344474349
-
Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer
-
Horak P., Pils D., Haller G., Pribill I., Roessler M., Tomek S., Horvat R., Zeillinger R., Zielinski C., and Krainer M. Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol. Cancer Res. 3 (2005) 335-343
-
(2005)
Mol. Cancer Res.
, vol.3
, pp. 335-343
-
-
Horak, P.1
Pils, D.2
Haller, G.3
Pribill, I.4
Roessler, M.5
Tomek, S.6
Horvat, R.7
Zeillinger, R.8
Zielinski, C.9
Krainer, M.10
-
10
-
-
29344473740
-
L and deregulation of the functional receptors DR4 and DR5
-
L and deregulation of the functional receptors DR4 and DR5. Clin. Cancer Res. 11 (2005) 8585-8591
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8585-8591
-
-
Horak, P.1
Pils, D.2
Kaider, A.3
Pinter, A.4
Elandt, K.5
Sax, C.6
Zielinzki, C.C.7
Horvat, R.8
Ziellinger, R.9
Reinthaller, A.10
Krainer, M.11
-
11
-
-
0023732557
-
Inhibtion of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleane-type triterpenoid compound
-
Nishino H., Nishino A., Takayasu J., Hasegawa T., Iwashima A., Hirabayashi K., Iwata S., and Shibata S. Inhibtion of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleane-type triterpenoid compound. Cancer Res. 48 (1988) 5210-5215
-
(1988)
Cancer Res.
, vol.48
, pp. 5210-5215
-
-
Nishino, H.1
Nishino, A.2
Takayasu, J.3
Hasegawa, T.4
Iwashima, A.5
Hirabayashi, K.6
Iwata, S.7
Shibata, S.8
-
12
-
-
0026525833
-
Anti-inflammatory activity of oleanolic acid in rats and mice
-
Singh G.B., Singh S., Bani S., Gupta B.D., and Banerjee S.K. Anti-inflammatory activity of oleanolic acid in rats and mice. J. Pharm. Pharmacol. 44 (1992) 456-458
-
(1992)
J. Pharm. Pharmacol.
, vol.44
, pp. 456-458
-
-
Singh, G.B.1
Singh, S.2
Bani, S.3
Gupta, B.D.4
Banerjee, S.K.5
-
13
-
-
0032491276
-
Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
-
Honda T., Rounds B.V., Gribble G.W., Suh N., Wang Y., and Sporn M.B. Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Biorg. Med. Chem. Lett. 8 (1998) 2711-2714
-
(1998)
Biorg. Med. Chem. Lett.
, vol.8
, pp. 2711-2714
-
-
Honda, T.1
Rounds, B.V.2
Gribble, G.W.3
Suh, N.4
Wang, Y.5
Sporn, M.B.6
-
14
-
-
0034025671
-
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages
-
Honda T., Gribble G.W., Suh N., Finlay H.J., Rounds B.V., Bore L., Favaloro F.G., Wang Y., and Sporn M.B. Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 43 (2000) 1866-1877
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1866-1877
-
-
Honda, T.1
Gribble, G.W.2
Suh, N.3
Finlay, H.J.4
Rounds, B.V.5
Bore, L.6
Favaloro, F.G.7
Wang, Y.8
Sporn, M.B.9
-
15
-
-
34247526984
-
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
-
Liby K.T., Yore M.M., and Sporn M.B. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat. Rev. Cancer 7 (2007) 357-369
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
16
-
-
0034077629
-
The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukaemia cells, by a caspase-8-dependent mechanism
-
Ito Y., Pandey P., Place A., Sporn M.B., Gribble G.W., Honda T., Kharbanda S., and Kufe D. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukaemia cells, by a caspase-8-dependent mechanism. Cell Growth Differ. 11 (2000) 261-267
-
(2000)
Cell Growth Differ.
, vol.11
, pp. 261-267
-
-
Ito, Y.1
Pandey, P.2
Place, A.3
Sporn, M.B.4
Gribble, G.W.5
Honda, T.6
Kharbanda, S.7
Kufe, D.8
-
17
-
-
0035037586
-
The novel triterpenoid CDDO induced apoptosis and differentiation of human osteosarcoma cells by a caspase-8-dependent mechanism
-
Ito Y., Pandey P., Sporn M.B., Datta R., Kharbanda S., and Kufe D. The novel triterpenoid CDDO induced apoptosis and differentiation of human osteosarcoma cells by a caspase-8-dependent mechanism. Mol. Pharmacol. 59 (2001) 1094-1099
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 1094-1099
-
-
Ito, Y.1
Pandey, P.2
Sporn, M.B.3
Datta, R.4
Kharbanda, S.5
Kufe, D.6
-
18
-
-
0036095959
-
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukaemia
-
Konopleva M., Tsao T., Ruvolo P., Stiouf I., Estrov Z., Leysath C.E., et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukaemia. Blood 99 (2002) 326-335
-
(2002)
Blood
, vol.99
, pp. 326-335
-
-
Konopleva, M.1
Tsao, T.2
Ruvolo, P.3
Stiouf, I.4
Estrov, Z.5
Leysath, C.E.6
-
19
-
-
0037151079
-
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
-
Kim Y., Suh N., Sporn M.B., and Reed J.C. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem. 277 (2002) 22320-22329
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22320-22329
-
-
Kim, Y.1
Suh, N.2
Sporn, M.B.3
Reed, J.C.4
-
20
-
-
0037108441
-
The triterpenoid CDDO induces apoptosis in refractory CLL B-cells
-
Pedersen I.M., Kitada S., Schimmer A., Kim Y., Zapata J.M., Charboneau L., et al. The triterpenoid CDDO induces apoptosis in refractory CLL B-cells. Blood 100 (2002) 2965-2972
-
(2002)
Blood
, vol.100
, pp. 2965-2972
-
-
Pedersen, I.M.1
Kitada, S.2
Schimmer, A.3
Kim, Y.4
Zapata, J.M.5
Charboneau, L.6
-
21
-
-
12444337488
-
The novel triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo
-
Place A.E., Suh N., Williams C.R., Risingson R., Honda T., Honda Y., Gribble G.W., Leesnitzer L.M., Stimmel J.B., Willson T.M., Rosen E., and Sporn M.B. The novel triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin. Cancer Res. 9 (2003) 2798-2806
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 2798-2806
-
-
Place, A.E.1
Suh, N.2
Williams, C.R.3
Risingson, R.4
Honda, T.5
Honda, Y.6
Gribble, G.W.7
Leesnitzer, L.M.8
Stimmel, J.B.9
Willson, T.M.10
Rosen, E.11
Sporn, M.B.12
-
22
-
-
0242643655
-
Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL
-
Suh W.S., Kim Y.S., Schimmer A.D., Kitada S., Minden M., Andreef M., Suh N., Sporn M., and Reed J.C. Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL. Leukemia 17 (2003) 2122-2129
-
(2003)
Leukemia
, vol.17
, pp. 2122-2129
-
-
Suh, W.S.1
Kim, Y.S.2
Schimmer, A.D.3
Kitada, S.4
Minden, M.5
Andreef, M.6
Suh, N.7
Sporn, M.8
Reed, J.C.9
-
23
-
-
41649085883
-
C-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) in Human Lung Cancer Cells
-
Zou W., Chen S., Liu X., Yue P., Sporn M.B., Khuri F.R., and Sun S.Y. C-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) in Human Lung Cancer Cells. Cancer Biol. Ther. 6 (2007) 1614-1620
-
(2007)
Cancer Biol. Ther.
, vol.6
, pp. 1614-1620
-
-
Zou, W.1
Chen, S.2
Liu, X.3
Yue, P.4
Sporn, M.B.5
Khuri, F.R.6
Sun, S.Y.7
-
24
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., and Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139 (1991) 271-279
-
(1991)
J. Immunol. Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
25
-
-
24944458177
-
Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
-
Georgakis G.V., Li Y., Humphreys R., Andreef M., O'Brien S., Younes M., Carbone A., Albert V., and Younes A. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Br. J. Haematol. 130 (2005) 501-510
-
(2005)
Br. J. Haematol.
, vol.130
, pp. 501-510
-
-
Georgakis, G.V.1
Li, Y.2
Humphreys, R.3
Andreef, M.4
O'Brien, S.5
Younes, M.6
Carbone, A.7
Albert, V.8
Younes, A.9
-
26
-
-
21044441651
-
HGS-ETR1, a fully human TRAIL-R1 monoclonal antibody, induces cell death in multiple tumor types in vitro and in vivo
-
Pukac L., Kanakaraj P., Humphreys R., Alderson R., Bloom M., Sung C., Riccobene T., Johnson R., et al. HGS-ETR1, a fully human TRAIL-R1 monoclonal antibody, induces cell death in multiple tumor types in vitro and in vivo. Br. J. Cancer 92 (2005) 1430-1444
-
(2005)
Br. J. Cancer
, vol.92
, pp. 1430-1444
-
-
Pukac, L.1
Kanakaraj, P.2
Humphreys, R.3
Alderson, R.4
Bloom, M.5
Sung, C.6
Riccobene, T.7
Johnson, R.8
-
27
-
-
0031984816
-
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein
-
Grignani F., Kinsella T., Mencarelli A., Valtieri M., Riganelli D., Grignani F., Lanfrancone L., Peschle C., Nolan G.P., and Pelicci P.G. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res. 58 (1998) 14-19
-
(1998)
Cancer Res.
, vol.58
, pp. 14-19
-
-
Grignani, F.1
Kinsella, T.2
Mencarelli, A.3
Valtieri, M.4
Riganelli, D.5
Grignani, F.6
Lanfrancone, L.7
Peschle, C.8
Nolan, G.P.9
Pelicci, P.G.10
-
28
-
-
0029833422
-
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
-
Kinsella T.M., and Nolan G.P. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7 (1996) 1405-1413
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1405-1413
-
-
Kinsella, T.M.1
Nolan, G.P.2
-
29
-
-
0029101644
-
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
-
Zamzami N., Marchetti P., Castedo M., Decaudin D., Macho A., Hirsch T., Susin S.A., Petit P.X., Mignotte B., and Kroemer G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182 (1995) 367-377
-
(1995)
J. Exp. Med.
, vol.182
, pp. 367-377
-
-
Zamzami, N.1
Marchetti, P.2
Castedo, M.3
Decaudin, D.4
Macho, A.5
Hirsch, T.6
Susin, S.A.7
Petit, P.X.8
Mignotte, B.9
Kroemer, G.10
-
30
-
-
33646838466
-
Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis
-
Ward M.W., Rehm M., Duessmann H., Kacmar S., Concannon C.G., and Prehn J.H. Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis. J. Biol. Chem. 281 (2006) 5837-5844
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5837-5844
-
-
Ward, M.W.1
Rehm, M.2
Duessmann, H.3
Kacmar, S.4
Concannon, C.G.5
Prehn, J.H.6
-
31
-
-
27544446991
-
Life in the balance: how BH3-only proteins induce apoptosis
-
Willis S.N., and Adams J.M. Life in the balance: how BH3-only proteins induce apoptosis. Curr. Opin. Cell. Biol. 17 (2005) 617-625
-
(2005)
Curr. Opin. Cell. Biol.
, vol.17
, pp. 617-625
-
-
Willis, S.N.1
Adams, J.M.2
-
32
-
-
17644421083
-
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
-
Tan T.T., Degenhardt K., Nelson D.A., Beudoin B., Nieves-Neira W., Bouillet P., Villunger A., Adams J.M., and White E. Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell 7 (2005) 227-238
-
(2005)
Cancer Cell
, vol.7
, pp. 227-238
-
-
Tan, T.T.1
Degenhardt, K.2
Nelson, D.A.3
Beudoin, B.4
Nieves-Neira, W.5
Bouillet, P.6
Villunger, A.7
Adams, J.M.8
White, E.9
-
33
-
-
33750976014
-
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells
-
Liby K., Voong N., Williams C.R., Risingsong R., Royce D.B., Honda T., Gribble G.W., Sporn M.B., and Letterio J.J. The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. Clin. Cancer Res. 12 (2006) 4288-4293
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4288-4293
-
-
Liby, K.1
Voong, N.2
Williams, C.R.3
Risingsong, R.4
Royce, D.B.5
Honda, T.6
Gribble, G.W.7
Sporn, M.B.8
Letterio, J.J.9
-
34
-
-
58849152837
-
CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells
-
Duan Z., Ames R.Y., Ryan M., Horniceck F.J., Mankin H., and Seiden M.V. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother. Pharmacol. 63 (2009) 681-689
-
(2009)
Cancer Chemother. Pharmacol.
, vol.63
, pp. 681-689
-
-
Duan, Z.1
Ames, R.Y.2
Ryan, M.3
Horniceck, F.J.4
Mankin, H.5
Seiden, M.V.6
-
35
-
-
1842425398
-
Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian cancer cell lines not dependent on peroxisome proliferator activated receptor-γ expression
-
Melichar B., Konopleva M., Hu W., Melicharova K., Andreef M., and Freedman R.S. Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian cancer cell lines not dependent on peroxisome proliferator activated receptor-γ expression. Gynecol. Oncol. 93 (2004) 149-154
-
(2004)
Gynecol. Oncol.
, vol.93
, pp. 149-154
-
-
Melichar, B.1
Konopleva, M.2
Hu, W.3
Melicharova, K.4
Andreef, M.5
Freedman, R.S.6
-
36
-
-
42349083382
-
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer
-
Hyer M.L., Shi R., Kraiewska M., Meyer C., Lebedeva I.V., Fisher P.B., and C Reed J. Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer. Cancer Res. 68 (2008) 2927-2933
-
(2008)
Cancer Res.
, vol.68
, pp. 2927-2933
-
-
Hyer, M.L.1
Shi, R.2
Kraiewska, M.3
Meyer, C.4
Lebedeva, I.V.5
Fisher, P.B.6
C Reed, J.7
-
37
-
-
21144438719
-
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells
-
Hyer M.L., Croxton R., Krajewska M., Krajewski S., Kress C.L., Lu M., Suh N., Sporn M.B., Cryns V.L., Zapata J.M., and Reed J.C. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res. 65 (2005) 4799-4808
-
(2005)
Cancer Res.
, vol.65
, pp. 4799-4808
-
-
Hyer, M.L.1
Croxton, R.2
Krajewska, M.3
Krajewski, S.4
Kress, C.L.5
Lu, M.6
Suh, N.7
Sporn, M.B.8
Cryns, V.L.9
Zapata, J.M.10
Reed, J.C.11
-
38
-
-
0034077629
-
The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-25-oic acid induces apoptosis of human myeloid leukemia cells, by a caspase-8-dependent mechanism
-
Ikeda T., Sporn M., Honda T., Gribble G.W., and Honda T. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-25-oic acid induces apoptosis of human myeloid leukemia cells, by a caspase-8-dependent mechanism. Cell Death Differ. 11 (2000) 261-267
-
(2000)
Cell Death Differ.
, vol.11
, pp. 261-267
-
-
Ikeda, T.1
Sporn, M.2
Honda, T.3
Gribble, G.W.4
Honda, T.5
-
39
-
-
33646771034
-
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me)
-
Yue P., Zhou Z., Khuri F.R., and Sun S.Y. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me). Cancer Biol. Ther. 5 (2006) 492-497
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 492-497
-
-
Yue, P.1
Zhou, Z.2
Khuri, F.R.3
Sun, S.Y.4
-
40
-
-
27744464884
-
2-Cyano-3,12-dioxooleana-1,9-dien-28-Imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
-
Samudio I., Konopleva M., Hail N., Shi Y.X., McQueen T., Hsu T., et al. 2-Cyano-3,12-dioxooleana-1,9-dien-28-Imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J. Biol. Chem. 280 (2005) 36273-36282
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 36273-36282
-
-
Samudio, I.1
Konopleva, M.2
Hail, N.3
Shi, Y.X.4
McQueen, T.5
Hsu, T.6
-
41
-
-
4344625883
-
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukaemia cells
-
Friesen C., Kiess Y., and Debatin K.M. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukaemia cells. Cell Death Diff. 11 (2004) S73-S85
-
(2004)
Cell Death Diff.
, vol.11
-
-
Friesen, C.1
Kiess, Y.2
Debatin, K.M.3
-
42
-
-
33846419151
-
GSH-dependent regulation of Fas-mediated caspases-8 activation by acrolein
-
Hristova M., Heuvelmans S., and Van Der Vliet A. GSH-dependent regulation of Fas-mediated caspases-8 activation by acrolein. FEBS Lett. 581 (2007) 361-367
-
(2007)
FEBS Lett.
, vol.581
, pp. 361-367
-
-
Hristova, M.1
Heuvelmans, S.2
Van Der Vliet, A.3
-
43
-
-
0034066405
-
Caspase 8 is deleted or silenced in childhood neuroblastomas with amplification of MYCN
-
Teitz T., Wei T., Valentine M.B., Vanin E.F., Grenet J., Valentine V.A., et al. Caspase 8 is deleted or silenced in childhood neuroblastomas with amplification of MYCN. Nat. Med. 6 (2000) 529-535
-
(2000)
Nat. Med.
, vol.6
, pp. 529-535
-
-
Teitz, T.1
Wei, T.2
Valentine, M.B.3
Vanin, E.F.4
Grenet, J.5
Valentine, V.A.6
-
44
-
-
30144434107
-
Potentiation of neuroblastoma metastasis by loss of caspases-8
-
Stupack D.G., Teitz T., Potter M.D., Mikolon D., Houghton P.J., Kidd V.J., et al. Potentiation of neuroblastoma metastasis by loss of caspases-8. Nature 439 (2007) 95-99
-
(2007)
Nature
, vol.439
, pp. 95-99
-
-
Stupack, D.G.1
Teitz, T.2
Potter, M.D.3
Mikolon, D.4
Houghton, P.J.5
Kidd, V.J.6
-
45
-
-
19944414628
-
Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspases-8 gene silencing
-
Poulaki V., Mitsiades C.S., McMullan C., Fanourakis G., Negri J., Goudopoulou A., et al. Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspases-8 gene silencing. Invest. Ophthal. Vis. Sci. 46 (2005) 358-366
-
(2005)
Invest. Ophthal. Vis. Sci.
, vol.46
, pp. 358-366
-
-
Poulaki, V.1
Mitsiades, C.S.2
McMullan, C.3
Fanourakis, G.4
Negri, J.5
Goudopoulou, A.6
-
46
-
-
0346333258
-
Loss of caspases-8 protein expression correlates with unfavourable survival outcome in childhood medulloblastoma
-
Pingoud-Meier C., Lang D., Janss A.J., Rorke L.B., Phillips P.C., Shalaby T., and Grotzer M.A. Loss of caspases-8 protein expression correlates with unfavourable survival outcome in childhood medulloblastoma. Clin. Cancer Res. 9 (2003) 6401-6409
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 6401-6409
-
-
Pingoud-Meier, C.1
Lang, D.2
Janss, A.J.3
Rorke, L.B.4
Phillips, P.C.5
Shalaby, T.6
Grotzer, M.A.7
-
47
-
-
0041323118
-
Inactivating mutations of caspases-8 gene in colorectal carcinomas
-
Kim H.S., Lee J.W., Soung Y.H., Park W.S., Kim S.Y., Lee J.H., et al. Inactivating mutations of caspases-8 gene in colorectal carcinomas. Gastroenterology 125 (2003) 708-715
-
(2003)
Gastroenterology
, vol.125
, pp. 708-715
-
-
Kim, H.S.1
Lee, J.W.2
Soung, Y.H.3
Park, W.S.4
Kim, S.Y.5
Lee, J.H.6
-
48
-
-
13444309090
-
Caspase-8 gene is inactivated by somatic mutations in gastric carcinomas
-
Soung Y.H., Lee J.W., Kim S.Y., Jang J., Park Y.G., Park W.S., et al. Caspase-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res. 65 (2005) 815-821
-
(2005)
Cancer Res.
, vol.65
, pp. 815-821
-
-
Soung, Y.H.1
Lee, J.W.2
Kim, S.Y.3
Jang, J.4
Park, Y.G.5
Park, W.S.6
-
49
-
-
12444281807
-
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas
-
Soung Y.H., Lee Y.W., Kim S.Y., Soung Y.J., Park W.S., Nam S.W., et al. Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. Oncogene 24 (2005) 141-147
-
(2005)
Oncogene
, vol.24
, pp. 141-147
-
-
Soung, Y.H.1
Lee, Y.W.2
Kim, S.Y.3
Soung, Y.J.4
Park, W.S.5
Nam, S.W.6
-
50
-
-
42749092514
-
Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels
-
Riccioni R., Senese M., Diverio D., Riti V., Mariani G., Boe A., LoCoco F., Foà R., Peschle C., Sporn M., and Testa U. Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leukemia Res. 32 (2008) 1244-1258
-
(2008)
Leukemia Res.
, vol.32
, pp. 1244-1258
-
-
Riccioni, R.1
Senese, M.2
Diverio, D.3
Riti, V.4
Mariani, G.5
Boe, A.6
LoCoco, F.7
Foà, R.8
Peschle, C.9
Sporn, M.10
Testa, U.11
-
51
-
-
2442663092
-
Activated signal transducer and activator of transcription (STAT)3: localization in focal adhesions and function in ovarian cancer motility
-
Silver D.L., Naora H., Liu J., Cheng W., and Montell D.J. Activated signal transducer and activator of transcription (STAT)3: localization in focal adhesions and function in ovarian cancer motility. Cancer Res. 64 (2004) 3550-3558
-
(2004)
Cancer Res.
, vol.64
, pp. 3550-3558
-
-
Silver, D.L.1
Naora, H.2
Liu, J.3
Cheng, W.4
Montell, D.J.5
-
52
-
-
33748992592
-
Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer
-
Duan Z., Fostere R., Bell D.A., Mahoney T., Wolak K., Vaidja A., Hampel C., Lee H., and Seiden M.V. Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin. Cancer Res. 12 (2006) 5055-5063
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5055-5063
-
-
Duan, Z.1
Fostere, R.2
Bell, D.A.3
Mahoney, T.4
Wolak, K.5
Vaidja, A.6
Hampel, C.7
Lee, H.8
Seiden, M.V.9
-
53
-
-
35348850734
-
Hematopoietic cytokine receptor signaling
-
Baker S.J., Rane S.G., and P Reddy E. Hematopoietic cytokine receptor signaling. Oncogene 26 (2007) 6724-6737
-
(2007)
Oncogene
, vol.26
, pp. 6724-6737
-
-
Baker, S.J.1
Rane, S.G.2
P Reddy, E.3
-
54
-
-
0242348793
-
Stat3 protects against Fas. induced liver injury by redox-dependent and -independent mechanisms
-
Haga S., Terni K., Zhang H.Q., Enosawa S., Ogawa W., Inoue H., Okuyama T., Takeda K., Akira S., Ogino T., Irani K., and Ozaki M. Stat3 protects against Fas. induced liver injury by redox-dependent and -independent mechanisms. J. Clin. Invest. 112 (2003) 989-998
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 989-998
-
-
Haga, S.1
Terni, K.2
Zhang, H.Q.3
Enosawa, S.4
Ogawa, W.5
Inoue, H.6
Okuyama, T.7
Takeda, K.8
Akira, S.9
Ogino, T.10
Irani, K.11
Ozaki, M.12
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