Activities of Monomeric Insulin Analogs at Position A8 Are Uncorrelated with Their Thermodynamic Stabilities

Journal of Biological Chemistry

Volumn 276, Issue 43, 2001, Pages 40018-40024

  Weiss, Michael A ^a   Hua, Qing Xin ^a   Jia, Wenhua ^a   Nakagawa, Satoe H ^b   Chu, Ying Chi ^c   Hu, Shi Quan ^c   Katsoyannis, Panayotis G ^c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONES; INSULIN; MEMBRANES; MONOMERS; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTIONS; SULFUR COMPOUNDS; THERMODYNAMIC STABILITY; TITRATION;

HORMONE-RECEPTOR RECOGNITION;

BIOCHEMISTRY;

ARGININE; ASPARTIC ACID; GUANIDINE; HISTIDINE; HORMONE RECEPTOR; INSULIN DERIVATIVE; IODINE 125; LYSINE; PROLINE; THREONINE; DKP INSULIN; DKP-INSULIN; DRUG DERIVATIVE; INSULIN; INSULIN RECEPTOR; INSULIN, GLN(A8); INSULIN, GLN(A8)-; INSULIN, GLU(A8); INSULIN, GLU(A8)-;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DISULFIDE BOND; HORMONE ACTION; MEMBRANE BINDING; MOLECULAR RECOGNITION; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLACENTA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; THERMODYNAMICS; TITRIMETRY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG STABILITY; HEAT; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN DENATURATION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; DRUG STABILITY; GUANIDINE; HEAT; INSULIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; RECEPTOR, INSULIN; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0035955720     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104634200     Document Type: Article

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