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Volumn 84, Issue , 2007, Pages 291-304

Gene therapy approaches for the treatment of Parkinson's disease

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EID: 67649415136     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0072-9752(07)84045-0     Document Type: Chapter
Times cited : (9)

References (82)
  • 4
    • 0036897235 scopus 로고    scopus 로고
    • Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease
    • Azzouz M., Martin-Rendon E., Barber R.D., et al. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. J Neurosci 22 23 (2002) 10302-10312
    • (2002) J Neurosci , vol.22 , Issue.23 , pp. 10302-10312
    • Azzouz, M.1    Martin-Rendon, E.2    Barber, R.D.3
  • 5
    • 0033942230 scopus 로고    scopus 로고
    • Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
    • Bankiewicz K.S., Eberling J.L., Kohutnicka M., et al. Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 164 1 (2000) 2-14
    • (2000) Exp Neurol , vol.164 , Issue.1 , pp. 2-14
    • Bankiewicz, K.S.1    Eberling, J.L.2    Kohutnicka, M.3
  • 6
    • 30444455610 scopus 로고    scopus 로고
    • Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys
    • [Epub 2005 Dec 9]
    • Bankiewicz K.S., Daadi M., Pivirotto P., et al. Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol 197 2 (2006) 363-372 [Epub 2005 Dec 9]
    • (2006) Exp Neurol , vol.197 , Issue.2 , pp. 363-372
    • Bankiewicz, K.S.1    Daadi, M.2    Pivirotto, P.3
  • 7
    • 67649413078 scopus 로고    scopus 로고
    • Biological activity of CERE-120, an AAV2 vector encoding human neurturin, in the rat 6-hydroxydopamine model of nigrostriatal degeneration and in the young intact and aged rat
    • #545.1
    • Bartus R.T., Herzog C.D., Cunningham J.J., et al. Biological activity of CERE-120, an AAV2 vector encoding human neurturin, in the rat 6-hydroxydopamine model of nigrostriatal degeneration and in the young intact and aged rat. J Neurosci (2005) #545.1
    • (2005) J Neurosci
    • Bartus, R.T.1    Herzog, C.D.2    Cunningham, J.J.3
  • 8
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease
    • Bilang-Bleuel A., Revah F., Colin P., et al. Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci USA 94 16 (1997) 8818-8823
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.16 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3
  • 9
    • 0023117623 scopus 로고
    • Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease
    • Brundin P., Nilsson O.G., Strecker R.E., et al. Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res 65 1 (1986) 235-240
    • (1986) Exp Brain Res , vol.65 , Issue.1 , pp. 235-240
    • Brundin, P.1    Nilsson, O.G.2    Strecker, R.E.3
  • 10
    • 0031019795 scopus 로고    scopus 로고
    • Dopaminergic neurons protected from degeneration by GDNF gene therapy
    • Choi-Lundberg D.L., Lin Q., Chang Y.N., et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275 5301 (1997) 838-841
    • (1997) Science , vol.275 , Issue.5301 , pp. 838-841
    • Choi-Lundberg, D.L.1    Lin, Q.2    Chang, Y.N.3
  • 11
    • 0032423612 scopus 로고    scopus 로고
    • Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor
    • Choi-Lundberg D.L., Lin Q., Schallert T., et al. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Exp Neurol 154 2 (1998) 261-275
    • (1998) Exp Neurol , vol.154 , Issue.2 , pp. 261-275
    • Choi-Lundberg, D.L.1    Lin, Q.2    Schallert, T.3
  • 12
    • 0032936111 scopus 로고    scopus 로고
    • Therapeutic potential of nerve growth factors in Parkinson's disease
    • Review
    • Collier T.J., and Sortwell C.E. Therapeutic potential of nerve growth factors in Parkinson's disease. Drugs Aging 14 4 (1999) 261-287 Review
    • (1999) Drugs Aging , vol.14 , Issue.4 , pp. 261-287
    • Collier, T.J.1    Sortwell, C.E.2
  • 13
    • 0033374356 scopus 로고    scopus 로고
    • Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat
    • Connor B., Kozlowski D.A., Schallert T., et al. Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene Ther 6 12 (1999) 1936-1951
    • (1999) Gene Ther , vol.6 , Issue.12 , pp. 1936-1951
    • Connor, B.1    Kozlowski, D.A.2    Schallert, T.3
  • 14
    • 0021271074 scopus 로고
    • Effect of L-DOPA on course of Parkinson's disease
    • Curtis L., Lees A.J., Stern G.M., et al. Effect of L-DOPA on course of Parkinson's disease. Lancet 2 8396 (1984) 211-212
    • (1984) Lancet , vol.2 , Issue.8396 , pp. 211-212
    • Curtis, L.1    Lees, A.J.2    Stern, G.M.3
  • 15
    • 0029864580 scopus 로고    scopus 로고
    • Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve. Case report
    • Date I., Imaoka T., Miyoshi Y., et al. Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve. Case report. J Neurosurg 84 4 (1996) 685-689
    • (1996) J Neurosurg , vol.84 , Issue.4 , pp. 685-689
    • Date, I.1    Imaoka, T.2    Miyoshi, Y.3
  • 16
    • 16944366484 scopus 로고    scopus 로고
    • Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease
    • Deacon T., Schumacher J., Dinsmore J., et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med 3 3 (1997) 350-353
    • (1997) Nat Med , vol.3 , Issue.3 , pp. 350-353
    • Deacon, T.1    Schumacher, J.2    Dinsmore, J.3
  • 17
    • 0037130581 scopus 로고    scopus 로고
    • Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
    • Dass B., Iravani M.M., Jackson M.J., et al. Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets. Neuroscience 114 1 (2002) 99-109
    • (2002) Neuroscience , vol.114 , Issue.1 , pp. 99-109
    • Dass, B.1    Iravani, M.M.2    Jackson, M.J.3
  • 18
    • 67649395530 scopus 로고    scopus 로고
    • Adeno-associated virus mediated gene delivery of neurturin (CERE-120) in non-human primates
    • #790.19
    • Dass B., Herzog C.D., Gasmi M., et al. Adeno-associated virus mediated gene delivery of neurturin (CERE-120) in non-human primates. J Neurosci (2004) #790.19
    • (2004) J Neurosci
    • Dass, B.1    Herzog, C.D.2    Gasmi, M.3
  • 19
    • 33748354936 scopus 로고    scopus 로고
    • Adeno-associated virus mediated gene delivery of neurturin (CERE-120) prevents MPTP-induced motor disability following injection into the striatum of non-human primates
    • #545.6
    • Dass B., Herzog C.D., Gasmi M., et al. Adeno-associated virus mediated gene delivery of neurturin (CERE-120) prevents MPTP-induced motor disability following injection into the striatum of non-human primates. J Neurosci (2005) #545.6
    • (2005) J Neurosci
    • Dass, B.1    Herzog, C.D.2    Gasmi, M.3
  • 20
    • 18544366978 scopus 로고    scopus 로고
    • Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat
    • [Epub 2004 Dec 10]
    • Dass B., Iravani M.M., Huang C., et al. Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat. J Neural Transm 112 6 (2005) 763-778 [Epub 2004 Dec 10]
    • (2005) J Neural Transm , vol.112 , Issue.6 , pp. 763-778
    • Dass, B.1    Iravani, M.M.2    Huang, C.3
  • 21
    • 0035838997 scopus 로고    scopus 로고
    • Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease
    • de la Fuente-Fernandez R., Ruth T.J., Sossi V., et al. Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science 293 5532 (2001) 1164-1166
    • (2001) Science , vol.293 , Issue.5532 , pp. 1164-1166
    • de la Fuente-Fernandez, R.1    Ruth, T.J.2    Sossi, V.3
  • 22
    • 0031875751 scopus 로고    scopus 로고
    • In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
    • During M.J., Samulski R.J., Elsworth J.D., et al. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Ther 5 6 (1998) 820-827
    • (1998) Gene Ther , vol.5 , Issue.6 , pp. 820-827
    • During, M.J.1    Samulski, R.J.2    Elsworth, J.D.3
  • 23
    • 0035839562 scopus 로고    scopus 로고
    • Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation
    • During M.J., Kaplitt M.G., Stern M.B., et al. Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum Gene Ther 12 12 (2001) 1589-1591
    • (2001) Hum Gene Ther , vol.12 , Issue.12 , pp. 1589-1591
    • During, M.J.1    Kaplitt, M.G.2    Stern, M.B.3
  • 24
    • 0034671450 scopus 로고    scopus 로고
    • Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Eberhardt O., Coelln R.V., Kugler S., et al. Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neurosci 20 24 (2000) 9126-9134
    • (2000) J Neurosci , vol.20 , Issue.24 , pp. 9126-9134
    • Eberhardt, O.1    Coelln, R.V.2    Kugler, S.3
  • 25
    • 34250928307 scopus 로고
    • Verteilung von noradrenalin und dopamin (3-hydroxytyramine) im gerhin des menschen und ihr verhalten bei erkrantungen des extrapyramidalen systems
    • Ehringer H., and Hornykiewicz O. Verteilung von noradrenalin und dopamin (3-hydroxytyramine) im gerhin des menschen und ihr verhalten bei erkrantungen des extrapyramidalen systems. Kiln Wschr 38 (1960) 1236-1239
    • (1960) Kiln Wschr , vol.38 , pp. 1236-1239
    • Ehringer, H.1    Hornykiewicz, O.2
  • 26
    • 0345257314 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
    • Eslamboli A., Cummings R.M., Ridley R.M., et al. Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus). Exp Neurol 184 1 (2003) 536-548
    • (2003) Exp Neurol , vol.184 , Issue.1 , pp. 536-548
    • Eslamboli, A.1    Cummings, R.M.2    Ridley, R.M.3
  • 27
    • 12844287442 scopus 로고    scopus 로고
    • Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
    • Eslamboli A., Georgievska B., Ridley R.M., et al. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. J Neurosci 25 4 (2005) 769-777
    • (2005) J Neurosci , vol.25 , Issue.4 , pp. 769-777
    • Eslamboli, A.1    Georgievska, B.2    Ridley, R.M.3
  • 28
    • 0032970043 scopus 로고    scopus 로고
    • Subthalamic nucleus stimulation improves directly levodopa induced dyskinesias in Parkinson's disease
    • Figueiras-Mendez R., Marin-Zarza F., Antonio, Molina J., et al. Subthalamic nucleus stimulation improves directly levodopa induced dyskinesias in Parkinson's disease. J Neurol Neurosurg Psychiatry 66 4 (1999) 549-550
    • (1999) J Neurol Neurosurg Psychiatry , vol.66 , Issue.4 , pp. 549-550
    • Figueiras-Mendez, R.1    Marin-Zarza, F.2    Antonio, Molina, J.3
  • 29
    • 23644452944 scopus 로고    scopus 로고
    • Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct
    • Fjord-Larsen L., Johansen J.L., Kusk P., et al. Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct. Exp Neurol 195 1 (2005) 49-60
    • (2005) Exp Neurol , vol.195 , Issue.1 , pp. 49-60
    • Fjord-Larsen, L.1    Johansen, J.L.2    Kusk, P.3
  • 30
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed C.R., Greene P.E., Breeze R.E., et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344 10 (2001) 710-719
    • (2001) N Engl J Med , vol.344 , Issue.10 , pp. 710-719
    • Freed, C.R.1    Greene, P.E.2    Breeze, R.E.3
  • 31
    • 13344277993 scopus 로고    scopus 로고
    • Functional recovery in parkinsonian monkeys treated with GDNF
    • Gash D.M., Zhang Z., Ovadia A., et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380 6571 (1996) 252-255
    • (1996) Nature , vol.380 , Issue.6571 , pp. 252-255
    • Gash, D.M.1    Zhang, Z.2    Ovadia, A.3
  • 32
    • 0037148074 scopus 로고    scopus 로고
    • Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
    • Georgievska B., Kirik D., Rosenblad C., et al. Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector. Neuroreport 13 1 (2002) 75-82
    • (2002) Neuroreport , vol.13 , Issue.1 , pp. 75-82
    • Georgievska, B.1    Kirik, D.2    Rosenblad, C.3
  • 33
    • 0036434879 scopus 로고    scopus 로고
    • Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    • Georgievska B., Kirik D., and Bjorklund A. Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. Exp Neurol 177 2 (2002) 461-474
    • (2002) Exp Neurol , vol.177 , Issue.2 , pp. 461-474
    • Georgievska, B.1    Kirik, D.2    Bjorklund, A.3
  • 34
    • 3242762057 scopus 로고    scopus 로고
    • Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    • Georgievska B., Kirik D., and Bjorklund A. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. J Neurosci 24 29 (2004) 6437-6445
    • (2004) J Neurosci , vol.24 , Issue.29 , pp. 6437-6445
    • Georgievska, B.1    Kirik, D.2    Bjorklund, A.3
  • 35
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill S.S., Patel N.K., Hotton G.R., et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9 5 (2003) 589-595
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3
  • 36
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Hacein-Bey-Abina S., von Kalle C., Schmidt M., et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348 3 (2003) 255-256
    • (2003) N Engl J Med , vol.348 , Issue.3 , pp. 255-256
    • Hacein-Bey-Abina, S.1    von Kalle, C.2    Schmidt, M.3
  • 37
    • 33748347546 scopus 로고    scopus 로고
    • Enhanced 18F-dopa uptake in the striatum of aged rhesus monkeys following striatal delivery of CERE-120, an AAV2 vector encoding human neurturin
    • #545.7
    • Herzog C.D., Holden J.E., Bakay R.A., et al. Enhanced 18F-dopa uptake in the striatum of aged rhesus monkeys following striatal delivery of CERE-120, an AAV2 vector encoding human neurturin. J Neurosci (2005) #545.7
    • (2005) J Neurosci
    • Herzog, C.D.1    Holden, J.E.2    Bakay, R.A.3
  • 38
    • 4444235437 scopus 로고    scopus 로고
    • Differentiation and transcription factor gene therapy in experimental Parkinson's disease: Sonic Hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration
    • Hurtado-Lorenzo A., Millan E., Gonzalez-Nicolini V., et al. Differentiation and transcription factor gene therapy in experimental Parkinson's disease: Sonic Hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. Mol Ther 10 3 (2004) 507-524
    • (2004) Mol Ther , vol.10 , Issue.3 , pp. 507-524
    • Hurtado-Lorenzo, A.1    Millan, E.2    Gonzalez-Nicolini, V.3
  • 39
    • 0028169741 scopus 로고
    • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
    • Kaplitt M.G., Leone P., Samulski R.J., et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet 8 2 (1994) 148-154
    • (1994) Nat Genet , vol.8 , Issue.2 , pp. 148-154
    • Kaplitt, M.G.1    Leone, P.2    Samulski, R.J.3
  • 40
    • 0033773237 scopus 로고    scopus 로고
    • Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
    • Kirik D., Rosenblad C., and Bjorklund A. Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor. Eur J Neurosci 12 11 (2000) 3871-3882
    • (2000) Eur J Neurosci , vol.12 , Issue.11 , pp. 3871-3882
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3
  • 41
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • Kirik D., Rosenblad C., Bjorklund A., et al. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci 20 12 (2000) 4686-4700
    • (2000) J Neurosci , vol.20 , Issue.12 , pp. 4686-4700
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3
  • 42
    • 0037007106 scopus 로고    scopus 로고
    • Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-DOPA using rAAV-mediated gene transfer
    • [Epub 2002 Mar 26]
    • Kirik D., Georgievska B., Burger C., et al. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-DOPA using rAAV-mediated gene transfer. Proc Natl Acad Sci USA 99 7 (2002) 4708-4713 [Epub 2002 Mar 26]
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.7 , pp. 4708-4713
    • Kirik, D.1    Georgievska, B.2    Burger, C.3
  • 43
    • 0032704605 scopus 로고    scopus 로고
    • Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
    • Klein R.L., Lewis M.H., Muzyczka N., et al. Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain Res 847 2 (1999) 314-320
    • (1999) Brain Res , vol.847 , Issue.2 , pp. 314-320
    • Klein, R.L.1    Lewis, M.H.2    Muzyczka, N.3
  • 44
    • 0031577599 scopus 로고    scopus 로고
    • Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain
    • Kojima H., Abiru Y., Sakajiri K., et al. Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain. Biochem Biophys Res Commun 238 2 (1997) 569-573
    • (1997) Biochem Biophys Res Commun , vol.238 , Issue.2 , pp. 569-573
    • Kojima, H.1    Abiru, Y.2    Sakajiri, K.3
  • 45
    • 0028911848 scopus 로고
    • Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease
    • Kordower J.H., Freeman T.B., Snow B.J., et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 332 17 (1995) 1118-1124
    • (1995) N Engl J Med , vol.332 , Issue.17 , pp. 1118-1124
    • Kordower, J.H.1    Freeman, T.B.2    Snow, B.J.3
  • 46
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower J.H., Palfi S., Chen E.Y., et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann Neurol 46 3 (1999) 419-424
    • (1999) Ann Neurol , vol.46 , Issue.3 , pp. 419-424
    • Kordower, J.H.1    Palfi, S.2    Chen, E.Y.3
  • 47
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower J.H., Emborg M.E., Bloch J., et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290 5492 (2000) 767-773
    • (2000) Science , vol.290 , Issue.5492 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3
  • 48
    • 0029827559 scopus 로고    scopus 로고
    • Neurturin, a relative of glial-cell-line-derived neurotrophic factor
    • Kotzbauer P.T., Lampe B.A., Heuckeroth R.O., et al. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384 (1996) 467-470
    • (1996) Nature , vol.384 , pp. 467-470
    • Kotzbauer, P.T.1    Lampe, B.A.2    Heuckeroth, R.O.3
  • 49
    • 0031589698 scopus 로고    scopus 로고
    • Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease
    • Lapchak P.A., Araujo D.M., Hilt D.C., et al. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Brain Res 777 1-2 (1997) 153-160
    • (1997) Brain Res , vol.777 , Issue.1 -2 , pp. 153-160
    • Lapchak, P.A.1    Araujo, D.M.2    Hilt, D.C.3
  • 50
    • 0024362054 scopus 로고
    • Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up
    • Lindvall O., Rehncrona S., Brundin P., et al. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. Arch Neurol 46 6 (1989) 615-631
    • (1989) Arch Neurol , vol.46 , Issue.6 , pp. 615-631
    • Lindvall, O.1    Rehncrona, S.2    Brundin, P.3
  • 51
    • 5144225578 scopus 로고    scopus 로고
    • Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
    • Lo Bianco C., Deglon N., Pralong W., et al. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 17 2 (2004) 283-289
    • (2004) Neurobiol Dis , vol.17 , Issue.2 , pp. 283-289
    • Lo Bianco, C.1    Deglon, N.2    Pralong, W.3
  • 52
    • 0037064165 scopus 로고    scopus 로고
    • Subthalamic GAD gene therapy in a Parkinson's disease rat model
    • Luo J., Kaplitt M.G., Fitzsimons H.L., et al. Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science 298 5592 (2002) 425-429
    • (2002) Science , vol.298 , Issue.5592 , pp. 425-429
    • Luo, J.1    Kaplitt, M.G.2    Fitzsimons, H.L.3
  • 53
    • 0023152420 scopus 로고
    • Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease
    • Madrazo I., Drucker-Colin R., Diaz V., et al. Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N Engl J Med 316 14 (1987) 831-834
    • (1987) N Engl J Med , vol.316 , Issue.14 , pp. 831-834
    • Madrazo, I.1    Drucker-Colin, R.2    Diaz, V.3
  • 54
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel R.J., Spratt S.K., Snyder R.O., et al. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci USA 94 25 (1997) 14083-14088
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.25 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3
  • 55
    • 0032101756 scopus 로고    scopus 로고
    • Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease
    • Mandel R.J., Rendahl K.G., Spratt S.K., et al. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. J Neurosci 18 11 (1998) 4271-4284
    • (1998) J Neurosci , vol.18 , Issue.11 , pp. 4271-4284
    • Mandel, R.J.1    Rendahl, K.G.2    Spratt, S.K.3
  • 56
    • 0025232430 scopus 로고
    • Parkinson's disease
    • Marsden C.D. Parkinson's disease. Lancet 335 8695 (1990) 948-952
    • (1990) Lancet , vol.335 , Issue.8695 , pp. 948-952
    • Marsden, C.D.1
  • 57
    • 0017344150 scopus 로고
    • Success and problems of long-term levodopa therapy in Parkinson's disease
    • Marsden C.D., and Parkes J.D. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1 8007 (1977) 345-349
    • (1977) Lancet , vol.1 , Issue.8007 , pp. 345-349
    • Marsden, C.D.1    Parkes, J.D.2
  • 58
    • 0032904490 scopus 로고    scopus 로고
    • Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases
    • Review
    • Mufson E.J., Kroin J.S., Sendera T.J., et al. Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases. Prog Neurobiol 57 4 (1999) 451-484 Review
    • (1999) Prog Neurobiol , vol.57 , Issue.4 , pp. 451-484
    • Mufson, E.J.1    Kroin, J.S.2    Sendera, T.J.3
  • 59
    • 0036210202 scopus 로고    scopus 로고
    • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
    • Muramatsu S., Fujimoto K., Ikeguchi K., et al. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther 13 3 (2002) 345-354
    • (2002) Hum Gene Ther , vol.13 , Issue.3 , pp. 345-354
    • Muramatsu, S.1    Fujimoto, K.2    Ikeguchi, K.3
  • 60
    • 0038054338 scopus 로고    scopus 로고
    • AAV serotype 2 vectors preferentially integrate into active genes in mice
    • Nakai H., Montini E., Fuess S., et al. AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat Genet 34 3 (2003) 297-302
    • (2003) Nat Genet , vol.34 , Issue.3 , pp. 297-302
    • Nakai, H.1    Montini, E.2    Fuess, S.3
  • 61
    • 0034994657 scopus 로고    scopus 로고
    • Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration
    • Natsume A., Mata M., Goss J., et al. Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration. Exp Neurol 169 2 (2001) 231-238
    • (2001) Exp Neurol , vol.169 , Issue.2 , pp. 231-238
    • Natsume, A.1    Mata, M.2    Goss, J.3
  • 63
    • 0037435511 scopus 로고    scopus 로고
    • Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • ICV GDNF Study Group
    • Nutt J.G., Burchiel K.J., Comella C.L., et al., ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60 1 (2003) 69-73
    • (2003) Neurology , vol.60 , Issue.1 , pp. 69-73
    • Nutt, J.G.1    Burchiel, K.J.2    Comella, C.L.3
  • 64
    • 0037106092 scopus 로고    scopus 로고
    • Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons
    • Ostenfeld T., Tai Y.T., Martin P., et al. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. J Neurosci Res 69 6 (2002) 955-965
    • (2002) J Neurosci Res , vol.69 , Issue.6 , pp. 955-965
    • Ostenfeld, T.1    Tai, Y.T.2    Martin, P.3
  • 65
    • 0037096359 scopus 로고    scopus 로고
    • Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
    • Palfi S., Leventhal L., Chu Y., et al. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci 22 12 (2002) 4942-4954
    • (2002) J Neurosci , vol.22 , Issue.12 , pp. 4942-4954
    • Palfi, S.1    Leventhal, L.2    Chu, Y.3
  • 66
    • 0345528173 scopus 로고    scopus 로고
    • Genetically modified human embryonic stem cells relieve symptomatic motor behavior in a rat model of Parkinson's disease
    • Park S., Kim E.Y., Ghil G.S., et al. Genetically modified human embryonic stem cells relieve symptomatic motor behavior in a rat model of Parkinson's disease. Neurosci Lett 353 2 (2003) 91-94
    • (2003) Neurosci Lett , vol.353 , Issue.2 , pp. 91-94
    • Park, S.1    Kim, E.Y.2    Ghil, G.S.3
  • 67
    • 0029957115 scopus 로고    scopus 로고
    • Intraventricular infusion of basic fibroblast growth factor (bFGF) in the MPTP treated common marmoset
    • Pearce R.K.B., Collins P., Jenner P., et al. Intraventricular infusion of basic fibroblast growth factor (bFGF) in the MPTP treated common marmoset. Synapse 23 (1996) 192-200
    • (1996) Synapse , vol.23 , pp. 192-200
    • Pearce, R.K.B.1    Collins, P.2    Jenner, P.3
  • 68
    • 0032796522 scopus 로고    scopus 로고
    • Chronic supranigral infusion of BDNF in normal and MPTP treated common marmosets
    • Pearce R.K.B., Costa S., Jenner P., et al. Chronic supranigral infusion of BDNF in normal and MPTP treated common marmosets. J Neural Transm 106 (1999) 663-683
    • (1999) J Neural Transm , vol.106 , pp. 663-683
    • Pearce, R.K.B.1    Costa, S.2    Jenner, P.3
  • 69
    • 0025120490 scopus 로고
    • The clinical application of cell grafting techniques in patients with Parkinson's disease
    • Quinn N.P. The clinical application of cell grafting techniques in patients with Parkinson's disease. Prog Brain Res 82 (1990) 619-625
    • (1990) Prog Brain Res , vol.82 , pp. 619-625
    • Quinn, N.P.1
  • 70
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper S.E., Chirmule N., Lee F.S., et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 80 1-2 (2003) 148-158
    • (2003) Mol Genet Metab , vol.80 , Issue.1 -2 , pp. 148-158
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3
  • 71
    • 0034756359 scopus 로고    scopus 로고
    • Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats
    • Sanchez-Pernaute R., Harvey-White J., Cunningham J., et al. Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. Mol Ther 4 4 (2001) 324-330
    • (2001) Mol Ther , vol.4 , Issue.4 , pp. 324-330
    • Sanchez-Pernaute, R.1    Harvey-White, J.2    Cunningham, J.3
  • 72
    • 17544400499 scopus 로고    scopus 로고
    • Transplantation of embryonic porcine mesencephalic tissue in patients with PD
    • Schumacher J.M., Ellias S.A., Palmer E.P., et al. Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology 54 5 (2000) 1042-1050
    • (2000) Neurology , vol.54 , Issue.5 , pp. 1042-1050
    • Schumacher, J.M.1    Ellias, S.A.2    Palmer, E.P.3
  • 73
    • 0034691506 scopus 로고    scopus 로고
    • Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease
    • Shen Y., Muramatsu S.I., Ikeguchi K., et al. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Hum Gene Ther 11 11 (2000) 1509-1519
    • (2000) Hum Gene Ther , vol.11 , Issue.11 , pp. 1509-1519
    • Shen, Y.1    Muramatsu, S.I.2    Ikeguchi, K.3
  • 74
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin J.T., Gerhardt G.A., Smith C.D., et al. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J Neurosurg 102 2 (2005) 216-222
    • (2005) J Neurosurg , vol.102 , Issue.2 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3
  • 75
    • 18144409123 scopus 로고    scopus 로고
    • Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats
    • Smith A.D., Kozlowski D.A., Bohn M.C., et al. Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats. Exp Neurol 193 2 (2005) 420-426
    • (2005) Exp Neurol , vol.193 , Issue.2 , pp. 420-426
    • Smith, A.D.1    Kozlowski, D.A.2    Bohn, M.C.3
  • 76
    • 0347031446 scopus 로고    scopus 로고
    • Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats
    • Steece-Collier K., Collier T.J., Danielson P.D., et al. Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats. Mov Disord 18 (2003) 1442-1454
    • (2003) Mov Disord , vol.18 , pp. 1442-1454
    • Steece-Collier, K.1    Collier, T.J.2    Danielson, P.D.3
  • 77
    • 0029874398 scopus 로고    scopus 로고
    • Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system
    • Svendsen C.N., Clarke D.J., Rosser A.E., et al. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp Neurol 137 2 (1996) 376-388
    • (1996) Exp Neurol , vol.137 , Issue.2 , pp. 376-388
    • Svendsen, C.N.1    Clarke, D.J.2    Rosser, A.E.3
  • 78
    • 0029114190 scopus 로고
    • Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult
    • Tomac A., Widenfalk J., Lin L.F., et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci USA 92 18 (1995) 8274-8278
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.18 , pp. 8274-8278
    • Tomac, A.1    Widenfalk, J.2    Lin, L.F.3
  • 79
    • 85047698430 scopus 로고    scopus 로고
    • Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
    • Wang L., Muramatsu S., Lu Y., et al. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene Ther 9 6 (2002) 381-389
    • (2002) Gene Ther , vol.9 , Issue.6 , pp. 381-389
    • Wang, L.1    Muramatsu, S.2    Lu, Y.3
  • 80
    • 0030834093 scopus 로고    scopus 로고
    • Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease
    • Wenning G.K., Odin P., Morrish P., et al. Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease. Ann Neurol 42 1 (1997) 95-107
    • (1997) Ann Neurol , vol.42 , Issue.1 , pp. 95-107
    • Wenning, G.K.1    Odin, P.2    Morrish, P.3
  • 81
    • 0024326943 scopus 로고
    • Grafting fibroblasts genetically modified to produce L-DOPA in a rat model of Parkinson disease
    • Wolff J.A., Fisher L.J., Xu L., et al. Grafting fibroblasts genetically modified to produce L-DOPA in a rat model of Parkinson disease. Proc Natl Acad Sci USA 86 22 (1989) 9011-9014
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.22 , pp. 9011-9014
    • Wolff, J.A.1    Fisher, L.J.2    Xu, L.3
  • 82
    • 0033616576 scopus 로고    scopus 로고
    • Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo
    • Yamada M., Oligino T., Mata M., et al. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. Proc Natl Acad Sci USA 96 7 (1999) 4078-4083
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.7 , pp. 4078-4083
    • Yamada, M.1    Oligino, T.2    Mata, M.3


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