Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat

Journal of Neural Transmission

Volumn 112, Issue 6, 2005, Pages 763-778

  Dass, B ^a   Iravani, M M ^a   Huang, C ^b   Barsoum, J ^b,c   Engber, T M ^b   Galdes, A ^b   Jenner, P ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b BIOGEN   (United States)

^c Synta Pharmaceuticals Corp   (United States)

Author keywords

6 OHDA; Adeno associated virus; Parkinson's disease; Sonic hedgehog; Substantia nigra; Viral vector

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ADENOVIRUS VECTOR; AMPHETAMINE; BETA GALACTOSIDASE; DOPAMINE; OXIDOPAMINE; SONIC HEDGEHOG PROTEIN; TYROSINE 3 MONOOXYGENASE;

ADENO ASSOCIATED VIRUS; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DNA SEQUENCE; DNA TRANSFECTION; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MALE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VIRAL GENE DELIVERY SYSTEM; VIRUS PARTICLE;

ADENOVIRIDAE; ADRENERGIC AGENTS; ANIMALS; CORPUS STRIATUM; DOPAMINE; GENETIC VECTORS; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; MALE; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; TRANS-ACTIVATORS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

EID: 18544366978     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-004-0227-7     Document Type: Article

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