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Volumn 53, Issue 2, 2009, Pages 120-128

Hypothalamic regulation of food intake and clinical therapeutic applications;Regulação hipotalâmica da ingestão alimentar e suas aplicações terapêuticas clínicas

Author keywords

Appetite; Arcuate nucleus; Hypothalamus; Obesity; Orlistat; Sibutramine

Indexed keywords


EID: 67649406272     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302009000200002     Document Type: Review
Times cited : (109)

References (80)
  • 4
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 1969;164(880):719-21.
    • (1969) Science , vol.164 , Issue.880 , pp. 719-721
    • Olney, J.W.1
  • 5
    • 1642349297 scopus 로고    scopus 로고
    • Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
    • Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004;24(11):2797-805.
    • (2004) J Neurosci , vol.24 , Issue.11 , pp. 2797-2805
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 8
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000;26(1):97-102.
    • (2000) Nat Genet , vol.26 , Issue.1 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 9
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • Cone RD. Studies on the physiological functions of the melanocortin system. Endocr Rev. 2006;27(7):736-49.
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 736-749
    • Cone, R.D.1
  • 10
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med. 1999;5(9):1066-70.
    • (1999) Nat Med , vol.5 , Issue.9 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 11
    • 0033567543 scopus 로고    scopus 로고
    • Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
    • Bagnol D, Lu XY, Kaelin CB, Day HE, Ollmann M, Gantz I, et al. Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J Neurosci. 1999;19(18):RC26.
    • (1999) J Neurosci , vol.19 , Issue.18
    • Bagnol, D.1    Lu, X.Y.2    Kaelin, C.B.3    Day, H.E.4    Ollmann, M.5    Gantz, I.6
  • 12
  • 13
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19(2):155-7.
    • (1998) Nat Genet , vol.19 , Issue.2 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 16
    • 0034802121 scopus 로고    scopus 로고
    • Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet
    • Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, et al. Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology. 2001;142(10):4394-400.
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4394-4400
    • Asnicar, M.A.1    Smith, D.P.2    Yang, D.D.3    Heiman, M.L.4    Fox, N.5    Chen, Y.F.6
  • 17
    • 17844380766 scopus 로고    scopus 로고
    • Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei
    • Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, et al. Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology. 2001;142(8):3457-63.
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3457-3463
    • Abbott, C.R.1    Rossi, M.2    Wren, A.M.3    Murphy, K.G.4    Kennedy, A.R.5    Stanley, S.A.6
  • 18
    • 0141483502 scopus 로고    scopus 로고
    • A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation
    • Kong WM, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A, et al. A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation. FASEB J. 2003;17(12):1688-90.
    • (2003) FASEB J , vol.17 , Issue.12 , pp. 1688-1690
    • Kong, W.M.1    Stanley, S.2    Gardiner, J.3    Abbott, C.4    Murphy, K.5    Seth, A.6
  • 19
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA. 1998;95(25):15043-8.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.25 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hokfelt, T.5
  • 20
    • 26444540359 scopus 로고    scopus 로고
    • Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
    • Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, et al. Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J. 2005;19(12):1680-2.
    • (2005) FASEB J , vol.19 , Issue.12 , pp. 1680-1682
    • Bewick, G.A.1    Gardiner, J.V.2    Dhillo, W.S.3    Kent, A.S.4    White, N.E.5    Webster, Z.6
  • 21
    • 0021248888 scopus 로고
    • Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
    • Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 1984;115(1):427-9.
    • (1984) Endocrinology , vol.115 , Issue.1 , pp. 427-429
    • Clark, J.T.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 22
    • 0029099078 scopus 로고
    • Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat
    • Baker RA, Herkenham M. Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat. J Comp Neurol. 1995;358(4):518-30.
    • (1995) J Comp Neurol , vol.358 , Issue.4 , pp. 518-530
    • Baker, R.A.1    Herkenham, M.2
  • 23
    • 0000573907 scopus 로고    scopus 로고
    • Hypothalamic localization of the feeding effect of agoutirelated peptide and alpha-melanocyte-stimulating hormone
    • Kim MS, Rossi M, Abusnana S, Sunter D, Morgan DG, Small CJ, et al. Hypothalamic localization of the feeding effect of agoutirelated peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000;49(2):177-82.
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 177-182
    • Kim, M.S.1    Rossi, M.2    Abusnana, S.3    Sunter, D.4    Morgan, D.G.5    Small, C.J.6
  • 24
    • 0022343686 scopus 로고
    • Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action
    • Stanley BG, Chin AS, Leibowitz SF. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res Bull. 1985;14(6):521-4.
    • (1985) Brain Res Bull , vol.14 , Issue.6 , pp. 521-524
    • Stanley, B.G.1    Chin, A.S.2    Leibowitz, S.F.3
  • 25
    • 0033304761 scopus 로고    scopus 로고
    • Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
    • Legradi G, Lechan RM. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology. 1999;140(8):3643-52.
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3643-3652
    • Legradi, G.1    Lechan, R.M.2
  • 26
    • 31544474029 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis
    • Martin NM, Smith KL, Bloom SR, Small CJ. Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis. Peptides. 2006;27(2):333-9.
    • (2006) Peptides , vol.27 , Issue.2 , pp. 333-339
    • Martin, N.M.1    Smith, K.L.2    Bloom, S.R.3    Small, C.J.4
  • 27
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
    • Broberger C, De LL, Sutcliffe JG, Hokfelt T. Hypocretin/orexin and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol. 1998;402(4):460-74.
    • (1998) J Comp Neurol , vol.402 , Issue.4 , pp. 460-474
    • Broberger, C.1    de, L.L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 28
    • 0026766094 scopus 로고
    • The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization
    • Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, et al. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol. 1992;319(2):218-45.
    • (1992) J Comp Neurol , vol.319 , Issue.2 , pp. 218-245
    • Bittencourt, J.C.1    Presse, F.2    Arias, C.3    Peto, C.4    Vaughan, J.5    Nahon, J.L.6
  • 29
    • 18444375866 scopus 로고    scopus 로고
    • Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    • Chen Y, Hu C, Hsu CK, Zhang Q, Bi C, Asnicar M, et al. Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology. 2003;143(7):2469-77.
    • (2003) Endocrinology , vol.143 , Issue.7 , pp. 2469-2477
    • Chen, Y.1    Hu, C.2    Hsu, C.K.3    Zhang, Q.4    Bi, C.5    Asnicar, M.6
  • 30
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996;380(6571):243-7.
    • (1996) Nature , vol.380 , Issue.6571 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5    Cullen, M.J.6
  • 31
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573-85.
    • (1998) Cell , vol.92 , Issue.4 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 33
    • 0023372331 scopus 로고
    • The dorsomedial hypothalamic nucleus revisited: 1986 update
    • Bernardis LL, Bellinger LL. The dorsomedial hypothalamic nucleus revisited: 1986 update. Brain Res. 1987;434(3):321-81.
    • (1987) Brain Res , vol.434 , Issue.3 , pp. 321-381
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 34
    • 0000739329 scopus 로고
    • Alpha-melanocyte stimulating hormone: Immunohistochemical identification and mapping in neurons of rat brain
    • Jacobowitz DM, O'Donohue TL. Alpha-melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Proc Natl Acad. Sci USA. 1978;75(12):6300-4.
    • (1978) Proc Natl Acad. Sci USA , vol.75 , Issue.12 , pp. 6300-6304
    • Jacobowitz, D.M.1    O'Donohue, T.L.2
  • 35
    • 0035830716 scopus 로고    scopus 로고
    • Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus
    • Mihaly E, Fekete C, Legradi G, Lechan RM. Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus. Brain Res. 2001;891(1-):20-31.
    • (2001) Brain Res , vol.891 , Issue.1 , pp. 20-31
    • Mihaly, E.1    Fekete, C.2    Legradi, G.3    Lechan, R.M.4
  • 36
    • 0032569615 scopus 로고    scopus 로고
    • Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
    • Guan XM, Yu H, Trumbauer M, Frazier E, Van der Ploeg LH, Chen H. Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport. 1998;9(15):3415-9.
    • (1998) Neuroreport , vol.9 , Issue.15 , pp. 3415-3419
    • Guan, X.M.1    Yu, H.2    Trumbauer, M.3    Frazier, E.4    van der Ploeg, L.H.5    Chen, H.6
  • 37
    • 0030894709 scopus 로고    scopus 로고
    • Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome
    • Kesterson RA, Huszar D, Lynch CA, Simerly RB, Cone RD. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol. 1997;11(5):630-7.
    • (1997) Mol Endocrinol , vol.11 , Issue.5 , pp. 630-637
    • Kesterson, R.A.1    Huszar, D.2    Lynch, C.A.3    Simerly, R.B.4    Cone, R.D.5
  • 38
    • 0032856158 scopus 로고    scopus 로고
    • Altered hypothalamic function in response to glucose ingestion in obese humans
    • Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J, et al. Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes. 1999;48(9):1801-6.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1801-1806
    • Matsuda, M.1    Liu, Y.2    Mahankali, S.3    Pu, Y.4    Mahankali, A.5    Wang, J.6
  • 40
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003;6(7):736-42.
    • (2003) Nat Neurosci , vol.6 , Issue.7 , pp. 736-742
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5    Jones, K.R.6
  • 41
    • 43049096057 scopus 로고    scopus 로고
    • Adipokines and the peripheral and neural control of energy balance
    • Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol. 2008;22(5):1023-31.
    • (2008) Mol Endocrinol , vol.22 , Issue.5 , pp. 1023-1031
    • Ahima, R.S.1    Lazar, M.A.2
  • 43
    • 35549009434 scopus 로고    scopus 로고
    • Differential accessibility of circulating leptin to individual hypothalamic sites
    • Faouzi M, Leshan R, Bjornholm M, Hennessey T, Jones J, Munzberg H. Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology. 2007;148(11):5414-23.
    • (2007) Endocrinology , vol.148 , Issue.11 , pp. 5414-5423
    • Faouzi, M.1    Leshan, R.2    Bjornholm, M.3    Hennessey, T.4    Jones, J.5    Munzberg, H.6
  • 44
    • 0036827697 scopus 로고    scopus 로고
    • Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy
    • Bagnasco M, Dube MG, Kalra PS, Kalra SP. Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology. 2002;143(11):4409-21.
    • (2002) Endocrinology , vol.143 , Issue.11 , pp. 4409-4421
    • Bagnasco, M.1    Dube, M.G.2    Kalra, P.S.3    Kalra, S.P.4
  • 45
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480-4.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6
  • 46
    • 0026523608 scopus 로고
    • Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat
    • McGowan MK, Andrews KM, Grossman SP. Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat. Physiol Behav. 1992;51(4):753-66.
    • (1992) Physiol Behav , vol.51 , Issue.4 , pp. 753-766
    • McGowan, M.K.1    Andrews, K.M.2    Grossman, S.P.3
  • 47
    • 0037109670 scopus 로고    scopus 로고
    • The catabolic action of insulin in the brain is mediated by melanocortins
    • Benoit SC, Air EL, Coolen LM, Strauss R, Jackman A, Clegg DJ, et al. The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci. 2002;22(20):9048-52.
    • (2002) J Neurosci , vol.22 , Issue.20 , pp. 9048-9052
    • Benoit, S.C.1    Air, E.L.2    Coolen, L.M.3    Strauss, R.4    Jackman, A.5    Clegg, D.J.6
  • 48
    • 0021266185 scopus 로고
    • Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat
    • ter Horst GJ, Luiten PG, Kuipers F. Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat. J Auton Nerv Syst. 1984;11(1):59-75.
    • (1984) J Auton Nerv Syst , vol.11 , Issue.1 , pp. 59-75
    • ter Horst, G.J.1    Luiten, P.G.2    Kuipers, F.3
  • 49
    • 0024836522 scopus 로고
    • Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat
    • ter Horst GJ, de BP, Luiten PG, van Willigen JD. Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat. Neuroscience. 1989;31(3):785-97.
    • (1989) Neuroscience , vol.31 , Issue.3 , pp. 785-797
    • ter Horst, G.J.1    de, B.P.2    Luiten, P.G.3    van Willigen, J.D.4
  • 50
    • 0015701039 scopus 로고
    • Cholecystokinin decreases food intake in rats
    • Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol. 1973 84(3):488-95.
    • (1973) J Comp Physiol Psychol , vol.84 , Issue.3 , pp. 488-495
    • Gibbs, J.1    Young, R.C.2    Smith, G.P.3
  • 51
    • 0019381381 scopus 로고
    • C-terminal octapeptide of cholecystokinin decreases food intake in man
    • Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr. 1981;34(2):154-60.
    • (1981) Am J Clin Nutr , vol.34 , Issue.2 , pp. 154-160
    • Kissileff, H.R.1    Pi-Sunyer, F.X.2    Thornton, J.3    Smith, G.P.4
  • 52
    • 0024602756 scopus 로고
    • Evidence for a physiological role for CCK in the regulation of food intake in mice
    • Silver AJ, Flood JF, Song AM, Morley JE. Evidence for a physiological role for CCK in the regulation of food intake in mice. Am J Physiol. 1989;256(3 Pt 2):R646-R652.
    • (1989) Am J Physiol , vol.256 , Issue.3 PART. 2
    • Silver, A.J.1    Flood, J.F.2    Song, A.M.3    Morley, J.E.4
  • 53
    • 39649117330 scopus 로고    scopus 로고
    • Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration
    • Chen J, Scott KA, Zhao Z, Moran TH, Bi S. Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration. Neuroscience. 2008;152(1):178-88.
    • (2008) Neuroscience , vol.152 , Issue.1 , pp. 178-188
    • Chen, J.1    Scott, K.A.2    Zhao, Z.3    Moran, T.H.4    Bi, S.5
  • 54
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 1996;379(6560):69-72.
    • (1996) Nature , vol.379 , Issue.6560 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3    Beak, S.A.4    Edwards, C.M.5    Meeran, K.6
  • 55
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • Larsen PJ, Tang-Christensen M, Jessop DS. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology. 1997;138(10):4445-55.
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.S.3
  • 56
    • 50949094723 scopus 로고    scopus 로고
    • Arcuate GLP-1 receptors regulate glucose homeostasis but not food intake
    • Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ. Arcuate GLP-1 receptors regulate glucose homeostasis but not food intake. Diabetes. 2008;57(8):2046-54.
    • (2008) Diabetes , vol.57 , Issue.8 , pp. 2046-2054
    • Sandoval, D.A.1    Bagnol, D.2    Woods, S.C.3    D'Alessio, D.A.4    Seeley, R.J.5
  • 57
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, et al. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res. 2005;1044(1):127-31.
    • (2005) Brain Res , vol.1044 , Issue.1 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.6
  • 59
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003;37(4):649-61.
    • (2003) Neuron , vol.37 , Issue.4 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6
  • 61
    • 2942538088 scopus 로고    scopus 로고
    • Action of MT-II on ghrelininduced feeding in the paraventricular nucleus of the hypothalamus
    • Shrestha YB, Wickwire K, Giraudo SQ. Action of MT-II on ghrelininduced feeding in the paraventricular nucleus of the hypothalamus. Neuroreport. 2004;15(8):1365-7.
    • (2004) Neuroreport , vol.15 , Issue.8 , pp. 1365-1367
    • Shrestha, Y.B.1    Wickwire, K.2    Giraudo, S.Q.3
  • 62
  • 63
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol. 2003;23(22):7973-81.
    • (2003) Mol Cell Biol , vol.23 , Issue.22 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 65
    • 33646517058 scopus 로고    scopus 로고
    • Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
    • Boey D, Lin S, Karl T, Baldock P, Lee N, Enriquez R, et al. Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia. 2006;49(6):1360-70.
    • (2006) Diabetologia , vol.49 , Issue.6 , pp. 1360-1370
    • Boey, D.1    Lin, S.2    Karl, T.3    Baldock, P.4    Lee, N.5    Enriquez, R.6
  • 66
    • 0037847510 scopus 로고    scopus 로고
    • Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    • Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 2003;124(5):1325-36.
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1325-1336
    • Asakawa, A.1    Inui, A.2    Yuzuriha, H.3    Ueno, N.4    Katsuura, G.5    Fujimiya, M.6
  • 68
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway-new players upstream and downstream
    • Hardie DG. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci. 2004;117(Pt 23):5479-87.
    • (2004) J Cell Sci , vol.117 , Issue.PART. 23 , pp. 5479-5487
    • Hardie, D.G.1
  • 69
    • 1842484296 scopus 로고    scopus 로고
    • AMP kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004;428(6982):569-74.
    • (2004) Nature , vol.428 , Issue.6982 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5    Xue, B.6
  • 70
    • 40749132626 scopus 로고    scopus 로고
    • Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    • McCrimmon RJ, Shaw M, Fan X, Cheng H, Ding Y, Vella MC, et al. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes. 2008;57(2):444-50.
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 444-450
    • McCrimmon, R.J.1    Shaw, M.2    Fan, X.3    Cheng, H.4    Ding, Y.5    Vella, M.C.6
  • 71
    • 33750283223 scopus 로고    scopus 로고
    • Hindbrain catecholamine neurons control multiple glucoregulatory responses
    • Ritter S, Dinh TT, Li AJ. Hindbrain catecholamine neurons control multiple glucoregulatory responses. Physiol Behav. 2006;89(4):490-500.
    • (2006) Physiol Behav , vol.89 , Issue.4 , pp. 490-500
    • Ritter, S.1    Dinh, T.T.2    li, A.J.3
  • 72
    • 3843114555 scopus 로고    scopus 로고
    • Hypothalamic responses to long-chain fatty acids are nutritionally regulated
    • Morgan K, Obici S, Rossetti L. Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem. 2004;279(30):31139-48.
    • (2004) J Biol Chem , vol.279 , Issue.30 , pp. 31139-31148
    • Morgan, K.1    Obici, S.2    Rossetti, L.3
  • 74
    • 1042286441 scopus 로고    scopus 로고
    • Ventral striatal control of appetitive motivation: Role in ingestive behavior and reward-related learning
    • Kelley AE. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev. 2004;27(8):765-76.
    • (2004) Neurosci Biobehav Rev , vol.27 , Issue.8 , pp. 765-776
    • Kelley, A.E.1
  • 75
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev. 2006;27(1):73-100.
    • (2006) Endocr Rev , vol.27 , Issue.1 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3    Lutz, B.4    Pasquali, R.5
  • 77
    • 53749083810 scopus 로고    scopus 로고
    • Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
    • Ellrichman M, Kapelle M, Ritter PR, Holst JJ, Herzig KH, Schmidt WE, et al. Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations. J Clin Endocrinol Metab. 2008;93(10):3995-8.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 3995-3998
    • Ellrichman, M.1    Kapelle, M.2    Ritter, P.R.3    Holst, J.J.4    Herzig, K.H.5    Schmidt, W.E.6
  • 78
    • 42149124403 scopus 로고    scopus 로고
    • Targeting melanocortin receptors: An approach to treat weight disorders and sexual dysfunction
    • Wikberg JE, Mutulis F. Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nat Rev Drug Discov. 2008;7(4):307-23.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.4 , pp. 307-323
    • Wikberg, J.E.1    Mutulis, F.2
  • 79
    • 35348968460 scopus 로고    scopus 로고
    • Neuropeptide Y receptor selective ligands in the treatment of obesity
    • Kamiji MM, Inui A. Neuropeptide Y receptor selective ligands in the treatment of obesity. Endocr Rev. 2007;28(6):664-84.
    • (2007) Endocr Rev , vol.28 , Issue.6 , pp. 664-684
    • Kamiji, M.M.1    Inui, A.2
  • 80
    • 15444368875 scopus 로고    scopus 로고
    • Serotonin (5-HT) drugs: Effects on appetite expression and use for the treatment of obesity
    • Halford JC, Harrold JA, Lawton CL, Blundell JE. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets. 2005;6(2):201-13.
    • (2005) Curr Drug Targets , vol.6 , Issue.2 , pp. 201-213
    • Halford, J.C.1    Harrold, J.A.2    Lawton, C.L.3    Blundell, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.