Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13373-13383

  Rodríguez Escudero, Isabel ^a   Andrés Pons, Amparo ^b   Pulido, Rafael ^b   Molina, María ^a   Cid, Víctor J ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; ANIMAL CELLS; CATALYTIC ACTIVITY; CATALYTIC SUBUNITS; CELLULAR MEMBRANES; CO-EXPRESSION; DELETERIOUS EFFECTS; HYDROPHOBIC MOTIFS; IN-VIVO; ISOFORMS; MAMMALIAN PROTEINS; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; PLECKSTRIN HOMOLOGY DOMAINS; PROTEIN KINASE B; RE-LOCALIZATION; REPORTER SYSTEMS; S.CEREVISIAE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTIONAL TARGETS; WILD TYPES; YEAST CELL; YEAST CELL GROWTH; YEAST SYSTEMS;

CELL GROWTH; CHEMICAL ACTIVATION; GROWTH KINETICS; MAMMALS; PHOSPHORYLATION; TOXICITY; YEAST;

CELL MEMBRANES;

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110 ALPHA; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOENZYME; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO1 PROTEIN, S CEREVISIAE; ROM2 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SLT2 PROTEIN, S CEREVISIAE;

ARTICLE; CARCINOGENICITY; CATALYSIS; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; GROWTH INHIBITION; HYDROPHOBICITY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PLECKSTRIN HOMOLOGY DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WILD TYPE; YEAST CELL; ANIMAL; BIOLOGICAL MODEL; GENETICS; MAMMAL; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE;

ANIMALIA; MAMMALIA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; ISOENZYMES; MAMMALS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTAGENESIS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RHO GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 67649403598     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807867200     Document Type: Article

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