Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells

Toxicology

Volumn 262, Issue 1, 2009, Pages 57-64

  Andersson, Helén ^a   Piras, Elena ^a   Demma, Jemal ^a   Hellman, Björn ^a   Brittebo, Eva ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

1 Nitropyrene; Diesel exhaust; DNA damage; Endothelium; ER stress; HUVEC

Indexed keywords

1 NITROPYRENE; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; COMPLEMENTARY DNA; DICOUMAROL; GLUCOSE REGULATED PROTEIN 78; REACTIVE OXYGEN METABOLITE; RNA;

AIR POLLUTANT; ARTICLE; CELL STRESS; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; EXPOSURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; METABOLISM; METABOLITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UMBILICAL VEIN; WESTERN BLOTTING;

AIR POLLUTANTS; CELL SURVIVAL; DICUMAROL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; POLYCHLORINATED BIPHENYLS; PYRENES; REACTIVE OXYGEN SPECIES; UMBILICAL VEINS; VEHICLE EMISSIONS;

EID: 67649336393     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.05.008     Document Type: Article

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