Reductions of nitro and 9-oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro

Chemical Research in Toxicology

Volumn 13, Issue 8, 2000, Pages 793-800

  Ritter, C L ^a   Decker, R W ^a   Malejka Giganti, D ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NITROFLUORENE; 2,7 DINITROFLUORENE; 9 HYDROXY 2 NITROFLUORENE; 9 HYDROXY 2,7 DINITROFLUORENE; 9 OXO 2 NITROFLUORENE; 9 OXO 2,7 DINITROFLUORENE; FLUORENE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CATALYSIS; CONTROLLED STUDY; CYTOSOL; ENVIRONMENTAL EXPOSURE; FEMALE; GENOTOXICITY; METABOLIC INHIBITION; MICROSOME; NONHUMAN; RAT; REDUCTION; XENOBIOTIC METABOLISM;

AIR POLLUTANTS; ALLOPURINOL; ANIMALS; BREAST; CYTOSOL; DICUMAROL; FEMALE; FLUORENES; HYPOXANTHINE; INDOMETHACIN; MICROSOMES; NIACINAMIDE; OXIDATION-REDUCTION; OXYGEN; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RUTIN; VITAMIN K; XANTHINE;

ANIMALIA;

EID: 0033836892     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0000567     Document Type: Article

References (49)

1. Sampling of vehicle emissions for chemical analysis and biological testing
2. Ubiquitous occurrence of 2-nitrofluoranthene and 2-nitropyrene in air
3. 2-Nitrofluorene and related compounds: Prevalence and biological effects
4. In vivo metabolism and genotoxic effects of nitrated polycyclic aromatic hydrocarbons
5. Phototransformation of 2-aminofluorene into N-oxidized mutagens
6. 2-Nitrofluoren-9-one: A unique mutagen formed in the photooxidation of 2-aminofluorene
7. The carcinogenicity of compounds related to 2-acetylaminofluorene. II. Variations in the bridges and the 2-substituent
8. Carcinogenicities of derivatives of fluorene and biphenyl: Fluoro derivatives as probes for active sites in 2-acetylamino-fluorene
9. Induction and extinction of mammary cancer
10. Potent carcinogenicity of 2,7-dinitrofluorene, an environmental pollutant, for the mammary gland of female Sprague-Dawley rats
11. Induction of mammary cancer by 6-nitrochrysene in female CD rats
12. Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat
13. Environmental carcinogens that may be involved in human breast cancer etiology
14. Nitrated fluorene derivatives are potent frame-shift mutagens
15. Disubstituted amino-, nitroso-, and nitrofluorenes: A physicochemical basis for structure-activity relationships in Salmonella typhimurium
16. Metabolism of nitro-polycyclic aromatic hydrocarbons
17. Nitroreduction of nitrated and C-9 oxidized fluorenes in vitro
18. Nitroreduction of environmental nitrofluorenes by enzymes and mammary gland in vitro
19. The role of the intestinal microflora in the formation of mutagenic metabolites from the carcinogenic air pollutant 2-nitrofluorene
20. Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7-and 9-hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene
21. Substituted fluoren-9-ols
22. Debenzoylating and deacetylating activities of rat liver and mammary gland microsomes: Effect of ovariectomy
23. Activation of the carcinogen N-hydroxy-N-(2-fluorenyl)benzamide via chemical and enzymatic oxidations. Comparison to oxidations of the structural analogue N-hydroxy-N-(2-fluorenyl)acetamide
24. Subcellular localization of xanthine oxidase in rat hepatocytes: High-resolution immunoelectron microscopic study combined with biochemical analysis
25. Non-enzymatic and enzymatic activation of mitomycin c: Identification of a unique cytosolic activity
26. Reductive metabolism of nitroaromatic and nitropolycyclic aromatic hydrocarbons
27. Xanthine oxidase and aldehyde oxidase
28. Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)
29. Dinitropyrene nitroreductase activity of purified NAD(P)H-quinone oxidoreductase: Role in rat liver cytosol and induction by Aroclor-1254 pretreatment
30. Alcohol dehydrogenase
31. Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide
32. Nitro-reductase activity of mammalian liver aldehyde oxidase
33. Xenobiotic carbonyl reduction and physiological steroid oxidoreduction: The pluripotency of several hydroxysteroid dehydrogenases
34. Effect of dietary butylated hydroxytoluene on the in vivo distribution metabolism and DNA-binding of 7,12-dimethylbenz[a]anthracene
35. Cytosolic NAD(P)H:(Quinone- acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
36. Purification and some properties of two enzymes from rat liver cytosol that catalyze carbonyl reduction of 6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione, a metabollte of 3-tert-butyl-4-hydroxyanisole
37. Steroid metabolism in the normal mammary gland and in the dimethyl-benzanthracene-induced mammary tumor of rats
38. Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs
39. Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates
40. The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action: Role of type-1 11β-hydroxysteroid dehydrogenase in detoxification processes
41. DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: Effects of nitroreductase induction
42. 32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats
43. DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene
44. 2-deoxyguanosinyl DNA adducts upon nitroreduction of the environmental mutagen 1-nitropyrene
45. Nitroreduction of 4-nitropyrene is primarily responsible for DNA adduct formation in the mammary gland of female CD rats
46. Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction
47. Preneoplastic lesions and DNA adduct formation of the airborne genotoxic agents 2-nitrofluorene and 2,7-dinitrofluorene