The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically-competent MCL-5 cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 445, Issue 1, 1999, Pages 21-43

  Martin, Francis L ^a   Cole, Kathleen J ^a   Orme, Mariam H ^a   Grover, Philip L ^a   Phillips, David H ^a   Venitt, Stanley ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Comet assay; Cytosine arabinoside; DNA repair inhibitor; Genotoxicity; Hydroxyurea; MCL 5 cell; Single strand break

Indexed keywords

1 NITROPYRENE; 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 2 METHYLANILINE; 2 NITROFLUORENE; 3 METHYLCHOLANTHRENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANILINE; BENZENE; BENZO[A]PYRENE; BLEOMYCIN; CHROMIUM CHLORIDE; CISPLATIN; CYTARABINE; DIETHYLSTILBESTROL; HYDROXYUREA; LINDANE; METHYLNITRONITROSOGUANIDINE; PYRIDINE DERIVATIVE; QUINOXALINE DERIVATIVE; SODIUM CHROMATE;

ARTICLE; CELL VIABILITY; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS INHIBITION; EXCISION REPAIR; GEL ELECTROPHORESIS; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPRODUCIBILITY;

AMINES; BENZENE; BLEOMYCIN; CELL LINE; CELL SURVIVAL; CHLORIDES; CHROMATES; CHROMIUM COMPOUNDS; CISPLATIN; CYTARABINE; DIETHYLSTILBESTROL; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROXYUREA; LINDANE; METHYLNITRONITROSOGUANIDINE; MUTAGENICITY TESTS; NITRO COMPOUNDS; NUCLEIC ACID SYNTHESIS INHIBITORS; POLYCYCLIC HYDROCARBONS, AROMATIC; RADIATION, IONIZING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SODIUM COMPOUNDS; SUCROSE;

EID: 0032853153     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00116-3     Document Type: Article

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