Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate

American Journal of Clinical Nutrition

Volumn 86, Issue 4, 2007, Pages 1040-1044

  Zimmermann, Michael B ^a,b   Jooste, Pieter L ^c   Mabapa, Ngoako Solomon ^d   Schoeman, Serena ^c   Biebinger, Ralf ^a   Mushaphi, Linda F ^d   Mbhenyane, Xikombiso ^d  

^a ETH ZURICH   (Switzerland)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF VENDA   (South Africa)

Author keywords

Africa; Children; Deficiency; Iodine; Supplementation; Vitamin A

Indexed keywords

IODINE; RETINOL; RETINOL PALMITATE; THYROTROPIN;

ADOLESCENT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IODINE DEFICIENCY; MALE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RETINOL DEFICIENCY; SCHOOL CHILD; URINALYSIS; VITAMIN SUPPLEMENTATION;

EID: 35148844139     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.4.1040     Document Type: Article

References (40)

1. World Health Organization. Micronutrient deficiency information system. Internet: http://www.who.int/nut/dbr_mdis (accessed 25 September 2006).
2. World Health Organization. Vitamin A deficiency and iodine deficiency disorders: prevalence estimates for the global burden of disease. Micronutrient Deficiency Information System (MDIS). Geneva, Switzerland: World Health Organization, 2001.
3. World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination. Geneva, Switzerland: World Health Organization, 2001 (WHO/NHD/01.1.)
4. West KP. Extent of vitamin A deficiency among preschool children and women of reproductive age. J Nutr 2002;132(suppl):2857-66S
5. Zimmermann MB, Adou P, Zeder C, et al. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in the Côte d'Ivoire. Am J Clin Nutr 2000;71:88-93.
6. Chaouki N, Ottmani S, Saad A, et al. The prevalence of iodine deficiency disorders in children 6-12 years old in Morocco. Bull Epidemiol Morocco 1996;1:2-23.
7. The Ministry of Health. Micronutrient deficiencies: prevalence and strategies for control. Rabat, Morocco: Ministry of Health of Morocco, 2001.
8. Boyages SC. Iodine deficiency disorders. J Clin Endocrinol Metab 1993;77:587-91.
9. Thilly CH, Vanderpas JB, Bebe N, et al. Iodine deficiency, other trace elements and goitrogenic factors in the etiopathology of iodine deficiency disorders. Biol Trace Elem Res 1992;32:229-243.
10. Hurrell RF. Bioavailability of iodine. Eur J Clin Nutr 1997;51(suppl):S9-12.
11. Zimmermann MB, Köhrle J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid 2002;12:867-78.
12. Vanderpas JB, Contempre B, Duale NL, et al. Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. Am J Clin Nutr 1993;57(suppl):271S-5S.
13. Arthur JR, Beckett M, Mitchell JH. Interactions between selenium and iodine deficiencies in man and animals. Nutr Res Rev 1999;12:55-73.
14. Hess SY, Zimmermann MB. The effect of micronutrient deficiencies on iodine nutrition and thyroid metabolism. Int J Vitam Nutr Res 2004;74:103-15.
15. Zimmermann MB, Wegmueller R, Zeder C, Chaouki N, Torresani T. The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children. J Clin Endocrinol Metab 2004;89:5441-7.
16. Drill VA. Interrelations between thyroid function and vitamin metabolism. Physiol Rev 1943;23:355-79.
17. Nockels CF, Ewing DL, Phetteplace H, et al. Hypothyroidism: an early sign of vitamin A deficiency in chickens. J Nutr 1984;114:1733-6.
18. Oba K, Kimura S. Effects of vitamin A deficiency on thyroid function and serum thyroxine levels in the rat. J Nutr Sci Vitaminol (Tokyo) 1980;26:327-34.
19. Strum JM. Alterations within the rat thyroid gland during vitamin A deficiency. Am J Anat 1979;156:169-82.
20. Ingenbleek Y. Vitamin A deficiency impairs the normal mannosylation, conformation and iodination of the thyroglobulin: a new etiological approach to endemic goiter. Experientia Suppl 1983;44:264-97.
21. Morley JE, Damassa DA, Gordon J, et al. Thyroid function and vitamin A deficiency. Life Sci 1978;22:1901-5.
22. Brown G, Brennan RD, Yates FE. Simulation of the thyroid hormone-binding protein interactions in human plasma. J Clin Endocrinol Metab 1970;30:733-51.
23. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev 2002;60:374-7.
24. Brown NS, Smart A, Sharma V, et al. Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse. J Clin Invest 2000;106:73-9.
25. Haugen BR, Brown NS, Wood WM, et al. The thyrotrope-restricted isoform of the retinoid-X receptor-gamma1 mediates 9-cis-retinoic acid suppression of thyrotropin-beta promoter activity. Mol Endocrinol 1997;11:481-9.
26. Breen JJ, Matsuura T, Ross AC, et al. Regulation of thyroid-stimulating hormone beta-subunit and growth hormone messenger ribonucleic acid levels in the rat: effect of vitamin A status. Endocrinology 1995;136:543-9.
27. Coya R, Carro E, Mallo F, et al. Retinoic acid inhibits in vivo thyroid-stimulating hormone secretion. Life Sci 1997;60:247-50.
28. Biebinger R, Arnold M, Langhans W, Hurrell RF, Zimmermann MB. Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSH-beta gene expression and reduces thyroid hyperstimulation and thyroid size. J Nutr 2007;137:573-7.
29. Zimmermann MB, Hess SY, Molinari L, et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a WHO/NHD Iodine Deficiency Study Group Report. Am J Clin Nutr 2004;79:231-7.
30. Pino S, Fang SL, Braverman LE. Ammonium persulfate: a safe alternative oxidizing reagent for measuring urinary iodine. Clin Chem 1996;42:239-43.
31. Torresani T, Scherz R. Thyroid screening of neonates without use of radioactivity: evaluation of time-resolved fluoroimmunoassay of thyrotropin. Clin Chem 1986;32:1013-6.
32. Zimmermann MB, de Benoist B, Corigliano S, et al. Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. J Clin Endocrinol Metab 2006;Sep 12 (Epub ahead of print).
33. De Leenheer AP, de Bevre V, de Ruyter MGM, et al. Simultaneous determination of retinol and alpha-tocopherol in human serum by HPLC. J Chromatogr 1979;162:402.
34. World Health Organization. Indicators for assessing vitamin A deficiency and their application in monitoring and evaluating intervention programmes. Geneva, Switzerland: World Health Organization, 1996. (WHO/NUT/96.10.)
35. Morley JE, Melmed S, Reed A, et al. Effect of vitamin A on the hypothalamo-pituitary-thyroid axis. Am J Physiol 1980;238:E174-9.
36. Sherman SI, Gopal J, Haugen BR, et al. Central hypothyroidism associated with retinoid X receptor-selective ligands. N Engl J Med 1999;340:1075-9.
37. Ingenbleek Y, De Visscher M. Hormonal and nutritional status: critical conditions for endemic goiter epidemiology? Metabolism 1979;28:9-19.
38. Ingenbleek Y, Luypaert B, De Nayer P. Nutritional status and endemic goitre. Lancet 1980;1:388-91.
39. Wolde-Gebriel Z, West CE, Gebru H, et al. Interrelationship between vitamin A, iodine and iron status in schoolchildren in Shoa Region, central Ethiopia. Br J Nutr 1993;70:593-607.
40. Florentino RF, Tanchoco CC, Rodriguez MP, et al. Interactions among micronutrient deficiencies and undernutrition in the Philippines. Biomed Environ Sci 1996;9:348-57.