Administration of iodized oil during pregnancy: A summary of the published evidence

Bulletin of the World Health Organization

Volumn 74, Issue 1, 1996, Pages 101-108

  Delange, F ^a,b  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

^b SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE;

AFRICA; CONGENITAL HYPOTHYROIDISM; DRUG THERAPY; ENDEMIC DISEASE; EPIDEMIOLOGY; HUMAN; IODINE DEFICIENCY; PREGNANCY; PREVENTION; REVIEW; THYROID FUNCTION; WORLD HEALTH ORGANIZATION;

DEFICIENCY DISEASES; DELIVERY OF HEALTH CARE; DISEASES; FOOD SUPPLEMENTATION; HEALTH; HEALTH SERVICES; LITERATURE REVIEW; NUTRITION DISORDERS; NUTRITION PROGRAMS; PREGNANCY; PRIMARY HEALTH CARE; REPRODUCTION;

BRAIN DAMAGE, CHRONIC; CONGENITAL HYPOTHYROIDISM; FEMALE; HUMANS; HYPOTHYROIDISM; INFANT, NEWBORN; IODINE; IODIZED OIL; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 0030009013     PISSN: 00429686     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Dunn JT. The use of iodized oil and other alternatives for the elimination of iodine deficiency disorders. In: Hetzel BS, Pandav CS, eds. S.O.S. for a billion. The conquest of iodine deficiency disorders. New Delhi, Oxford University Press, 1994: 108-117.
2. Buttfield IH, Pharoah POD, Hetzel BS. Evidence of prevention of neurological defect in New Guinea children by iodized oil injection of mothers prior to pregnancy. In: Fellinger K, Höfer R, eds. Further advances in thyroid research. Vienna, Wiener Medizinische Akademie, 1971: 53-59.
3. Fierro-Benitez R et al. The effect of goitre prophylaxis with iodized oil on the prevention of endemic cretinism. In: Fellinger K, Höfer R, eds. Further advances in thyroid research. Vienna, Wiener Medizinische Akademie, 1971: 61-77.
4. Pharoah POD, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet, 1971, 1: 308-310.
5. Ramirez I et al. The results of prophylaxis of endemic cretinism with iodized oil in rural Andean Ecuador. In: Stanbury JB, Kroc RL, eds. Human development and the thyroid gland. Relation to endemic cretinism. New York, Plenum Press, 1972: 223-237.
6. Thilly CH et al. Endemic goitre prophylaxis by iodized oil: a reassessment. Journal of clinical endocrinology and metabolism, 1973, 36: 1196-1204.
7. Delange F et al. Evidence for fetal hypothyroidism in severe endemic goitre. In: Robbins J, Braverman LE, eds. Thyroid research. Amsterdam, Excerpta Medica, 1976: 493-496.
8. Thilly CH et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goitre. Journal of clinical endocrinology and metabolism, 1978, 47: 354-360.
9. Thilly C et al. Prevention of myxedematous cretinism with iodized oil during pregnancy. In: Ui N et al., eds. Current problems in thyroid research. Amsterdam, Excerpta Medica, 1983: 386-389.
10. Delange F. Anomalies in physical and intellectual development associated with severe endemic goitre. In: Dunn JT et al., eds. Towards eradication of endemic goitre, cretinism and iodine deficiency. Washington, Pan American Health Organization, 1986: 40-57 (PAHO Scietific Publ. No. 502).
11. Pharoah POD, Connolly KJ. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. International journal of epidemiology, 1987, 16: 68-73.
12. Vanderpas J, Thilly CH. Endemic neonatal, infantile and juvenile hypothyroidism in Ubangi, Northern Zaire: clinical consequences and prevention. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994: 209-224.
13. Cao XY et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. New England journal of medicine, 1994, 331: 1739-1744.
14. Dodge PR et al. Effect on intelligence of iodine in oil administered to young Andean children: a preliminary report. In: Stanbury JB, ed. Endemic goitre. Washington, Pan American Health Organization, 1969: 378-380 (PAHO Scientific Publ. No. 193).
15. Trowbridge FL. Intellectual assessment in primitive societies, with a preliminary export of a study of the effects of early iodine supplementation on intelligence. In: Stanbury JB, Kroc RL, eds. The thyroid gland: relation to endemic cretinism. New York, Plenum Press, 1972: 137-150.
16. Greene LS. Physical growth and development, neurological maturation and behavioral functioning in two Andean communities in which goitre is endemic. American journal of physical anthropology, 1973, 38: 119-134.
17. Fierro-Benitez R et al. The role of iodine deficiency in intellectual development in an area of endemic goitre In: Dunn J. Medeiros-Neto GA, eds. Endemic goitre and cretinism: continuing threats to world health. Washington, Pan American Health Organization, 1974: 135-142 (PAHO Scientific Publ. No. 292).
18. Connolly KJ, Pharoah POD, Hetzel BS. Fetal iodine deficiency and motor performance during childhood. Lancet, 1979, 2: 1149-1151.
19. Thilly C et al. Fetomaternal relationship, fetal hypothyroidism, and psychomotor retardation. In: Ermans AM et al., eds. Role of cassava in the etiology of endemic goitre and cretinism. Ottawa, International Development Research Center, 1980: 111-120.
20. Pharoah P et al. Maternal thyroid function and motor competence in the child. Developmental medicine and child neurology, 1981, 23: 76-82.
21. Bautista A et al. The effects of oral iodized oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goitre. American journal of clinical nutrition, 1982, 35: 127-134.
22. Pharoah POD et al. Maternal thyroid hormone levels in pregnancy and the subsequent cognitive and motor performance of the children. Clinical endocrinology, 1984, 21: 265-270,
23. Muzzo S, Leiva L, Carrasco D. Possible etiological factors and consequences of a moderate iodine deficiency on intellectual coefficient of school-age children. In: Medeiros-Neto GA, Gaitan E, eds. Frontiers of thyroidology. New York, Plenum Press, 1985: 1001-1005.
24. Kochupillai N et al. Iodine deficiency and neonatal hypothyroidism. Bulletin of the World Health Organization, 1986, 64: 547-551.
25. Fierro-Benitez R et al. Long-term effects of correction of iodine deficiency on psychomotor and intellectual development. In: Dunn JT et al., eds. Towards the eradication of endemic goitre, cretinism and iodine deficiency. Washington, Pan American Health Organization. 1986: 182-200 (PAHO Scientific Publ. No. 502).
26. Bleichrodt N et al. Developmental disorders associated with severe iodine deficiency. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The prevention and control of iodine deficiency disorders. Amsterdam, Elsevier, 1987: 65-84.
27. Boyages SC et al. Iodine deficiency impairs intellectual and neuromotor development in apparently normal persons. Medical journal of Australia, 1989, 150: 676-682.
28. Ma T et al. Neuropsychological studies in iodine deficiency areas in China. In: Delong GR, Robbins J, Condliffe G, eds. Iodine and the brain. New York, Plenum Press, 1989: 259-268.
29. Pharoah POD, Connolly KJ. Effects of maternal iodine supplementation during pregnancy. Archives of diseases in childhood, 1991, 66: 145-147.
30. Halpern JP et al. The neurology of endemic cretinism. Brain, 1991, 114: 825-841.
31. Bleichrodt N, Born MP. A metanalysis of research on iodine and its relationship to cognitive development, in: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994; 195-200.
32. Connolly KJ, Pharoah POD. Subclinical effects of iodine deficiency: problems of assessment. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994: 27-36.
33. Hetzel BS. Iodine deficiency and fetal brain damage. New England journal of medicine, 1994, 331: 1770-1771.
34. O'Donnell K et al. Iodine supplementation and infant psychological development in an IDD endemic area in China. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994: 287-292.
35. Pretell E, Caceres A. Impairment of mental development by iodine deficiency and its correction: a retrospective view of studies in Peru. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994: 287-292.
36. Shresta RM. Effect of iodine and iron supplementation on physical, psychomotor and mental development in primary schoolchildren in Malawi. Thesis, University of Wageningen, 1994 (ISBN 90-5485-234-8).
37. Pretell EA. The optimal program for prophylaxis of endemic goitre with iodized oil. In: Stanbury JB, Kroc RL, eds. Human development and the thyroid gland: relation to endemic cretinism. Advances in experimental medicine and biology, 1972, 30: 267-288.
38. Ibbertson HK. Goitre and cretinism in the Himalayas: a reassessment. In: Dunn JT, Medeiros-Neto GA, eds. Endemic goitre and cretinism: continuing threats to world health. Washington, Pan American Health Organization, 1974: 129-134 (PAHO Scientific Publ. No. 292).
39. Croxson MS, Gluckman PD, Ibbertson HK. The acute thyroidal response to iodized oil in severe endemic goitre. Journal of clinical endocrinology and metabolism, 1976, 42: 926.
40. Ibbertson HK. Endemic goitre and cretinism. Journal of clinical endocrinology and metabolism, 1979, 8: 97-128.
41. Matovinovic J. Complications of goitre prophylaxis. In: Stanbury JB, Hetzel BS, eds. Endemic goitre and endemic cretinism. New York, John Wiley, 1980: 533-549.
42. Hetzel BS et al. Iodized oil in the prevention of endemic goitre and cretinism. In: Stanbury JB, Hetzel BS, eds. Endemic goitre and endemic cretinism. New York, John Wiley, 1980: 513-532.
43. Matovinovic J. Endemic goitre and cretinism at the dawn of the third millennium. Annual review of nutrition, 1983, 3: 341-412.
44. Fradkin JE, Wolff J. Iodide-induced thyrotoxicosis. Medicine, 1983, 62: 1-20.
45. Martins MC et al. Natural course of iodine-induced thyrotoxicosis (Jodbasedow) in an endemic goitre area: a 5-year follow-up. Journal of endocrinological investigation, 1989, 12: 239-244.
46. Connolly RJ, Vidor GI, Stewart JC. Increase in thyrotoxicosis in endemic goitre area after iodation of bread. Lancet, 1970, 1: 500-502.
47. Fierro-Benitez R et al. Iodized oil in the prevention of endemic goitre and associated defects in the Andean region of Ecuador. I. Program design effects on goitre prevalence, thyroid function, and iodine excretion. In: Stanbury JB, ed. Endemic goitre. Washington, Pan American Health Organization, 1969: 306-321 (PAHO Scientific Publ. No. 193).
48. Pretell EA et al. Prophylaxis and treatment of endemic goitre in Peru with iodized oil. Journal of clinical endocrinology and metabolism, 1969, 29: 1586-1595.
49. Watanabe T et al. Iodized oil in the prophylaxis of endemic goitre in Argentina. In: Dunn JT, Medeiros-Neto GA, eds. Endemic goitre and cretinism: continuing threats to world health. Washington, Pan American Health Organization, 1974: 231-241 (PAHO Scientific Publ. No. 292).
50. Buttfield IH, Hetzel BS. Endemic goitre in New Guinea and the prophylactic program with iodinated poppy seed oil. In: Stanbury JB, ed. Endemic goitre. Washington, Pan American Health Organization, 1969: 132-148 (PAHO Scientific Publ. No. 193).
51. Lagasse R et al. Mass treatment with iodized oil. In: Ermans AM et al., eds. Role of cassava in the etiology of endemic goitre and cretinism. Ottawa, International Development Research Centre, 1980: 81-92.
52. Acharya S. Monitoring and evaluation of IDD control program in Nepal. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The prevention and control of iodine deficiency disorders. Amsterdam, Elsevier. 1987: 213-216.
53. Benmiloud M et al. Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection. Journal of clinical endocrinology and metabolism, 1994, 79: 20-24.
54. Djokomoeljanto R. Prevention of endemic cretinism in Indonesia. In: Kochupillai N, Karmakar MG, Ramalingaswami V, eds. Iodine nutrition, thyroxine and brain development. New Delhi, Tata McGraw-Hill, 1986: 80-86.
55. Clugston GA et al. Iodine deficiency disorders in south-east Asia. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The prevention and control of iodine deficiency disorders. Amsterdam, Elsevier, 1987: 273-308.
56. Zhu XY. Endemic goitre and cretinism in China with special reference to changes of iodine metabolism and pituitary-thyroid function two years after iodine prophylaxis in Gui-Zhou. In: Ui N et al., eds. Current problems in thyroid research. Amsterdam, Excerpta Medica, 1983: 13-18.
57. Ma T, Lu TZ. Iodine deficiency disorders in the Western Pacific region. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The prevention and control of iodine deficiency disorders. Amsterdam, Elsevier, 1987: 309-318.
58. Delange F. Correction of iodine deficiency: benefits and possible side effects. European journal of endocrinology, 1995, 132: 542-543.
59. Stanbury JB. The consequences of iodine deficiency. The endocrinologist, 1993, 3: 219-224.
60. Pretell EA et al. Iodine deficiency and the maternal-fetal relationship. In: Dunn JT, Medeiros-Neto GA, eds. Endemic goitre and cretinism: continuing threats to world health. Washington, Pan American Health Organization, 1974: 143-155 (PAHO Scientific Publ. No. 292).
61. Thilly C et al. Fetal hypothyroidism in endemic goitre: the probable pathogenic mechanism of endemic cretinism. In: Dunn JT, Medeiros-Neto GA, eds. Endemic goitre and cretinism: continuing threats to world health. Washington, Pan American Health Organization, 1974: 121-128 (PAHO Scientific Publ. No. 292).
62. Lagasse RK et al. Endemic goitre and cretinism in Ubangi. In. Ermans AM et al., eds. Role of cassava in the etiology of endemic goitre and cretinism. Ottawa, International Development Research Center, 1980: 45-60.
63. Ermans AM et al. Congential hypothyroidism in developing countries. In: Burrow GN, Dussautt JH, eds. Neonatal thyroid screening. New York, Raven Press, 1980: 61-73.
64. Delange F et al. Influence of dietary gottrogens during pregnancy in humans on thyroid function of the newborn. In: Delange F et al., eds. Nutritional factors involved in the goitrogenic action of cassava. Ottawa, International Development Research Centre, 1982: 40-50.
65. Thilly C et al. Maternal, fetal, and juvenile hypothyroidism, birthweight, and infant mortality in the etiopathogenesis of the IDD spectrum in Zaire and Malawi. In: Stanbury JB, ed. The damaged brain of iodine deficiency. New York, Cognizant Communication, 1994: 241-250.
66. Chaouki ML et al. Endemic cretinism and congenital hypothyroidism in endemic goitre in Algeria. In: Medeiros-Neto GA, Gaitan E, eds. Frontiers of thyroidology. New York, Plenum Press, 1986: 1055-1060.
67. Chaouki ML, Benmiloud M. Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. European journal of endocrinology, 1994, 130: 547-551.
68. Moreno-Reyes R et al. Oral iodized oil in the prevention of neonatal hypothyroidism (Abstract). Annales d'endocrinologie, 1991, 52: 58.
69. Berghout A et al. Thyroid function and thyroid size in normal pregnant women living in an iodine replete area. Clinical endocrinology, 1994, 41: 375-379.
70. Glinoer D et al. A randomized trial for the treatment of excessive thyroidal stimulation in pregnancy: maternal and neonatal effects. Journal of clinical endocrinology and metabolism, 1995, 80: 258-269.
71. Kochupillai N et al. Neonatal thyroid status in the iodine deficient environment of the sub-Himalayan region of India. In: Hall R, Kobberting J, eds. Thyroid disorders associated with iodine deficiency and excess. New York, Raven Press, 1985: 61-67.
72. Kochupillai N et al. Environmental iodine deficiency, neonatal chemical hypothyroidism (NCH) and iodized oil prophylaxis. In: Kochupillai N, Karmakar MG, Ramalingaswami V, eds. Iodine nutrition, thyroxine and brain development. New Delhi, Tata McGraw-Hill, 1986: 87-93.
73. Kochupillai N, Pandav CS. Neonatal chemical hypothyroidism in iodine-deficient environments. In: Hetzel BS, Dunn JT, Stanbury JB, eds. The prevention and control of iodine deficiency disorders. Amsterdam, Elsevier, 1987: 85-93.
74. Kochupillai N. Prevention and control of goitre. Demerits of iodized oil injections. Bulletin of the Nutrition Foundation of India, 1991, 12: 1-5.