Mathematical model of a network of interaction between p53 and Bcl-2 during genotoxic-induced apoptosis

Biophysical Chemistry

Volumn 143, Issue 1-2, 2009, Pages 44-54

  Dogu, Yasam ^a   Díaz, José ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

Author keywords

Apoptosis; Genotoxic damage; Modular network; Nonlinear dynamics; p53; Puma

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; PUMA PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CHEMICAL INTERACTION; CONTROLLED STUDY; CYTOPLASM; FIBROBLAST; GAMMA RADIATION; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN CELL; IONIZING RADIATION; MATHEMATICAL MODEL; NONLINEAR SYSTEM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RADIATION INJURY; ULTRAVIOLET RADIATION; X RAY;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CYTOPLASM; DNA DAMAGE; FIBROBLASTS; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67349270568     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2009.03.012     Document Type: Article

References (23)

1. Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nature Medicine 10 (2004) 789-799
2. Okada H., and Mak T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Reviews/Cancer 4 (2004) 592-603
3. Haupt S., Berger M., Goldberg Z., and Haupt Y. Apoptosis - the p53 network. Journal of Cell Sciience 116 (2003) 4077-4085
4. Norbury C.J., and Zhivotovsky B. Damage-induced apoptosis. Oncogene 23 (2004) 2797-2808
5. Fussenegger M., Bailey J.E., and Varner J. A mathematical model of caspase function in apoptosis. Nature Biotechnology 18 (2000) 768-774
6. Gupta S. Molecular signaling in death receptor and mitochondrial pathways of apoptosis. International Journal of Oncology 22 (2003) 15-20
7. Su T.T. Cellular responses to DNA damage: one signal, multiple choices. Annual Review of Genetics 40 (2006) 187-208
8. Chickarmane V., Nadim A., Ray A., and Sauro H.M. A p53 oscillator model of DNA break repair control. Quantitative Biology-Molecular Networks 1 (2005) arXiv: q- bio. MN/ 0510002 v1
9. Chipuk J.E., Bouchier-Hayes L., Kuwana T., Newmeyer D.D., and Green D.R. Puma couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309 (2005) 1732-1735
10. Ming L., Wang P., Bank A., Yu J., and Zhang L. Puma dissociates bax and Bcl-xL to induce apoptosis in colon cancer cells. Journal of Biological Chemistry 281 (2006) 16034-16042
11. Tomita Y., Marchenko N., Erster S., Nemajerova A., Dehner A., Klein C., Pan H., Kessler H., Pancosta P., Moll U.M., and p53 but Not Tumor-derived Mutants W.T. Bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. Journal of Biological Chemistry 281 (2006) 8600-8606
12. Eungdamrong N.J., and Iyengar R. Computational approaches for modeling regulatory cellular networks. Trends in Cell Biology 14 (2004) 661-668
13. Albert R. Network inference, analysis, and modeling in systems biology. The Plant Cell 19 (2007) 3327-3338
14. Qi J.P., Shao S.H., Xie J., and Zhu Y. A mathematical model of P53 gene regulatory networks under radiotherapy. Biosystems 90 (2007) 698-706
15. Ma L., Wagner J., Rice J.J., Hu W., and Levine A.J. Gustavo A. Stolovitzky, a plausible model for the digital response of p53 to DNA damage. PNAS 102 (2005) 14266-14271
16. Geva-Zatorsky N., Rosenfeld N., Itzkovitz S., Milo R., Sigal A., Dekel E., Yarnitzky T., Liron Y., Polak P., Lahav G., and Alon U. Oscillations and variability in the p53 system. Molecular Systems Biology msb4100068 (2006) E1-E13
17. Bagci E.Z., Vodovotz Y., Billiar T.R., Ermentrout G.B., and Bahar I. Bistability in apoptosis: roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophysical Journal 90 (2006) 1546-1559
18. Cui J., Chen C., Lu H., Sun T., and Shen P. Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch. Plos One 3 (2008) e1469
19. Hua F., Cornejo M.G., Cardone M.H., Stokes C.L., and Lauffenburger D.A. Effects of Bcl2 Levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. The Journal of Immunology 175 (2005) 985-995
20. Raffo A.J., Kim A.L., and Fine R.L. Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis. Oncogene 19 (2000) 6216-6228
21. Lodish H., Berk A., Kaiser C.A., Krieger M., Scott M.P., Bretscher A., Ploegh H., and Matsudaira P. Molecular Cell Biology. 6th Edition (2008), Freeman, New York
22. Gostissa M., Hofmann T.G., Will H., and Sal G.D. Regulation of p53 functions: let's meet at the nuclear bodies. Current Opinion in Cell Biology 15 (2003) 351-357
23. Bakkenist C.J., and Kastan M.B. Initiating cellular stress responses. Cell 118 (2004) 9-17