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Muratani M., Gerlich D., Janicki S.M., Gebhard M., Eils R., Spector D.L. Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nat. Cell Biol. 4:2002;106-110 Using expression of a yellow fluorescent protein tagged Sp100 protein as an integral promyelocytic leukaemia nuclear body (PML NB) component, the authors show that, based on their dynamic properties in living cells, three different classes of PML NBs can be distinguished. These results suggest that functionally different PML NB classes exist within a cell.
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