-
1
-
-
0033569641
-
Epigenetics: regulation through repression
-
Wolffe A.P., and Matzke M.A. Epigenetics: regulation through repression. Science 286 (1999) 481-486
-
(1999)
Science
, vol.286
, pp. 481-486
-
-
Wolffe, A.P.1
Matzke, M.A.2
-
2
-
-
20344392202
-
Epigenetics - an epicenter of gene regulation: histones and histone-modifying enzymes
-
Biel M., Wascholowski V., and Giannis A. Epigenetics - an epicenter of gene regulation: histones and histone-modifying enzymes. Angew. Chem., Int. Ed. Engl. 44 (2005) 3186-3216
-
(2005)
Angew. Chem., Int. Ed. Engl.
, vol.44
, pp. 3186-3216
-
-
Biel, M.1
Wascholowski, V.2
Giannis, A.3
-
3
-
-
23844514827
-
Chromatin modifications as targets for new anticancer drugs
-
Schafer S., and Jung M. Chromatin modifications as targets for new anticancer drugs. Arch. Pharm. (Weinheim) 338 (2005) 347-357
-
(2005)
Arch. Pharm. (Weinheim)
, vol.338
, pp. 347-357
-
-
Schafer, S.1
Jung, M.2
-
4
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
5
-
-
27544505676
-
Chromatin modifier enzymes. The histone code and cancer
-
Santos-Rosa H., and Caldas C. Chromatin modifier enzymes. The histone code and cancer. Eur. J. Cancer 41 (2005) 2381-2402
-
(2005)
Eur. J. Cancer
, vol.41
, pp. 2381-2402
-
-
Santos-Rosa, H.1
Caldas, C.2
-
6
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 389 (1997) 349-352
-
(1997)
Nature
, vol.389
, pp. 349-352
-
-
Grunstein, M.1
-
7
-
-
2942564591
-
Sirtuins: Sir2-related NAD-dependent protein deacetylases
-
North B.J., and Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol. 5 (2004) 224
-
(2004)
Genome Biol.
, vol.5
, pp. 224
-
-
North, B.J.1
Verdin, E.2
-
8
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert C., Guardiola A., Shao R., Kawaguchi Y., Ito A., Nixon A., Yoshida M., Wang X.F., and Yao T.P. HDAC6 is a microtubule-associated deacetylase. Nature 417 (2002) 455-458
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
Kawaguchi, Y.4
Ito, A.5
Nixon, A.6
Yoshida, M.7
Wang, X.F.8
Yao, T.P.9
-
9
-
-
12244295468
-
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation
-
Matsuyama A., Shimazu T., Sumida Y., Saito A., Yoshimatsu Y., Seigneurin-Berny D., Osada H., Komatsu Y., Nishino N., Khochbin S., Horinouchi S., and Yoshida M. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 21 (2002) 6820-6831
-
(2002)
EMBO J.
, vol.21
, pp. 6820-6831
-
-
Matsuyama, A.1
Shimazu, T.2
Sumida, Y.3
Saito, A.4
Yoshimatsu, Y.5
Seigneurin-Berny, D.6
Osada, H.7
Komatsu, Y.8
Nishino, N.9
Khochbin, S.10
Horinouchi, S.11
Yoshida, M.12
-
10
-
-
0037416151
-
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
-
Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., and Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 22 (2003) 1168-1179
-
(2003)
EMBO J.
, vol.22
, pp. 1168-1179
-
-
Zhang, Y.1
Li, N.2
Caron, C.3
Matthias, G.4
Hess, D.5
Khochbin, S.6
Matthias, P.7
-
12
-
-
29344471072
-
Understanding microtubule dynamics for improved cancer therapy
-
Honore S., Pasquier E., and Braguer D. Understanding microtubule dynamics for improved cancer therapy. Cell. Mol. Life Sci. 62 (2005) 3039-3056
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 3039-3056
-
-
Honore, S.1
Pasquier, E.2
Braguer, D.3
-
13
-
-
20044379059
-
Review: tubulin function. Action of antitubulin drugs, and new drug development
-
Pellegrini F., and Budman D.R. Review: tubulin function. Action of antitubulin drugs, and new drug development. Cancer Invest. 23 (2005) 264-273
-
(2005)
Cancer Invest.
, vol.23
, pp. 264-273
-
-
Pellegrini, F.1
Budman, D.R.2
-
14
-
-
34548416641
-
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
-
Boyault C., Zhang Y., Fritah S., Caron C., Gilquin B., Kwon S.H., Garrido C., Yao T.P., Vourc'h C., Matthias P., and Khochbin S. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 (2007) 2172-2181
-
(2007)
Genes Dev.
, vol.21
, pp. 2172-2181
-
-
Boyault, C.1
Zhang, Y.2
Fritah, S.3
Caron, C.4
Gilquin, B.5
Kwon, S.H.6
Garrido, C.7
Yao, T.P.8
Vourc'h, C.9
Matthias, P.10
Khochbin, S.11
-
15
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
Hideshima T., Bradner J.E., Wong J., Chauhan D., Richardson P., Schreiber S.L., and Anderson K.C. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc. Natl. Acad. Sci. USA 102 (2005) 8567-8572
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
Chauhan, D.4
Richardson, P.5
Schreiber, S.L.6
Anderson, K.C.7
-
16
-
-
34249993174
-
SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib
-
Emanuele S., Lauricella M., Carlisi D., Vassallo B., DAnneo A., Di Fazio P., Vento R., and Tesoriere G. SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib. Apoptosis 12 (2007) 1327-1338
-
(2007)
Apoptosis
, vol.12
, pp. 1327-1338
-
-
Emanuele, S.1
Lauricella, M.2
Carlisi, D.3
Vassallo, B.4
DAnneo, A.5
Di Fazio, P.6
Vento, R.7
Tesoriere, G.8
-
17
-
-
54749101159
-
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis
-
Lee Y.S., Lim K.H., Guo X., Kawaguchi Y., Gao Y., Barrientos T., Ordentlich P., Wang X.F., Counter C.M., and Yao T.P. The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res. 68 (2008) 7561-7569
-
(2008)
Cancer Res.
, vol.68
, pp. 7561-7569
-
-
Lee, Y.S.1
Lim, K.H.2
Guo, X.3
Kawaguchi, Y.4
Gao, Y.5
Barrientos, T.6
Ordentlich, P.7
Wang, X.F.8
Counter, C.M.9
Yao, T.P.10
-
18
-
-
53449090857
-
Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells
-
Fiskus W., Rao R., Fernandez P., Herger B., Yang Y., Chen J., Kolhe R., Mandawat A., Wang Y., Joshi R., Eaton K., Lee P., Atadja P., Peiper S., and Bhalla K. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. Blood 112 (2008) 2896-2905
-
(2008)
Blood
, vol.112
, pp. 2896-2905
-
-
Fiskus, W.1
Rao, R.2
Fernandez, P.3
Herger, B.4
Yang, Y.5
Chen, J.6
Kolhe, R.7
Mandawat, A.8
Wang, Y.9
Joshi, R.10
Eaton, K.11
Lee, P.12
Atadja, P.13
Peiper, S.14
Bhalla, K.15
-
19
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey U.B., Nie Z., Batlevi Y., McCray B.A., Ritson G.P., Nedelsky N.B., Schwartz S.L., DiProspero N.A., Knight M.A., Schuldiner O., Padmanabhan R., Hild M., Berry D.L., Garza D., Hubbert C.C., Yao T.P., Baehrecke E.H., and Taylor J.P. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447 (2007) 859-863
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
DiProspero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
20
-
-
53249114029
-
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
-
10.1093/hmg/ddn1273
-
Pallos J., Bodai L., Lukacsovich T., Purcell J.M., Steffan J.S., Thompson L.M., and Marsh J.L. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum. Mol. Genet. (2008) 10.1093/hmg/ddn1273
-
(2008)
Hum. Mol. Genet.
-
-
Pallos, J.1
Bodai, L.2
Lukacsovich, T.3
Purcell, J.M.4
Steffan, J.S.5
Thompson, L.M.6
Marsh, J.L.7
-
21
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
Richon V.M., Webb Y., Merger R., Sheppard T., Jursic B., Ngo L., Civoli F., Breslow R., Rifkind R.A., and Marks P.A. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc. Natl. Acad. Sci. USA 93 (1996) 5705-5708
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
Sheppard, T.4
Jursic, B.5
Ngo, L.6
Civoli, F.7
Breslow, R.8
Rifkind, R.A.9
Marks, P.A.10
-
22
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
Richon V.M., Emiliani S., Verdin E., Webb Y., Breslow R., Rifkind R.A., and Marks P.A. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc. Natl. Acad. Sci. USA 95 (1998) 3003-3007
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
Webb, Y.4
Breslow, R.5
Rifkind, R.A.6
Marks, P.A.7
-
23
-
-
0033839037
-
Development of cytodifferentiating agents for cancer chemotherapy
-
Breslow R., Belvedere S., and Gershell L. Development of cytodifferentiating agents for cancer chemotherapy. Helv. Chim. Acta 83 (2000) 1685-1692
-
(2000)
Helv. Chim. Acta
, vol.83
, pp. 1685-1692
-
-
Breslow, R.1
Belvedere, S.2
Gershell, L.3
-
24
-
-
0025673805
-
Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents
-
Itazaki H., Nagashima K., Sugita K., Yoshida H., Kawamura Y., Yasuda Y., Matsumoto K., Ishii K., Uotani N., Nakai H., et al. Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents. J. Antibiot. (Tokyo) 43 (1990) 1524-1532
-
(1990)
J. Antibiot. (Tokyo)
, vol.43
, pp. 1524-1532
-
-
Itazaki, H.1
Nagashima, K.2
Sugita, K.3
Yoshida, H.4
Kawamura, Y.5
Yasuda, Y.6
Matsumoto, K.7
Ishii, K.8
Uotani, N.9
Nakai, H.10
-
25
-
-
0029294663
-
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function
-
Yoshida M., Horinouchi S., and Beppu T. Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17 (1995) 423-430
-
(1995)
Bioessays
, vol.17
, pp. 423-430
-
-
Yoshida, M.1
Horinouchi, S.2
Beppu, T.3
-
26
-
-
0033614993
-
Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives
-
Suzuki T., Ando T., Tsuchiya K., Fukazawa N., Saito A., Mariko Y., Yamashita T., and Nakanishi O. Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. J. Med. Chem. 42 (1999) 3001-3003
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3001-3003
-
-
Suzuki, T.1
Ando, T.2
Tsuchiya, K.3
Fukazawa, N.4
Saito, A.5
Mariko, Y.6
Yamashita, T.7
Nakanishi, O.8
-
27
-
-
0038522853
-
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
-
Haggarty S.J., Koeller K.M., Wong J.C., Butcher R.A., and Schreiber S.L. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10 (2003) 383-396
-
(2003)
Chem. Biol.
, vol.10
, pp. 383-396
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Butcher, R.A.4
Schreiber, S.L.5
-
28
-
-
0344640906
-
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
-
Haggarty S.J., Koeller K.M., Wong J.C., Grozinger C.M., and Schreiber S.L. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. USA 100 (2003) 4389-4394
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
29
-
-
33744514787
-
Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases
-
Hildmann C., Wegener D., Riester D., Hempel R., Schober A., Merana J., Giurato L., Guccione S., Nielsen T.K., Ficner R., and Schwienhorst A. Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases. J. Biotechnol. 124 (2006) 258-270
-
(2006)
J. Biotechnol.
, vol.124
, pp. 258-270
-
-
Hildmann, C.1
Wegener, D.2
Riester, D.3
Hempel, R.4
Schober, A.5
Merana, J.6
Giurato, L.7
Guccione, S.8
Nielsen, T.K.9
Ficner, R.10
Schwienhorst, A.11
-
30
-
-
45749103747
-
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum
-
Chen Y., Lopez-Sanchez M., Savoy D.N., Billadeau D.D., Dow G.S., and Kozikowski A.P. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. J. Med. Chem. 51 (2008) 3437-3448
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3437-3448
-
-
Chen, Y.1
Lopez-Sanchez, M.2
Savoy, D.N.3
Billadeau, D.D.4
Dow, G.S.5
Kozikowski, A.P.6
-
31
-
-
49449113465
-
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6
-
Kozikowski A.P., Tapadar S., Luchini D.N., Kim K.H., and Billadeau D.D. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J. Med. Chem. 51 (2008) 4370-4373
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4370-4373
-
-
Kozikowski, A.P.1
Tapadar, S.2
Luchini, D.N.3
Kim, K.H.4
Billadeau, D.D.5
-
32
-
-
0037130244
-
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in friend leukemic cells
-
Wittich S., Scherf H., Xie C., Brosch G., Loidl P., Gerhauser C., and Jung M. Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in friend leukemic cells. J. Med. Chem. 45 (2002) 3296-3309
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3296-3309
-
-
Wittich, S.1
Scherf, H.2
Xie, C.3
Brosch, G.4
Loidl, P.5
Gerhauser, C.6
Jung, M.7
-
33
-
-
20844450898
-
Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines
-
Wittich S., Scherf H., Xie C., Heltweg B., Dequiedt F., Verdin E., Gerhauser C., and Jung M. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. Anticancer Drugs 16 (2005) 635-643
-
(2005)
Anticancer Drugs
, vol.16
, pp. 635-643
-
-
Wittich, S.1
Scherf, H.2
Xie, C.3
Heltweg, B.4
Dequiedt, F.5
Verdin, E.6
Gerhauser, C.7
Jung, M.8
-
34
-
-
38949141196
-
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)
-
Schafer S., Saunders L., Eliseeva E., Velena A., Jung M., Schwienhorst A., Strasser A., Dickmanns A., Ficner R., Schlimme S., Sippl W., and Verdin E. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem. 16 (2008) 2011-2033
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 2011-2033
-
-
Schafer, S.1
Saunders, L.2
Eliseeva, E.3
Velena, A.4
Jung, M.5
Schwienhorst, A.6
Strasser, A.7
Dickmanns, A.8
Ficner, R.9
Schlimme, S.10
Sippl, W.11
Verdin, E.12
-
35
-
-
60849105362
-
Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors
-
Schäfer S., Saunders L., Schlimme S., Valkov V., Wagner J.M., Kratz F., Sippl W., Verdin E., and Jung M. Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors. Chem. Med. Chem. 4 (2009) 283-290
-
(2009)
Chem. Med. Chem.
, vol.4
, pp. 283-290
-
-
Schäfer, S.1
Saunders, L.2
Schlimme, S.3
Valkov, V.4
Wagner, J.M.5
Kratz, F.6
Sippl, W.7
Verdin, E.8
Jung, M.9
-
36
-
-
51649126046
-
Destabilization of ERBB2 transcripts by targeting 3' UTR mRNA associated HuR and histone deacetylase-6 (HDAC6)
-
Scott G.K., Marx C., Berger C.E., Saunders L.R., Verdin E., Schäfer S., Jung M., and Benz C.C. Destabilization of ERBB2 transcripts by targeting 3' UTR mRNA associated HuR and histone deacetylase-6 (HDAC6). Mol. Cancer Res. 6 (2008) 1250-1258
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 1250-1258
-
-
Scott, G.K.1
Marx, C.2
Berger, C.E.3
Saunders, L.R.4
Verdin, E.5
Schäfer, S.6
Jung, M.7
Benz, C.C.8
-
37
-
-
35848945959
-
Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors
-
Itoh Y., Suzuki T., Kouketsu A., Suzuki N., Maeda S., Yoshida M., Nakagawa H., and Miyata N. Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J. Med. Chem. 50 (2007) 5425-5438
-
(2007)
J. Med. Chem.
, vol.50
, pp. 5425-5438
-
-
Itoh, Y.1
Suzuki, T.2
Kouketsu, A.3
Suzuki, N.4
Maeda, S.5
Yoshida, M.6
Nakagawa, H.7
Miyata, N.8
-
38
-
-
33746894565
-
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate
-
Suzuki T., Kouketsu A., Itoh Y., Hisakawa S., Maeda S., Yoshida M., Nakagawa H., and Miyata N. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J. Med. Chem. 49 (2006) 4809-4812
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4809-4812
-
-
Suzuki, T.1
Kouketsu, A.2
Itoh, Y.3
Hisakawa, S.4
Maeda, S.5
Yoshida, M.6
Nakagawa, H.7
Miyata, N.8
-
39
-
-
4744370522
-
Subtype selective substrates for histone deacetylases
-
Heltweg B., Dequiedt F., Marshall B.L., Brauch C., Yoshida M., Nishino N., Verdin E., and Jung M. Subtype selective substrates for histone deacetylases. J. Med. Chem. 47 (2004) 5235-5243
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5235-5243
-
-
Heltweg, B.1
Dequiedt, F.2
Marshall, B.L.3
Brauch, C.4
Yoshida, M.5
Nishino, N.6
Verdin, E.7
Jung, M.8
-
40
-
-
0018387446
-
Promotion of microtubule assembly in vitro by taxol
-
Schiff P.B., Fant J., and Horwitz S.B. Promotion of microtubule assembly in vitro by taxol. Nature 277 (1979) 665-667
-
(1979)
Nature
, vol.277
, pp. 665-667
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
41
-
-
20944437248
-
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase
-
Marcus A.I., Zhou J., O'Brate A., Hamel E., Wong J., Nivens M., El-Naggar A., Yao T.P., Khuri F.R., and Giannakakou P. The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res. 65 (2005) 3883-3893
-
(2005)
Cancer Res.
, vol.65
, pp. 3883-3893
-
-
Marcus, A.I.1
Zhou, J.2
O'Brate, A.3
Hamel, E.4
Wong, J.5
Nivens, M.6
El-Naggar, A.7
Yao, T.P.8
Khuri, F.R.9
Giannakakou, P.10
-
42
-
-
22744446856
-
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer
-
Saji S., Kawakami M., Hayashi S., Yoshida N., Hirose M., Horiguchi S., Itoh A., Funata N., Schreiber S.L., Yoshida M., and Toi M. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 24 (2005) 4531-4539
-
(2005)
Oncogene
, vol.24
, pp. 4531-4539
-
-
Saji, S.1
Kawakami, M.2
Hayashi, S.3
Yoshida, N.4
Hirose, M.5
Horiguchi, S.6
Itoh, A.7
Funata, N.8
Schreiber, S.L.9
Yoshida, M.10
Toi, M.11
-
46
-
-
0035914304
-
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
-
Grozinger C.M., Chao E.D., Blackwell H.E., Moazed D., and Schreiber S.L. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 276 (2001) 38837-38843
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38837-38843
-
-
Grozinger, C.M.1
Chao, E.D.2
Blackwell, H.E.3
Moazed, D.4
Schreiber, S.L.5
-
47
-
-
0037086045
-
A microplate reader-based nonisotopic histone deacetylase activity assay
-
Heltweg B., and Jung M. A microplate reader-based nonisotopic histone deacetylase activity assay. Anal. Biochem. 302 (2002) 175-183
-
(2002)
Anal. Biochem.
, vol.302
, pp. 175-183
-
-
Heltweg, B.1
Jung, M.2
-
48
-
-
14544269435
-
Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis
-
Dai X., Hayashi K., Nozaki H., Cheng Y., and Zhao Y. Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proc. Natl. Acad. Sci. USA 102 (2005) 3129-3134
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3129-3134
-
-
Dai, X.1
Hayashi, K.2
Nozaki, H.3
Cheng, Y.4
Zhao, Y.5
-
49
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern S.L., Caselli E., Grigorieff N., and Shoichet B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45 (2002) 1712-1722
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
50
-
-
67349179803
-
Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect
-
Lara E., Mai A., Calvanese V., Altucci L., Lopez-Nieva P., Martinez-Chantar M.L., Varela-Rey M., Rotili D., Nebbioso A., Ropero S., Montoya G., Oyarzabal J., Velasco S., Serrano M., Witt M., Villar-Garea A., Inhof A., Mato J.M., Esteller M., and Fraga M.F. Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008)
-
(2008)
Oncogene
-
-
Lara, E.1
Mai, A.2
Calvanese, V.3
Altucci, L.4
Lopez-Nieva, P.5
Martinez-Chantar, M.L.6
Varela-Rey, M.7
Rotili, D.8
Nebbioso, A.9
Ropero, S.10
Montoya, G.11
Oyarzabal, J.12
Velasco, S.13
Serrano, M.14
Witt, M.15
Villar-Garea, A.16
Inhof, A.17
Mato, J.M.18
Esteller, M.19
Fraga, M.F.20
more..
-
51
-
-
28144438533
-
Design, synthesis and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors
-
Mai A., Massa S., Lavu S., Pezzi R., Simeoni S., Ragno R., Mariotti F.R., Chiani F., Camilloni G., and Sinclair D.A. Design, synthesis and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J. Med. Chem. 48 (2005) 7789-7795
-
(2005)
J. Med. Chem.
, vol.48
, pp. 7789-7795
-
-
Mai, A.1
Massa, S.2
Lavu, S.3
Pezzi, R.4
Simeoni, S.5
Ragno, R.6
Mariotti, F.R.7
Chiani, F.8
Camilloni, G.9
Sinclair, D.A.10
-
52
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg B., Gatbonton T., Schuler A.D., Posakony J., Li H., Goehle S., Kollipara R., Depinho R.A., Gu Y., Simon J.A., and Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66 (2006) 4368-4377
-
(2006)
Cancer Res.
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
Schuler, A.D.3
Posakony, J.4
Li, H.5
Goehle, S.6
Kollipara, R.7
Depinho, R.A.8
Gu, Y.9
Simon, J.A.10
Bedalov, A.11
-
53
-
-
33845476236
-
+-dependent histone deacetylases, from kinase to sirtuin inhibition
-
+-dependent histone deacetylases, from kinase to sirtuin inhibition. J. Med. Chem. 49 (2006) 7307-7316
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7307-7316
-
-
Trapp, J.1
Jochum, A.2
Meier, R.3
Saunders, L.4
Marshall, B.5
Kunick, C.6
Verdin, E.7
Goekjian, P.8
Sippl, W.9
Jung, M.10
-
55
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro T.F., Kontopoulos E., Altmann S.M., Kufareva I., Strathearn K.E., Amore A.M., Volk C.B., Maxwell M.M., Rochet J.C., McLean P.J., Young A.B., Abagyan R., Feany M.B., Hyman B.T., and Kazantsev A.G. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 (2007) 516-519
-
(2007)
Science
, vol.317
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
56
-
-
0024385914
-
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation
-
Lyall R.M., Zilberstein A., Gazit A., Gilon C., Levitzki A., and Schlessinger J. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J. Biol. Chem. 264 (1989) 14503-14509
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 14503-14509
-
-
Lyall, R.M.1
Zilberstein, A.2
Gazit, A.3
Gilon, C.4
Levitzki, A.5
Schlessinger, J.6
-
57
-
-
0035910031
-
Identification of a small molecule inhibitor of Sir2p
-
Bedalov A., Gatbonton T., Irvine W.P., Gottschling D.E., and Simon J.A. Identification of a small molecule inhibitor of Sir2p. Proc. Natl. Acad. Sci. USA 98 (2001) 15113-15118
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 15113-15118
-
-
Bedalov, A.1
Gatbonton, T.2
Irvine, W.P.3
Gottschling, D.E.4
Simon, J.A.5
-
58
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans S., Pedal A., North B.J., Kaehlcke K., Marshall B.L., Dorr A., Hetzer-Egger C., Henklein P., Frye R., McBurney M.W., Hruby H., Jung M., Verdin E., and Ott M. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 3 (2005) e41
-
(2005)
PLoS Biol.
, vol.3
-
-
Pagans, S.1
Pedal, A.2
North, B.J.3
Kaehlcke, K.4
Marshall, B.L.5
Dorr, A.6
Hetzer-Egger, C.7
Henklein, P.8
Frye, R.9
McBurney, M.W.10
Hruby, H.11
Jung, M.12
Verdin, E.13
Ott, M.14
-
59
-
-
41649103241
-
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
-
Neugebauer R.C., Uchiechowska U., Meier R., Hruby H., Valkov V., Verdin E., Sippl W., and Jung M. Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J. Med. Chem. 51 (2008) 1203-1213
-
(2008)
J. Med. Chem.
, vol.51
, pp. 1203-1213
-
-
Neugebauer, R.C.1
Uchiechowska, U.2
Meier, R.3
Hruby, H.4
Valkov, V.5
Verdin, E.6
Sippl, W.7
Jung, M.8
-
61
-
-
29144501185
-
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
-
Napper A.D., Hixon J., McDonagh T., Keavey K., Pons J.F., Barker J., Yau W.T., Amouzegh P., Flegg A., Hamelin E., Thomas R.J., Kates M., Jones S., Navia M.A., Saunders J.O., DiStefano P.S., and Curtis R. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 48 (2005) 8045-8054
-
(2005)
J. Med. Chem.
, vol.48
, pp. 8045-8054
-
-
Napper, A.D.1
Hixon, J.2
McDonagh, T.3
Keavey, K.4
Pons, J.F.5
Barker, J.6
Yau, W.T.7
Amouzegh, P.8
Flegg, A.9
Hamelin, E.10
Thomas, R.J.11
Kates, M.12
Jones, S.13
Navia, M.A.14
Saunders, J.O.15
DiStefano, P.S.16
Curtis, R.17
-
62
-
-
57549089690
-
Thiobarbiturates as Sirtuin inhibitors: virtual screening, free energy calculations and biological testing
-
Uciechowska U., Schemies J., Neugebauer R.C., Huda E.-M., Schmitt M.L., Meier R., Verdin E., Jung M., and Sippl W. Thiobarbiturates as Sirtuin inhibitors: virtual screening, free energy calculations and biological testing. Chem. Med. Chem. 3 (2008) 1965-1976
-
(2008)
Chem. Med. Chem.
, vol.3
, pp. 1965-1976
-
-
Uciechowska, U.1
Schemies, J.2
Neugebauer, R.C.3
Huda, E.-M.4
Schmitt, M.L.5
Meier, R.6
Verdin, E.7
Jung, M.8
Sippl, W.9
-
63
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain S., Hollick J.J., Campbell J., Staples O.D., Higgins M., Aoubala M., McCarthy A., Appleyard V., Murray K.E., Baker L., Thompson A., Mathers J., Holland S.J., Stark M.J., Pass G., Woods J., Lane D.P., and Westwood N.J. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 (2008) 454-463
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
Staples, O.D.4
Higgins, M.5
Aoubala, M.6
McCarthy, A.7
Appleyard, V.8
Murray, K.E.9
Baker, L.10
Thompson, A.11
Mathers, J.12
Holland, S.J.13
Stark, M.J.14
Pass, G.15
Woods, J.16
Lane, D.P.17
Westwood, N.J.18
-
64
-
-
9744284968
-
An in silico approach to discovering novel inhibitors of human sirtuin type 2
-
Tervo A.J., Kyrylenko S., Niskanen P., Salminen A., Leppanen J., Nyronen T.H., Jarvinen T., and Poso A. An in silico approach to discovering novel inhibitors of human sirtuin type 2. J. Med. Chem. 47 (2004) 6292-6298
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6292-6298
-
-
Tervo, A.J.1
Kyrylenko, S.2
Niskanen, P.3
Salminen, A.4
Leppanen, J.5
Nyronen, T.H.6
Jarvinen, T.7
Poso, A.8
-
65
-
-
33845964698
-
N,N′-Bisbenzylidenebenzene-1,4-diamines and N,N′-bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors
-
Kiviranta P.H., Leppanen J., Kyrylenko S., Salo H.S., Lahtela-Kakkonen M., Tervo A.J., Wittekindt C., Suuronen T., Kuusisto E., Jarvinen T., Salminen A., Poso A., and Wallen E.A. N,N′-Bisbenzylidenebenzene-1,4-diamines and N,N′-bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors. J. Med. Chem. 49 (2006) 7907-7911
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7907-7911
-
-
Kiviranta, P.H.1
Leppanen, J.2
Kyrylenko, S.3
Salo, H.S.4
Lahtela-Kakkonen, M.5
Tervo, A.J.6
Wittekindt, C.7
Suuronen, T.8
Kuusisto, E.9
Jarvinen, T.10
Salminen, A.11
Poso, A.12
Wallen, E.A.13
-
66
-
-
33845355601
-
Discovering inhibitors of human sirtuin type 2: novel structural scaffolds
-
Tervo A.J., Suuronen T., Kyrylenko S., Kuusisto E., Kiviranta P.H., Salminen A., Leppanen J., and Poso A. Discovering inhibitors of human sirtuin type 2: novel structural scaffolds. J. Med. Chem. 49 (2006) 7239-7241
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7239-7241
-
-
Tervo, A.J.1
Suuronen, T.2
Kyrylenko, S.3
Kuusisto, E.4
Kiviranta, P.H.5
Salminen, A.6
Leppanen, J.7
Poso, A.8
-
67
-
-
34447317859
-
Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
-
Gey C., Kyrylenko S., Hennig L., Nguyen L.H., Buttner A., Pham H.D., and Giannis A. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew. Chem., Int. Ed. Engl. 46 (2007) 5219-5222
-
(2007)
Angew. Chem., Int. Ed. Engl.
, vol.46
, pp. 5219-5222
-
-
Gey, C.1
Kyrylenko, S.2
Hennig, L.3
Nguyen, L.H.4
Buttner, A.5
Pham, H.D.6
Giannis, A.7
-
68
-
-
38949141196
-
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)
-
Schäfer S., Saunders L., Eliseeva E.D., Velena A., Jung M., Schwienhorst A., Strasser A., Dickmanns A., Ficner R., Schlimme S., Sippl W., Verdin E., and Jung M. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem. 16 (2008) 2011-2033
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 2011-2033
-
-
Schäfer, S.1
Saunders, L.2
Eliseeva, E.D.3
Velena, A.4
Jung, M.5
Schwienhorst, A.6
Strasser, A.7
Dickmanns, A.8
Ficner, R.9
Schlimme, S.10
Sippl, W.11
Verdin, E.12
Jung, M.13
-
69
-
-
30544445468
-
Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
-
Ota H., Tokunaga E., Chang K., Hikasa M., Iijima K., Eto M., Kozaki K., Akishita M., Ouchi Y., and Kaneki M. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25 (2006) 176-185
-
(2006)
Oncogene
, vol.25
, pp. 176-185
-
-
Ota, H.1
Tokunaga, E.2
Chang, K.3
Hikasa, M.4
Iijima, K.5
Eto, M.6
Kozaki, K.7
Akishita, M.8
Ouchi, Y.9
Kaneki, M.10
|