Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 2011-2033

  Schäfer, Stefan ^a   Saunders, Laura ^b   Eliseeva, Elena ^c   Velena, Alfredo ^c   Jung, Mira ^c   Schwienhorst, Andreas ^d   Strasser, Anja ^d   Dickmanns, Achim ^d   Ficner, Ralf ^d   Schlimme, Sonja ^e   Sippl, Wolfgang ^e   Verdin, Eric ^b   Jung, Manfred ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Class I and II HDAC inhibitor; Gold docking; Histone deacetylase (HDAC); Hydroxamic acid; Subtype selectivity

Indexed keywords

2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO) 3 (4 THIOPHEN 2 YL PHENYL)PROPIONIC ACID METHYLESTER; 2 (8 HYDROXYCARBAMOYLOCTANOYLAMINO) 3 (4 THIOPHEN 3 YL PHENYL)PROPIONIC ACID METHYLESTER; 3 (4 BROMOPHENYL) 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYLESTER; 3 (4 BROMOPHENYL) 2 (8 HYDROXYCARBAMOYLOCTANOYLAMINO)PROPIONIC ACID METHYLESTER; 3 (4 FURAN 3 YL PHENYL) 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYLESTER; 3 (4 FURAN 3 YL PHENYL) 2 (8 HYDROXYCARBAMOYLOCTANOYLAMINO)PROPIONIC ACID METHYLESTER; 3 BIPHENYL 4 YL 2 (8 HYDROXYCARBAMOYLOCTANOYLAMINO)PROPIONIC ACID METHYLESTER; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; PHENYLALANINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR DOCKING; WESTERN BLOTTING; X RAY ANALYSIS;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; PHENYLALANINE; PROTEIN BINDING; TUBULIN;

BACTERIA (MICROORGANISMS);

EID: 38949141196     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.092     Document Type: Article

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