Involvement of multidrug resistance-associated protein 1 in intestinal toxicity of methotrexate

Pharmaceutical Research

Volumn 26, Issue 6, 2009, Pages 1467-1476

  Kato, Sayaka ^a   Ito, Katsuaki ^a   Kato, Yukio ^a   Wakayama, Tomohiko ^a   Kubo, Yoshiyuki ^a   Iseki, Shoichi ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Intestinal crypt compartment cells; Methotrexate; MRP1; Toxicity; Transporters

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DRUG ACCUMULATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; GASTROINTESTINAL TOXICITY; INTESTINE VILLUS ATROPHY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTIRHEUMATIC AGENTS; BODY WEIGHT; GENE KNOCKOUT TECHNIQUES; INTESTINAL MUCOSA; INTESTINE, SMALL; METHOTREXATE; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 67349207415     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9858-6     Document Type: Article

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