Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations

Human Pathology

Volumn 40, Issue 7, 2009, Pages 934-941

  Kim, Jeung Il ^a   Suh, Jeung Tak ^a   Choi, Kyung Un ^a   Kang, Hyun Jeong ^a   Shin, Dong Hoon ^a   Lee, In Sook ^a   Moon, Tae Yong ^a   Kim, Won Taek ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

K ras; MGMT; Soft tissue sarcoma

Indexed keywords

K RAS PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHILD; FEMALE; GENE EXPRESSION; GENE LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; MUTATION; ONCOGENE K RAS; PROMOTER REGION; PROTEIN EXPRESSION; SOFT TISSUE SARCOMA; DNA METHYLATION; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; ONCOGENE RAS; PRESCHOOL CHILD; PROGNOSIS; SARCOMA; SURVIVAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; INFANT; MALE; MIDDLE AGED; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROGNOSIS; SARCOMA; SURVIVAL ANALYSIS;

EID: 67349187920     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.01.005     Document Type: Article

References (36)

1. Weiss S.W., and Goldblum J.R. Enzinger and Weiss's soft tissue tumors. 5th ed. vol 1 (2008), Mosby, St. Louis
2. Esteller M., Corn P.G., Baylin S.B., and Herman J.G. A gene hypermethylation profile of human cancer. Cancer Res 61 (2001) 3225-3229
3. Kawaguchi K., Oda Y., Saito T., et al. Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosis. J Pathol 201 (2003) 487-495
4. Seidel C., Bartel F., Rastetter M., et al. Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. Int J Cancer 114 (2005) 442-447
5. Brinck U., Schlott T., Storber S., et al. Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas. Anticancer Res 26 (2006) 3461-3465
6. Kawaguchi K., Oda Y., Saito T., et al. DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol 19 (2006) 106-114
7. 6-methylguanine-DNA methyltransferase activity and promoter methylation status in pediatric rhabdomyosarcoma. J Pediatr Hematol Oncol 25 (2003) 941-947
8. 6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. Br J Cancer 86 (2002) 1888-1892
9. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59 (1999) 793-797
10. Esteller M., Garcia-Foncillas J., Andion E., et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343 (2000) 1350-1354
11. 6-methylguanine DNA methyltransferase in human cancer. Oncogene 23 (2004) 1-8
12. Grasbon-Frodl E.M., Kreth F.W., Ruiter M., et al. Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. Int J Cancer 121 (2007) 2458-2464
13. 6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer 122 (2008) 2429-2436
14. 6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the middle east. Hum Pathol 37 (2006) 742-748
15. 6-methylguanine-DNA methyltransferase in pulmonary squamous cell carcinoma and adenocarcinoma. Pathol Int 55 (2005) 303-309
16. Hengstler J.G., Tanner B., Moller L., Meinert R., and Kaina B. Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer. Int J Cancer 84 (1999) 388-395
17. Kang G.H., Lee S., Lee H.J., and Hwang K.S. Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia. J Pathol 202 (2004) 233-240
18. 6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clin Cancer Res 11 (2005) 5167-5174
19. Hegi M.E., Diserens A.C., Gorlia T., et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352 (2005) 997-1003
20. Hill M.A., Gong C., Casey T.J., et al. Detection of K-ras mutations in resected primary leiomyosarcoma. Cancer Epidemiol Biomarkers Prev 6 (1997) 1095-1100
21. Stratton M.R., Fisher C., Gusterson B.A., and Cooper C.S. Detection of point mutations in N-ras and K-ras genes of human embryonal rhabdomyosarcomas using oligonucleotide probes and the polymerase chain reaction. Cancer Res 49 (1989) 6324-6327
22. Yoo J., and Robinson R.A. H-ras and K-ras mutations in soft tissue sarcoma: comparative studies of sarcomas from Korean and American patients. Cancer 86 (1999) 58-63
23. Yoo J., Robinson R.A., and Lee J.Y. H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes. Mod Pathol 12 (1999) 775-780
24. Esteller M., Risques R.A., Toyota M., et al. Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61 (2001) 4689-4692
25. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60 (2000) 2368-2371
26. Park T.J., Han S.U., Cho Y.K., Paik W.K., Kim Y.B., and Lim I.K. Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma. Cancer 92 (2001) 2760-2768
27. Laiho P., Launonen V., Lahermo P., et al. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res 62 (2002) 1166-1170
28. 6-methylguanine-DNA methyltransferase gene: More common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Res 63 (2003) 4842-4848
29. Komine C., Watanabe T., Katayama Y., Yoshino A., Yokoyama T., and Fukushima T. Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas. Brain Pathol 13 (2003) 176-184
30. Blanc J.L., Wager M., Guilhot J., et al. Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas. J Neurooncol 68 (2004) 275-283
31. Oue N., Shigeishi H., Kuniyasu H., et al. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma. Int J Cancer 93 (2001) 805-809
32. Gerson S.L. MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4 (2004) 296-307
33. Kawaguchi K., Oda Y., Takahira T., et al. Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas. Oncol Rep 13 (2005) 241-246
34. 6-alkylguanine-DNA alkyltransferase. Cancer Chemother Pharmacol 43 (1999) 80-85
35. 6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. Cancer Chemother Pharmacol 58 (2006) 634-639
36. Patra S.K. Ras regulation of DNA-methylation and cancer. Exp Cell Res 314 (2008) 1193-1201