Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas

Oncology Reports

Volumn 13, Issue 2, 2005, Pages 241-246

  Kawaguchi, Ken Ichi ^a   Oda, Yoshinao ^a   Takahira, Tomonari ^a   Saito, Tsuyoshi ^a   Yamamoto, Hidetaka ^a   Kobayashi, Chikashi ^a   Tamiya, Sadafumi ^a   Oda, Shinya ^b   Iwamoto, Yukihide ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL KYUSHU CANCER CENTER   (Japan)

Author keywords

Microsatellite instability; Mismatch repair protein; Promoter hypermethylation; Soft tissue sarcoma

Indexed keywords

CARRIER PROTEIN; DNA BINDING PROTEIN; MICROSATELLITE DNA; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MSH2; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; DNA METHYLATION; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; SARCOMA; SOFT TISSUE TUMOR;

ADULT; AGED; CARRIER PROTEINS; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; SARCOMA; SOFT TISSUE NEOPLASMS;

EID: 16244389683     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Thibodeau SN, Bren G and Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260: 816-819, 1993. (Pubitemid 23167612)
2. Han HJ, Yanagisawa A, Kato Y, Park JG and Nakamura Y: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 53: 5087-5089, 1993. (Pubitemid 23333368)
3. Rhyu MG, Park WS and Meltzer SJ: Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9: 29-32, 1994.
4. Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslem G, Baker SM, Liskay RM, Burgart LJ, Honchel R and Halling KC: Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 56: 4836-4840, 1996. (Pubitemid 26374414)
5. Murata H, Khattar NH, Kang Y, Gu L and Li GM: Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability. Oncogene 21: 5696-5703, 2002. (Pubitemid 35333002)
6. Leach FS, Polyak K, Burrell M, Johnson KA, Hill D, Dunlop MG, Wyllie AH, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW and Vogelstein B: Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. Cancer Res 56: 235-240, 1996. (Pubitemid 26026346)
7. Fishel R and Kolodner RD: Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 5: 382-395, 1995.
8. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA and Baylin SB: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95: 6870-6875, 1998. (Pubitemid 28278073)
9. Marcus VA, Madlensky L, Gryfe R, Kim H, So K, Millar A, Temple LK, Hsieh E, Hiruki T, Narod S, Bapat BV, Gallinger S and Redston M: Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient rumors. Am J Surg Pathol 23: 1248-1255, 1999. (Pubitemid 29474595)
10. Simpkins SB, Backer T, Swisher EM, Mutch DG, Gersell DJ, Kovatich AJ, Palazzo JP, Fishel R and Goodfellow PJ: MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Hum Mol Genet 8: 661-666, 1999. (Pubitemid 29139981)
11. Mastrangelo D, Hadjistilianou T, Mazzotta C and Lore C: Microsatellite instability in three cases of embryonal rhabdomyosarcoma of the orbit. Med Pediatr Oncol 39: 132-133, 2002. (Pubitemid 34700724)
12. Aue G, Hedges LK, Schwartz HS, Bridge J A, Neff JR and Butler MG: Clear cell sarcoma or malignant melanoma of soft parts: molecular analysis of microsatellite instability with clinical correlation. Cancer Genet Cytogenet 105: 24-28, 1998. (Pubitemid 28345988)
13. Martin SS, Hurt WG, Hedges LK, Butler MG and Schwartz HS: Microsatellite instability in sarcomas. Ann Sura Oncol 5: 356-360, 1998. (Pubitemid 28272440)
14. Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Sakamoto A, Tamiya S, Iwamoto Y and Tsuneyoshi M: Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma. Hum Pathol 34: 841-849, 2003. (Pubitemid 37169612)
15. Suwa K, Ohmori M and Miki H: Microsatellite alterations in various sarcomas in Japanese patients. J Orthop Sci 4: 223-230, 1999. (Pubitemid 29274700)
16. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kawaguchi K, Kobayashi C, Oda S, Iwamoto Y and Tsuneyoshi M: Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberans. Hum Pathol 35: 240-245, 2004. (Pubitemid 38240908)
17. Kang GH, Shim YH and Ro JY: Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. Lab Invest 79:903-909, 1999. (Pubitemid 29344503)
18. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG and Melzer SJ: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 59: 1090-1095, 1999. (Pubitemid 29135970)
19. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN and Srivastava S: A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58: 5248-5257, 1998. (Pubitemid 28521189)
20. Oda S, Oki E, Maehara Y and Sugimachi K: Precise assessment of microsatellite instability using high resolution fluorescent microsatellite analysis. Nucleic Acids Res 25: 3415-3420, 1997. (Pubitemid 27359214)
21. Oda S, Maehara Y, Sumiyoshi Y and Sugimachi K: Microsatellite instability in cancer: what problems remain unanswered? Surgery 131: S55-62, 2002. (Pubitemid 34118617)
22. Ikeda Y, Oda S, Abe T, Ohno S, Maehara Y and Sugimachi K: Features of microsatellite instability in colorectal cancer: comparison between colon and rectum. Oncology 61: 168-174, 2001. (Pubitemid 32786212)
23. Tokunaga E, Oki E, Oda S, Kataoka A, Kitamura K, Ohno S, Maehara Y and Sugimachi K: Frequency of microsatellite instability in breast cancer determined by high-resolution fluorescent microsatellite analysis. Oncology 59: 44-49, 2000. (Pubitemid 30435835)
24. Taubert HW, Barrel F, Kappler M, Schuster K, Meye A, Lautenschlager C, Thamm-Muche B, Bache M, Schmidt H, Holzhausen HJ and Wurl P: Reduced expression of hMLH2 protein is correlated to poor survival for soft tissue sarcoma patients. Cancer 97: 2273-2278, 2003. (Pubitemid 36444072)
25. Idikio HA: Expression of DNA mismatch repair proteins hMSH2 and hMLH1 and the cyclin G1 inhibitor, p21 (wafl/cip1) in pediatric tumors: correlation with response to therapy. Oncol Rep 8: 965-971. 2001.
26. Catto JWF, Xinarianos G, Burton JL, Meuth M and Hamdy FC: Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability, [nt J Cancer 105: 484-490, 2003. (Pubitemid 36578551)
27. Jin T-X, Furihata M, Yamasaki I, Kamada M, Liang SB, Ohtsuki Y and Shuin T: Human mismatch repair gene (hMSH2) product expression in relation to recurrence of transitional cell carcinoma of the urinary bladder. Cancer 85: 478-484, 1999. (Pubitemid 29051305)
28. Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS and Ho JC: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 59: 159-164, 1999. (Pubitemid 29062972)
29. Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, Baylin SB and Issa JP: Aberrant methylation in gastric cancer associated with the CpG island melhylator phenotype. Cancer Res 59: 5938-5942, 1999.
30. Thibodeau SN, French AJ, Cunningham JM, Tester D, Burgart LJ, Roche PC, McDonnell SK, Schaid DJ, Vockley CW, Michels VV, Farr GH Jr and O'Connell MJ: Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 58: 1713-1718, 1998. (Pubitemid 28215098)
31. Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM and Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57: 808-811, 1997. (Pubitemid 27097998)
32. Ropke M, Boltze C, Neumann HW, Roessner A and Schneider-Stock R: Genetic and epigenetic alterations in tumor progression in a dedifferentiated chondrosarcoma. Pathol Res Pract 199: 437-444, 2003. (Pubitemid 36974832)
33. Deng G, Chen A, Hong J, Chae HS and Kim YS: Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of acne expression. Cancer Res 59: 2029-2033, 1999. (Pubitemid 29217657)