Differential methotrexate hepatotoxicity on rat hepatocytes in 2-D monolayer culture and 3-D gel entrapment culture

Chemico-Biological Interactions

Volumn 180, Issue 3, 2009, Pages 368-375

  Yin, Jian ^a   Meng, Qin ^a   Zhang, Guoliang ^b   Sun, Yonghong ^c  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c Exploitation and Medicinal Effectiveness Appraise for Cardio Cerebral Vascular and Nervous System of   (China)

Author keywords

Cyclosporine A; Hepatotoxicity; Methotrexate; Multidrug resistance associated protein 2; Primary rat hepatocytes; Probenecid

Indexed keywords

DEXAMETHASONE; GLUCAGON; INSULIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; LIVER CELL CULTURE; LIVER TOXICITY; MALE; MEMBRANE TRANSPORT; MONOLAYER CULTURE; NONHUMAN; RAT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; HEPATOCYTES; METHOTREXATE; RATS;

RATTUS;

EID: 67349127924     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.04.004     Document Type: Article

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