Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures

British Journal of Pharmacology

Volumn 153, Issue 4, 2008, Pages 784-791

  Shen, C ^a   Meng, Q ^a   Zhang, G ^a,b   Hu, W ^c  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Hepatotoxicity; Human hepatocytes; Isoniazid; Rat hepatocytes; Rifampicin; Tissue like culture

Indexed keywords

4 NITROCATECHOL; ALBUMIN; CYTOCHROME P450 2E1; GLUTATHIONE; ISONIAZID; MESSENGER RNA; RIFAMPICIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; ALBUMINS; ANIMALS; ANTITUBERCULAR AGENTS; CATECHOLS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INDUCTION; FEMALE; GLUTATHIONE; HEPATOCYTES; HUMANS; ISONIAZID; MALE; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; RIFAMPIN; RNA, MESSENGER; SPECIES SPECIFICITY;

EID: 39449117503     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707611     Document Type: Article

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