No effect of phenobarbital pretreatment of rats on methotrexate pharmacokinetics in the isolated liver perfused in a single-pass way

Pharmacology

Volumn 62, Issue 2, 2001, Pages 92-97

  Chládek, Jaroslav ^a   Martínková, Jiřina ^a   Šišpera, Luděk ^a   Chládková, Jiřina ^a   Cermanová, Jolana ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

7 Hydroxymethotrexate; Hepatobiliary transport of MTX; Metabolism of MTX; Methotrexate pharmacokinetics; Perfusion, single pass way; Phenobarbital pretreatment, rats

Indexed keywords

BOVINE SERUM ALBUMIN; BROMSULFOPHTHALEIN; CARRIER PROTEIN; GLUCOSE; GLUTATHIONE; METHOTREXATE; PHENOBARBITAL; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HYDROXYLATION; ERYTHROCYTE; FLOW RATE; GENE EXPRESSION; HEPATOBILIARY SYSTEM; ISOLATED LIVER; LIVER CLEARANCE; LIVER METABOLISM; LIVER PERFUSION; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; UREA CYCLE; VASCULAR RESISTANCE;

ANIMALS; BILE; EXCITATORY AMINO ACID ANTAGONISTS; FOLIC ACID ANTAGONISTS; LIVER; MALE; METHOTREXATE; OXYGEN CONSUMPTION; PHENOBARBITAL; RATS; RATS, WISTAR; VASCULAR RESISTANCE;

EID: 0035121696     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056077     Document Type: Article

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