Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes

Biochemical Pharmacology

Volumn 78, Issue 4, 2009, Pages 420-429

  Samanta, Uttamkumar ^a   Kirby, Stephen D ^a,b   Srinivasan, Prabhavathi ^a   Cerasoli, Douglas M ^b   Bahnson, Brian J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Lp PLA2; Nerve agent; Organophosphate; PAF AH; Phospholipase A2

Indexed keywords

DYFLOS; ORGANOPHOSPHORUS COMPOUND; OXIME; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 GROUP VIIA; SARIN; SOMAN; TABUN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHIRALITY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY; STEREOISOMERISM; TOXICOKINETICS;

BINDING SITES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESTERS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOLIPASES A2; PHOSPHORIC ACID ESTERS; SARIN; SYNAPSES;

EID: 67349111963     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.04.018     Document Type: Article

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