Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H 4 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5251-5256

  Terzioglu, Nalan ^a,b   Van Rijn, Richard M ^b   Bakker, Remko A ^b   De Esch, Iwan J P ^b   Leurs, Rob ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Antagonists; Histamine H 4 receptor

Indexed keywords

(5 CHLORO 1H INDOL 2 YL) (4 METHYLPIPERAZIN 1 YL)METHANONE; ANTIHISTAMINIC AGENT; BENZIMIDAZOLE DERIVATIVE; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; INDOLE; LIGAND; PIPERAZINE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; BINDING, COMPETITIVE; CELL LINE; HISTAMINE H1 ANTAGONISTS; HUMANS; INDOLES; LIGANDS; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344236080     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.035     Document Type: Article

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