Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors

Journal of Physiology

Volumn 583, Issue 2, 2007, Pages 731-742

  Breunig, Eva ^a   Michel, Klaus ^a   Zeller, Florian ^b   Seidl, Stefan ^a   Weyhern, Claus Werner Hann V ^a   Schemann, Michael ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Clinical Centre Freising   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLHISTAMINE; ALPHA METHYLHISTAMINE; BETAINE DERIVATIVE; CLOBENPROPIT; DIMAPRIT; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR AGONIST; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE RECEPTOR; MEPYRAMINE; PIPERAZINE DERIVATIVE; RANITIDINE; 1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; HISTAMINE H2 RECEPTOR AGONIST; HISTAMINE H3 RECEPTOR AGONIST; HISTAMINE H4 RECEPTOR ANTAGONIST; OMEGA CONOTOXIN MVIIA;

ADULT; AGED; AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; DRUG TARGETING; ENTERITIS; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; GANGLION; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE FUNCTION DISORDER; INTESTINE INNERVATION; LARGE INTESTINE; MAJOR CLINICAL STUDY; MALE; MICROINJECTION; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROIMAGING; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; SMALL INTESTINE; SPIKE WAVE; ACTION POTENTIAL; CELL ACTIVITY; CELL COUNT; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG MECHANISM; EVOKED RESPONSE; INFLAMMATORY BOWEL DISEASE; MYENTERIC PLEXUS; NERVE CELL; NERVE CELL STIMULATION; PHARMACOLOGICAL BLOCKING; RECEPTOR BLOCKING;

ACTION POTENTIALS; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HISTAMINE; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; HUMANS; INTESTINE, LARGE; INTESTINE, SMALL; MALE; MEMBRANE POTENTIALS; MICROINJECTIONS; MIDDLE AGED; PRESYNAPTIC TERMINALS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H2; RECEPTORS, HISTAMINE H3; SUBMUCOUS PLEXUS; TIME FACTORS;

EID: 34548319667     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.139352     Document Type: Article

References (39)

1. 3-receptor isoforms. Inflamm Res 53, 509-516.
2. Barbara G, Stanghellini V, de Giorgio R & Corinaldesi R (2006). Functional gastrointestinal disorders and mast cells: Implications for therapy. Neurogastroenterol Motil 18, 6-17.
3. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM & Corinaldesi R (2004). Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126, 693-702.
4. Bischoff S & Crowe SE (2005). Gastrointestinal food allergy: New insights into pathophysiology and clinical perspectives. Gastroenterology 128, 1089-1113.
5. 3 receptor antagonists reach out for the clinic. Drug Discov Today 10, 1613-1627.
6. 2 receptor-induced cyclical secretion in the guinea pig colon. Am J Physiol Gastrointest Liver Physiol 268, G465-G470.
7. Crowe SE & Perdue MH (1993). Anti-immunoglobulin E-stimulated ion transport in human large and small intestine. Gastroenterology 105, 764-772.
8. Crowe SE, Sestini P & Perdue MH (1990). Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology 99, 74-82.
9. 4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sci 26, 462-469.
10. Frieling T, Cooke HJ & Wood JD (1993). Histamine receptors on submucous neurons in guinea pig colon. Am J Physiol Gastrointest Liver Physiol 264, G74-G80.
11. Frieling T, Cooke HJ & Wood JD (1994). Neuroimmune communication in the submucous plexus of guinea pig colon after sensitization to milk antigen. Am J Physiol Gastrointest Liver Physiol 267, G1087-G1093.
12. Haas H & Panula P (2003). The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci 4, 121-130.
13. 3 receptor heterogeneity. Life Sci 73, 3043-3072.
14. He SH (2004). Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol 10, 309-318.
15. Ireland-Denny L, Parihar AS, Miller TR, Kang CH, Krueger KM, Esbenshade TA & Hancock AA (2001). Species-related pharmacological heterogeneity of histamine H 3 receptors. Eur J Pharmacol 433, 141-150.
16. Keely SJ, Stack WA, O'Donoghue DP & Baird AW (1995). Regulation of ion transport by histamine in human colon. Eur J Pharmacol 279, 203-209.
17. 3 receptor drugs. Nat Rev Drug Discov 4, 107-120.
18. 4 receptor agonist. J Pharmacol Exp Ther 314, 1310-1321.
19. 3 receptor-mediated suppression of inhibitory synaptic transmission in the submucous plexus of guinea-pig small intestine. Eur J Pharmacol 397, 49-54.
20. Lomax AE, Fernandez E & Sharkey KA (2005). Plasticity of the enteric nervous system during intestinal inflammation. Neurogastroenterol Motil 17, 4-15.
21. MacGlashan D Jr (2003). Histamine: A mediator of inflammation. J Allergy Clin Immunol 112, S53-S59.
22. Maurer M, Theoharides T, Granstein RD, Bischoff SC, Bienenstock J, Henz B, Kovanen P, Piliponsky AM, Kambe N, Vliagoftis H, Levi-Schaffer F, Metz M, Miyachi Y, Befus D, Forsythe P, Kitamura Y & Galli S (2003). What is the physiological role of mast cells? Exp Dermatol 12, 886-910.
23. 3 receptors. Gastroenterology 128, 1317-1326.
24. Nemeth PR, Ort CA & Wood JD (1984). Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. J Physiol 355, 411-425.
25. Neunlist M, Peters S & Schemann M (1999). Multisite optical recording of excitability in the enteric nervous system. Neurogastroenterol Motil 11, 393-402.
26. Raithel M, Matek M, Baenkler HW, Jorde W & Hahn EG (1995). Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy. Int Arch Allergy Immunol 108, 127-133.
27. Sander LE, Lorentz A, Sellge G, Coeffier M, Neipp M, Veres T, Frieling T, Meier PN, Manns MP & Bischoff SC (2006). Selective expression of histamine receptors H1R, H2R and H4R, but not H3R, in the human intestinal tract. Gut 55, 498-504.
28. Schemann M, Michel K, Ceregrzyn M, Zeller F, Seidl S & Bischoff SC (2005). Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system. Neurogastroenterol Motil 17, 281-289.
29. Schemann M, Michel K, Peters S, Bischoff SC & Neunlist M (2002). Cutting-edge technology. III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system. Am J Physiol Gastrointest Liver Physiol 282, G919-G925.
30. Schemann M & Neunlist M (2004). The human enteric nervous system. Neurogastroenterol Motil 16, 55-59.
31. Schneider J, Jehle EC, Starlinger MJ, Neunlist M, Michel K, Hoppe S & Schemann M (2001). Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease. Neurogastroenterol Motil 13, 255-264.
32. Stack WA, Keely SJ, O'Donoghue DP & Baird AW (1995). Immune regulation of human colonic electrolyte transport in vitro. Gut 36, 395-400.
33. Stead RH, Dixon MF, Bramwell NH, Riddell RH & Bienenstock J (1989). Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 97, 575-585.
34. Tamura K, Palmer JM & Wood JD (1988). Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience 25, 171-179.
35. 4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 309, 404-413.
36. 4 receptor antagonists on experimental colitis in the rat. Eur J Pharmacol 522, 130-138.
37. Wood JD (2004). Enteric neuroimmunophysiology and pathophysiology. Gastroenterology 127, 635-657.
38. Wood JD (2006). Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies. Gut 55, 445-447.
39. Xie H & He S (2005). Roles of histamine and its receptors in allergic and inflammatory bowel diseases. World J Gastroenterol 11, 2851-2857.