Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 20-21, 2009, Pages 1937-1942

  Chytil, Lukáš ^a   Štícha, Martin ^a   Matoušková, Olga ^a   Perlík, František ^a   Slanař, Ondřej ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cytochrome P450 2D6; Enantiomeric separation; Excretion; Metabolic phenotype; O Desmethyltramadol; Probe drug; Tramadol; Urine

Indexed keywords

CYTOCHROME P450 2D6; ENANTIOMERIC SEPARATION; EXCRETION; METABOLIC PHENOTYPE; O-DESMETHYLTRAMADOL; TRAMADOL; URINE;

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; CONCENTRATION (PROCESS); CYCLODEXTRINS; EXTRACTION; IONIZATION OF GASES; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; PROBES; SPECTRUM ANALYSIS;

GAS CHROMATOGRAPHY;

BETA CYCLODEXTRIN; NEFOPAM; TRAMADOL;

ALKYLATION; ARTICLE; CALIBRATION; CHIRALITY; CONCENTRATION (PARAMETERS); DRUG STRUCTURE; ENANTIOMER; HUMAN; MASS FRAGMENTOGRAPHY; PHARMACOGENETICS; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; STANDARD; STEREOCHEMISTRY; URINALYSIS;

ANALGESICS, OPIOID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; SOLID PHASE EXTRACTION; STEREOISOMERISM; TRAMADOL;

EID: 67049145399     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.04.042     Document Type: Article

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