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Volumn 949, Issue 1-2, 2002, Pages 11-22

High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma - Application to a bioequivalence study in humans

(9) Nobilis, M a Kopecky J a Kvetina J a Chladek J a Svoboda, Z a Vorisek V b Perlik F b Pour, M c Kunes J c

a INSTITUTE OF MATHEMATICS (Czech Republic)

b CHARLES UNIVERSITY (Czech Republic)

c Charles University in Prague Faculty of Pharmacy (Czech Republic)

Author keywords

Bioequivalence; O desmethyltramadol; Pharmacokinetics in humans; Tramadol

Indexed keywords

ACETONITRILE; BLOOD; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; PH; PHARMACODYNAMICS;

MOBILE PHASE;

DRUG PRODUCTS;

ACETONITRILE; DRUG METABOLITE; O NORTRAMADOL; PROTRADON; TRAMADOL; UNCLASSIFIED DRUG; WATER;

ADULT; ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; MALE; METHYLATION; NORMAL HUMAN; PH; PLASMA; PRIORITY JOURNAL;

ANALGESICS, OPIOID; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; REFERENCE STANDARDS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; THERAPEUTIC EQUIVALENCY; TRAMADOL;

EID: 0037040557 PISSN: 00219673 EISSN: None Source Type: Journal
DOI: 10.1016/S0021-9673(01)01567-9 Document Type: Article

Times cited : (72)

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