Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 152-159

  Mehvar, Reza ^a   Elliott, Katherine ^a   Parasrampuria, Ridhi ^a   Eradiri, Okponanabofa ^b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Biovail Technologies Ltd   (United States)

Author keywords

Active metabolite; Enantioselective assay; Stereoselective metabolism; Stereoselective pharmacokinetics; Stereospecific assay; Tramadol

Indexed keywords

N,O-DEMETHYLATED (M5); O-DEMETHYLATED (M1); STEREOSPECIFIC ASSAY; TRAMADOL;

ACIDITY; ENANTIOMERS; FLUORESCENCE; METABOLITES; ORGANIC COMPOUNDS; PLASMA (HUMAN);

LIQUID CHROMATOGRAPHY;

ALCOHOL; DIETHYLAMINE; HEXANE; O DEMETHYL N DEMETHYL TRAMADOL; O DEMETHYL TRAMADOL; PENBUTOLOL; TERT BUTYL METHYL ETHER; TRAMADOL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENANTIOMER; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY;

ANALGESICS, OPIOID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; METHYLATION; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; TRAMADOL;

EID: 34249684380     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.01.004     Document Type: Article

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