Improved liquid chromatographic method for the simultaneous determination of tramadol and its three main metabolites in human plasma, urine and saliva

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 5, 2007, Pages 1168-1173

  Ardakani, Yalda H ^a   Rouini, Mohammad Reza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Monolithic; N Desmethyltramadol; O,N Didesmethyltramadol; O Desmethyltramadol; Plasma; Saliva; Tramadol; Urine

Indexed keywords

METHANOL; PHOSPHORIC ACID; TRAMADOL; WATER;

ARTICLE; CALIBRATION; CONCENTRATION RESPONSE; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EXCRETION; DRUG ISOLATION; DRUG SALIVA LEVEL; DRUG URINE LEVEL; FLOW RATE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; METABOLITE; NORMAL HUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SINGLE DRUG DOSE; URINARY EXCRETION;

ANALGESICS, OPIOID; CALIBRATION; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; METHANOL; MOLECULAR STRUCTURE; PHOSPHORIC ACIDS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SALIVA; SENSITIVITY AND SPECIFICITY; SOLUTIONS; STEREOISOMERISM; TABLETS; TIME FACTORS; TRAMADOL; WATER;

EID: 34547816010     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.04.012     Document Type: Article

References (23)

1. Guo W.Y., Zhan Q., Zhao Y., and Wang L. Biomed. Chromatogr. 12 (1998) 13-14
2. Scott L.J., and Perry C.M. Drugs 60 (2000) 139-176
3. Lewis K.S., and Han N.H. Am. J. Health Syst. Pharm. 54 (1997) 643-652
4. Lintz W., Barth H., Becker R., Frankus E., and Schmidt-Bothelt E. Arzneimittelforschung 48 (1998) 436-447
5. Budd K., and Langford R. Br. J. Anaesth. 82 (1999) 493-495
6. Lintz W., Erlacin S., Frankus E., and Uragg H. Arzneimittelforschung 31 (1981) 1932-1943 (German)
7. Subrahmanyam V., Renwick A.B., Walters D.G., Young P.J., Price R.J., Tonelli A.P., and Lake B.G. Drug Metab. Dispos. 29 (2001) 1146-1155
8. Gan S.H., and Ismail R. J. Chromatogr. B Biomed. Sci. Appl. 759 (2001) 325-335
9. Yeh G.C., Sheu M.T., Yen C.L., Wang Y.W., Liu C.H., and Ho H.O. J. Chromatogr. B Biomed. Sci. Appl. 723 (1999) 247-253
10. Gan S.H., Ismail R., Wan Adnan W.A., and Wan Z. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 772 (2002) 123-129
11. Overbeck P., and Blaschke G. J. Chromatogr. B Biomed. Sci. Appl. 732 (1999) 185-192
12. Nobilis M., Kopecky J., Kvetina J., Chladek J., Svoboda Z., Vorisek V., Perlik F., Pour M., and Kunes J. J. Chromatogr. A 949 (2002) 11-22
13. Gu Y., and Fawcett J.P. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 821 (2005) 240-243
14. Valle M., Pavon J.M., Calvo R., Campanero M.A., and Troconiz I.F. J. Chromatogr. B Biomed. Sci. Appl. 724 (1999) 83-89
15. Zhao L.M., Chen X.Y., Cui J.J., Sunita M., and Zhong D.F. Yao Xue Xue Bao 39 (2004) 458-462
16. Ceccato A., Chiap P., Hubert P., and Crommen J. J. Chromatogr. B Biomed. Sci. Appl. 698 (1997) 161-170
17. Campanero M.A., Calahorra B., Valle M., Troconiz I.F., and Honorato J. Chirality 11 (1999) 272-279
18. Ceccato F.V., Pabst J.Y., and Streel B. J. Chromatogr. B Biomed. Sci. Appl. 748 (2000) 65-76
19. Campanero M.A., Garcia-Quetglas E., Sadaba B., and Azanza J.R. J. Chromatogr. A 1031 (2004) 219-228
20. Rouini M.R., Ardakani Y.H., Soltani F.K., Aboul-Enein H.Y., and Foroumadi A. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 830 (2006) 207-211
21. Abdel-Rahman S.M., Leeder J.S., Wilson J.T., Gaedigk A., Gotschall R.R., Medve R., and Liao S. J. Clin. Pharmacol. 42 (2002) 24-29
22. Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER), 2001.
23. O'Neal C.L., Crouch D.J., Rollins D.E., Fatah A., and Cheever M.L. J. Anal. Toxicol. 23 (1999) 452-459