The pharmacology of tramadol;Pharmacologie du tramadol

Drugs

Volumn 53, Issue SUPPL. 2, 1997, Pages 18-24

  Dayer, Pierre ^a   Desmeules, Jules ^a   Collart, Laurence ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CYTOCHROME P450; MONOAMINE OXIDASE INHIBITOR; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NORADRENALIN; OPIATE; SEROTONIN; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT;

ANALGESIA; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CONSTIPATION; DEMETHYLATION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG MONITORING; DRUG SELECTIVITY; DRUG TOLERABILITY; DYSPHORIA; ENANTIOMER; HUMAN; MAXIMUM PERMISSIBLE DOSE; NAUSEA; ORAL DRUG ADMINISTRATION; PAIN; RACEMIC MIXTURE; RECEPTOR AFFINITY; RESPIRATION DEPRESSION; SEROTONIN UPTAKE;

EID: 0031003065     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199700532-00006     Document Type: Conference Paper

References (39)

1. Hennies HH, Friderichs E, Schneider J. Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung 1988; 38: 877-80
2. Raffa RB, Friderichs E, Reimann W, et al. Opioid and non-opioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992; 260: 275-85
3. Raffa RB, Nayak RK, Liao S, et al. The mechanism(s) of action and pharmacokinetics of tramadol hydrochloride. Rev Cont Pharmacother 1995; 6: 485-98
4. Raffa RB. A novel approach to the pharmacology of analgesics. Am J Med 1996; 101 Suppl 1A: 40-6S
5. Paar WD, Frankus P, Dengler HJ. The metabolism of tramadol by human liver microsomes. Clin Invest 1992; 70: 708-10
6. Raffa RB, Vaught JL, Shank RP, et al. Tramadol, a centrally acting analgesic: the contribution of its enantiomers to antinociception and lowered side effects in mice [abstract]. 7th World Congress on Pain: 1993 Aug 22-27: Paris: 521
7. Carlsson KH, Jurna I. Effects of tramadol on motor and sensory responses of the spinal nociceptive system in the rat. Eur J Pharmacol 1987; 139: 1-10
8. Mattia A, Vanderah T, Raffa RB, et al. Characterization of the unusual antinociceptive profile of tramadol in mice. Drug Dev Res 1993; 31: 1932-43
9. Kayser V, Besson JM, Guildbaud G. Effects of the analgesic-agent tramadol in normal and arthritic rats: comparison with the effects of different opioids, including tolerance and cross-tolerance to morphine. Eur J Pharmacol 1991; 195: 37-45
10. Hennies HH, Friderichs E, Wilsman K, et al. Effect of the opioid analgesic tramadol on inactivution of norepinephrine and serotonin. Biochem Pharmacol 1982; 31: 1654-5
11. Kayser V, Besson JM, Guildbaud G. Evidence for noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat. Eur J Pharmacol 1992; 224: 83-8
12. Collart L, Luthy C, Dayer P. Partial inhibition of tramadol antinociceptive effect by naloxone in man. Proceedings of the British Pharmacological Society, London, September 1992. Br J Clin Pharmacol 1993; 35: 73P
13. Collart L, Luthy C, Dayer P. Multimodal analgesic effect of tramadol. Annual Meeting of the American Society of Clinical Pharmacology and Therapeutics, Honolulu, March 1993: Clin Pharmacol Ther 1993; 53: 223
14. Desmeules JA, Piguet V, Collart L, et al. Contribution of mono-aminergic modulation to the analgesic effect of tramadol. Br J Clin Pharmacol 1996; 41: 7-12
15. Boiteau R, Tenaillon A, Perrin-Gachadoat D, et al. Haemodynamic and respiratory effects of tramadol and propacetamol in acute exacerbation of chronic heart failure [abstract 832]. 7th World Congress on Pain: 1993 Aug 22-27: Paris: 310
16. Canet J, Aguilar JL, Segrí A, et al. Oral ramadol does not depress the respiratory response to CO2 [abstract A294]. Br J Anaesth 1995; 74 Suppl. 1: 90
17. Lee CR, McTavish D, Sorkin EM. Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs 1993; 46: 313-40
18. Stankov S. Haemodynamic effects of tramadol and morphine in patients with acute myocardial infarction [abstract 780]. 7th World Congress on Pain. 1993 Aug 22-27: Paris: 293
19. Staritz M, Poralla T, Manns M, et al. Effect of modern analgesic drugs (tramadol, pentazocine and buprenorphine) on the bile duct sphincter in man. Gut 1986; 27: 567-9
20. Wilder-Smith Ch, Bettiga A. Gastrointestinal transit and smooth muscle tone are not affected by the analgesic tramadol. Part I: helthy volunteers [abstract]. Gastroenterology 1996; 110 (4) Suppl.: A780
21. Liao S, Hill JF, Nayak RK. Pharmacokinetics of tramadol following single and multiple oral doses in man [abstract PPDM 8206]. Pharm Res 1992; 9 Suppl. 1: 308
22. Lintz W, Barth H, Osterloh G, et al. The bioavailability of enteral tramadol formulations - 1st communication: capsules, Arzneimittelforschung 1986; 36: 1278-83
23. Gibson TP. Pharmacokinetics, efficacy and safety of analgesia with a focus on tramadol HCl. Am J Med 1996; 101 Suppl 1A: 47-53S
24. Lintz W, Beier H, Gerloff J. Absolute bioavailability of tramadol after intramuscular administration of tramal®-50 solution for injection in 12 male volunteers [abstract 1426]. 7th World Congress on Pain: 1993 Aug 22-27: Paris: 537
25. Lintz W, Erlacin S, Frankus E, et al. Metabolismus von Tramadol bei Mensch und Teir. Arzneimittelforschung 1981; 31: 1932-43
26. Leemann T, Dayer P, Meyer UA. Single dose quinidine treatment inhibits metoprolol oxidation in extensive metabolisers. Eur J Clin Pharmacol 1986; 29: 739-41
27. Katz WA. Pharmacology and clinical experience with tramadol in osteoarthritis. Drugs 1996; 52 Suppl. 3: 39-47
28. Sunshine A. New clinical experience with tramadol. Drugs 1994; 47 Suppl. 1: 8-18
29. Piletta P, Porchet HC, Dayer P. Central analgesic effect of acetaminophen but not of aspirin. Clin Pharmacol Ther 1991; 49: 350-354
30. Desmeules J, Gascon MP, Dayer P, et al. Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol 1991; 41: 23-6
31. Brown J, Jackson A, Wan Wagoner D, et al. Tramadol HCl: dose response in pain following caesarean section. Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Orlando, March 1992. Clin Pharmacol Ther 1992; 51: 121
32. Murphy D, Murphy MB. A comparison of the effects of tramadol and morphine on gastric emptying in man. 18th Annual Meeting of the European Academy of Anaesthesiology: 1996 Aug 29-Sep 1: Copenhagen, Denmark: 31
33. Cossmann M, Wilsman KM. Wirkung und Begleitwirkungen von Tramadol. Therapiewoche 1987; 37: 3475-85
34. Cossmann, Wilsmann KM. Treatment of prolonged pain: assessment of the efficacy and safety of repeated administration of tramadol. Munch Med Wochenschr 1987; 129: 851-4
35. Cossmann M, Wilsmann KM. Anwendung der Tramadol-Injektionslösung (Tramal®) beim akuten Schmerz. Offene Prüfung zur Beurteilung der Akutwirkung und der Verträglichkeit beieinmaliger perenteraler Anwendung. Munch Med Wochenschr 1988; 130: 633-6
36. Radbruch L, Grond S, Lehmann KA. A risk-benefit assessment of tramadol in the management of pain. Drug Saf 1996; 15: 8-29
37. Nightingale SL. Important new safety information for tramadol hydrochloride. JAMA 1996; 275 (16): 1224
38. Riedel F, von Stockhausen HB. Severe cerebral depression after intoxication with tramadol in a 6-month old infant. Eur J Clin Pharmacol 1984; 26: 631-32
39. Keup W. Missbrauchmuster bei Abhängigkeit von Alkohol, Medikamenten und Drogen - Frühwarnsystem-Daten für die Bundesrepublik Deutschland 1976-1990. Lambertus Verlag, Freiburg im Breisgau; 1993