Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway

Molecular Pharmacology

Volumn 75, Issue 6, 2009, Pages 1356-1363

  Cui, B ^a   Johnson, S P ^a   Bullock, N ^a   Ali Osman, F ^a   Bigner, D D ^a   Friedman, H S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ATR PROTEIN; CAFFEINE; CARMUSTINE; CHECKPOINT KINASE 1; SERINE; SMALL INTERFERING RNA; WORTMANNIN;

ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; ENZYME ACTIVATION; HUMANS; MUTS DNA MISMATCH-BINDING PROTEIN; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SIGNAL TRANSDUCTION;

EID: 66849084009     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053124     Document Type: Article

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