Activation of the S phase DNA damage checkpoint by mitomycin C

Journal of Cellular Physiology

Volumn 211, Issue 2, 2007, Pages 468-476

  Mladenov, Emil ^a   Tsaneva, Irina ^b   Anachkova, Boyka ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CAFFEINE; DNA; HISTONE H2AX; MITOMYCIN C; RAD51 PROTEIN;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL NUCLEUS MATRIX; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ANDROSTADIENES; ANTIBIOTICS, ANTINEOPLASTIC; ATAXIA TELANGIECTASIA; CAFFEINE; CELL CYCLE PROTEINS; CELL NUCLEUS; CHROMATIN; CROSS-LINKING REAGENTS; DNA DAMAGE; DNA REPLICATION; DNA-BINDING PROTEINS; HELA CELLS; HISTONES; HUMANS; MITOMYCIN; NUCLEAR MATRIX; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; S PHASE; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 34147201571     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20957     Document Type: Article

References (42)

1. Abraham RT. 2004. PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways. DNA Repair (Amst) 3:883-887.
2. Akkari YM, Bateman RL, Reifsteck CA, Olson SB, Grompe M. 2000. DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links. Mol Cell Biol 20:8283-8289.
3. Anachkova B, Djeliova V, Russev G. 2005. Nuclear matrix support of DNA replication. J Cell Biochem 96:951-961.
4. Atanassov B, Gospodinov A, Stoimenov I, Mladenov E, Russev G, Tsaneva I, Anachkova B. 2005. Repair of DNA interstrand crosslinks may take place at the nuclear matrix. J Cell Biochem 96:126-136.
5. Bischof O, Kim SH, Irving J, Beresten S, Ellis NA, Campisi J. 2001. Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153:367-380.
6. Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A. 2003. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol 5:675-679.
7. Cortez D. 2003. Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. J Biol Chem 278:37139-37145.
8. Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O. 2006. ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med 203:297-303.
9. Dronkert ML, Kanaar R. 2001. Repair of DNA interstrand cross-links. Mutat Res 486:217-247.
10. Essers J, Houtsmuller AB, van Veelen L, Paulusma C, Nigg AL, Pastink A, Vermeulen W, Hoeijmakers JH, Kanaar R. 2002. Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. Embo J 21:2030-2037.
11. Guo N, Faller DV, Vaziri C. 2002. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth Differ 13:77-86.
12. Haaf T, Golub EI, Reddy G, Radding CM, Ward DC. 1995. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci USA 92:2298-2302.
13. Huber LJ, Chodosh LA. 2005. Dynamics of DNA repair suggested by the subcellular localization of Brca1 and Brca2 proteins. J Cell Biochem 96:47-55.
14. Joerges C, Kuntze I, Herzinger T. 2003. Induction of a caffeine-sensitive S-phase cell cycle checkpoint by psoralen plus ultraviolet A radiation. Oncogene 22:6119-6128.
15. Kaufmann WK, Heffernan TP, Beaulieu LM, Doherty S, Frank AR, Zhou Y, Bryant MF, Zhou T, Luche DD, Nikolaishvili-Feinberg N, Simpson DA, Cordeiro-Stone M. 2003. Caffeine and human DNA metabolism: The magic and the mystery. Mutat Res 532:85-102.
16. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
17. Liu Y, Maizels N. 2000. Coordinated response of mammalian Rad51 and Rad52 to DNA damage. EMBO Rep 1:85-90.
18. McHugh PJ, Spanswick VJ, Hartley JA. 2001. Repair of DNA interstrand crosslinks: Molecular mechanisms and clinical relevance. Lancet Oncol 2:483-490.
19. Mladenov E, Anachkova B. 2003. DNA breaks induction by mimosine. Z Naturforsch [C] 58:732-735.
20. Mladenov E, Anachkova B, Tsaneva I. 2006. Sub-nuclear localization of Rad51 in response to DNA damage. Genes Cells 11:513-524.
21. Mladenova V, Russev G. 2006. Enhanced repair of DNA interstrand crosslinks in S-phase. FEBS Lett 580:1631-1634.
22. Morgan SE, Kastan MB. 1997. p53 and ATM: Cell cycle, cell death, and cancer. Adv Cancer Res 71:1-25.
23. Niedernhofer LJ, Lalai AS, Hoeijmakers JH. 2005. Fanconi anemia (cross)linked to DNA repair. Cell 123:1191-1198.
24. O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. 2003. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 33:497-501.
25. Pichierri P, Rosselli F. 2004a. The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. Embo J 23:1178-1187.
26. Pichierri P, Rosselli F. 2004b. Fanconi anemia proteins and the S-phase checkpoint. Cell Cycle 3:698-700.
27. Qiao F, Moss A, Kupfer GM. 2001. Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage-and cell cycle-regulated manner. J Biol Chem 276:23391-23396.
28. Reddy MC, Vasquez KM. 2005. Repair of genome destabilizing lesions. Radiat Res 164:345-356.
29. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868.
30. Rothfuss A, Grompe M. 2004. Repair kinetics of genomic interstrand DNA cross-links: Evidence for DNA double-strand break-dependent activation of the Fanconi anemia/ BRCA pathway. Mol Cell Biol 24:123-134.
31. Rotman G, Shiloh Y. 1998. ATM: From gene to function. Hum Mol Genet 7:1555-1563.
32. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85.
33. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. 1998. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 58:4375-4382.
34. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT. 1999. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
35. Sorensen CS, Hansen LT, Dziegielewski J, Syljuasen RG, Lundin C, Bartek J, Helleday T. 2005. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 7:195-201.
36. Stein GS, Zaidi SK, Braastad CD, Montecino M, van Wijnen AJ, Choi JY, Stein JL, Lian JB, Javed A. 2003. Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair. Trends Cell Biol 13:584-592.
37. Syljuasen RG, Sorensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J. 2005. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 25:3553-3562.
38. Tan TL, Essers J, Citterio E, Swagemakers SM, de Wit J, Benson FE, Hoeijmakers JH, Kanaar R. 1999. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation. Curr Biol 9:325-328.
39. Tarsounas M, Davies AA, West SC. 2004. RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci 359:87-93.
40. Warren AJ, Hamilton JW. 1996. Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand cross-link in a model synthetic 23 base pair oligonucleotide DNA duplex. Chem Res Toxicol 9:1063-1071.
41. West SC. 2003. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 4:435-445.
42. Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. 2005. The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep 6:118-133.