Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU

Oncogene

Volumn 24, Issue 13, 2005, Pages 2175-2183

  Yan, Ling ^a   Donze, Jon R ^a   Liu, Lili ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle checkpoint; DNA damage; MGMT; Mitosis

Indexed keywords

CARMUSTINE; COMPLEMENTARY DNA; CYCLIN B1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; DRUG DERIVATIVE; GUANINE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MITOSIS; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CELL DEATH; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENETICS; SITE DIRECTED MUTAGENESIS; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; CARMUSTINE; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; G2 PHASE; GUANINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 16444365995     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208250     Document Type: Article

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