Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients

Journal of Hepatology

Volumn 37, Issue 6, 2002, Pages 837-842

  Westin, Johan ^a,b   Nordlinder, Hans ^a   Lagging, Martin ^a   Norkrans, Gunnar ^a   Wejstål, Rune ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Hepatitis C; Liver fibrosis; Liver steatosis

Indexed keywords

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; FATTY LIVER; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VIRUS GENE; VIRUS PATHOGENESIS; GENETICS; LIVER CIRRHOSIS; MIDDLE AGED; PATHOLOGY; TIME; VIROLOGY;

ADULT; DISEASE PROGRESSION; FATTY LIVER; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; OBESITY; PREVALENCE; TIME FACTORS;

EID: 0036892355     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00299-4     Document Type: Article

References (31)

1. Scheuer PJ, Ashrafzadeh P, Sherlock S, Brown D, Dusheiko GM. The pathology of hepatitis C. Hepatology 1992;15(4):567-571.
2. Bach N, Thung SN, Schaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: A comparative analysis. Hepatology 1992;15(4):572-577.
3. Mihm S, Fayyazi A, Hartmann H, Ramadori G. Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 1997;25(3):735-739.
4. Rubbia-Brandt L, Quadri R, Abid K, Giostra E, Male PJ, Mentha G, et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000;33(1):106-115.
5. Adinolfi LE, Utili R, Andreana A, Tripodi MF, Rosario P, Mormone G, et al. Relationship between genotypes of hepatitis C virus and histopathological manifestations in chronic hepatitis C patients. Eur J Gastroenterol Hepatol 2000;12(3):299-304.
6. Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K, Matsuura Y. et al. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 1997:78(Pt 7):1527-1531.
7. Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors. Hepatology 1990;12(5):1106-1110.
8. Hourigan LF, Macdonald GA, Purdie D, Whitehall VH, Shorthouse C, Clouston A, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 1999;29(4):1215-1219.
9. Hwang SJ, Luo JC, Chu CW, Lai CR, Lu CL, Tsay SH, et al. Hepatic steatosis in chronic hepatitis C virus infection: Prevalence and clinical correlation. J Gastroenterol Hepatol 2001;16(2):190-195.
10. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Host- and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol 1998;29(2):198-206.
11. Fiore G, Fera G, Napoli N, Vella F, Schiraldi O. Liver steatosis and chronic hepatitis C: A spurious association?. Eur J Gastroenterol Hepatol 1996;8(2):125-129.
12. Ong JP, Younossi ZM, Speer C, Olano A, Gramlich T, Boparai N. Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. Liver 2001;21(4):266-271.
13. Adinolfi LE, Gambardella M. Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001;33(6):1358-1364.
14. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22(6):696-699.
15. Westin J. Lagging LM, Wejstal R, Norkrans G, Dhillon AP. Inter-observer study of liver histopathology using the Ishak score in patients with chronic hepatitis C virus infection. Liver 1999;19(3):183-187.
16. Widell A, Shev S, Mansson S, Zhang YY, Foberg U, Norkrans G, et al. Genotyping of hepatitis C virus isolates by a modified polymerase chain reaction assay using type specific primers: Epidemiological applications. J Med Virol 1994;44(3):272-279.
17. Altman DG. Practical Statistics for Medical Research, London: Chapman and Hall, 1991. pp. 351-358.
18. Lefkowitch JH, Apfelbaum TF. Non-A, non-B hepatitis: Characterization of liver biopsy pathology. J Clin Gastroenterol 1989;11(2):225-232.
19. Lefkowitch JH, Schiff ER, Davis GL, Perrillo RP, Lindsay K, Bodenheimer Jr. HC, et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology 1993;104(2):595-603.
20. Rubbia-Brandt L, Leandro G, Spahr L, Giostra E, Quadri R, Male PJ, et al. Liver steatosis in chronic hepatitis C: A morphological sign suggesting infection with HCV genotype 3. Histopathology 2001;39(2):119-124.
21. Baiocchi L, Tisone G, Palmieri G, Rapicetta M, Pisani F, Orlando G, et al. Hepatic steatosis: A specific sign of hepatitis C reinfection after liver transplantation. Liver Transpl Surg 1998;4(6):441-447.
22. Jonsson J, Hourigan L, Purdie D, Clouston A, Macdonald G, Powell E. Body composition and hepatic steatosis as precursors of fibrosis in chronic hepatitis C patients. Hepatology 1999;30(6):1530-1531.
23. Clouston AD, Jonsson JR, Purdie DM, Macdonald GA, Pandeya N, Shorthouse C, et al. Steatosis and chronic hepatitis C: Analysis of fibrosis and stellate cell activation. J Hepatol 2001;34(2):314-320.
24. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121(1):91-100.
25. Fujie H, Yotsuyanagi H, Moriya K, Shintani Y, Tsutsumi T, Takayama T, et al. Steatosis and intrahepatic hepatitis C virus in chronic hepatitis. J Med Virol 1999;59(2):141-145.
26. Clouston AD, Jonsson JR, Hickman I, Shorthouse C, Mori T, Prins J, et al. Weight reduction in patients with chronic hepatitis C improves liver histology and biochemistry (abstract). Hepatology 2000;33:308A.
27. Adinolfi LE, Utili R, Andreana A, Tripodi MF, Marracino M, Gambardella M, et al. Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C. Dig Dis Sci 2001;46(8):1677-1683.
28. Lagging LM, Westin J, Svensson E, Aires N, Dhillon AP, Lindh M, et al. Progression of fibrosis in untreated patients with hepatitis C virus infection. Liver 2002;22:136-144.
29. Poynard T, Ratziu V, Charlotte F, Goodman Z, McHutchison J, Albrecht J. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C. J Hepatol 2001;34(5):730-739.
30. Westin J, Lindh M, Lagging LM, Norkrans G, Wejstal R. Chronic hepatitis C in Sweden: Genotype distribution over time in different epidemiological settings. Scand J Infect Dis 1999;31(4):355-358.
31. Pawlotsky JM, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, et al. Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C. J Infect Dis 1995;171(6):1607-1610.