Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: Roles of MAPKerk and MAPKp38

Diabetes

Volumn 52, Issue 5, 2003, Pages 1073-1080

  Au, Wo Shing ^b   Kung, Hsiang Fu ^b   Lin, Marie C ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ERK; MITOGEN ACTIVATED PROTEIN KINASE P38; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; DYSLIPIDEMIA; ENVIRONMENTAL FACTOR; GENE; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN GENE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION;

CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN; KINETICS; LIVER NEOPLASMS; MICROSOMES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0242516072     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.5.1073     Document Type: Article

References (44)

1. Taskinen MR: Diabetic dyslipidemia. Atheroscler Suppl 3:47-51, 2002
2. Wagner AM, Perez A, Calvo F, Bonet R, Castellvi A, Ordonez J: Apolipoprotein(B) identifies dyslipidemic phenotypes associated with cardiovascular risk in normocholesterolemic type 2 diabetic patients. Diabetes Care 22:812-817, 1999
3. Davis RA, Hui TY: 2000 George Lyman Duff Memorial Lecture: atherosclerosis is a liver disease of the heart. Arterioscler Thromb Vasc Biol 21:887-898, 2001
4. Verges BL: Dyslipidaemia in diabetes mellitus. Review of the main lipoprotein abnormalities and their consequences on the development of atherogenesis. Diabetes Metab 25 (Suppl. 3):32-40, 1999
5. Duvillard L, Pont F, Florentin E, Galland-Jos C, Gambert P, Verges B: Metabolic abnormalities of apolipoprotein B-containing lipoproteins in non-insulin-dependent diabetes: a stable isotope kinetic study. Eur J Clin Invest 30:685-694, 2000
6. Wetterau JR, Lin MC, Jamil H: Microsomal triglyceride transfer protein. Biochim Biophys Acta 1345:136-150, 1997
7. Nielsen LB, Veniant M, Boren J, Raabe M, Wong JS, Tam C, Flynn L, Vanni-Reyes T, Gunn MD, Goldberg IJ, Hamilton RL, Young SG: Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. Circulation 98:13-16, 1998
8. Gordon DA, Jamil H, Gregg RE, Olofsson SO, Boren J: Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J Biol Chem 271:33047-33053, 1996
9. Rustaeus S, Stillemark P, Lindberg K, Gordon D, Olofsson SO: The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McARH7777 cells. J Biol Chem 273:5196-5203, 1998
10. Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois KG, Kunselman LK, Lan SJ, Maccagnan TJ, Ricci B, Yan M, Young D, Chen Y, Fryszman OM, Logan JV, Musial CL, Poss MA, Robl JA, Simpkins LM, Biller SA, et al.: An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 282:751-754, 1998
11. Chang BH, Liao W, Li L, Nakamuta M, Mack D, Chan L: Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse. J Biol Chem 274:6051-6055, 1999
12. Raabe M, Veniant MM, Sullivan MA, Zlot CH, Bjorkegren J, Nielsen LB, Wong JS, Hamilton RL, Young SG: Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 103:1287-1298, 1999
13. Leung GK, Veniant MM, Kim SK, Zlot CH, Raabe M, Bjorkegren J, Neese RA, Hellerstein MK, Young SG: A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem 275:7515-7520, 2000
14. Tietge UJ, Bakillah A, Maugeais C, Tsukamoto K, Hussain M, Rader DJ: Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B. J Lipid Res 40:2134-2139, 1999
15. Kuriyama H, Yamashita S, Shimomura I, Funahashi T, Ishigami M, Aragane K, Miyaoka K, Nakamura T, Takemura K, Man Z, Toide K, Nakayama N, Fukuda Y, Lin MC, Wetterau JR, Matsuzawa Y: Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Hepatology 27:557-562, 1998
16. Taghibiglou C, Carpentier A, Van Iderstine SC, Chen B, Rudy D, Aiton A, Lewis GF, Adeli K: Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J Biol Chem 275:8416-8425, 2000
17. Taghibiglou C, Rashid-Kolvear F, Van Iderstine SC, Le Tien H, Fantus IG, Lewis GF, Adeli K: Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem 277:793-803, 2002
18. Bartels ED, Lauritsen M, Nielsen LB: Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice. Diabetes 51:1233-1239, 2002
19. Carpentier A, Taghibiglou C, Leung N, Szeto L, Van Iderstine SC, Uffelman KD, Buckingham R, Adeli K, Lewis GF: Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamsters. J Biol Chem 277:28795-28802, 2002
20. Lin MC, Gordon D, Wetterau JR: Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res 36:1073-1081, 1995
21. Hagan DL, Kienzle B, Jamil H, Hariharan N: Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. J Biol Chem 269:28737-28744, 1994
22. Javitt NB: Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. FASEB J 4:161-168, 1990
23. Sparks JD, Sparks CE: Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes. J Biol Chem 265:8854-8862, 1990
24. Phung TL, Roncone A, Jensen KL, Sparks CE, Sparks JD: Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum. J Biol Chem 272:30693-30702, 1997
25. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM: Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632, 1998
26. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ: Increasing complexity of Ras signaling. Oncogene 17:1395-1413, 1998
27. Garcia AM, Rowell C, Ackermann K, Kowalczyk JJ, Lewis MD: Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. J Biol Chem 268:18415-18418, 1993
28. Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE: Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res 61:8758-8768, 2001
29. Singh RP, Dhawan P, Golden C, Kapoor GS, Mehta KD: One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade. J Biol Chem 274:19593-19600, 1999
30. Zhang H, Shi X, Hampong M, Blanis L, Pelech S: Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase. J Biol Chem 276:6905-6908, 2001
31. Moule SK, Denton RM: Multiple signaling pathways involved in the metabolic effects of insulin. Am J Cardiol 80:41A-49A, 1997
32. Kumar A, Middleton A, Chambers TC, Mehta KD: Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells. J Biol Chem 273:15742-15748, 1998
33. Carel K, Kummer JL, Schubert C, Leitner W, Heidenreich KA, Draznin B: Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. J Biol Chem 271:30625-30630, 1996
34. Lin MC, Arbeeny C, Bergquist K, Kienzle B, Gordon D, Wetterau J: Cloning and dietary regulation of hamster microsomal triglyceride transfer protein. J Biol Chem 269:29138-29145, 1994
35. Dhawan P, Bell A, Kumar A, Golden C, Mehta KD: Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/Mek-1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression. J Lipid Res 40:1911-1919, 1999
36. Kotzka J, Muller-Wieland D, Roth G, Kremer L, Munck M, Schurmann S, Knebel B, Krone W: Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. J Lipid Res 41:99-108, 2000
37. Sato R, Miyamoto W, Inoue J, Terada T, Imanaka T, Maeda M: Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. J Biol Chem 274:24714-24720, 1999
38. Mehta KD, Miller L: Inhibition of stress-activated p38 mitogen-activated protein kinase induces low-density lipoprotein receptor expression. Trends Cardiovasc Med 9:201-205, 1999
39. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746, 1994
40. Keeton AB, Amsler MO, Venable DY, Messina JL: Insulin signal transduction pathways and insulin-induced gene expression. J Biol Chem 277:48565-48573, 2002
41. Tomlinson DR: Mitogen-activated protein kinases as glucose transducers for diabetic complications. Diabetologia 42:1271-1281, 1999
42. Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL: Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 11:267-274, 2000
43. Jenkins AJ, Velarde V, Klein RL, Joyce KC, Phillips KD, Mayfield RK, Lyons TJ, Jaffa AA: Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells. Diabetes 49:2160-2169, 2000
44. Kyriakis JM, Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869, 2001