Identification of embryonic pancreatic genes using Xenopus DNA microarrays

Developmental Dynamics

Volumn 238, Issue 6, 2009, Pages 1455-1466

  Hayata, Tadayoshi ^a,b   Blitz, Ira L ^a   Iwata, Nahoko ^a,c   Cho, Ken W Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Gene expression; Organogenesis; Pancreas; Xenopus

Indexed keywords

ANIMAL TISSUE; ARTICLE; DNA MICROARRAY; EMBRYO; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; IN SITU HYBRIDIZATION; MARKER GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PANCREAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ANIMALS; BIOLOGICAL MARKERS; CLUSTER ANALYSIS; DIABETES MELLITUS; FIBROBLAST GROWTH FACTORS; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREAS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 66349124401     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21868     Document Type: Article

References (99)

1. Afelik S, Chen Y, Pieler T. 2004. Pancreatic protein disulfide isomerase (XPDIp) is an early marker for the exocrine lineage of the developing pancreas in Xenopus laevis embryos. Gene Expr Patterns 4:71-76. (Pubitemid 37498296)
2. Ahlgren U, Jonsson J, Edlund H. 1996. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409-1416. (Pubitemid 26159631)
3. Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J. 2003. Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol 23:6713-6724. (Pubitemid 37214643)
4. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H. 1999. Notch signalling controls pancreatic cell differentiation. Nature 400:877-881. (Pubitemid 29406724)
5. Aridome K, Tsutsui J, Takao S, Kadomatsu K, Ozawa M, Aikou T, Muramatsu T. 1995. Increased midkine gene expression in human gastrointestinal cancers. Jpn J Cancer Res 86:655-661.
6. Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, Penninger JM. 2000. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403:211-216. (Pubitemid 30050966)
7. Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R. 2001. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128:5109-5117. (Pubitemid 34083036)
8. Blitz IL, Andelfinger G, Horb ME. 2006. Germ layers to organs: using Xenopus to study "later" development. Semin Cell Dev Biol 17:133-145.
9. Boyle S, Shioda T, Perantoni AO, de Caestecker M. 2007. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn 236:2321-2330. (Pubitemid 47293774)
10. Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, Rouault JP, Wrutniak-Cabello C, Cabello G. 2005. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. Oncogene 24:1698-1710. (Pubitemid 40461126)
11. Chalmers AD, Slack JM. 1998. Development of the gut in Xenopus laevis. Dev Dyn 212:509-521. (Pubitemid 28355495)
12. Chen Y, Pan FC, Brandes N, Afelik S, Solter M, Pieler T. 2004. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 271:144-160. (Pubitemid 38757782)
13. Chen Y, Haviernik P, Bunting KD, Yang YC. 2007. Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood 110:2889-2898. (Pubitemid 350006942)
14. Chiang MK, Melton DA. 2003. Single-cell transcript analysis of pancreas development. Dev Cell 4:383-393. (Pubitemid 36342363)
15. Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind JS, Shevach E, Gu H. 2000. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403:216-220. (Pubitemid 30050967)
16. Cmarik JL, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H, Matsuhashi S, Colburn NH. 1999. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci U S A 96:14037-14042.
17. Constable JR, Graham ME, Morgan A, Burgoyne RD. 2005. Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms. J Biol Chem 280:31615-31623. (Pubitemid 41291907)
18. Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A. 2005. Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 15:1677-1683. (Pubitemid 41323747)
19. Devendra D, Liu E, Eisenbarth GS. 2004. Type 1 diabetes: recent developments. BMJ 328:750-754. (Pubitemid 38406430)
20. Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P. 2003. Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn 226:663-674. (Pubitemid 36396875)
21. Dunwoodie SL, Rodriguez TA, Beddington RS. 1998. Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev 72:27-40. (Pubitemid 28186704)
22. Ellinger-Ziegelbauer H, Hihi AK, Laudet V, Keller H, Wahli W, Dreyer C. 1994. FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis. Mol Cell Biol 14:2786-2797. (Pubitemid 24108259)
23. Fayard E, Schoonjans K, Annicotte JS, Auwerx J. 2003. Liver receptor homolog 1 controls the expression of carboxyl ester lipase. J Biol Chem 278:35725-35731. (Pubitemid 37102348)
24. Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. 2004. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 131:165-179. (Pubitemid 38111424)
25. Harland RM. 1991. In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol 36:685-695.
26. Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH. 1999. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23:71-75. (Pubitemid 29418791)
27. Hebrok M, Kim SK, Melton DA. 1998. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 12:1705-1713. (Pubitemid 28299520)
28. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. 2000. Regulation of pancreas development by hedgehog signaling. Development 127:4905-4913.
29. Hirose T, Tamaru T, Okumura N, Nagai K, Okada M. 1997. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Eur J Biochem 249:481-488. (Pubitemid 27455790)
30. Horb ME, Slack JM. 2002. Expression of amylase and other pancreatic genes in Xenopus. Mech Dev 113:153-157. (Pubitemid 34311742)
31. Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP. 2000. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 20:4445-4454. (Pubitemid 30346639)
32. Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS. 2006. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290:189-199. (Pubitemid 43083614)
33. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD. 2000. Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44. (Pubitemid 30041417)
34. Kadomatsu K, Muramatsu T. 2004. Midkine and pleiotrophin in neural development and cancer. Cancer Lett 204:127-143. (Pubitemid 38167717)
35. Kadomatsu K, Huang RP, Suganuma T, Murata F, Muramatsu T. 1990. A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis. J Cell Biol 110:607-616. (Pubitemid 20088928)
36. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. 2002. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32:128-134. (Pubitemid 34977207)
37. Kelly OG, Melton DA. 2000. Development of the pancreas in Xenopus laevis. Dev Dyn 218:615-627. (Pubitemid 30604914)
38. Khetchoumian K, Teletin M, Mark M, Lerouge T, Cervino M, Oulad-Abdelghani M, Chambon P, Losson R. 2004. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem 279:48329-48341. (Pubitemid 39540989)
39. Kim SK, MacDonald RJ. 2002. Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 12:540-547.
40. Kim SK, Hebrok M, Melton DA. 1997. Notochord to endoderm signaling is required for pancreas development. Development 124:4243-4252. (Pubitemid 27496860)
41. Kim SK, Melton DA. 1998. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A 95:13036-13041. (Pubitemid 28509519)
42. Kofron M, Wylie C, Heasman J. 2004. The role of Mixer in patterning the early Xenopus embryo. Development 131:2431-2441. (Pubitemid 38877650)
43. Koide T, Hayata T, Cho KW. 2005. Xenopus as a model system to study transcriptional regulatory networks. Proc Natl Acad Sci U S A 102:4943-4948. (Pubitemid 40503719)
44. Kosoy R, Yokoi N, Seino S, Concannon P. 2004.Polymorphic variation in the CBLB gene in human type 1 diabetes. Genes Immun 5:232-235. (Pubitemid 38967658)
45. Kosugi T, Yuzawa Y, Sato W, Kawai H, Matsuo S, Takei Y, Muramatsu T, Kadomatsu K. 2006. Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Am J Pathol 168:9-19. (Pubitemid 43062555)
46. Kruger O, Plum A, Kim JS, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers WH, Willecke K. 2000. Defective vascular development in connexin 45-deficient mice. Development 127:4179-4193.
47. Lankat-Buttgereit B, Gregel C, Knolle A, Hasilik A, Arnold R, Göke R. 2004. Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. Mol Cell Endocrinol 214:149-153. (Pubitemid 38210124)
48. Latinkic BV, Kotecha S, Mohun TJ. 2003. Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants. Development 130:3865-3876. (Pubitemid 37039090)
49. Lee MA, Heasman J, Whitman M. 2001. Timing of endogenous activin-like signals and regional specification of the Xenopus embryo. Development 128:2939-2952. (Pubitemid 32771626)
50. Lee CS, Friedman JR, Fulmer JT, Kaestner KH. 2005. The initiation of liver development is dependent on Foxa transcription factors. Nature 435:944-947. (Pubitemid 40896319)
51. Li H, Arber S, Jessell TM, Edlund H. 1999. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 23:67-70. (Pubitemid 29418790)
52. Mally MI, Cirulli V, Hayek A, Otonkoski T. 1996. ICA69 is expressed equally in the human endocrine and exocrine pancreas. Diabetologia 39:474-480. (Pubitemid 26093876)
53. Manfroid I, Delporte F, Baudhuin A, Motte P, Neumann CJ, Voz ML, Martial JA, Peers B. 2007. Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development. Development 134:4011-4021. (Pubitemid 350269418)
54. Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dolle P, Gradwohl G. 2005. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 284:399-411. (Pubitemid 41188144)
55. Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R. 1999. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 96:6267-6272. (Pubitemid 29256654)
56. Murtaugh LC, Melton DA. 2003. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol 19:71-89. (Pubitemid 37487343)
57. Murtaugh LC, Law AC, Dor Y, Melton DA. 2005. Beta-catenin is essential for pancreatic acinar but not islet development. Development 132:4663-4674. (Pubitemid 41685277)
58. Niehrs C, Pollet N. 1999. Synexpression groups in eukaryotes. Nature 402:483-487.
59. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995. (Pubitemid 26096002)
60. Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N, Cho KW. 2007. TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis. Genes Dev 21:1817-1831. (Pubitemid 47076480)
61. Oinuma I, Katoh H, Harada A, Negishi M. 2003. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. J Biol Chem 278:25671-25677. (Pubitemid 36835322)
62. Palmer KJ, Konkel JE, Stephens DJ. 2005. PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J Cell Sci 118:3839-3847. (Pubitemid 41410268)
63. Pan FC, Chen Y, Bayha E, Pieler T. 2007. Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms. Mech Dev 124:518-531. (Pubitemid 47135627)
64. Papadopoulou S, Edlund H. 2005. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54:2844-2851. (Pubitemid 41401078)
65. Pare JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Belanger L. 2004. The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem 279:21206-21216. (Pubitemid 38656525)
66. Park EC, Hayata T, Cho KW, Han JK. 2007. Xenopus cDNA microarray identification of genes with endodermal organ expression. Dev Dyn 236:1633-1649. (Pubitemid 46932367)
67. Pietropaolo M, Castaño L, Babu S, Buelow R, Kuo YL, Martin S, Martin A, Powers AC, Prochazka M, Naggert J, Leiter EH, Eisenbarth GS. 1993. Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest 92:359-371. (Pubitemid 23209017)
68. Prevot D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L. 2001. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. J Biol Chem 276:9640-9648. (Pubitemid 37391858)
69. Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC. 2007. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J 26:4445-4456. (Pubitemid 350036639)
70. Rouault JP, Rimokh R, Tessa C, Paranhos G, Ffrench M, Duret L, Garoccio M, Germain D, Samarut J, Magaud JP. 1992. BTG1, a member of a new family of antiproliferative genes. EMBO J 11:1663-1670.
71. Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK. 2007. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A 104:6247-6252.
72. Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H. 2004. RTP family members induce functional expression of mammalian odorant receptors. Cell 119:679-691. (Pubitemid 39535755)
73. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M. 2000. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development 127:5533-5540. (Pubitemid 32049205)
74. Scales SJ, Hesser BA, Masuda ES, Scheller RH. 2002. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem 277:28271-28279. (Pubitemid 34966782)
75. Schlange T, Andree B, Arnold H, Brand T. 2000. Expression analysis of the chicken homologue of CITED2 during early stages of embryonic development. Mech Dev 98:157-160.
76. Schwitzgebel VM. 2001. Programming of the pancreas. Mol Cell Endocrinol 185:99-108. (Pubitemid 33103958)
77. Shin Y, Kitayama A, Koide T, Peiffer DA, Mochii M, Liao A, Ueno N, Cho KW. 2005. Identification of neural genes using Xenopus DNA microarrays. Dev Dyn 232:432-444. (Pubitemid 40129797)
78. Sinner D, Rankin S, Lee M, Zorn AM. 2004. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 131:3069-3080. (Pubitemid 39077432)
79. Sogame A, Hayata T, Asashima M. 2003. Screening for novel pancreatic genes from in vitro-induced pancreas in Xenopus. Dev Growth Differ 45:143-152. (Pubitemid 36566885)
80. Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M. 2003. Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem 278:26166-26173. (Pubitemid 36835386)
81. Stafford D, Prince VE. 2002. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 12:1215-1220. (Pubitemid 34801169)
82. Stafford D, Hornbruch A, Mueller PR, Prince VE. 2004. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol 214:432-441. (Pubitemid 39378351)
83. Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, Prince VE. 2006. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development 133:949-956.
84. Stainier DY. 2002. A glimpse into the molecular entrails of endoderm formation. Genes Dev 16:893-907. (Pubitemid 34408539)
85. Stark KL, McMahon JA, McMahon AP. 1991. FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development 113:641-651.
86. Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP. 2003. Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Genomics 82:130-142. (Pubitemid 36808615)
87. Theis M, Mas C, Doring B, Degen J, Brink C, Caille D, Charollais A, Kruger O, Plum A, Nepote V, Herrera P, Meda P, Willecke K. 2004. Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets. Exp Cell Res 294:18-29.
88. Torres-Vazquez J, Gitler AD, Fraser SD, Berk JD, Van N Pham, Fishman MC, Childs S, Epstein JA, Weinstein BM. 2004. Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell 7:117-123. (Pubitemid 39172693)
89. Wang Z, Shu W, Lu MM, Morrisey EE. 2005. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol 25:5022-5030. (Pubitemid 40781102)
90. Wardle FC, Smith JC. 2006. Transcriptional regulation of mesendoderm formation in Xenopus. Semin Cell Dev Biol 17:99-109. (Pubitemid 43344467)
91. Weber H, Symes CE, Walmsley ME, Rodaway AR, Patient RK. 2000. A role for GATA5 in Xenopus endoderm specification. Development 127:4345-4360.
92. Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM. 2007. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7:4. (Pubitemid 46201620)
93. Weninger WJ, Floro KL, Bennett MB, Withington SL, Preis JI, Barbera JP, Mohun TJ, Dunwoodie SL. 2005. Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development 132:1337-1348. (Pubitemid 40528793)
94. Xanthos JB, Kofron M, Wylie C, Heasman J. 2001. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development 128:167-180. (Pubitemid 32124143)
95. Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC. 2002. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A 99:10488-10493.
96. Ylipaasto P, Kutlu B, Rasilainen S, Rasschaert J, Salmela K, Teerijoki H, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otonkoski T, Roivainen M. 2005. Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia 48:1510-1522. (Pubitemid 41175504)
97. Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S. 2002. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 31:391-394. (Pubitemid 35154448)
98. Zhang J, Houston DW, King ML, Payne C, Wylie C, Heasman J. 1998. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell 94:515-524. (Pubitemid 28391867)
99. Zorn AM, Mason J. 2001. Gene expression in the embryonic Xenopus liver. Mech Dev 103:153-157. (Pubitemid 32463268)