A Ser365→Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates lhh/PTHrP signals and causes severe achondroplasia

Human Molecular Genetics

Volumn 10, Issue 5, 2001, Pages 457-465

  Chen, Lin ^a,b   Li, Cuiling ^a   Qiao, Wenhui ^a   Xu, Xiaoling ^a   Deng, Chuxia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN; SERINE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; FGFR3 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; PRIMER DNA; PROTEIN TYROSINE KINASE; TRANSACTIVATOR PROTEIN;

ACHONDROPLASIA; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DYSPLASIA; BONE GROWTH; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; EMBRYO; ENCHONDRAL OSSIFICATION; GENE EXPRESSION; GENE MUTATION; GROWTH PLATE; IN VIVO STUDY; LONG BONE; METATARSAL BONE; MISSENSE MUTATION; MOUSE; MUTANT; NEWBORN DEATH; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR INTRINSIC ACTIVITY; SHORT LIMBED DWARFISM; SIGNAL TRANSDUCTION; THANATOPHORIC DWARFISM; ANIMAL; CELL DIVISION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HISTOLOGY; IN SITU HYBRIDIZATION; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; ERINACEIDAE;

ACHONDROPLASIA; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CHONDROCYTES; CYSTEINE; DNA PRIMERS; DOWN-REGULATION; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GROWTH PLATE; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; MICE; MUTAGENESIS, SITE-DIRECTED; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECEPTORS, FIBROBLAST GROWTH FACTOR; SERINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0035263614     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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