PTHrP expression in chondrocytes, regulation by TGF-β, and interactions between epiphyseal and growth plate chondrocytes

Experimental Cell Research

Volumn 256, Issue 2, 2000, Pages 555-562

  Pateder, Dhruv B ^a   Rosier, Randy N ^a   Schwarz, Edward M ^a   Reynolds, Paul R ^a   Puzas, J Edward ^a   D'Souza, Mary ^a   O'Keefe, Regis J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Chondrocyte; Epiphysis; Growth plate; PTHrP; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN; PARATHYROID HORMONE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CHICKEN; ENCHONDRAL OSSIFICATION; EPIPHYSIS PLATE; GROWTH PLATE; METATARSAL BONE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 0034194023     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4860     Document Type: Article

References (37)

1. Lewinson D., Silbermann M. Chondroclasts and endothelial cells collaborate in the process of cartilage resorption. Anat. Rec. 233:1992;504-514.
2. Buckwalter J. A., Mower D., Ungar R., Schaeffer J., Ginsberg B. Morphometric analysis of chondrocyte hypertrophy. J. Bone Joint Surg. 68A:1986;243-255.
3. Hatori M., Klatte K. J., Teixeira C. C., Shapiro I. M. End labeling studies of fragmented DNA in the avian growth plate: Evidence of apoptoss in terminally differentiated chondrocytes. J. Bone Miner. Res. 10:1995;1960-1968.
4. O'Keefe R. J., Loveys L., Hicks D. G., Reynolds P. R., Crabb I. D., Puzas J. E., Rosier R. N. Differential regulation of type II and type X collagen synthesis by PTHrP in chick growth plate chondrocytes. J. Orthop. Res. 15:1997;162-174.
5. Lee K., Lanske B., Karaplis A. C., Deeds J. D., Kohno H., Nissenson R. A., Kronenberg H. M., Segre G. V. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 137:1996;5109-5118.
6. Amizuka N., Warshawsky H., Henderson J., Goltzman D., Karaplis A. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J. Cell Biol. 126:1994;1611-1623.
7. Karaplis A., Luz A., Glowacki J., Bronson R., Tybulewicz V., Kronenberg H., Mulligan R. Lethal skeletal dysplasia form targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8:1994;277-289.
8. Weir E. C., Philbrick W. M., Amling M., Neff L. A., Baron R., Broadus A. E. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc. Natl. Acad. Sci. USA. 93:1996;10240-10245.
9. Vortkamp A., Lee K., Lanske B., Segre G. V., Kronenberg H. M., Tabin C. J. Regulation of rate of cartilage differentiation by indian hedgehog and PTH-related protein. Science. 273:1996;613-622.
10. Vortkamp A., Pathi S., Peretti G. M., Caruso. E. M., Zaleske D. J., Tabin C. J. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech. Dev. 71:1998;65-76.
11. Lanske B., Karaplis A. C., Lee K., Lutz A., Vortkamp A., Pirro A., Karperien M., Defize L. H. K., Ho C., Mulligan R., Abou-Samra A. B., Juppner H., Segre G. V., Kronenberg H. M. PTH/PTHrp receptor in early development and Indian hedgehog-regulated bone growth. Science. 273:1996;663-666.
12. Grimsrud C. D., Romano P. R., D'Souza M., Puzas J. E., Reynolds P. R., Rosier R. N., O'Keefe R. J. BMP-6 is an autocrine stimulator of chondrocyte differentiation. J. Bone Miner. Res. 14:1999;475-482.
13. Zou H., Wieser R., Massague J., Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 11:1997;2191-2203.
14. Serra R., Karaplis A., Sohn P. Parthyroid hormone-related peptid (PTHrP)-dependent and independent effects of transforming growth factor β (TGFβ) on endochondral bone formation. J. Cell Biol. 145:1999;783-794.
15. Crabb I. D., O'Keefe R. J., Puzas J. E., Rosier R. N. Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif. Tissue Int. 50:1992;61-66.
16. O'Keefe R. J., Crabb I. D., Puzas J. E., Rosier R. N. Countercurrent centrifugal elutriation: High-resolution method for the separation of growth plate chondrocytes. J. Bone Joint Surg. 71A:1989;607-620.
17. O'Keefe R. J., Puzas J. E., Loveys L., Hicks D. G., Rosier R. N. Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: Rapid induction of type X collagen in culture. J. Bone Miner. Res. 9:1994;1713-1722.
18. O'Keefe R. J., Puzas J. E., Brand J. S., Rosier R. N. Effect of transforming growth factor β on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum. Calc. Tissue Int. 43:1988;352-358.
19. Grimsrud C., Rosier R. N., Puzas J. E., Reynold S. P. R., Reynolds S. D. BMP-7 in growth plate chondrocytes: Differential expression during maturation and regulation by retinoic acid. J. Orthop. Res. 16:1998;247-255.
20. Massague J. Receptors for the TGF-β family. Cell. 69:1992;1067-1070.
21. Gelb D., Rosier R., Puzas J. E. The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture. Endicrinology. 127:1990;1941-1947.
22. St. Jacques B., Hammerschmidt M., McMahon A. P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13:1999;2072-2086.
23. Terkeltaub R., Lotz M., Johnson K., Deng D., Hashimot S., Goldring M. B., Burton D., Deftos L. J. Parathyroid hormone-related proteins is abundant inosteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate. Arthritis Rheum. 41:1998;2152-2164.
24. Yasui T., Uemura H., Irahara M., Aono T. Effects of transforming growth factor-beta on the production of parathyroid hormone-related peptide in a human ovarian cancer cell line. J. Obstet. Gynecol. Res. 23:1997;231-238.
25. Yin J. J., Selander K., Chirgwin J. M., Dallas M., Grubbs B. G., Wieser R., Massague J., Mundy G. R., Guise T. A. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer and bone metastases development. J. Clin. Invest. 103:1999;197-206.
26. Werkmeister J. R., Blomme E. A., Weckmann M. T., Grone A., McCauley L. K., Wade A. B., O'Rourke J., Capen C. C., Rosol T. J. Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro. Endocrine. 8:1998;291-299.
27. Terkeltaub R. A., Johnson K., Rohnow D., Goomer R., Burton D., Deftos L. J. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells). J. Bone Miner. Res. 13:1998;931-941.
28. Candia A. F., Watabe T., Hawley S. H. B., Onichtchouk D., Zhang Y., Derynck R., Niehrs C., Cho K. W. Y. Cellular interpretation of multiple TGF beta signals: Intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development. 124:1997;4467-4480.
29. Pedrozo H. A., Schwatz Z., Mokeyev T., Ornoy A., Xin-Sheng W., Bonewald L. F., Dean D. D., Boyan B. D. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. J. Cell. Biochem. 72:1999;151-165.
30. Jackowlew S. B., Dillard P. J., Winokur T. S., Flanders K. C., Sporn M. B., Roberts A. B. Expression of transforming growth factor-βs 1-4 in chicken embryo chondroctyes and myocytes. Dev. Biol. 143:1991;135-148.
31. Massague J. TGFb signalling: Receptors, transducers, and Mad Proteins. Cell. 85:1996;947-950.
32. Pedrozo H. A., Schwartz Z., Gomez R., Ornoy A., Xin-Sheng W., Dallas S. L., Bonewald L. F., Dean D. D., Boyan B. D. Growth plate chondocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. J. Cell. Physiol. 177:1998;343-354.
33. Oursler M. J. Osteoclast synthesis and secretion and activation of latent transforming growth factor beta. J. Bone Miner. Res. 9:1994;443-452.
34. Chu T. M., Kawinski E. Plasmin, subtilisin-like endoproteases, tissue plaminogen activator, and urokinase plaminogen activator are involved in activation of latent TGF-beta 1 in human seminal plasma. Biochem. Biophys. Res. Commun. 253:1998;128-134.
35. O'Keefe R. J., Puzas J. E., Brand J. S., Rosier R. N. Effects of transforming growth factor-β on matrix synthesis by chich growth plate chondrocytes. Endocrinology. 122:1988;2953-2961.
36. Rosselot B., Vasilatos-Younken R., Leach R. M. Effect of growth hormone, insulin like growth factor 1, basic fibroblast growth factor, and transforming growth factor beta on cell proliferation and proteoglycan synthesis by avian postembryonic growth plate chondrocytes. J. Bone Miner. Res. 9:1994;431-439.
37. Serra R., Johnson M., Filvaroff E., LaBorde J., Sheehan D., Derynck R., Moses H. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal muscle promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol. 139:1997;541-552.