Ceramide: Does it matter for T cells?

Trends in Immunology

Volumn 23, Issue 1, 2002, Pages 1-4

  Adam, Dieter ^a   Heinrich, Michael ^a   Kabelitz, Dieter ^a   Schütze, Stefan ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; T LYMPHOCYTE RECEPTOR;

CELL DEATH; CELL GROWTH; CELL STIMULATION; CELL SURFACE; GROWTH DISORDER; MEMBRANE FLUIDITY; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CERAMIDES; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036152211     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02091-9     Document Type: Review

References (24)

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2. Enzymes of sphingolipid metabolism: From modular to integrative signaling
3. A role for neutral sphingomyelinase-mediated ceramide production in T-cell-receptor-induced apoptosis and mitogen-activated protein-kinase-mediated signal transduction
4. Changes in the balance between mitogenic and antimitogenic lipid second messengers during proliferation, cell arrest and apoptosis in T lymphocytes
5. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal
6. Ceramide-induced TCR up-regulation
7. T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the ζ chain
8. Ligation of the WC1 receptor induces γδ T-cell growth arrest through fumonisin-B1-sensitive increases in cellular ceramide
9. Generation of nitric oxide by the inducible nitric oxide synthase protects γδ T cells from Mycobacterium-tuberculosis-induced apoptosis
10. Autocrine nitric oxide modulates CD95-induced apoptosis in γδ T lymphocytes
11. CD28 signals through acidic sphingomyelinase
12. Sphingomyelin-ceramide turnover in CD28 costimulatory signaling
13. Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals
14. Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells
15. The amplification of TCR signaling by dynamic membrane microdomains
16. CD95-mediated apoptosis in vivo involves acid sphingomyelinase
17. Role of acidic sphingomyelinase in Fas/CD95-mediated cell death
18. CD95 signaling via ceramide-rich membrane rafts
19. Ceramide enables Fas to cap and kill
20. CD95: More than just a death factor?
21. Fas triggers an alternative, caspase-8-independent cell-death pathway using the kinase RIP as effector molecule
22. Overexpression of acid ceramidase protects from tumor-necrosis-factor-induced cell death
23. Cathepsin D targeted by acid-sphingomyelinase-derived ceramide
24. Induction of apoptosis through B-cell receptor cross-linking occurs via de-novo-generated C16-ceramide and involves mitochondria