Rational design of α-conotoxin analogues targeting α7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives

Journal of Biological Chemistry

Volumn 284, Issue 14, 2009, Pages 9498-9512

  Armishaw, Christopher ^a,c   Jensen, Anders A ^b   Balle, Thomas ^a   Clark, Richard J ^a   Harpsøe, Kasper ^a   Skonberg, Christian ^a   Liljefors, Tommy ^a   Strømgaard, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE-BINDING PROTEINS; AMINO-TERMINAL DOMAIN; ANTAGONISTIC ACTIVITY; BINDING AFFINITIES; CHARGED GROUPS; COCRYSTAL STRUCTURE; CONOTOXIN; CONOTOXINS; DIRECT INTERACTIONS; HYDROPHOBIC BINDING; HYDROPHOBIC SUBSTITUENTS; LIGAND BINDING; LIGAND-GATED ION CHANNELS; MARINE SNAILS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); PHARMACOLOGICAL CHARACTERIZATION; PHENYL SUBSTITUENTS; PROLINE DERIVATIVES; PROLINE RESIDUES; RATIONAL DESIGN; SEQUENCE HOMOLOGY; SIDE CHAINS;

AMINES; ANTIGENS; BINDING ENERGY; COBALT; COBALT COMPOUNDS; CRYSTAL STRUCTURE; HYDROPHOBICITY; LIGANDS; METABOLITES;

TOXIC MATERIALS;

ACETYLCHOLINE BINDING PROTEIN; ALPHA CONOTOXIN; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; CONOTOXIN; EPIBATIDINE; ION CHANNEL; NICOTINIC RECEPTOR; PROLINE; PROLINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; ALPHA-BUNGAROTOXIN RECEPTOR; DRUG DERIVATIVE; NICOTINIC RECEPTOR BLOCKING AGENT;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; APLYSIA; ARTICLE; BINDING AFFINITY; BULINUS; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; HYDROPHOBICITY; INHIBITION KINETICS; LIQUID CHROMATOGRAPHY; LYMNAEA; MARINE SNAIL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DRUG DESIGN; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; RAT;

GASTROPODA;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CIRCULAR DICHROISM; CONOTOXINS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NICOTINIC ANTAGONISTS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROLINE; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, NICOTINIC;

EID: 66149116389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806136200     Document Type: Article

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