Determinants of Potency on α-Conotoxin MII, a Peptide Antagonist of Neuronal Nicotinic Receptors

Biochemistry

Volumn 43, Issue 10, 2004, Pages 2732-2737

  Everhart, Drew ^a   Cartier, G Edward ^b,d   Malhotra, Arun ^a   Gomes, Aldrin V ^a   McIntosh, J Michael ^b,c   Luetje, Charles W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR STRUCTURE; NEUROPHYSIOLOGY; PH EFFECTS; PROTEINS; TOXICITY;

BIORECEPTORS; NICOTIN; TOXIN POTENCY;

BIOCHEMISTRY;

ALANINE; ALPHA CONOTOXIN MII; ALPHA3 BETA2 NICOTINIC RECEPTOR; ASPARAGINE; CONOTOXIN; HISTIDINE; IMIDAZOLE; MUTANT PROTEIN; NICOTINIC RECEPTOR; PROLINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CONUS MAGUS; IC 50; MOLECULAR MODEL; NERVE CELL; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RAT; SNAIL; XENOPUS;

ALANINE; ANIMALS; CIRCULAR DICHROISM; CONOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEURONS; NICOTINIC ANTAGONISTS; OOCYTES; PEPTIDES; PROTEIN SUBUNITS; RATS; RECEPTORS, NICOTINIC; STRUCTURAL HOMOLOGY, PROTEIN; XENOPUS LAEVIS;

ANIMALIA; CONUS MAGUS; GASTROPODA;

EID: 1542267785     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036180h     Document Type: Article

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