Human mitochondrial thymidine kinase is selectively inhibited by 3′-thiourea derivatives of β-thymidine: Identification of residues crucial for both inhibition and catalytic activity

Molecular Pharmacology

Volumn 75, Issue 5, 2009, Pages 1127-1136

  Balzarini, Jan ^a   Van Daele, Ineke ^b   Negri, Ana ^c   Solaroli, Nicola ^d   Karlsson, Anna ^d   Liekens, Sandra ^a   Gago, Federico ^c   Van Calenbergh, Serge ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF ALCALÁ   (Spain)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 DEOXYTHYMIDIN 3 YL) 3 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL)THIOUREA; 1 (3' DEOXYTHYMIDIN 3' YL) 3 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL)THIOUREA; ADENOSINE TRIPHOSPHATE; TELBIVUDINE; THIOUREA DERIVATIVE; THYMIDINE KINASE 1; THYMIDINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MITOCHONDRION; MOLECULAR MODEL; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE; VARICELLA ZOSTER VIRUS;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CELLS, CULTURED; COMPUTER SIMULATION; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; MICE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THIOUREA; THYMIDINE KINASE;

EID: 66049117566     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053785     Document Type: Article

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