Nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Proteins: Structure, Function and Genetics

Volumn 41, Issue 4, 2000, Pages 545-553

  Vogt, Joachim ^a   Perozzo, Remo ^b   Pautsch, Alex ^a   Prota, Andrea ^b   Schelling, Pierre ^b   Pilger, Bea ^b   Folkers, Gerd ^b   Scapozza, Leonardo ^b   Schulz, Georg E ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Adenine analogue; Enzyme prodrug gene therapy; Kinase; Nucleoside binding; Thymidine; X ray crystallography

Indexed keywords

ACICLOVIR; GANCICLOVIR; GUANINE DERIVATIVE; NUCLEOSIDE; POLYPEPTIDE; THYMIDINE DERIVATIVE; THYMIDINE KINASE;

ANALYTIC METHOD; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME MODIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE THERAPY; HERPES SIMPLEX VIRUS 1; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ADENINE; ADENOSINE; ADENOSINE MONOPHOSPHATE; AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HERPESVIRUS 1, HUMAN; MUTATION; NUCLEOSIDES; PHOSPHONIC ACIDS; PRODRUGS; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE; VIRAL PROTEINS; WATER;

HERPES; HUMAN HERPESVIRUS 1;

EID: 0034563459     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20001201)41:4<545::AID-PROT110>3.0.CO;2-8     Document Type: Article

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