PTH and PTH antagonist induce different conformational changes in the PTHR1 receptor

Journal of Bone and Mineral Research

Volumn 24, Issue 5, 2009, Pages 925-934

  Thomas, Beena E ^a   Sharma, Sandhya ^a   Mierke, Dale F ^b   Rosenblatt, Michael ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dartmouth College   (United States)

Author keywords

Agonist; Antagonist; Conformational shifts; Engineered disulfide bond formation; PTH receptor; Transmembrane helices

Indexed keywords

CYSTEINE DERIVATIVE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN COS7; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; DRUG RECEPTOR BINDING; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE; DISULFIDES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

EID: 65949084700     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.081228     Document Type: Article

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