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Volumn 18, Issue 7, 2004, Pages 1798-1807

Crystal structures of the multispecific 17β-hydroxysteroid dehydrogenase type 5: Critical androgen regulation in human peripheral tissues

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHENYLALANINE; TESTOSTERONE 17BETA DEHYDROGENASE; TRYPTOPHAN;

EID: 3042829462     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0032     Document Type: Article
Times cited : (70)

References (50)
  • 1
    • 0035931115 scopus 로고    scopus 로고
    • A guide to 17β-hydroxysteroid dehydrogenases
    • Adamski J, Jakob FJ 2001 A guide to 17β-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 171:1-4
    • (2001) Mol Cell Endocrinol , vol.171 , pp. 1-4
    • Adamski, J.1    Jakob, F.J.2
  • 3
    • 0033591454 scopus 로고    scopus 로고
    • Human brain short chain L-3-hydroxyacyl coenzyme a dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17β-hydroxysteroid dehydrogenase
    • He XY, Merz G, Mehta P, Schulz H, Yang SY 1999 Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17β-hydroxysteroid dehydrogenase. J Biol Chem 274:15014-15019
    • (1999) J Biol Chem , vol.274 , pp. 15014-15019
    • He, X.Y.1    Merz, G.2    Mehta, P.3    Schulz, H.4    Yang, S.Y.5
  • 4
    • 0032727093 scopus 로고    scopus 로고
    • Determination of cDNA, gene structure and chromosomal localization of the novel human 17β-hydroxysteroid dehydrogenase type 7(1)
    • Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J 1999 Determination of cDNA, gene structure and chromosomal localization of the novel human 17β-hydroxysteroid dehydrogenase type 7(1). FEBS Lett 29:373-379
    • (1999) FEBS Lett , vol.29 , pp. 373-379
    • Krazeisen, A.1    Breitling, R.2    Imai, K.3    Fritz, S.4    Moller, G.5    Adamski, J.6
  • 5
    • 0001429526 scopus 로고    scopus 로고
    • Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
    • Dufort I, Rheault P, Huang X-F, Soucy P, Luu-The V 1999 Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase. Endocrinology 140:1-7
    • (1999) Endocrinology , vol.140 , pp. 1-7
    • Dufort, I.1    Rheault, P.2    Huang, X.-F.3    Soucy, P.4    Luu-The, V.5
  • 6
    • 0033303649 scopus 로고    scopus 로고
    • Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17β/3α-hydroxysteroid/retinoid short chain dehydrogenase/reductase
    • Su J, Lin M, Napoli JL 1999 Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17β/3α-hydroxysteroid/ retinoid short chain dehydrogenase/reductase. Endocrinology 140:5275-5284
    • (1999) Endocrinology , vol.140 , pp. 5275-5284
    • Su, J.1    Lin, M.2    Napoli, J.L.3
  • 7
    • 0032575502 scopus 로고    scopus 로고
    • Characterization of Ke 6, a new 17β-hydroxysteroid dehydrogenase, and its expression in gonadal tissues
    • Fomitcheva J, Baker ME, Anderson E, Lee GY, Aziz N 1998 Characterization of Ke 6, a new 17β-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. J Biol Chem 273:22664-22671
    • (1998) J Biol Chem , vol.273 , pp. 22664-22671
    • Fomitcheva, J.1    Baker, M.E.2    Anderson, E.3    Lee, G.Y.4    Aziz, N.5
  • 8
    • 0032440139 scopus 로고    scopus 로고
    • Cloning and expression of a novel tissue specific 17β-hydroxysteroid dehydrogenase
    • Li KX, Smith RE, Krozowski ZS 1998 Cloning and expression of a novel tissue specific 17β-hydroxysteroid dehydrogenase. Endocr Res 24:663-667
    • (1998) Endocr Res , vol.24 , pp. 663-667
    • Li, K.X.1    Smith, R.E.2    Krozowski, Z.S.3
  • 9
    • 0032230308 scopus 로고    scopus 로고
    • Expression cloning of a novel estrogenic mouse 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat
    • Nokelainen P, Peltoketo H, Vihko R, Vihko P 1998 Expression cloning of a novel estrogenic mouse 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol 12:1048-1059
    • (1998) Mol Endocrinol , vol.12 , pp. 1048-1059
    • Nokelainen, P.1    Peltoketo, H.2    Vihko, R.3    Vihko, P.4
  • 10
    • 0030991226 scopus 로고    scopus 로고
    • Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenases from rat and human prostate
    • Biswas MG, Russell DW 1997 Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem 272:15959-15966
    • (1997) J Biol Chem , vol.272 , pp. 15959-15966
    • Biswas, M.G.1    Russell, D.W.2
  • 11
    • 0029091370 scopus 로고
    • Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3α-hydroxysteroid dehydrogenases
    • Khanna M, Qin KN, Wang RW, Cheng KC 1995 Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3α-hydroxysteroid dehydrogenases. J Biol Chem 270:20162-20168
    • (1995) J Biol Chem , vol.270 , pp. 20162-20168
    • Khanna, M.1    Qin, K.N.2    Wang, R.W.3    Cheng, K.C.4
  • 13
    • 0027225486 scopus 로고
    • Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 α-hydroxysteroid dehydrogenase activity
    • Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 α-hydroxysteroid dehydrogenase activity. J Biol Chem 268:12964-12969
    • (1993) J Biol Chem , vol.268 , pp. 12964-12969
    • Wu, L.1    Einstein, M.2    Geissler, W.M.3    Chan, H.K.4    Elliston, K.O.5    Andersson, S.6
  • 14
    • 0024361957 scopus 로고
    • Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: Evidence of two mRNA species with distinct 5′-termini in human placenta
    • Luu-The V, Labrie C, Zhao H-F, Couet J, Lachance Y, Simard J, Leblanc G, Labrie F 1989 Characterization of cDNAs for human estradiol 17β- dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Mol Endocrinol 3:1301-1309
    • (1989) Mol Endocrinol , vol.3 , pp. 1301-1309
    • Luu-The, V.1    Labrie, C.2    Zhao, H.-F.3    Couet, J.4    Lachance, Y.5    Simard, J.6    Leblanc, G.7    Labrie, F.8
  • 15
    • 0023691704 scopus 로고
    • Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA
    • Peltoketo H 1988 Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett 239:73-77
    • (1988) FEBS Lett , vol.239 , pp. 73-77
    • Peltoketo, H.1
  • 16
    • 0032586817 scopus 로고    scopus 로고
    • 17β-Hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
    • Peltoketo H, Luu-The V, Simard J, Adamski J 1999 17β-Hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes. J Mol Endocrinol 23:1-11
    • (1999) J Mol Endocrinol , vol.23 , pp. 1-11
    • Peltoketo, H.1    Luu-The, V.2    Simard, J.3    Adamski, J.4
  • 18
    • 0029761692 scopus 로고    scopus 로고
    • Crystal structure of human estrogenic 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol
    • Azzi A, Rehse PH, Zhu DW, Campbell RL, Labrie F, Lin S-X 1996 Crystal structure of human estrogenic 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol. Nat Struct Biol 3:665-668
    • (1996) Nat Struct Biol , vol.3 , pp. 665-668
    • Azzi, A.1    Rehse, P.H.2    Zhu, D.W.3    Campbell, R.L.4    Labrie, F.5    Lin, S.-X.6
  • 19
    • 0030586820 scopus 로고    scopus 로고
    • The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors
    • Breton R, Housset D, Mazza C, Fontecilla-Camps JC 1996 The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure 4:905-915
    • (1996) Structure , vol.4 , pp. 905-915
    • Breton, R.1    Housset, D.2    Mazza, C.3    Fontecilla-Camps, J.C.4
  • 20
    • 0036831679 scopus 로고    scopus 로고
    • A concerted, rational design of type 1 17β-hydroxysteroid dehydrogenase inhibitors: Estradiol-adenosine hybrids with high affinity
    • Qiu W, Campbell RL, Gangloff A, Dupuis P, Boivin RP, Tremblay MR, Poirier D, Lin S-X 2002 A concerted, rational design of type 1 17β-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity. FASEB J 16:1829-1831
    • (2002) FASEB J , vol.16 , pp. 1829-1831
    • Qiu, W.1    Campbell, R.L.2    Gangloff, A.3    Dupuis, P.4    Boivin, R.P.5    Tremblay, M.R.6    Poirier, D.7    Lin, S.-X.8
  • 21
    • 0022852328 scopus 로고
    • The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications
    • Petrow V 1986 The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications. Prostate 9:343-361
    • (1986) Prostate , vol.9 , pp. 343-361
    • Petrow, V.1
  • 22
    • 0022405204 scopus 로고
    • Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: A marked improvement in response and survival
    • Labrie F, Dupont A, Belanger A, Giguere M, Lacoursiere Y, Emond J, Monfette G, Bergeron V 1985 Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival. J Steroid Biochem 23:833-841
    • (1985) J Steroid Biochem , vol.23 , pp. 833-841
    • Labrie, F.1    Dupont, A.2    Belanger, A.3    Giguere, M.4    Lacoursiere, Y.5    Emond, J.6    Monfette, G.7    Bergeron, V.8
  • 23
    • 0024433951 scopus 로고
    • Combined androgen blockade
    • Crawford ED 1989 Combined androgen blockade. Urology 34:22-26
    • (1989) Urology , vol.34 , pp. 22-26
    • Crawford, E.D.1
  • 26
    • 0037989013 scopus 로고    scopus 로고
    • Extragonadal synthesis of sex steroids: Intracrinology
    • Paris
    • Labrie F 2003 Extragonadal synthesis of sex steroids: intracrinology. Ann Endocrinol (Paris) 64:95-107
    • (2003) Ann Endocrinol , vol.64 , pp. 95-107
    • Labrie, F.1
  • 27
    • 3042735882 scopus 로고    scopus 로고
    • Intracrinology and the local enzymatic control of hormone distribution and metabolism: Dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens
    • Kuhn-Velten WN 2000 Intracrinology and the local enzymatic control of hormone distribution and metabolism: dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens. Eur J Clin Invest 3:34-38
    • (2000) Eur J Clin Invest , vol.3 , pp. 34-38
    • Kuhn-Velten, W.N.1
  • 29
    • 0032914659 scopus 로고    scopus 로고
    • Localization of type 5 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
    • El-Alfy M, Luu-The V, Huang X-F, Berger L, Labrie F, Pelleter G 1999 Localization of type 5 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. Endocrinology 140:1481-1491
    • (1999) Endocrinology , vol.140 , pp. 1481-1491
    • El-Alfy, M.1    Luu-The, V.2    Huang, X.-F.3    Berger, L.4    Labrie, F.5    Pelleter, G.6
  • 30
    • 0033622471 scopus 로고    scopus 로고
    • Expression of 17β-hydroxysteroid dehydrogenase type 5 in human ovary: A pilot study
    • Qin KN, Rosenfield RL 2000 Expression of 17β-hydroxysteroid dehydrogenase type 5 in human ovary: a pilot study. J Soc Gynecol Investig 7:61-64
    • (2000) J Soc Gynecol Investig , vol.7 , pp. 61-64
    • Qin, K.N.1    Rosenfield, R.L.2
  • 34
    • 0034287545 scopus 로고    scopus 로고
    • Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    • Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K 2001 Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 351:67-77
    • (2001) Biochem J , vol.351 , pp. 67-77
    • Penning, T.M.1    Burczynski, M.E.2    Jez, J.M.3    Hung, C.F.4    Lin, H.K.5    Ma, H.6    Moore, M.7    Palackal, N.8    Ratnam, K.9
  • 35
    • 0025284257 scopus 로고
    • The evolution of α/β barrel enzymes
    • Farber GK, Petsko GA 1990 The evolution of α/β barrel enzymes. Trends Biochem Sci 15:228-234
    • (1990) Trends Biochem Sci , vol.15 , pp. 228-234
    • Farber, G.K.1    Petsko, G.A.2
  • 36
    • 0037317465 scopus 로고    scopus 로고
    • Pseudosymmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17β-hydroxysteroid dehydrogenase
    • Gangloff A, Shi R, Nahoum V, Lin S-X 2003 Pseudosymmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17β-hydroxysteroid dehydrogenase. FASEB J 17:274-276
    • (2003) FASEB J , vol.17 , pp. 274-276
    • Gangloff, A.1    Shi, R.2    Nahoum, V.3    Lin, S.-X.4
  • 37
    • 3042853173 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 38
    • 0031570663 scopus 로고    scopus 로고
    • Steroid recognition and regulation of hormone action: Crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase
    • Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M 1997 Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase. Structure 5:799-812
    • (1997) Structure , vol.5 , pp. 799-812
    • Bennett, M.J.1    Albert, R.H.2    Jez, J.M.3    Ma, H.4    Penning, T.M.5    Lewis, M.6
  • 40
    • 0043095539 scopus 로고    scopus 로고
    • Human 20α-hydroxysteroid dehydrogenase: Crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids
    • Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R 2003 Human 20α-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J Mol Biol 331:593-604
    • (2003) J Mol Biol , vol.331 , pp. 593-604
    • Couture, J.F.1    Legrand, P.2    Cantin, L.3    Luu-The, V.4    Labrie, F.5    Breton, R.6
  • 42
    • 0028274855 scopus 로고
    • Three-dimensional structure of rat liver 3α-hydroxysteroid/ dihydrodiol dehydrogenase: A member of the aldo-keto reductase superfamily
    • Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M 1994 Three-dimensional structure of rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc Natl Acad Sci USA 91:2517-2521
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2517-2521
    • Hoog, S.S.1    Pawlowski, J.E.2    Alzari, P.M.3    Penning, T.M.4    Lewis, M.5
  • 43
    • 0029764218 scopus 로고    scopus 로고
    • Structure of 3α-hydroxysteroid/dihdrodiol dehydrogenase complexed with NADP+
    • Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M 1996 Structure of 3α-hydroxysteroid/dihdrodiol dehydrogenase complexed with NADP+. Biochemistry 35:10702-10711
    • (1996) Biochemistry , vol.35 , pp. 10702-10711
    • Bennett, M.J.1    Schlegel, B.P.2    Jez, J.M.3    Penning, T.M.4    Lewis, M.5
  • 44
    • 0035964182 scopus 로고    scopus 로고
    • Crystal structure of human type III 3α-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
    • Jin Y, Stayrook SE, Albert RH, Palackal NT, Penning TM, Lewis M 2001 Crystal structure of human type III 3α-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Biochemistry 40:10161-10168
    • (2001) Biochemistry , vol.40 , pp. 10161-10168
    • Jin, Y.1    Stayrook, S.E.2    Albert, R.H.3    Palackal, N.T.4    Penning, T.M.5    Lewis, M.6
  • 45
    • 0036615864 scopus 로고    scopus 로고
    • Purification, crystallization and preliminary x-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5
    • Zhou M, Qiu W, Chang H-J, Gangloff A, Lin S-X 2002 Purification, crystallization and preliminary x-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5. Acta Crystallogr D 58:1048-1050
    • (2002) Acta Crystallogr D , vol.58 , pp. 1048-1050
    • Zhou, M.1    Qiu, W.2    Chang, H.-J.3    Gangloff, A.4    Lin, S.-X.5
  • 46
    • 0031059866 scopus 로고    scopus 로고
    • Processing of x-ray diffraction data collected in osillation mode
    • Otwinowski Z, Minor W 1997 Processing of x-ray diffraction data collected in osillation mode. Methods Enzymol 276:307-326
    • (1997) Methods Enzymol , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 47
    • 0033081529 scopus 로고    scopus 로고
    • Rapid automated molecular replacement by evolutionary search
    • Kissinger CR, Gehlhaar DK. Fogel DB 1999 Rapid automated molecular replacement by evolutionary search. Acta Crystallogr D 55:484-491
    • (1999) Acta Crystallogr D , vol.55 , pp. 484-491
    • Kissinger, C.R.1    Gehlhaar, D.K.2    Fogel, D.B.3
  • 48
    • 0032964481 scopus 로고    scopus 로고
    • Automated protein model building combined with iterative structure refinement
    • Perrakis A, Morris R, Lamzin VS 1999 Automated protein model building combined with iterative structure refinement. Nat Struct Biol 6:458-463
    • (1999) Nat Struct Biol , vol.6 , pp. 458-463
    • Perrakis, A.1    Morris, R.2    Lamzin, V.S.3
  • 49
    • 84889120137 scopus 로고
    • Improved methods for binding protein models in electron density maps and the location of errors in these models
    • Jones TA, Zou JY, Cowan SW, Kjeldgaard M 1991 Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47:110-119
    • (1991) Acta Crystallogr A , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 50
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project Number 4 1994 The CCP4 suite: programs for protein crystallography. Acta Crystallogr D 50:760-763
    • (1994) Acta Crystallogr D , vol.50 , pp. 760-763


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