Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: The example of rat liver 3α-HSD (AKR1C9)

Journal of Biological Chemistry

Volumn 282, Issue 46, 2007, Pages 33484-33493

  Cooper, William C ^a   Jin, Yi ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDO-KETO REDUCTASE; STEROID;

ANIMAL CELL CULTURE; BIOSYNTHESIS; HORMONES; ISOTOPES;

ENZYME KINETICS;

ANDROSTANEDIONE; ANDROSTERONE; CARBONYL REDUCTASE; HYDROXYSTEROID DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; PROTEIN AKR1C9; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; HORMONE ACTION; HORMONE SYNTHESIS; KINETICS; LIGAND BINDING; LIVER; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; STEADY STATE;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); ANIMALS; CRYSTALLOGRAPHY, X-RAY; KINETICS; LIVER; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NADP; OXYGEN; PROTEIN CONFORMATION; RATS; TESTOSTERONE; THERMODYNAMICS; TIME FACTORS;

MAMMALIA; RATTUS;

EID: 36349001861     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703414200     Document Type: Article

References (40)

1. Penning, T. M. (1997) Endocr. Rev. 18, 281-305
2. Payne, A. H., and Hales, D. B. (2004) Endocr. Rev. 25, 947-970
3. Funder, J. W., Pearce, P. T., Smith, R., and Smith, A. I. (1988) Science 242, 583-585
4. Draper, N., and Stewart, P. M. (2005) J. Endocrinol. 186, 251-271
5. Rižner, T. L., Lin, H.-K., Peehl, D. M., Steckelbroeck, S., Bauman, D. R., and Penning, T. M. (2003) Endocrinology 144, 2922-2932
6. Bauman, D. R., Steckelbroeck, S., Williams, M. V., Peehl, D. M., and Penning, T. M. (2006) Mol. Endocrinol. 20, 444-458
7. Penning, T. M., Bauman, D. R., Jin, Y., and Rižner, T. L. (2007) Mol. Cell. Endocrinol. 265-266, 77-82
8. Liden, M., Tryggvason, K., and Eriksson, U. (2003) Mol. Aspects of Med. 24, 403-409
9. Jez, J. M., Bennett, M. J., Schlegel, B. P., Lewis, M., and Penning, T. M. (1997) Biochem. J. 326, 625-636
10. Jörnvall, H., Persson, B., Krook, M., Atrian, S., Gonzàlez-Duarte, R., Jeffery, J., and Ghosh, D. (1995) Biochemistry 34, 6003-6013
11. Penning, T. M. (2003) Hum. Reprod. Update 9, 193-205
12. Ogg, D., Elleby, B., Norstrom, C., Stefansson, K., Abrahmsen, L., Oppermann, U., and Svensson, S. (2005) J. Biol. Chem. 280, 3789-3794
13. Hosfield, D. J., Wu, Y., Skene, R. J., Hilgers, M., Jennings, A., Snell, G. P., and Aertgeerts, K. (2005) J. Biol. Chem. 280, 4639-4648
14. Penning, T. M., Burczynski, M. E., Jez, J. M., Hung, C.-F., Lin, H.-K., Ma, H., Moore, M., Palackal, N., and Ratnam, K. (2000) Biochem. J. 351, 67-77
15. Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., and Penning, T. M. (2004) J. Biol. Chem. 279, 10784-10795
16. Ricigliano, J. W., and Penning, T. M. (1990) Biochem. J. 269, 749-755
17. Askonas, L. J., Ricigliano, J. W., and Penning, T. M. (1991) Biochem. J. 278, 835-841
18. Hoog, S. S., Pawlowski, J. E., Alzari, P. M., Penning, T. M., and Lewis, M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2517-2521
19. Bennett, M. J., Schlegel, B. P., Jez, J. M., Penning, T. M., and Lewis, M. (1996) Biochemistry 35, 10702-10711
20. Bennett, M. J., Albert, R. H., Jez, J. M., Ma, H., Penning, T. M., and Lewis, M. (1997) Steroids 5, 799-812
21. Veech, R. L., Eggleston, I. V., and Krebs, H. A. (1969) Biochem. J. 115, 609-619
22. Williamson, D. H., Lund, P., and Krebs, H. A. (1967) Biochem. J. 103, 514-527
23. Khun, N., Sharma, K. K., Andersson, S., and Auchus, R. J. (2004) Arch. Biochem. Biophys. 429, 50-59
24. Papari-Zareei, M., Brandmaier, A., and Auchus, R. J. (2006) Endocrinology 147, 1591-1597
25. Ratnam, K., Ma, H., and Penning, T. M. (1999) Biochemistry 38, 7856-7864
26. Cleland, W. W., (1979) Methods Enzymol. 63, 103-138
27. Cleland, W. W. (1977) Adv. in Enzymol. 45, 273-387
28. Segel, I. H. (1993) Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems, Wiley & Sons, New York, pp. 274-574
29. Hermes, J. D., Morrical, S. W., O'Leary, M. H., and Cleland, W. W. (1984) Biochemistry 23, 5479-5488
30. Viola, R. E., Cook, P. F., and Cleland, W. W. (1979) Anal. Biochem. 96, 334-340
31. Northrop, D. B. (1982) Methods Enzymol. 87, 607-625
32. Talalay, P., and Levy, H. R. (1959) Ciba Foundation Study Group No. 2: Steric Course of Microbiological Reactions, pp. 64-66, Little, Brown & Co., Boston
33. Jez, J. M., Schlegel, B. P., and Penning, T. M. (1996) J. Biol. Chem. 271, 30190-30198
34. Stone, S. R., and Le Bonniec, B. F. (1997) J. Mol. Biol. 265, 344-362
35. Johnson, K. A. (1992) The Enzymes 20, 1-62
36. Heredia, V. V., and Penning, T. M. (2004) Biochemistry 43, 12028-12037
37. Heredia, V. V., Cooper, W. C., Kruger, R. G., Jin, Y., and Penning, T. M. (2004) Biochemistry 43, 5832-5841
38. Grimshaw, C. E., Bohren, K. M., Lai, C.-J., and Gabbay, K. H. (1995) Biochemistry 34, 14356-14365
39. Jin, Y., and Penning, T. M. (2006) Biochemistry 45, 13054-13063
40. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S. H., Kloosterboer, H. J., and Penning, T. M. (2006) J. Pharmacol. Exp. Ther. 316, 1300-1309