Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1112-1118

  Verheul, Herman A M ^a   Timmer, C J ^a   Van Iersel, M L P S ^a   Delbressine, L P C ^a   Kloosterboer, H J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; GESTAGEN; TIBOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG FECES LEVEL; DRUG SULFATION; FEMALE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MONKEY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG ADMINISTRATION SCHEDULE; FECES; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MACACA FASCICULARIS; NORPREGNENES; OVARIECTOMY; REPRODUCIBILITY OF RESULTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SULFATES; TANDEM MASS SPECTROMETRY;

MACACA FASCICULARIS;

EID: 34250734505     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.014159     Document Type: Article

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