Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): Association of the high- enzyme activity val allele with ADHD impulsive-hyperactive phenotype

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 5, 1999, Pages 497-502

  Eisenberg, Jacques ^a   Mei Tal, Galit ^a   Steinberg, Avraham ^b   Tartakovsky, Eduardo ^a   Zohar, Ada ^c   Gritsenko, Inga ^a   Nemanov, Lubov ^a   Ebstein, Richard P ^a  

^a HERZOG HOSPITAL   (Israel)

^b SHAARE ZEDEK MEDICAL CENTER   (Israel)

^c NONE

Author keywords

Association; Attention deficit hyperactivity disorder (ADHD); Catechol O methyltransferase (COMT); Complex genetic disease; Haplotype relative risk; Impulsive; Polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; ENZYME ACTIVITY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HERITABILITY; HUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD, PRESCHOOL; EXONS; FEMALE; GENETIC HETEROGENEITY; GENOTYPE; HAPLOTYPES; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 0033570041     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19991015)88:5<497::AID-AJMG12>3.0.CO;2-F     Document Type: Article

References (44)

1. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. 1996. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 12:81-84 .
2. Biederman J. 1998. Attention-deficit/hyperactivity disorder: a life-span perspective. J Clin Psychiatry (Suppl 7) 59:4-16.
3. Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE. 1995. Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics 5:121-141.
4. Bolting N, Powls A, Cooke RW, Marlow N. 1997. Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birth weight children at 12 years. J Child Psychol Psychiatry 38:931-941.
5. Brockel BJ, Cory-Slechta DA. 1998. Lead, attention, and impulsive behavior: changes in a fixed-ratio waiting-for-reward paradigm. Pharmacol Biochem Behav 60:545-552.
6. Carlson C, Papolos D, Pandita RK, Faedda GL, Veit S, Goldberg R, Shprintzen R, Kucherlapati R, Morrow B. 1997a. Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders. Am J Hum Genet 60:851-859.
7. Carlson C, Sirotkin H, Pandita R, Goldberg R, McKie J, Wadey R, Patanjali SR, Weissman SM, Anyane-Yeboa K, Warburton D, Scambler P, Shprintzen R, Kucherlapati R, Morrow BE. 1997b. Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients. Am J Hum Genet 61:620-629.
8. Conners CK. 1998. Rating scales in attention-deficit/hyperactivity disorder: use in assessment and treatment monitoring. J Clin Psychiatry 59(7 suppl):24-30.
9. Corkum PV, Siegel LS. 1993. Is the continuous performance task a valuable research tool for use with children with attention deficit hyperactivity disorder? J Child Psychol Psychiatry Allied Disc 34:1217-1239.
10. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen MJ. 1996. No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity. Am J Psychiatry 153:268-270.
11. de Sonneville LM, Njiokiktjien C, Bos H. 1994. Methylphenidate and information processing. Part 1: Differentiation between responders and nonresponders; part 2: efficacy in responders. J Clin Exp Neuropsychol 16:877-897.
12. Doudet DJ, Chan GL, Holden JE, Pate BD, Morrison KS, Calne DB, Ruth TJ. 1997. Effects of monoamine oxidase and catechol-0-methyltransferase inhibition on dopamine turnover: a PET study with 6-[18F]L-DOPA. Eur J Pharmacol 334:31-38.
13. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH. 1996. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12:78-80.
14. Ernst M, Zametkin AJ, Phillips RL, Cohen RM. 1998. Age-related changes in brain glucose metabolism in adults with attention-deficit/hyperactivity disorder and control subjects. J Neuropsychiatry Clin Neurosci 10:168-177.
15. Ewens WJ, Spielman RS. 1995. The transmission/disequilibrium test: history, subdivision and admixture. Am J Hum Genet 57:455-464.
16. Falk CT, Rubenstein P. 1987. Haplotype relative risk: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233.
17. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313.
18. Hudziak JJ, Heath AC, Madden PF, Reich W, Bucholz KK, Slutske W, Bierut LJ, Neuman RJ, Todd RD. 1998. Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents [In Process Citation]. J Am Acad Child Adolesc Psychiatry 37:848-857.
19. Kaplan HI, Sadock BJ, Grebb JA. 1994. Synopsis of psychiatry. Baltimore: Williams and Wilkins.
20. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. 1997. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 94:4572-4575.
21. Kirov G, Murphy KC, Arranz MJ, Jones I, McCandles F, Kunugi H, Murray RM, McGufiin P, Collier DA, Owen MJ, Craddock N. 1998. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Mol Psychiatry 3:342-345.
22. Kotler M, Peretz B, Cohen H, Averbuch AV, Grinshpoon A, Gritsenko I, Nemanov L, Ebstein RP. 1999. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet (in press).
23. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. 1996. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243-250.
24. LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL. 1996. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1:121-124.
25. Levy F, Barr C, Sunohara G. 1998. Directions of aetiologic research on attention deficit hyperactivity disorder [In Process Citation]. Aust NZ J Psychiatry 32:97-103.
26. Levy F, Hobbes G. 1997. Discrimination of attention deficit hyperactivity disorder by the continuous performance test. J Paediatr Child Health 33:384-387.
27. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J. 1995. ics of human soluble and membrane-bound catechol-O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34:4202-4210.
28. Milberger S, Biederman J, Faraone SV, Chen L, Jones J. 1997a. Further evidence of an association between attention-deficit/hyperactivity disorder and cigarette smoking. Findings from a high-risk sample of siblings. Am J Addict 6:205-217.
29. Milberger S, Biederman J, Faraone SV, Wilens T, Chu MP. 1997b. Associations between ADHD and psychoactive substance use disorders. Findings from a longitudinal study of high-risk siblings of ADHD children. Am J Addict 6:318-329.
30. Nutt JG. 1998. Catechol O-methyltransferase inhibition and the treatment of Parkinson's disease. Adv Pharmacol 42:331-334.
31. Papolos DF, Veit S, Faedda GL, Saito T, Lachman HM. 1998. Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele [In Process Citation]. Mol Psychiatry 3:346-349.
32. Perez de Castro I, Ibanez A, Torres P, Saiz-Ruiz J, Fernandez-Piqueras J. 1997. Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics 7:345-348.
33. Popper CW. 1997. Antidepressants in the treatment of attention-deficit/ hyperactivity disorder. J Clin Psychiatry 58(14 suppl):14-29.
34. Puumala T, Sirvio J. 1998. Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task. Neuroscience 83:489-499.
35. Rowe DC, Stever C, Gard JM, Cleveland HH, Sanders ML, Abramowitz A, Kozol ST, Mohr JH, Sherman SL, Waldman ID. 1998. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behav Genet 28:215-225.
36. Sangal JM, Sangal RB, Persky B. 1996. Prolonged P300 latency in attention deficit hyperactivity disorder predicts poor response to imipramine. Clin Electroencephalogr 27:191-201.
37. Shanee N. 1966. Psychometric properties of the K-SAD-PL in an Israeli adolescent clinical population. Isr J Psychiatry 34:179-186.
38. Spencer T, Biederman J, Wilens TE, Faraone SV. 1998. Adults with attention-deficit/hyperactivity disorder: a controversial diagnosis. J Clin Psychiatry (Suppl 7) 59:59-68.
39. Stratton J, Gailfus D. 1998. A new approach to substance abuse treatment. Adolescents and adults with ADHD. J Subst Abuse Treat 15:89-94.
40. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. 1997. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 69:71-77.
41. Sunohara GA, Voros JG, Malone MA, Taylor MJ. 1997. Effects of methylphenidate in children with attention deficit hyperactivity disorder: a comparison of event-related potentials between medication responders and non-responders. Int J Psychophysiol 27:9-14.
42. Swanson JM, Sunohara GA, Kennedy JL, Regino R, Fineberg E, Wigal T, Lerner M, Williams L, LaHoste GJ, Wigal S. 1998. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Mol Psychiatry 3:38-41.
43. Vandenbergh DJ, Rodriguez LA, Miller IT, Uhl GR, Lachman HM. 1997. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am J Med Genet 74:439-442.
44. Weinshilboum R, Dunnette J. 1981. Thermal stability and the biochemical genetics of erythrocyte catechol-O-methyltransferase and plasma dopamine-beta-hydroxylase. Clin Genet 19:426-437.