Dopamine transporter 3′UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD

BMC Psychiatry

Volumn 8, Issue , 2008, Pages

  Karama, Sherif ^a,b   Grizenko, Natalie ^a,b   Sonuga Barke, Edmund ^c   Doyle, Alysa ^d   Biederman, Joseph ^d   Mbekou, Valentin ^b   Polotskaia, Anna ^b   Ter Stepanian, Marina ^b   De Guzman, Rosherrie ^b   Bellingham, Johanne ^b   Sengupta, Sarojini ^b   Joober, Ridha ^a,b,e  

^a MCGILL UNIVERSITY   (Canada)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE TRANSPORTER; SLC6A3 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHILD PSYCHIATRY; COGNITION; CONTROLLED STUDY; FEMALE; GENETIC MARKER; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; PATHOGENESIS; STATISTICAL SIGNIFICANCE; VARIABLE NUMBER OF TANDEM REPEAT; WECHSLER INTELLIGENCE SCALE; WISCONSIN CARD SORTING TEST; COGNITIVE DEFECT; DEMOGRAPHY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE FREQUENCY; GENETICS; PSYCHOMETRY;

3' UNTRANSLATED REGIONS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; COGNITION DISORDERS; DEMOGRAPHY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; MINISATELLITE REPEATS; PSYCHOMETRICS; WECHSLER SCALES;

EID: 48949116255     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-8-45     Document Type: Article

References (55)

1. Biederman J Faraone SV Attention-deficit hyperactivity disorder Lancet 2005, 366:237-248. 10.1016/S0140-6736(05)66915-2 16023516
2. Doyle AE Willcutt EG Seidman LJ Biederman J Chouinard VA Silva J Faraone SV Attention-deficit/hyperactivity disorder endophenotypes Biol Psychiatry 2005, 57:1324-1335. 10.1016/j.biopsych.2005.03.015 15950005
3. Astbury J Orgill A Bajuk B Relationship between two-year behaviour and neurodevelopmental outcome at five years of very low-birthweight survivors Dev Med Child Neurol 1987, 29:370-379. 3596073
4. Brown RT Pacini JN Perceived family functioning, marital status, and depression in parents of boys with attention deficit disorder J Learn Disabil 1989, 22:581-587. 2809411
5. Milberger S Faraone SV Biederman J Chu MP Feighner JA Substance use disorders in high-risk adolescent offspring Am J Addict 1999, 8:211-219. 10.1080/105504999305820 10506902
6. Faraone SV Perlis RH Doyle AE Smoller JW Goralnick JJ Holmgren MA Sklar P Molecular genetics of attention-deficit/hyperactivity disorder Biol Psychiatry 2005, 57:1313-1323. 10.1016/j.biopsych.2004.11.024 15950004
7. Rasmussen ER Neuman RJ Heath AC Levy F Hay DA Todd RD Replication of the latent class structure of Attention-Deficit/Hyperactivity Disorder (ADHD) subtypes in a sample of Australian twins J Child Psychol Psychiatry 2002, 43:1018-1028. 10.1111/1469-7610.00229 12455923
8. Spencer T Biederman J Wilens T Pharmacotherapy of attention deficit hyperactivity disorder Child Adolesc Psychiatr Clin N Am 2000, 9:77-97. 10674191
9. Larisch R Sitte W Antke C Nikolaus S Franz M Tress W Muller HW Striatal dopamine transporter density in drug naive patients with attention-deficit/hyperactivity disorder Nucl Med Commun 2006, 27:267-270. 10.1097/00006231-200603000-00010 16479247
10. Dresel S Krause J Krause KH LaFougere C Brinkbaumer K Kung HF Hahn K Tatsch K Attention deficit hyperactivity disorder: Binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment Eur J Nucl Med 2000, 27:1518-1524. 10.1007/ s002590000330 11083541
11. Krause KH Dresel SH Krause J Kung HF Tatsch K Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography Neurosci Lett 2000, 285:107-110. 10.1016/S0304-3940(00)01040-5 10793238
12. Curran S Mill J Tahir E Kent L Richards S Gould A Huckett L Sharp J Batten C Fernando S Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples Mol Psychiatry 2001, 6:425-428. 10.1038/sj.mp.4000914 11443527
13. Maher BS Marazita ML Ferrell RE Vanyukov MM Dopamine system genes and attention deficit hyperactivity disorder: A meta-analysis Psychiatr Genet 2002, 12:207-215. 10.1097/00041444-200212000-00003 12454525
14. Cook EH Jr Stein MA Krasowski MD Cox NJ Olkon DM Kieffer JE Leventhal BL Association of attention-deficit disorder and the dopamine transporter gene Am J Hum Genet 1995, 56:993-998. 1801209 7717410
15. Yang B Chan RC Jing J Li T Sham P Chen RY A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3′-UTR of dopamine transporter gene and attention deficit hyperactivity disorder Am J Med Genet B Neuropsychiatr Genet 2007, 144B(4):541-550. 17440978 10.1002/ajmg.b.30453
16. Li D Sham PC Owen MJ He L Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD) Hum Mol Genet 2006, 15:2276-2284. 10.1093/hmg/ddl152 16774975
17. Loo SK Specter E Smolen A Hopfer C Teale PD Reite ML Functional effects of the DAT1 polymorphism on EEG measures in ADHD J Am Acad Child Adolesc Psychiatry 2003, 42:986-993. 10.1097/01.CHI.0000046890.27264.88 12874502
18. Mill J Caspi A Williams BS Craig I Taylor A Polo-Tomas M Berridge CW Poulton R Moffitt TE Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: Evidence from 2 birth cohorts Arch Gen Psychiatry 2006, 63:462-469. 10.1001/ archpsyc.63.4.462 16585476
19. Winsberg BG Comings DE Association of the dopamine transporter gene (DAT1) with poor methylphenidate response J Am Acad Child Adolesc Psychiatry 1999, 38:1474-1477. 10.1097/00004583-199912000-00006 10596245
20. Roman T Szobot C Martins S Biederman J Rohde LA Hutz MH Dopamine transporter gene and response to methylphenidate in attention-deficit/ hyperactivity disorder Pharmacogenetics 2002, 12:497-499. 10.1097/ 00008571-200208000-00011 12172219
21. Inkster B Muglia P Jain U Kennedy JL Linkage disequilibrium analysis of the dopamine beta-hydroxylase gene in persistent attention deficit hyperactivity disorder Psychiatr Genet 2004, 14:117-120. 10.1097/ 01.ypg.0000107932.32051.1c 15167700
22. Cornish KM Manly T Savage R Swanson J Morisano D Butler N Grant C Cross G Bentley L Hollis CP Association of the dopamine transporter (DAT1) 10/ 10-repeat genotype with ADHD symptoms and response inhibition in a general population sample Mol Psychiatry 2005, 10:686-698. 10.1038/ sj.mp.4001641 15809660
23. Joober R Grizenko N Sengupta S Amor LB Schmitz N Schwartz G Karama S Lageix P Fathalli F Torkaman-Zehi A Stepanian MT Dopamine Transporter 3′-UTR VNTR Genotype and ADHD: A Pharmaco-Behavioural Genetic Study with Methylphenidate Neuropsychopharmacology 2006.
24. Barkley RA Smith KM Fischer M Navia B An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood Am J Med Genet B Neuropsychiatr Genet 2006, 141B(5):487-498. 16741944 10.1002/ajmg.b.30326
25. Pennington BF Ozonoff S Executive functions and developmental psychopathology J Child Psychol Psychiatry 1996, 37:51-87. 10.1111/ j.1469-7610.1996.tb01380.x 8655658
26. Willcutt EG Doyle AE Nigg JT Faraone SV Pennington BF Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review Biol Psychiatry 2005, 57:1336-1346. 10.1016/ j.biopsych.2005.02.006 15950006
27. Willcutt EG Pennington BF Boada R Ogline JS Tunick RA Chhabildas NA Olson RK A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder J Abnorm Psychol 2001, 110:157-172. 10.1037/0021-843X.110.1.157 11261391
28. Barkley RA Edwards G Laneri M Fletcher K Metevia L Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) J Abnorm Child Psychol 2001, 29:541-556. 10.1023/ A:1012233310098 11761287
29. Miyake A Friedman NP Emerson MJ Witzki AH Howerter A Wager TD The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: A latent variable analysis Cognit Psychol 2000, 41:49-100. 10.1006/cogp.1999.0734 10945922
30. Robbins TW James M Owen AM Sahakian BJ Lawrence AD McInnes L Rabbitt PM A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery J Int Neuropsychol Soc 1998, 4:474-490. 10.1017/S1355617798455073 9745237
31. Hazy TE Frank MJ O'Reilly RC Banishing the homunculus: Making working memory work Neuroscience 2006, 139:105-118. 10.1016/ j.neuroscience.2005.04.067 16343792
32. Aron AR Poldrack RA The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder Biol Psychiatry 2005, 57:1285-1292. 10.1016/ j.biopsych.2004.10.026 15950000
33. Dunnett SB Meldrum A Muir JL Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat Neuroscience 2005, 135:1055-1065. 10.1016/j.neuroscience.2005.07.033 16165288
34. Dirnberger G Frith CD Jahanshahi M Executive dysfunction in Parkinson's disease is associated with altered pallidal-frontal processing Neuroimage 2005, 25:588-599. 10.1016/j.neuroimage.2004.11.023 15784438
35. Seidman LJ Valera EM Makris N Structural brain imaging of attention-deficit/hyperactivity disorder Biol Psychiatry 2005, 57:1263-1272. 10.1016/j.biopsych.2004.11.019 15949998
36. Durston S Fossella JA Casey BJ Hulshoff Pol HE Galvan A Schnack HG Steenhuis MP Minderaa RB Buitelaar JK Kahn RS van Engeland H Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls Mol Psychiatry 2005, 10:678-685. 10.1038/sj.mp.4001649 15724142
37. Bertolino A Blasi G Latorre V Rubino V Rampino A Sinibaldi L Caforio G Petruzzella V Pizzuti A Scarabino T Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain J Neurosci 2006, 26:3918-3922. 10.1523/ JNEUROSCI.4975-05.2006 16611807
38. Lahey BB Applegate B McBurnett K Biederman J Greenhill L Hynd GW Barkley RA Newcorn J Jensen P Richters J DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents Am J Psychiatry 1994, 151:1673-1685. 7943460
39. Saffer D Fisher P Lucas C Diagnostic Interview Schedule for Children, Version IV New York: Columbia University, Division of Psychiatry 1998.
40. Achenbach TM The Child Behavior Checklist/4-18 and 1991 profile Burlington: University of Vermont 1991.
41. Wechsler D Wechsler Intelligence Scale for Children-Third Edition: Manul San Antonio, TX 1991.
42. Heaton RK Chelune GJ Talley JL Kay GG Curtiss G The Wisconsin Card Sorting Test Manual-Revised and expanded Odessa, FL 1993.
43. Petrides M Milner B Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man Neuropsychologia 1982, 20:249-262. 10.1016/ 0028-3932(82)90100-2 7121793
44. Shallice T Specific impairments of planning Philos Trans R Soc Lond B Biol Sci 1982, 298:199-209. 10.1098/rstb.1982.0082 6125971
45. Taerk E Grizenko N Ben Amor L Lageix P Mbekou V Deguzman R Torkaman-Zehi A Ter Stepanian M Baron C Joober R Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD BMC Med Genet 2004, 5:30. 544598 15613245 10.1186/ 1471-2350-5-30
46. Lawrence V Houghton S Douglas G Durkin K Whiting K Tannock R Executive function and ADHD: A comparison of children's performance during neuropsychological testing and real-world activities J Atten Disord 2004, 7:137-149. 10.1177/108705470400700302 15260171
47. Ross TP Hanouskova E Giarla K Calhoun E Tucker M The reliability and validity of the self-ordered pointing task Arch Clin Neuropsychol 2007, 22:449-458. 10.1016/j.acn.2007.01.023 17321716
48. Shue KL Douglas VI Attention deficit hyperactivity disorder and the frontal lobe syndrome Brain Cogn 1992, 20:104-124. 10.1016/ 0278-2626(92)90064-S 1389116
49. Sergeant JA Geurts H Oosterlaan J How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behav Brain Res 2002, 130:3-28. 10.1016/S0166-4328(01)00430-2 11864714
50. Adler LA Spencer T Faraone SV Reimherr FW Kelsey D Michelson D Biederman J Training raters to assess adult ADHD: Reliability of ratings J Atten Disord 2005, 8:121-126. 10.1177/1087054705277168 16009660
51. Joober R Toulouse A Benkelfat C Lal S Bloom D Labelle A Lalonde P Turecki G Rouleau GA DRD3 and DAT1 genes in schizophrenia: An association study J Psychiatr Res 2000, 34:285-291. 10.1016/ S0022-3956(00)00018-2 11104840
52. Sankoh AJ Huque MF Dubey SD Some comments on frequently used multiple endpoint adjustment methods in clinical trials Stat Med 1997, 16:2529-2542. 10.1002/ (SICI)1097-0258(19971130)16:22<2529::AID-SIM692>3.0.CO;2-J 9403954
53. Jacobsen LK Staley JK Zoghbi SS Seibyl JP Kosten TR Innis RB Gelernter J Prediction of dopamine transporter binding availability by genotype: A preliminary report Am J Psychiatry 2000, 157:1700-1703. 10.1176/ appi.ajp.157.10.1700 11007732
54. Heinz A Goldman D Jones DW Palmour R Hommer D Gorey JG Lee KS Linnoila M Weinberger DR Genotype influences in vivo dopamine transporter availability in human striatum Neuropsychopharmacology 2000, 22:133-139. 10.1016/S0893-133X(99)00099-8 10649826
55. Martinez D Gelernter J Abi-Dargham A van Dyck CH Kegeles L Innis RB Laruelle M The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans Neuropsychopharmacology 2001, 24:553-560. 10.1016/S0893-133X(00)00216-5 11282255