No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD

Journal of Neural Transmission

Volumn 114, Issue 4, 2007, Pages 523-526

  Schimmelmann, B G ^a   Friedel, S ^a   Dempfle, A ^b   Warnke, A ^c   Lesch, K P ^c   Walitza, S ^c   Renner, T J ^c   Romanos, M ^c   Herpertz Dahlmann, B ^d   Linder, M ^e   Schafer H ^b   Seitz, C ^f   Palmason, H ^g   Freitag, C ^f   Meyer, J ^g   Konrad, K ^d   Hinney, A ^a   Hebebrand, J ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e Bezirksklinik Regensburg ^*  (Germany)

^f SAARLAND UNIVERSITY   (Germany)

^g UNIVERSITY OF TRIER   (Germany)

Author keywords

Attention deficit; Hyperactivity disorder; Neurotrophic factor; Polymorphism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; VALINE;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMISSION; PATHOGENESIS; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; VALINE;

EID: 33947513564     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-006-0616-1     Document Type: Article

References (30)

1. American Psychiatric Association 1994 Diagnostic and statistical manual of mental disorders 4th edn. American Psychiatric Association Washington, DC
2. M Cargill D Altshuler J Ireland P Sklar K Ardlie N Patil N Shaw CR Lane EP Lim N Kalyanaraman J Nemesh L Ziaugra L Friedland A Rolfe J Warrington R Lipshutz GQ Daley ES Lander 1999 Characterization of single-nucleotide polymorphisms in coding regions of human genes Nat Genet 22 3 231 238
3. MF Egan M Kojima JH Callicott TE Goldberg BS Kolachana A Bertolino E Zaitsev B Gold D Goldman M Dean B Lu DR Weinberger 2003 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2 257 269
4. SV Faraone J Biederman 1998 Neurobiology of attention-deficit hyperactivity disorder Biol Psychiatry 44 10 951 958
5. T Ford R Goodman H Meltzer 2003 The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders J Am Acad Child Adolesc Psychiatry 42 10 1203 1211
6. S Friedel FF Horro AK Wermter F Geller A Dempfle K Reichwald J Smidt G Bronner K Konrad B Herpertz-Dahlmann A Warnke U Hemminger M Linder H Kiefl HP Goldschmidt W Siegfried H Remschmidt A Hinney J Hebebrand 2005 Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder Am J Med Genet B Neuropsychiatr Genet 132 1 96 99
7. WJ Gauderman 2002 Sample size requirements for association studies of gene-gene interaction Am J Epidemiol 155 5 478 484
8. B Geller JA Badner R Tillman SL Christian K Bolhofner EH Cook Jr 2004 Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype Am J Psychiatry 161 9 1698 1700
9. EK Green R Raybould S Macgregor S Hyde AH Young MC O'Donovan MJ Owen G Kirov L Jones I Jones N Craddock 2006 Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK Br J Psychiatry 188 21 25
10. AR Hariri TE Goldberg VS Mattay BS Kolachana JH Callicott MF Egan DR Weinberger 2003 Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance J Neurosci 23 17 6690 6694
11. Z Hawi R Segurado J Conroy K Sheehan N Lowe A Kirley D Shields M Fitzgerald L Gallagher M Gill 2005 Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder Am J Hum Genet 77 6 958 965
12. J Hebebrand A Dempfle K Saar H Thiele B Herpertz-Dahlmann M Linder H Kiefl H Remschmidt U Hemminger A Warnke U Knolker P Heiser S Friedel A Hinney H Schafer P Nurnberg K Konrad 2006 A genome-wide scan for attention-deficit/ hyperactivity disorder in 155 German sib-pairs Mol Psychiatry 11 2 196 205
13. P Heiser S Friedel A Dempfle K Konrad J Smidt J Grabarkiewicz B Herpertz-Dahlmann H Remschmidt J Hebebrand 2004 Molecular genetic aspects of attention-deficit/hyperactivity disorder Neurosci Biobehav Rev 28 6 625 641
14. CJ Hong SJ Huo FC Yen CL Tung GM Pan SJ Tsai 2003 Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior Neuropsychobiology 48 4 186 189
15. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (2005) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging [Epub Dec 9 ahead of print]
16. L Kent E Green Z Hawi A Kirley F Dudbridge N Lowe R Raybould K Langley N Bray M Fitzgerald MJ Owen MC O'Donovan M Gill A Thapar N Craddock 2005 Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD Mol Psychiatry 10 10 939 943
17. M Knapp T Becker 2003 Family-based association analysis with tightly linked markers Hum Hered 56 1-3 2 9
18. H Kunugi Y Iijima M Tatsumi M Yoshida R Hashimoto T Kato K Sakamoto T Fukunaga T Inada T Suzuki N Iwata N Ozaki K Yamada T Yoshikawa 2004 No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study Biol Psychiatry 56 5 376 378
19. UE Lang R Hellweg P Kalus M Bajbouj KP Lenzen T Sander D Kunz J Gallinat 2005 Association of a functional BDNF polymorphism and anxiety-related personality traits Psychopharmacology (Berl) 180 1 95 99
20. M Lanktree P Muglia A Squassina M Krinsky U Jain F Macciardi 2004 A potential role for brain derived neurotrophic factor (BDNF) in adult ADHD Am J Med Gen 130B 96 97
21. FW Lohoff T Sander TN Ferraro JP Dahl J Gallinat WH Berrettini 2005 Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder Am J Med Genet B Neuropsychiatr Genet 139 1 51 53
22. JR O'Connell DE Weeks 1998 PedCheck: a program for identification of genotype incompatibilities in linkage analysis Am J Hum Genet 63 259 266
23. A Rosa MJ Cuesta M Fatjo-Vilas V Peralta A Zarzuela L Fananas 2006 The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study Am J Med Genet B Neuropsychiatr Genet 141 2 135 138
24. Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE, Flint J (2006) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J Psychiatr Res [Epub Feb 23 ahead of print]
25. JM Swanson JA Sergeant E Taylor EJ Sonuga-Barke PS Jensen DP Cantwell 1998 Attention-deficit hyperactivity disorder and hyperkinetic disorder Lancet 351 9100 429 433
26. S Unnewehr S Schneider J Margraf 1995 Kinder-DIPS: Diagnostisches Interview bei psychischen Störungen von Kindern und Jugendlichen Christoph Dornier-Stiftung für klinische Psychologie Springer Berlin
27. CR Weinberg 1999 Methods for detection of parent-of-origin effects in genetic studies of case-parents triads Am J Hum Genet 65 1 229 235
28. JE Wigginton GR Abecasis 2005 PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data Bioinformatics 21 16 3445 3447
29. SA Willis-Owen J Fullerton PG Surtees NW Wainwright S Miller J Flint 2005 The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism Biol Psychiatry 58 9 738 742
30. H Zhao S Zhang KR Merikangas M Trixler DB Wildenauer F Sun KK Kidd 2000 Transmission/disequilibrium tests using multiple tightly linked markers Am J Hum Genet 67 4 936 946