-
1
-
-
36749011232
-
The malignant clone and the bone-marrow environment
-
DOI 10.1016/j.beha.2007.08.002, PII S1521692607000631, New Insights into the Biology and Advances in the Management of Multiple Myeloma
-
Podar K, Richardson PG, Hideshima T, et al. The malignant clone and the bone-marrow environment. Best Pract Res 2007;20:597-612 (Pubitemid 350215375)
-
(2007)
Best Practice and Research in Clinical Haematology
, vol.20
, Issue.4
, pp. 597-612
-
-
Podar, K.1
Richardson, P.G.2
Hideshima, T.3
Chauhan, D.4
Anderson, K.C.5
-
2
-
-
42449114035
-
Multiple myeloma
-
Kyle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111:2962-2972
-
(2008)
Blood
, vol.111
, pp. 2962-2972
-
-
Kyle, R.A.1
Rajkumar, S.V.2
-
3
-
-
0014661330
-
Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens
-
Alexanian R, Haut A, Khan AU, et al. Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. JAMA 1969;208:1680-1685
-
(1969)
JAMA
, vol.208
, pp. 1680-1685
-
-
Alexanian, R.1
Haut, A.2
Khan, A.U.3
-
4
-
-
0018668451
-
The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia
-
Bergsagel DE, Bailey AJ, Langley GR, et al. The chemotherapy on plasma-cell myeloma and the incidence of acute leukemia. N Engl J Med 1979;301:743-748 (Pubitemid 10250478)
-
(1979)
New England Journal of Medicine
, vol.301
, Issue.14
, pp. 743-748
-
-
Bergsagel, D.E.1
Bailey, A.J.2
Langley, G.R.3
-
5
-
-
0033864110
-
Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: A Finnish Leukaemia Group study
-
DOI 10.1034/j.1600-0609.2000.90218.x
-
Finnish Leukaemia Group. Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: a Finnish Leukaemia Group study. Eur J Haematol 2000;65:123-127 (Pubitemid 30615087)
-
(2000)
European Journal of Haematology
, vol.65
, Issue.2
, pp. 123-127
-
-
Olivanen, T.1
-
6
-
-
0020578180
-
High-dose intravenous melphalan for plasma-cell leukaemia and myeloma
-
McElwain TJ, Powles RL. High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Lancet 1983;2:822-824
-
(1983)
Lancet
, vol.2
, pp. 822-824
-
-
McElwain, T.J.1
Powles, R.L.2
-
7
-
-
0022510876
-
High-dose melphalan with autologous bone marrow transplantation for multiple myeloma
-
Barlogie B, Hall R, Zander A, et al. High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood 1986;67:1298-1301 (Pubitemid 16080597)
-
(1986)
Blood
, vol.67
, Issue.5
, pp. 1298-1301
-
-
Barlogie, B.1
Hall, R.2
Zander, A.3
-
8
-
-
0023552805
-
High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma
-
Barlogie B, Alexanian R, Dicke KA, et al. High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Blood 1987;70:869-872 (Pubitemid 18027425)
-
(1987)
Blood
, vol.70
, Issue.3
, pp. 869-872
-
-
Barlogie, B.1
Alexanian, R.2
Dicke, K.A.3
Zagars, G.4
Spitzer, G.5
Jagannath, S.6
Horwitz, L.7
-
9
-
-
8944220233
-
A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma
-
DOI 10.1056/NEJM199607113350204
-
Attal M, Harousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med 1996;335:91-97 (Pubitemid 26240110)
-
(1996)
New England Journal of Medicine
, vol.335
, Issue.2
, pp. 91-97
-
-
Attal, M.1
Harousseau, J.-L.2
Stoppa, A.-M.3
Sotto, J.-J.4
Fuzibet, J.-G.5
Rossi, J.-F.6
Casassus, P.7
Maisonneuve, H.8
Facon, T.9
Ifrah, N.10
Payen, C.11
Bataille, R.12
-
10
-
-
0037739753
-
High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
-
DOI 10.1056/NEJMoa022340
-
Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003;348:1875-1883 (Pubitemid 36532313)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.19
, pp. 1875-1883
-
-
Child, J.A.1
Morgan, G.J.2
Davies, F.E.3
Owen, R.G.4
Bell, S.E.5
Hawkins, K.6
Brown, J.7
Drayson, M.T.8
Selby, P.J.9
-
11
-
-
14144254245
-
Less than half of patients aged 65 years or under with myeloma proceed to transplantation: Results of a two region population-based survey
-
DOI 10.1111/j.1365-2141.2004.05340.x
-
Morris TC, Velangi M, Jackson G, et al. Less than half of patients aged 65 years or under with myeloma proceed to transplantation: results of a two region population-based survey. Br J Haematol 2005;128(4):510-512 (Pubitemid 40283169)
-
(2005)
British Journal of Haematology
, vol.128
, Issue.4
, pp. 510-512
-
-
Morris, T.C.M.1
Velangi, M.2
Jackson, G.3
Marks, D.I.4
Ranaghan, L.5
-
13
-
-
0021322023
-
Effective treatment of advanced multiple myeloma refractory to alkylating agents
-
Barlogie B, Smith L, Alexanian R. Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984;310(21):1353-1356 (Pubitemid 14149087)
-
(1984)
New England Journal of Medicine
, vol.310
, Issue.21
, pp. 1353-1356
-
-
Barlogie, B.1
Smith, L.2
Alexanian, R.3
-
14
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999;341(21):1565-1571
-
(1999)
N Engl J Med
, vol.341
, Issue.21
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
15
-
-
0035880229
-
Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: Identification of prognostic factors in a phase 2 study of 169 patients
-
Barlogie B, Desikan R, Eddlemon P, et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Blood 2001;98(2):492-494
-
(2001)
Blood
, vol.98
, Issue.2
, pp. 492-494
-
-
Barlogie, B.1
Desikan, R.2
Eddlemon, P.3
-
16
-
-
0033815863
-
Thalidomide in the treatment of relapsed multiple myeloma
-
Rajkumar SV, Fonseca R, Dispenzieri A, et al. Thalidomide in the treatment of relapsed multiple myeloma. Mayo Clin Proc 2000;75(9):897-901 (Pubitemid 30690161)
-
(2000)
Mayo Clinic Proceedings
, vol.75
, Issue.9
, pp. 897-901
-
-
Vincent Rajkumar, S.1
Fonseca, R.2
Dispenzieri, A.3
Lacy, M.Q.4
Lust, J.A.5
Witzig, T.E.6
Kyle, R.A.7
Gertz, M.A.8
Greipp, P.R.9
-
17
-
-
0347383742
-
Thalidomide with or without Dexamethasone for Refractory or Relapsing Multiple Myeloma
-
Alexanian R, Weber D, Anagnostopoulos A, et al. Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma. Semin Hematol 2003;40(4 Suppl 4):3-7 (Pubitemid 37532254)
-
(2003)
Seminars in Hematology
, vol.40
, Issue.4 SUPPL. 4
, pp. 3-7
-
-
Alexanian, R.1
Weber, D.2
Anagnostopoulos, A.3
Delasalle, K.4
Wang, M.5
Rankin, K.6
-
18
-
-
0034899464
-
Thalidomide and dexamethasone combination for refractory multiple myeloma
-
DOI 10.1023/A:1011132808904
-
Dimopoulos MA, Zervas K, Kouvatseas G, et al. Thalidomide and dexamethasone combination for refractory multiple myeloma. Ann Oncol 2001;12(7):991-995 (Pubitemid 32725775)
-
(2001)
Annals of Oncology
, vol.12
, Issue.7
, pp. 991-995
-
-
Dimopoulos, M.A.1
Zervas, K.2
Kouvatseas, G.3
Galani, E.4
Grigoraki, V.5
Kiamouris, Ch.6
Vervessou, E.7
Samantas, E.8
Papadimitriou, Ch.9
Economou, O.10
Gika, D.11
Panayiotidis, P.12
Christakis, I.13
Anagnostopoulos, N.14
-
19
-
-
26844541520
-
Thalidomide plus dexamethasone is an effective salvage regimen for myeloma patients relapsing after autologous transplant
-
DOI 10.1111/j.1600-0609.2005.00533.x
-
Palumbo A, Falco P, Ambrosini MT, et al. Thalidomide plus dexamethasone is an effective salvage regimen for myeloma patients relapsing after autologous transplant. Eur J Haematol 2005;75(5):391-395 (Pubitemid 41445078)
-
(2005)
European Journal of Haematology
, vol.75
, Issue.5
, pp. 391-395
-
-
Palumbo, A.1
Falco, P.2
Ambrosini, M.T.3
Petrucci, M.T.4
Musto, P.5
Caravita, T.6
Pregno, P.7
Bertola, A.8
Cavallo, F.9
Ciccone, G.10
Boccadoro, M.11
-
20
-
-
11144356289
-
Pulsed cyclophosphamide, thalidomide and dexamethasone: An oral regimen for previously treated patients with multiple myeloma
-
DOI 10.1038/sj.thj.6200326
-
Dimopoulos MA, Hamilos G, Zomas A, et al. Pulsed cyclophosphamide, thalidomide and dexamethasone: an oral regimen for previously treated patients with multiple myeloma. Hematol J 2004;5(2):112-117 (Pubitemid 38519259)
-
(2004)
Hematology Journal
, vol.5
, Issue.2
, pp. 112-117
-
-
Dimopoulos, M.A.1
Hamilos, G.2
Zomas, A.3
Gika, D.4
Efstathiou, E.5
Grigoraki, V.6
Poziopoulos, C.7
Xilouri, I.8
Zorzou, M.P.9
Anagnostopoulos, N.10
Anagnostopoulos, A.11
-
21
-
-
0035895104
-
Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
-
Moehler TM, Neben K, Benner A, et al. Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy. Blood 2001;98(13):3846-3848
-
(2001)
Blood
, vol.98
, Issue.13
, pp. 3846-3848
-
-
Moehler, T.M.1
Neben, K.2
Benner, A.3
-
22
-
-
32544447241
-
Low-dose thalidomide with pegylated liposomal doxorubicin and high-dose dexamethasone for relapsed/refractory multiple myeloma: A prospective, multicenter, phase II study
-
Offidani M, Corvatta L, Marconi M, et al. Low-dose thalidomide with pegylated liposomal doxorubicin and high-dose dexamethasone for relapsed/refractory multiple myeloma: a prospective, multicenter, phase II study. Haematologica 2006;91(1):133-136 (Pubitemid 43235397)
-
(2006)
Haematologica
, vol.91
, Issue.1
, pp. 133-136
-
-
Offidani, M.1
Corvatta, L.2
Marconi, M.3
Visani, G.4
Alesiani, F.5
Brunori, M.6
Galieni, P.7
Catarini, M.8
Burattini, M.9
Centurioni, R.10
Rupoli, S.11
Scortechini, A.R.12
Giuliodori, L.13
Candela, M.14
Capelli, D.15
Montanari, M.16
Olivieri, A.17
Piersantelli, M.-N.18
Leoni, P.19
-
23
-
-
0041629471
-
DTPACE: An effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma
-
DOI 10.1200/JCO.2003.01.055
-
Lee CK, Barlogie B, Munshi N, et al. DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma. J Clin Oncol 2003;21(14):2732-2739 (Pubitemid 46606319)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.14
, pp. 2732-2739
-
-
Lee, C.-K.1
Barlogie, B.2
Munshi, N.3
Zangari, M.4
Fassas, A.5
Jacobson, J.6
Van Rhee, F.7
Cottler-Fox, M.8
Muwalla, F.9
Tricot, G.10
-
24
-
-
0003234481
-
Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT)
-
Zangari M, Tricot G, Zeldis G, et al. Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT). Blood 2001;98;775a
-
(2001)
Blood
, vol.98
-
-
Zangari, M.1
Tricot, G.2
Zeldis, G.3
-
25
-
-
0036839013
-
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
-
DOI 10.1182/blood-2002-03-0996
-
Richardson PG, Schlossman RL, Weller E, et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002;100(9):3063-3067 (Pubitemid 35217050)
-
(2002)
Blood
, vol.100
, Issue.9
, pp. 3063-3067
-
-
Richardson, P.G.1
Schlossman, R.L.2
Weller, E.3
Hideshima, T.4
Mitsiades, C.5
Davies, F.6
Leblanc, R.7
Catley, L.P.8
Doss, D.9
Kelly, K.10
McKenney, M.11
Mechlowicz, J.12
Freeman, A.13
Deocampo, R.14
Rich, R.15
Ryoo, J.J.16
Chauhan, D.17
Balinski, K.18
Zeldis, J.19
Anderson, K.C.20
more..
-
26
-
-
36349010285
-
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
-
DOI 10.1056/NEJMoa070596
-
Weber DM, Chen C, Niesvizky R, et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007;357(21):2133-2142 (Pubitemid 350146108)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.21
, pp. 2133-2142
-
-
Weber, D.M.1
Chen, C.2
Niesvizky, R.3
Wang, M.4
Belch, A.5
Stadtmauer, E.A.6
Siegel, D.7
Borrello, I.8
Rajkumar, S.V.9
Chanan-Khan, A.A.10
Lonial, S.11
Yu, Z.12
Patin, J.13
Olesnyckyj, M.14
Zeldis, J.B.15
Knight, R.D.16
-
27
-
-
36349023319
-
Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
-
DOI 10.1056/NEJMoa070594
-
Dimopoulos M, Spencer A, Attal M, et al. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357(21):2123-2132 (Pubitemid 350146107)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.21
, pp. 2123-2132
-
-
Dimopoulos, M.1
Spencer, A.2
Attal, M.3
Prince, H.M.4
Harousseau, J.-L.5
Dmoszynska, A.6
San Miguel, J.7
Hellmann, A.8
Facon, T.9
Foa, R.10
Corso, A.11
Masliak, Z.12
Olesnyckyj, M.13
Yu, Z.14
Patin, J.15
Zeldis, J.B.16
Knight, R.D.17
-
28
-
-
33845350847
-
Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: Safety and efficacy
-
DOI 10.1093/annonc/mdl313, Special Issue: Gender and the Politics of Scale
-
Baz R, Walker E, Karam MA, et al. Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann Oncol 2006;17(12):1766-1771 (Pubitemid 44884050)
-
(2006)
Annals of Oncology
, vol.17
, Issue.12
, pp. 1766-1771
-
-
Baz, R.1
Walker, E.2
Karam, M.A.3
Choueiri, T.K.4
Jawde, R.A.5
Bruening, K.6
Reed, J.7
Faiman, B.8
Ellis, Y.9
Brand, C.10
Srkalovic, G.11
Andresen, S.12
Knight, R.13
Zeldis, J.14
Hussein, M.A.15
-
29
-
-
34047233904
-
Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients
-
DOI 10.1111/j.1365-2141.2007.06538.x
-
Morgan GJ, Schey SA, Wu P, et al. Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients. Br J Haematol 2007;137(3):268-269 (Pubitemid 46537629)
-
(2007)
British Journal of Haematology
, vol.137
, Issue.3
, pp. 268-269
-
-
Morgan, G.J.1
Schey, S.A.2
Wu, P.3
Srikanth, M.4
Phekoo, K.J.5
Jenner, M.6
Davies, F.E.7
-
30
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61(7):3071-3076 (Pubitemid 32691956)
-
(2001)
Cancer Research
, vol.61
, Issue.7
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.J.4
Elliott, P.J.5
Adams, J.6
Anderson, K.C.7
-
31
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
DOI 10.1200/JCO.2002.01.133
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20(22):4420-4427 (Pubitemid 35334752)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.22
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
Shea, T.C.4
Baldwin, A.S.5
Stahl, S.6
Adams, J.7
Esseltine, D.-L.8
Elliott, P.J.9
Pien, C.S.10
Guerciolini, R.11
Anderson, J.K.12
Depcik-Smith, N.D.13
Bhagat, R.14
Lehman, M.J.15
Novick, S.C.16
O'Connor, O.A.17
Soignet, S.L.18
-
32
-
-
0037973279
-
A phase 2 study of Bortezomib in relapsed, refractory myeloma
-
DOI 10.1056/NEJMoa030288
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348(26):2609-2617 (Pubitemid 36741588)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.26
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
Rajkumar, S.V.7
Srkalovic, G.8
Alsina, M.9
Alexanian, R.10
Siegel, D.11
Orlowski, R.Z.12
Kuter, D.13
Limentani, S.A.14
Lee, S.15
Hideshima, T.16
Esseltine, D.-L.17
Kauffman, M.18
Adams, J.19
Schenkein, D.P.20
Anderson, K.C.21
more..
-
33
-
-
67649582868
-
Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma
-
abstract #2717
-
Jagannath J, Barlogie B, Berenson JR, et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma [abstract #2717]. Blood 2007;110(11)
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Jagannath, J.1
Barlogie, B.2
Berenson, J.R.3
-
34
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
DOI 10.1056/NEJMoa043445
-
Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005;352(24):2487-2498 (Pubitemid 41007864)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.24
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
Harousseau, J.-L.7
Ben-Yehuda, D.8
Lonial, S.9
Goldschmidt, H.10
Reece, D.11
San-Miguel, J.F.12
Blade, J.13
Boccadoro, M.14
Cavenagh, J.15
Dalton, W.S.16
Boral, A.L.17
Esseltine, D.L.18
Porter, J.B.19
Schenkein, D.20
Anderson, K.C.21
more..
-
35
-
-
35148825003
-
Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial
-
DOI 10.1182/blood-2006-08-036947
-
Richardson PG, Sonneveld P, Schuster M, et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial. Blood 2007;110(10):3557-3560 (Pubitemid 350159621)
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3557-3560
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.3
Irwin, D.4
Stadtmauer, E.5
Facon, T.6
Harousseau, J.-L.7
Ben-Yehuda, D.8
Lonial, S.9
Goldschmidt, H.10
Reece, D.11
San Miguel, J.12
Blade, J.13
Boccadoro, M.14
Cavenagh, J.15
Alsina, M.16
Rajkumar, S.V.17
Lacy, M.18
Jakubowiak, A.19
Dalton, W.20
Boral, A.21
Esseltine, D.-L.22
Schenkein, D.23
Anderson, K.C.24
more..
-
36
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
-
DOI 10.1182/blood-2002-06-1768
-
Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003;101(6):2377-2380 (Pubitemid 36302084)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2377-2380
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
Poulaki, V.4
Tai, Y.-T.5
Chauhan, D.6
Fanourakis, G.7
Gu, X.8
Bailey, C.9
Joseph, M.10
Libermann, T.A.11
Schlossman, R.12
Munshi, N.C.13
Hideshima, T.14
Anderson, K.C.15
-
37
-
-
34548539381
-
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
-
DOI 10.1200/JCO.2006.10.5460
-
Orlowski RZ, Nagler A, Sonneveld P, et al. Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol 2007;25(25):3892-3901 (Pubitemid 47477266)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.25
, pp. 3892-3901
-
-
Orlowski, R.Z.1
Nagler, A.2
Sonneveld, P.3
Blade, J.4
Hajek, R.5
Spencer, A.6
San Miguel, J.7
Robak, T.8
Dmoszynska, A.9
Horvath, N.10
Spicka, I.11
Sutherland, H.J.12
Suvorov, A.N.13
Zhuang, S.H.14
Parekh, T.15
Xiu, L.16
Yuan, Z.17
Rackoff, W.18
Harousseau, J.-L.19
-
38
-
-
27744489202
-
Role of VAD in the initial treatment of multiple myeloma
-
author reply 3674-3675
-
Lane SW, Gill D, Mollee PN, Rajkumar SV. Role of VAD in the initial treatment of multiple myeloma. Blood 2005;106(10):3674M; author reply 3674-3675
-
(2005)
Blood
, vol.106
, Issue.10
-
-
Lane, S.W.1
Gill, D.2
Mollee, P.N.3
Rajkumar, S.V.4
-
39
-
-
33644824325
-
High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: Long-term results of a randomized control trial from the group myelome-autogreffe
-
DOI 10.1200/JCO.2005.03.0551
-
Fermand JP, Katsahian S, Divine M, et al. High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the group myelome-autogreffe. J Clin Oncol 2005;23(36):9227-9233 (Pubitemid 46260178)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.36
, pp. 9227-9233
-
-
Fermand, J.-P.1
Katsahian, S.2
Divine, M.3
Leblond, V.4
Dreyfus, F.5
Macro, M.6
Arnulf, B.7
Royer, B.8
Mariette, X.9
Pertuiset, E.10
Belanger, C.11
Janvier, M.12
Chevret, S.13
Brouet, J.C.14
Ravaud, P.15
-
40
-
-
33644920953
-
Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: Final results of phase III US intergroup trial S9321
-
DOI 10.1200/JCO.2005.04.5807
-
Barlogie B, Kyle RA, Anderson KC, et al. Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321. J Clin Oncol 2006;24(6):929-936 (Pubitemid 46638847)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.6
, pp. 929-936
-
-
Barlogie, B.1
Kyle, R.A.2
Anderson, K.C.3
Greipp, P.R.4
Lazarus, H.M.5
Hurd, D.D.6
McCoy, J.7
Dakhil, S.R.8
Lanier, K.S.9
Chapman, R.A.10
Cromer, J.N.11
Salmon, S.E.12
Durie, B.13
Crowley, J.C.14
-
41
-
-
28444494386
-
High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: Long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA
-
DOI 10.1182/blood-2005-03-1301
-
Blade J, Rosinol L, Sureda A, et al. High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA. Blood 2005;106(12):3755-3759 (Pubitemid 41739009)
-
(2005)
Blood
, vol.106
, Issue.12
, pp. 3755-3759
-
-
Blade, J.1
Rosinol, L.2
Sureda, A.3
Ribera, J.M.4
Diaz-Mediavilla, J.5
Garcia-Larana, J.6
Mateos, M.V.7
Palomera, L.8
Fernandez-Calvo, J.9
Marti, J.M.10
Giraldo, P.11
Carbonell, F.12
Callis, M.13
Trujillo, J.14
Gardella, S.15
Moro, M.J.16
Barez, A.17
Soler, A.18
Font, L.19
Fontanillas, M.20
San Miguel, J.21
more..
-
42
-
-
0031001279
-
Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma
-
Barlogie B, Jagannath S, Vesole DH, et al. Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma. Blood 1997;89(3):789-793 (Pubitemid 27121271)
-
(1997)
Blood
, vol.89
, Issue.3
, pp. 789-793
-
-
Barlogie, B.1
Jagannath, S.2
Vesole, D.H.3
Naucke, S.4
Cheson, B.5
Mattox, S.6
Bracy, D.7
Salmon, S.8
Jacobson, J.9
Crowley, J.10
Tricot, G.11
-
43
-
-
0032929769
-
Total therapy with tandem transplants for newly diagnosed multiple myeloma
-
Barlogie B, Jagannath S, Desikan KR, et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood 1999;93(1):55-65 (Pubitemid 29019388)
-
(1999)
Blood
, vol.93
, Issue.1
, pp. 55-65
-
-
Barlogie, B.1
Jagannath, S.2
Desikan, K.R.3
Mattox, S.4
Vesole, D.5
Siegel, D.6
Tricot, G.7
Munshi, N.8
Fassas, A.9
Singhal, S.10
Mehta, J.11
Anaissie, E.12
Dhodapkar, D.13
Naucke, S.14
Cromer, J.15
Sawyer, J.16
Epstein, J.17
Spoon, D.18
Ayers, D.19
Cheson, B.20
Crowley, J.21
more..
-
44
-
-
0019944218
-
Identical twin marrow transplantation in multiple myeloma
-
Osserman EF, Dire LB, Dire J, et al. Identical twin marrow transplantation in multiple myeloma. Acta Haematol 1982;68(3):215-223
-
(1982)
Acta Haematol
, vol.68
, Issue.3
, pp. 215-223
-
-
Osserman, E.F.1
Dire, L.B.2
Dire, J.3
-
45
-
-
0023216770
-
Bone marrow transplantation in multiple myeloma: Report from the European Cooperative Group for Bone Marrow Transplantation
-
Gahrton G, Tura S, Flesch M, et al. Bone marrow transplantation in multiple myeloma: report from the European Cooperative Group for Bone Marrow Transplantation. Blood 1987;69(4):1262-1264 (Pubitemid 17080954)
-
(1987)
Blood
, vol.69
, Issue.4
, pp. 1262-1264
-
-
Gahrton, G.1
Tura, S.2
Flesch, M.3
-
46
-
-
0029822773
-
Allogeneic marrow transplantation for multiple myeloma: An analysis of risk factors on outcome
-
Bensinger WI, Buckner CD, Anasetti C, et al. Allogeneic marrow transplantation for multiple myeloma: an analysis of risk factors on outcome. Blood 1996;88(7):2787-2793 (Pubitemid 26327535)
-
(1996)
Blood
, vol.88
, Issue.7
, pp. 2787-2793
-
-
Bensinger, W.I.1
Buckner, C.D.2
Anasetti, C.3
Clift, R.4
Storb, R.5
Barnett, T.6
Chauncey, T.7
Shulman, H.8
Appelbaum, F.R.9
-
47
-
-
0035883066
-
T-cell-depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: Induction of graft-versus-myeloma effect
-
Alyea E, Weller E, Schlossman R, et al. T-cell-depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect. Blood 2001;98(4):934-939
-
(2001)
Blood
, vol.98
, Issue.4
, pp. 934-939
-
-
Alyea, E.1
Weller, E.2
Schlossman, R.3
-
48
-
-
0038135027
-
Partially T-cell-depleted allogeneic stem-cell transplantation for first-line treatment of multiple myeloma: A prospective evaluation of patients treated in the phase III study HOVON 24 MM
-
DOI 10.1200/JCO.2003.04.033
-
Lokhorst HM, Segeren CM, Verdonck LF, et al. Partially T-cell-depleted allogeneic stem-cell transplantation for first-line treatment of multiple myeloma: a prospective evaluation of patients treated in the phase III study HOVON 24 MM. J Clin Oncol 2003;21(9):1728-1733 (Pubitemid 46638584)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.9
, pp. 1728-1733
-
-
Lokhorst, H.M.1
Segeren, C.M.2
Verdonck, L.F.3
Van Der Holt, B.4
Raymakers, R.5
Van Oers, M.H.J.6
Barge, R.M.Y.7
Schouten, H.C.8
Westveer, P.H.M.9
Steijaert, M.M.C.10
Cornelissen, J.J.11
Sonneveld, P.12
-
49
-
-
0036498782
-
Improved outcome of allogeneic transplantation in high-risk multiple myeloma patients after nonmyeloablative conditioning
-
DOI 10.1200/JCO.20.5.1295
-
Badros A, Barlogie B, Siegel E, et al. Improved outcome of allogeneic transplantation in high-risk multiple myeloma patients after nonmyeloablative conditioning. J Clin Oncol 2002;20(5):1295-1303 (Pubitemid 34177436)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.5
, pp. 1295-1303
-
-
Badros, A.1
Barlogie, B.2
Siegel, E.3
Cottler-Fox, M.4
Zangari, M.5
Fassas, A.6
Morris, C.7
Anaissie, E.8
Van Rhee, F.9
Tricot, G.10
-
50
-
-
0036682491
-
Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma
-
DOI 10.1182/blood-2002-01-0131
-
Kroger N, Schwerdtfeger R, Kiehl M, et al. Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma. Blood 2002;100(3):755-760 (Pubitemid 34832597)
-
(2002)
Blood
, vol.100
, Issue.3
, pp. 755-760
-
-
Kroger, N.1
Schwerdtfeger, R.2
Kiehl, M.3
Sayer, H.G.4
Renges, H.5
Zabelina, T.6
Fehse, B.7
Togel, F.8
Wittkowsky, G.9
Kuse, R.10
Zander, A.R.11
-
51
-
-
0142152420
-
Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma
-
DOI 10.1182/blood-2002-09-2955
-
Maloney DG, Molina AJ, Sahebi F, et al. Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma. Blood 2003;102(9):3447-3454 (Pubitemid 37314788)
-
(2003)
Blood
, vol.102
, Issue.9
, pp. 3447-3454
-
-
Maloney, D.G.1
Molina, A.J.2
Sahebi, F.3
Stockerl-Goldstein, K.E.4
Sandmaier, B.M.5
Bensinger, W.6
Storer, B.7
Hegenbart, U.8
Somlo, G.9
Chauncey, T.10
Bruno, B.11
Appelbaum, F.R.12
Blume, K.G.13
Forman, S.J.14
McSweeney, P.15
Storb, R.16
-
52
-
-
30144439125
-
Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: Final results of the prospective and randomized IFM 99-04 protocol
-
DOI 10.1182/blood-2005-06-2573
-
Moreau P, Hullin C, Garban F, et al. Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol. Blood 2006;107(1):397-403 (Pubitemid 43053569)
-
(2006)
Blood
, vol.107
, Issue.1
, pp. 397-403
-
-
Moreau, P.1
Hullin, C.2
Garban, F.3
Yakoub-Agha, I.4
Benboubker, L.5
Attal, M.6
Marit, G.7
Fuzibet, J.-G.8
Doyen, C.9
Voillat, L.10
Berthou, C.11
Ketterer, N.12
Casassus, P.13
Monconduit, M.14
Michallet, M.15
Najman, A.16
Sotto, J.-J.17
Bataille, R.18
Harousseau, J.-L.19
-
53
-
-
33947197286
-
A comparison of allografting with autografting for newly diagnosed myeloma
-
DOI 10.1056/NEJMoa065464
-
Bruno B, Rotta M, Patriarca F, et al. A comparison of allografting with autografting for newly diagnosed myeloma. N Engl J Med 2007;356(11):1110-1120 (Pubitemid 46425595)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.11
, pp. 1110-1120
-
-
Bruno, B.1
Rotta, M.2
Patriarca, F.3
Mordini, N.4
Allione, B.5
Carnevale-Schianca, F.6
Giaccone, L.7
Sorasio, R.8
Omede, P.9
Baldi, I.10
Bringhen, S.11
Massaia, M.12
Aglietta, M.13
Levis, A.14
Gallamini, A.15
Fanin, R.16
Palumbo, A.17
Storb, R.18
Ciccone, G.19
Boccadoro, M.20
more..
-
54
-
-
0037208595
-
Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
-
Weber D, Rankin K, Gavino M, et al. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol 2003;21(1):16-19
-
(2003)
J Clin Oncol
, vol.21
, Issue.1
, pp. 16-19
-
-
Weber, D.1
Rankin, K.2
Gavino, M.3
-
55
-
-
33644831033
-
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the eastern cooperative oncology group
-
DOI 10.1200/JCO.2005.03.0221
-
Rajkumar SV, Blood E, Vesole D, et al. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006;24(3):431-436 (Pubitemid 46630462)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.3
, pp. 431-436
-
-
Rajkumar, S.V.1
Blood, E.2
Vesole, D.3
Fonseca, R.4
Greipp, P.R.5
-
56
-
-
0036843032
-
Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma
-
DOI 10.1200/JCO.2002.02.116
-
Rajkumar SV, Hayman S, Gertz MA, et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J Clin Oncol 2002;20(21):4319-4323 (Pubitemid 35266292)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.21
, pp. 4319-4323
-
-
Rajkumar, S.V.1
Hayman, S.2
Gertz, M.A.3
Dispenzieri, A.4
Lacy, M.Q.5
Greipp, P.R.6
Geyer, S.7
Iturria, N.8
Fonseca, R.9
Lust, J.A.10
Kyle, R.A.11
Witzig, T.E.12
-
57
-
-
34548173936
-
VAD-doxil versus VAD-doxil plus thalidomide as initial treatment for multiple myeloma: Results of a multicenter randomized trial of the Greek myeloma study group
-
DOI 10.1093/annonc/mdm178
-
Zervas K, Mihou D, Katodritou E, et al. VAD-doxil versus VAD-doxil plus thalidomide as initial treatment for multiple myeloma: results of a multicenter randomized trial of the Greek Myeloma Study Group. Ann Oncol 2007;18(8):1369-1375 (Pubitemid 47305012)
-
(2007)
Annals of Oncology
, vol.18
, Issue.8
, pp. 1369-1375
-
-
Zervas, K.1
Mihou, D.2
Katodritou, E.3
Pouli, A.4
Mitsouli, C.H.5
Anagnostopoulos, A.6
Delibasi, S.7
Kyrtsonis, M.C.8
Anagnostopoulos, N.9
Terpos, E.10
Zikos, P.11
Maniatis, A.12
Dimopoulos, M.A.13
-
58
-
-
38549144944
-
Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma
-
DOI 10.3324/haematol.11644
-
Lokhorst HM, Schmidt-Wolf I, Sonneveld P, et al. Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma. Haematologica 2008;93(1):124-127 (Pubitemid 351156161)
-
(2008)
Haematologica
, vol.93
, Issue.1
, pp. 124-127
-
-
Lokhorst, H.M.1
Schmidt-Wolf, I.2
Van Der Holt, P.S.3
Martin, H.4
Barge, R.5
Bertsch, U.6
Schlenzka, J.7
Bos, G.M.J.8
Croockewit, S.9
Zweegman, S.10
Breitkreuz, I.11
Joosten, P.12
Scheid, C.13
Van Marwijk-Kooy, M.14
Salwender, H.-J.15
Van Oers, M.H.J.16
Schaafsma, R.17
Naumann, R.18
Sinnige, H.19
Blau, I.20
Verhoef, G.21
De Weerdt, O.22
Wijermans, P.23
Wittebol, S.24
Duersen, U.25
Vellenga, E.26
Goldschmidt, H.27
more..
-
59
-
-
39149109289
-
Prevention of thalidomide- And lenalidomide-associated thrombosis in myeloma
-
DOI 10.1038/sj.leu.2405062, PII 2405062
-
Palumbo A, Rajkumar SV, Dimopoulos MA, et al. Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia 2008;22(2):414-423 (Pubitemid 351255436)
-
(2008)
Leukemia
, vol.22
, Issue.2
, pp. 414-423
-
-
Palumbo, A.1
Rajkumar, S.V.2
Dimopoulos, M.A.3
Richardson, P.G.4
San Miguel, J.5
Barlogie, B.6
Harousseau, J.7
Zonder, J.A.8
Cavo, M.9
Zangari, M.10
Attal, M.11
Belch, A.12
Knop, S.13
Joshua, D.14
Sezer, O.15
Ludwig, H.16
Vesole, D.17
Blade, J.18
Kyle, R.19
Westin, J.20
Weber, D.21
Bringhen, S.22
Niesvizky, R.23
Waage, A.24
Von Lilienfeld-Toal, M.25
Lonial, S.26
Morgan, G.J.27
Orlowski, R.Z.28
Shimizu, K.29
Anderson, K.C.30
Boccadoro, M.31
Durie, B.G.32
Sonneveld, P.33
Hussein, M.A.34
more..
-
60
-
-
27744492561
-
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
-
DOI 10.1182/blood-2005-07-2817
-
Rajkumar SV, Hayman SR, Lacy MQ, et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005;106(13):4050-4053 (Pubitemid 41775908)
-
(2005)
Blood
, vol.106
, Issue.13
, pp. 4050-4053
-
-
Rajkumar, S.V.1
Hayman, S.R.2
Lacy, M.Q.3
Dispenzieri, A.4
Geyer, S.M.5
Kabat, B.6
Zeldenrust, S.R.7
Kumar, S.8
Greipp, P.R.9
Fonseca, R.10
Lust, J.A.11
Russell, S.J.12
Kyle, R.A.13
Witzig, T.E.14
Gertz, M.A.15
-
61
-
-
34848824393
-
Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma
-
Lacy MQ, Gertz MA, Dispenzieri A, et al. Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma. Mayo Clin Proc 2007;82(10):1179-1184 (Pubitemid 47502875)
-
(2007)
Mayo Clinic Proceedings
, vol.82
, Issue.10
, pp. 1179-1184
-
-
Lacy, M.Q.1
Gertz, M.A.2
Dispenzieri, A.3
Hayman, S.R.4
Geyer, S.5
Kabat, B.6
Zeldenrust, S.R.7
Kumar, S.8
Greipp, P.R.9
Fonseca, R.10
Lust, J.A.11
Russell, S.J.12
Kyle, R.A.13
Witzig, T.E.14
Bergsagel, P.L.15
Stewart, A.K.16
Rajkumar, S.V.17
-
62
-
-
21344469223
-
Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
-
DOI 10.1111/j.1365-2141.2005.05540.x
-
Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005;129(6):776-783 (Pubitemid 40904528)
-
(2005)
British Journal of Haematology
, vol.129
, Issue.6
, pp. 776-783
-
-
Jagannath, S.1
Durie, B.G.M.2
Wolf, J.3
Camacho, E.4
Irwin, D.5
Lutzky, J.6
McKinley, M.7
Gabayan, E.8
Mazumder, A.9
Schenkein, D.10
Crowley, J.11
-
63
-
-
54749087249
-
Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study
-
abstract 8520
-
Richardson PG, Lonial S, Jakubowiak A, et al. Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study [abstract 8520]. J Clin Oncol 2008;26
-
(2008)
J Clin Oncol
, vol.26
-
-
Richardson, P.G.1
Lonial, S.2
Jakubowiak, A.3
-
64
-
-
44649143334
-
Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma
-
DOI 10.1038/sj.leu.2405100, PII 2405100
-
Paripati H, Stewart AK, Cabou S, et al. Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma. Leukemia 2008;22(6):1282-1284 (Pubitemid 351833805)
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1282-1284
-
-
Paripati, H.1
Stewart, A.K.2
Cabou, S.3
Dueck, A.4
Zepeda, V.J.5
Pirooz, N.6
Ehlenbeck, C.7
Reeder, C.8
Slack, J.9
Leis, J.F.10
Boesiger, J.11
Torloni, A.S.12
Fonseca, R.13
Bergsagel, P.L.14
-
65
-
-
44649149612
-
VELCADE/Dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantion (ASCT) in newly diagnosed multiple myeloma (MM): Updated results of the IFM 2005/01 trial
-
abstract #450
-
Harousseau JL, Mathiot C, Attal A, et al. VELCADE/Dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantion (ASCT) in newly diagnosed multiple myeloma (MM): updated results of the IFM 2005/01 trial [abstract #450]. Blood 2007;110(11)
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Harousseau, J.L.1
Mathiot, C.2
Attal, A.3
-
66
-
-
33644843725
-
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial
-
DOI 10.1016/S0140-6736(06)68338-4, PII S0140673606683384
-
Palumbo A, Bringhen S, Caravita T, et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet 2006;367(9513):825-831 (Pubitemid 43363369)
-
(2006)
Lancet
, vol.367
, Issue.9513
, pp. 825-831
-
-
Palumbo, A.1
Bringhen, S.2
Caravita, T.3
Merla, E.4
Capparella, V.5
Callea, V.6
Cangialosi, C.7
Grasso, M.8
Rossini, F.9
Galli, M.10
Catalano, L.11
Zamagni, E.12
Petrucci, M.T.13
De Stefano, V.14
Ceccarelli, M.15
Ambrosini, M.T.16
Avonto, I.17
Falco, P.18
Ciccone, G.19
Liberati, A.M.20
Musto, P.21
Boccadoro, M.22
more..
-
67
-
-
54049135250
-
Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: Updated results of a randomized, controlled trial
-
Palumbo A, Bringhen S, Liberati AM, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized, controlled trial. Blood 2008;112(8):3107-3114
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3107-3114
-
-
Palumbo, A.1
Bringhen, S.2
Liberati, A.M.3
-
68
-
-
34848833957
-
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial
-
DOI 10.1016/S0140-6736(07)61537-2, PII S0140673607615372
-
Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet 2007;370(9594):1209-1218 (Pubitemid 47516593)
-
(2007)
Lancet
, vol.370
, Issue.9594
, pp. 1209-1218
-
-
Facon, T.1
Mary, J.Y.2
Hulin, C.3
Benboubker, L.4
Attal, M.5
Pegourie, B.6
Renaud, M.7
Harousseau, J.L.8
Guillerm, G.9
Chaleteix, C.10
Dib, M.11
Voillat, L.12
Maisonneuve, H.13
Troncy, J.14
Dorvaux, V.15
Monconduit, M.16
Martin, C.17
Casassus, P.18
Jaubert, J.19
Jardel, H.20
Doyen, C.21
Kolb, B.22
Anglaret, B.23
Grosbois, B.24
Yakoub-Agha, I.25
Mathiot, C.26
Avet-Loiseau, H.27
more..
-
69
-
-
64749104456
-
Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma
-
Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma. Blood 2008
-
(2008)
Blood
-
-
Ludwig, H.1
Hajek, R.2
Tothova, E.3
-
70
-
-
35348923502
-
Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: A report from the GIMEMA - Italian Multiple Myeloma Network
-
DOI 10.1200/JCO.2007.12.3463
-
Palumbo A, Falco P, Corradini P, et al. Melphalan, prednisone, and lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA - Italian Multiple Myeloma Network. J Clin Oncol 2007;25(28):4459-4465 (Pubitemid 350063804)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.28
, pp. 4459-4465
-
-
Palumbo, A.1
Falco, P.2
Corradini, P.3
Falcone, A.4
Di Raimondo, F.5
Giuliani, N.6
Crippa, C.7
Ciccone, G.8
Omede, P.9
Ambrosini, M.T.10
Gay, F.11
Bringhen, S.12
Musto, P.13
Foa, R.14
Knight, R.15
Zeldis, J.B.16
Boccadoro, M.17
Petrucci, M.T.18
-
71
-
-
51349103508
-
Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: Results of the canadian MM016 trial
-
abstract #3597
-
Bahlis NJ, Song K, Trieu Y, et al. Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: results of the canadian MM016 trial [abstract #3597]. Blood 2007;110(11)
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Bahlis, N.J.1
Song, K.2
Trieu, Y.3
-
72
-
-
33845518467
-
Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
-
DOI 10.1038/sj.leu.2404442, PII 2404442
-
Jagannath S, Richardson PG, Sonneveld P, et al. Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia 2007;21(1):151-157 (Pubitemid 44921846)
-
(2007)
Leukemia
, vol.21
, Issue.1
, pp. 151-157
-
-
Jagannath, S.1
Richardson, P.G.2
Sonneveld, P.3
Schuster, M.W.4
Irwin, D.5
Stadtmauer, E.A.6
Facon, T.7
Harousseau, J.-L.8
Cowan, J.M.9
Anderson, K.C.10
-
73
-
-
50449086728
-
Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
-
San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma. N Engl J Med 2008;359(9):906-917
-
(2008)
N Engl J Med
, vol.359
, Issue.9
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
74
-
-
9044219839
-
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma
-
DOI 10.1056/NEJM199602223340802
-
Berenson JR, Lichtenstein A, Porter L, et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 1996;334(8):488-493 (Pubitemid 26067736)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.8
, pp. 488-493
-
-
Berenson, J.R.1
Lichtenstein, A.2
Porter, L.3
Dimopoulos, M.A.4
Bordoni, R.5
George, S.6
Lipton, A.7
Keller, A.8
Ballester, O.9
Kovacs, M.J.10
Blacklock, H.A.11
Bell, R.12
Simeone, J.13
Reitsma, D.J.14
Heffernan, M.15
Seaman, J.16
Knight, R.D.17
-
75
-
-
34347260332
-
American Society of Clinical Oncology 2007 Clinical Practice Guideline Update on the Role of Bisphosphonates in Multiple Myeloma
-
Kyle RA, Yee GC, Somerfield MR, et al. American Society of Clinical Oncology 2007 Clinical Practice Guideline Update on the Role of Bisphosphonates in Multiple Myeloma. J Clin Oncol 2007;25(17):1-9
-
(2007)
J Clin Oncol
, vol.25
, Issue.17
, pp. 1-9
-
-
Kyle, R.A.1
Yee, G.C.2
Somerfield, M.R.3
-
76
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
DOI 10.1016/j.ccr.2005.10.013, PII S153561080500334X
-
Chauhan D, Catley L, Li G, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 2005;8(5):407-419 (Pubitemid 41579835)
-
(2005)
Cancer Cell
, vol.8
, Issue.5
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
Ovaa, H.11
Berkers, C.12
Nicholson, B.13
Chao, T.-H.14
Neuteboom, S.T.C.15
Richardson, P.16
Palladino, M.A.17
Anderson, K.C.18
-
77
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
DOI 10.1182/blood-2007-01-065888
-
Kuhn DJ, Chen Q, Voorhees PM, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007;110(9):3281-3290 (Pubitemid 350106321)
-
(2007)
Blood
, vol.110
, Issue.9
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
Strader, J.S.4
Shenk, K.D.5
Sun, C.M.6
Demo, S.D.7
Bennett, M.K.8
Van Leeuwen, F.W.B.9
Chanan-Khan, A.A.10
Orlowski, R.Z.11
-
78
-
-
34247859271
-
Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma
-
DOI 10.1586/14737140.7.4.551
-
Podar K, Richardson PG, Chauhan D, Anderson KC. Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma. Expert Rev Anticancer Ther 2007;7(4):551-566 (Pubitemid 46690962)
-
(2007)
Expert Review of Anticancer Therapy
, vol.7
, Issue.4
, pp. 551-566
-
-
Podar, K.1
Richardson, P.G.2
Chauhan, D.3
Anderson, K.C.4
-
79
-
-
67649579824
-
-
Available from
-
Available from: http://clinicaltrials.gov/
-
-
-
-
80
-
-
67649588244
-
-
Available from
-
Available from: http://www.multiplemyeloma.org/
-
-
-
-
81
-
-
67649618662
-
-
Availbale from
-
Availbale from: http://myeloma.org/
-
-
-
-
82
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4(6):423-436 (Pubitemid 38745528)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.6
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
83
-
-
34547106018
-
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
-
Hideshima T, Mitsiades C, Tonon G, et al. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007;7(8):585-598
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.8
, pp. 585-598
-
-
Hideshima, T.1
Mitsiades, C.2
Tonon, G.3
-
84
-
-
33745779502
-
The molecular classification of multiple myeloma
-
DOI 10.1182/blood-2005-11-013458
-
Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood 2006;108(6):2020-2028 (Pubitemid 44395016)
-
(2006)
Blood
, vol.108
, Issue.6
, pp. 2020-2028
-
-
Zhan, F.1
Huang, Y.2
Colla, S.3
Stewart, J.P.4
Hanamura, I.5
Gupta, S.6
Epstein, J.7
Yaccoby, S.8
Sawyer, J.9
Burington, B.10
Anaissie, E.11
Hollmig, K.12
Pineda-Roman, M.13
Tricot, G.14
Van Rhee, F.15
Walker, R.16
Zangari, M.17
Crowley, J.18
Barlogie, B.19
Shaughnessy Jr., J.D.20
more..
-
85
-
-
33947217497
-
Avalidated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
-
DOI 10.1182/blood-2006-07-038430
-
Shaughnessy JD Jr, Zhan F, Burington BE, et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood 2007;109(6):2276-2284 (Pubitemid 46425864)
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2276-2284
-
-
Shaughnessy Jr., J.D.1
Zhan, F.2
Burington, B.E.3
Huang, Y.4
Colla, S.5
Hanamura, I.6
Stewart, J.P.7
Kordsmeier, B.8
Randolph, C.9
Williams, D.R.10
Xiao, Y.11
Xu, H.12
Epstein, J.13
Anaissie, E.14
Krishna, S.G.15
Cottler-Fox, M.16
Hollmig, K.17
Mohiuddin, A.18
Pineda-Roman, M.19
Tricot, G.20
Van Rhee, F.21
Sawyer, J.22
Alsayed, Y.23
Walker, R.24
Zangari, M.25
Crowley, J.26
Barlogie, B.27
more..
-
86
-
-
27244445489
-
Molecular pathogenesis and a consequent classification of multiple myeloma
-
DOI 10.1200/JCO.2005.05.021
-
Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005;23(26):6333-6338 (Pubitemid 46218843)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.26
, pp. 6333-6338
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
-
87
-
-
3242777803
-
Advances in biology of multiple myeloma: Clinical applications
-
DOI 10.1182/blood-2004-01-0037
-
Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood 2004;104(3):607-618 (Pubitemid 38970551)
-
(2004)
Blood
, vol.104
, Issue.3
, pp. 607-618
-
-
Hideshima, T.1
Bergsagel, P.L.2
Kuehl, W.M.3
Anderson, K.C.4
-
88
-
-
1942456800
-
Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
-
DOI 10.1182/blood-2003-10-3650
-
Trudel S, Ely S, Farooqi Y, et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 2004;103(9):3521-3528 (Pubitemid 38525687)
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3521-3528
-
-
Trudel, S.1
Ely, S.2
Farooqi, Y.3
Affer, M.4
Robbiani, D.F.5
Chesi, M.6
Bergsagel, P.L.7
-
89
-
-
15944378835
-
CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
-
DOI 10.1182/blood-2004-10-3913
-
Trudel S, Li ZH, Wei E, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005;105(7):2941-2948 (Pubitemid 40446289)
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2941-2948
-
-
Trudel, S.1
Li, Z.H.2
Wei, E.3
Wiesmann, M.4
Chang, H.5
Chen, C.6
Reece, D.7
Heise, C.8
Stewart, A.K.9
-
90
-
-
33646555792
-
The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells
-
DOI 10.1182/blood-2005-10-4179
-
Trudel S, Stewart AK, Rom E, et al. The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells. Blood 2006;107(10):4039-4046 (Pubitemid 43726812)
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 4039-4046
-
-
Trudel, S.1
Stewart, A.K.2
Rom, E.3
Wei, E.4
Zhi, H.L.5
Kotzer, S.6
Chumakov, I.7
Singer, Y.8
Chang, H.9
Liang, S.-B.10
Yayon, A.11
-
91
-
-
0032212243
-
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
-
Chesi M, Nardini E, Lim RS, et al. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 1998;92(9):3025-3034 (Pubitemid 28492306)
-
(1998)
Blood
, vol.92
, Issue.9
, pp. 3025-3034
-
-
Chesi, M.1
Nardini, E.2
Lim, R.S.C.3
Smith, K.D.4
Michael Kuehl, W.5
Bergsagel, P.L.6
-
92
-
-
1442285889
-
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
-
DOI 10.1016/S1535-6108(04)00019-4, PII S1535610804000194
-
Hurt EM, Wiestner A, Rosenwald A, et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 2004;5(2):191-199 (Pubitemid 38283804)
-
(2004)
Cancer Cell
, vol.5
, Issue.2
, pp. 191-199
-
-
Hurt, E.M.1
Wiestner, A.2
Rosenwald, A.3
Shaffer, A.L.4
Campo, E.5
Grogan, T.6
Bergsagel, P.L.7
Kuehl, W.M.8
Staudt, L.M.9
-
93
-
-
0035892119
-
Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
-
Avet-Loiseau H, Gerson F, Magrangeas F, et al. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood 2001;98(10):3082-3086
-
(2001)
Blood
, vol.98
, Issue.10
, pp. 3082-3086
-
-
Avet-Loiseau, H.1
Gerson, F.2
Magrangeas, F.3
-
94
-
-
0034602691
-
Diverse karyotypic abnormalities of the c-myc locus associated with c- Myc dysregulation and tumor progression in multiple myeloma
-
DOI 10.1073/pnas.97.1.228
-
Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci USA 2000;97(1):228-233 (Pubitemid 30055813)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.1
, pp. 228-233
-
-
Shou, Y.1
Martelli, M.L.2
Gabrea, A.3
Qi, Y.4
Brents, L.A.5
Roschke, A.6
Dewald, G.7
Kirsch, I.R.8
Bergsagel, P.L.9
Kuehl, W.M.10
-
95
-
-
0037589018
-
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
-
DOI 10.1182/blood-2002-11-3514
-
Mitsiades N, Mitsiades CS, Richardson PG, et al. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood 2003;101(10):4055-4062 (Pubitemid 36857886)
-
(2003)
Blood
, vol.101
, Issue.10
, pp. 4055-4062
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
McMullan, C.4
Poulaki, V.5
Fanourakis, G.6
Schlossman, R.7
Chauhan, D.8
Munshi, N.C.9
Hideshima, T.10
Richon, V.M.11
Marks, P.A.12
Anderson, K.C.13
-
96
-
-
0141593496
-
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
-
DOI 10.1182/blood-2003-01-0233
-
Catley L, Weisberg E, Tai YT, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood 2003;102(7):2615-2622 (Pubitemid 37193603)
-
(2003)
Blood
, vol.102
, Issue.7
, pp. 2615-2622
-
-
Catley, L.1
Weisberg, E.2
Tai, Y.-T.3
Atadja, P.4
Remiszewski, S.5
Hideshima, T.6
Mitsiades, N.7
Shringarpure, R.8
Leblanc, R.9
Chauhan, D.10
Munshi, N.C.11
Schlossman, R.12
Richardson, P.13
Griffin, J.14
Anderson, K.C.15
-
97
-
-
33751172982
-
Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
-
DOI 10.1182/blood-2006-04-016055
-
Catley L, Weisberg E, Kiziltepe T, et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006;108(10):3441-3449 (Pubitemid 44776885)
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3441-3449
-
-
Catley, L.1
Weisberg, E.2
Kiziltepe, T.3
Tai, Y.-T.4
Hideshima, T.5
Neri, P.6
Tassone, P.7
Atadja, P.8
Chauhan, D.9
Munshi, N.C.10
Anderson, K.C.11
-
98
-
-
33745258655
-
The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance
-
DOI 10.1158/0008-5472.CAN-05-4186
-
Maiso P, Carvajal-Vergara X, Ocio EM, et al. The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res 2006;66(11):5781-5789 (Pubitemid 43927132)
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5781-5789
-
-
Maiso, P.1
Carvajal-Vergara, X.2
Ocio, E.M.3
Lopez-Perez, R.4
Mateo, G.5
Gutierrez, N.6
Atadja, P.7
Pandiella, A.8
San Miguel, J.F.9
-
99
-
-
34848873093
-
The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage
-
DOI 10.1111/j.1365-2141.2007.06772.x
-
Feng R, Oton A, Mapara MY, et al. The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage. Br J Haematol 2007;139(3):385-397 (Pubitemid 47512171)
-
(2007)
British Journal of Haematology
, vol.139
, Issue.3
, pp. 385-397
-
-
Feng, R.1
Oton, A.2
Mapara, M.Y.3
Anderson, G.4
Belani, C.5
Lentzsch, S.6
-
100
-
-
34347375499
-
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
-
DOI 10.1182/blood-2006-03-013128
-
Miller CP, Ban K, Dujka ME, et al. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 2007;110(1):267-277 (Pubitemid 47026844)
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 267-277
-
-
Miller, C.P.1
Ban, K.2
Dujka, M.E.3
McConkey, D.J.4
Munsell, M.5
Palladino, M.6
Chandra, J.7
-
101
-
-
2042505684
-
Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma
-
DOI 10.1111/j.1365-2141.2004.04882.x
-
Khan SB, Maududi T, Barton K, et al. Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma. Br J Haematol 2004;125(2):156-161 (Pubitemid 38534966)
-
(2004)
British Journal of Haematology
, vol.125
, Issue.2
, pp. 156-161
-
-
Khan, S.B.1
Maududi, T.2
Barton, K.3
Ayers, J.4
Alkan, S.5
-
102
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
DOI 10.1073/pnas.0503221102
-
Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci USA 2005;102(24):8567-8572 (Pubitemid 40862776)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.24
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
Chauhan, D.4
Richardson, P.5
Schreiber, S.L.6
Anderson, K.C.7
-
103
-
-
18144407693
-
Targeting signalling pathways for the treatment of multiple myeloma
-
DOI 10.1517/14728222.9.2.359
-
Podar K, Hideshima T, Chauhan D, Anderson KC. Targeting signalling pathways for the treatment of multiple myeloma. Expert Opin Ther Targets 2005;9(2):359-381 (Pubitemid 40613874)
-
(2005)
Expert Opinion on Therapeutic Targets
, vol.9
, Issue.2
, pp. 359-381
-
-
Podar, K.1
Hideshima, T.2
Chauhan, D.3
Anderson, K.C.4
-
104
-
-
0343355828
-
High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
-
Avet-Loiseau H, Li JY, Facon T, et al. High incidence of translocations t(11;14) (q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies. Cancer Res 1998;58(24):5640-5645 (Pubitemid 29006396)
-
(1998)
Cancer Research
, vol.58
, Issue.24
, pp. 5640-5645
-
-
Avet-Loiseau, H.1
Li, J.-Y.2
Facon, T.3
Brigaudeau, C.4
Morineau, N.5
Maloisel, F.6
Rapp, M.-J.7
Talmant, P.8
Trimoreau, F.9
Jaccard, A.10
Harousseau, J.-L.11
Bataille, R.12
-
105
-
-
0030922231
-
Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
-
DOI 10.1038/ng0797-260
-
Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14) (p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997;16(3):260-264 (Pubitemid 27280209)
-
(1997)
Nature Genetics
, vol.16
, Issue.3
, pp. 260-264
-
-
Chesi, M.1
Nardini, E.2
Brents, L.A.3
Schrock, E.4
Ried, T.5
Kuehl, W.M.6
Bergsagel, P.L.7
-
106
-
-
1542283717
-
Characterization of clonogenic multiple myeloma cells
-
DOI 10.1182/blood-2003-09-3064
-
Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells. Blood 2004;103(6):2332-2336 (Pubitemid 38326254)
-
(2004)
Blood
, vol.103
, Issue.6
, pp. 2332-2336
-
-
Matsui, W.1
Huff, C.A.2
Wang, Q.3
Malehorn, M.T.4
Barber, J.5
Tanhehco, Y.6
Smith, B.D.7
Civin, C.I.8
Jones, R.J.9
-
107
-
-
34247192972
-
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
-
DOI 10.1073/pnas.0611682104
-
Peacock CD, Wang Q, Gesell GS, et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA 2007;104(10):4048-4053 (Pubitemid 47181576)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.10
, pp. 4048-4053
-
-
Peacock, C.D.1
Wang, Q.2
Gesell, G.S.3
Corcoran-Schwartz, I.M.4
Jones, E.5
Kim, J.6
Devereux, W.L.7
Rhodes, J.T.8
Huff, C.A.9
Beachy, P.A.10
Watkins, D.N.11
Matsui, W.12
-
108
-
-
38549132452
-
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance
-
Matsui W, Wang Q, Barber JP, et al. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res 2008;68(1):190-197
-
(2008)
Cancer Res
, vol.68
, Issue.1
, pp. 190-197
-
-
Matsui, W.1
Wang, Q.2
Barber, J.P.3
-
109
-
-
22144476861
-
Cytokines and signal transduction
-
DOI 10.1016/j.beha.2005.01.003, PII S1521692605000046
-
Hideshima T, Podar K, Chauhan D, Anderson KC. Cytokines and signal transduction. Best pract Res 2005;18(4):509-524 (Pubitemid 40984111)
-
(2005)
Best Practice and Research: Clinical Haematology
, vol.18
, Issue.4 SPEC. ISS
, pp. 509-524
-
-
Hideshima, T.1
Podar, K.2
Chauhan, D.3
Anderson, K.C.4
-
110
-
-
0024811225
-
Ras oncogene mutation in multiple myeloma
-
Neri A, Murphy JP, Cro L, et al. Ras oncogene mutation in multiple myeloma. J Exp Med 1989;170(5):1715-1725 (Pubitemid 19284568)
-
(1989)
Journal of Experimental Medicine
, vol.170
, Issue.5
, pp. 1715-1725
-
-
Neri, A.1
Murphy, J.P.2
Cro, L.3
Ferrero, D.4
Tarella, C.5
Baldini, L.6
Dalla-Favera, R.7
-
111
-
-
0029819604
-
Activating mutations of N- And K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group phase III trial
-
Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood 1996;88(7):2699-2706 (Pubitemid 26327523)
-
(1996)
Blood
, vol.88
, Issue.7
, pp. 2699-2706
-
-
Liu, P.1
Leong, T.2
Quam, L.3
Billadeau, D.4
Kay, N.E.5
Greipp, P.6
Kyle, R.A.7
Oken, M.M.8
Van Ness, B.9
-
112
-
-
43749090639
-
Genetic aberrations and survival in plasma cell leukemia
-
DOI 10.1038/leu.2008.4, PII LEU20084
-
Tiedemann RE, Gonzalez-Paz N, Kyle RA, et al. Genetic aberrations and survival in plasma cell leukemia. Leukemia 2008;22(5):1044-1052 (Pubitemid 351689887)
-
(2008)
Leukemia
, vol.22
, Issue.5
, pp. 1044-1052
-
-
Tiedemann, R.E.1
Gonzalez-Paz, N.2
Kyle, R.A.3
Santana-Davila, R.4
Price-Troska, T.5
Van Wier, S.A.6
Chng, W.J.7
Ketterling, R.P.8
Gertz, M.A.9
Henderson, K.10
Greipp, P.R.11
Dispenzieri, A.12
Lacy, M.Q.13
Rajkumar, S.V.14
Bergsagel, P.L.15
Stewart, A.K.16
Fonseca, R.17
-
113
-
-
33644826253
-
RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies
-
Martin P, Santon A, Garcia-Cosio M, Bellas C. RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies. Int J Oncol 2005;27(4):1023-1028
-
(2005)
Int J Oncol
, vol.27
, Issue.4
, pp. 1023-1028
-
-
Martin, P.1
Santon, A.2
Garcia-Cosio, M.3
Bellas, C.4
-
114
-
-
0026747866
-
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
-
Kato K, Cox AD, Hisaka MM, et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 1992;89(14):6403-6407
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.14
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
-
115
-
-
0037328558
-
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
-
DOI 10.1038/sj.leu.2402832
-
Bolick SC, Landowski TH, Boulware D, et al. The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells. Leukemia 2003;17(2):451-457 (Pubitemid 36266924)
-
(2003)
Leukemia
, vol.17
, Issue.2
, pp. 451-457
-
-
Bolick, S.C.E.1
Landowski, T.H.2
Boulware, D.3
Oshiro, M.M.4
Ohkanda, J.5
Hamilton, A.D.6
Sebti, S.M.7
Dalton, W.S.8
-
116
-
-
0142078327
-
Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro
-
DOI 10.1182/blood-2003-03-0851
-
Ochiai N, Uchida R, Fuchida S, et al. Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro. Blood 2003;102(9):3349-3353 (Pubitemid 37314777)
-
(2003)
Blood
, vol.102
, Issue.9
, pp. 3349-3353
-
-
Ochiai, N.1
Uchida, R.2
Fuchida, S.-I.3
Okano, A.4
Okamoto, M.5
Ashihara, E.6
Inaba, T.7
Fujita, N.8
Matsubara, H.9
Shimazaki, C.10
-
117
-
-
4444314787
-
R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways
-
Beaupre DM, Cepero E, Obeng EA, et al. R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways. Mol Cancer Ther 2004;3(2):179-186 (Pubitemid 39193692)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.2
, pp. 179-186
-
-
Beaupre, D.M.1
Cepero, E.2
Obeng, E.A.3
Boise, L.H.4
Lichtenheld, M.G.5
-
118
-
-
0037372488
-
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
-
DOI 10.1182/blood-2002-07-1973
-
Cortes J, Albitar M, Thomas D, et al. Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood 2003;101(5):1692-1697 (Pubitemid 36237561)
-
(2003)
Blood
, vol.101
, Issue.5
, pp. 1692-1697
-
-
Cortes, J.1
Albitar, M.2
Thomas, D.3
Giles, F.4
Kurzrock, R.5
Thibault, A.6
Rackoff, W.7
Koller, C.8
O'Brien, S.9
Garcia-Manero, G.10
Talpaz, M.11
Kantarjian, H.12
-
119
-
-
34548844157
-
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis
-
DOI 10.1182/blood-2007-03-081240
-
Tai YT, Fulciniti M, Hideshima T, et al. Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis. Blood 2007;110(5):1656-1663 (Pubitemid 47443984)
-
(2007)
Blood
, vol.110
, Issue.5
, pp. 1656-1663
-
-
Tai, Y.-T.1
Fulciniti, M.2
Hideshima, T.3
Song, W.4
Leiba, M.5
Li, X.-F.6
Rumizen, M.7
Burger, P.8
Morrison, A.9
Podar, K.10
Chauhan, D.11
Tassone, P.12
Richardson, P.13
Munshi, N.C.14
Ghobrial, I.M.15
Anderson, K.C.16
-
120
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
DOI 10.1016/0092-8674(89)90438-8
-
Taga T, Hibi M, Hirata Y, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989;58(3):573-581 (Pubitemid 19203542)
-
(1989)
Cell
, vol.58
, Issue.3
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
Hirano, T.7
Kishimoto, T.8
-
121
-
-
0028344845
-
Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, GP130
-
Nishimoto N, Ogata A, Shima Y, et al. Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. J Exp Med 1994;179(4):1343-1347 (Pubitemid 24091793)
-
(1994)
Journal of Experimental Medicine
, vol.179
, Issue.4
, pp. 1343-1347
-
-
Nishimoto, N.1
Ogata, A.2
Shima, Y.3
Tani, Y.4
Ogawa, H.5
Nakagawa, M.6
Sugiyama, H.7
Yoshizaki, K.8
Kishimoto, T.9
-
122
-
-
0029052318
-
Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association
-
Matsuda T, Fukada T, Takahashi-Tezuka M, et al. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association. J Biol Chem 1995;270(19):11037-11039
-
(1995)
J Biol Chem
, vol.270
, Issue.19
, pp. 11037-11039
-
-
Matsuda, T.1
Fukada, T.2
Takahashi-Tezuka, M.3
-
123
-
-
0033083941
-
Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes
-
Kurth I, Horsten U, Pflanz S, et al. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. J Immunol 1999;162(3):1480-1487 (Pubitemid 29307020)
-
(1999)
Journal of Immunology
, vol.162
, Issue.3
, pp. 1480-1487
-
-
Kurth, I.1
Horsten, U.2
Pflanz, S.3
Dahmen, H.4
Kuster, A.5
Grotzinger, J.6
Heinrich, P.C.7
Muller-Newen, G.8
-
124
-
-
0028349735
-
Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264(5155):95-98 (Pubitemid 24144493)
-
(1994)
Science
, vol.264
, Issue.5155
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell Jr., J.E.3
-
125
-
-
0023849455
-
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
-
DOI 10.1038/332083a0
-
Kawano M, Hirano T, Matsuda T, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988;332(6159):83-85 (Pubitemid 18083553)
-
(1988)
Nature
, vol.332
, Issue.6159
, pp. 83-84
-
-
Kawano, M.1
Hirano, T.2
Matsuda, T.3
Taga, T.4
Horii, Y.5
Iwato, K.6
Asaoku, H.7
Tang, B.8
Tanabe, O.9
Tanaka, H.10
Kuramoto, A.11
Kishimoto, T.12
-
126
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
-
Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 1996;87(3):1104-1112 (Pubitemid 26043538)
-
(1996)
Blood
, vol.87
, Issue.3
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
Urashima, M.4
Yamamoto, K.-I.5
Libermann, T.A.6
Anderson, K.C.7
-
127
-
-
0027133422
-
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
-
Uchiyama H, Barut BA, Mohrbacher AF, et al. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 1993;82(12):3712-3720 (Pubitemid 24006055)
-
(1993)
Blood
, vol.82
, Issue.12
, pp. 3712-3720
-
-
Uchiyama, H.1
Barut, B.A.2
Mohrbacher, A.F.3
Chauhan, D.4
Anderson, K.C.5
-
128
-
-
0032428364
-
Interleukin-1 in multiple myeloma: Producer cells and their role in the control of IL-6 production
-
DOI 10.1046/j.1365-2141.1998.01101.x
-
Costes V, Portier M, Lu ZY, et al. Interleukin-1 in multiple myeloma: producer cells and their role in the control of IL-6 production. Br J Haematol 1998;103(4):1152-1160 (Pubitemid 29012658)
-
(1998)
British Journal of Haematology
, vol.103
, Issue.4
, pp. 1152-1160
-
-
Costes, V.1
Portier, M.2
Lu, Z.-Y.3
Rossi, J.-F.4
Bataille, R.5
Klein, B.6
-
129
-
-
0034655957
-
Vascular endothelial growth factor and interleukin-6 in paracrine tumor- Stromal cell interactions in multiple myeloma
-
Dankbar B, Padro T, Leo R, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 2000;95(8):2630-2636 (Pubitemid 30210543)
-
(2000)
Blood
, vol.95
, Issue.8
, pp. 2630-2636
-
-
Dankbar, B.1
Padro, T.2
Leo, R.3
Feldmann, B.4
Kropff, M.5
Mesters, R.M.6
Serve, H.7
Berdel, W.E.8
Kienast, J.9
-
130
-
-
0035195019
-
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
-
Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 2001;15(12):1950-1961 (Pubitemid 33115003)
-
(2001)
Leukemia
, vol.15
, Issue.12
, pp. 1950-1961
-
-
Gupta, D.1
Treon, S.P.2
Shima, Y.3
Hideshima, T.4
Podar, K.5
Tai, Y.T.6
Lin, B.7
-
131
-
-
0035958517
-
The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: Therapeutic applications
-
DOI 10.1038/sj.onc.1204623
-
Hideshima T, Chauhan D, Schlossman R, et al. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001;20(33):4519-4527 (Pubitemid 32772434)
-
(2001)
Oncogene
, vol.20
, Issue.33
, pp. 4519-4527
-
-
Hideshima, T.1
Chauhan, D.2
Schlossman, R.3
Richardson, P.4
Anderson, K.C.5
-
132
-
-
21144440687
-
Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo
-
DOI 10.1182/blood-2004-09-3794
-
Hamasaki M, Hideshima T, Tassone P, et al. Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. Blood 2005;105(11):4470-4476 (Pubitemid 40720796)
-
(2005)
Blood
, vol.105
, Issue.11
, pp. 4470-4476
-
-
Hamasaki, M.1
Hideshima, T.2
Tassone, P.3
Neri, P.4
Ishitsuka, K.5
Yasui, H.6
Shiraishi, N.7
Raje, N.8
Kumar, S.9
Picker, D.H.10
Jacob, G.S.11
Richardson, P.G.12
Munshi, N.C.13
Anderson, K.C.14
-
133
-
-
33750298971
-
Pyridone 6, a Pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
-
DOI 10.1158/0008-5472.CAN-05-4280
-
Pedranzini L, Dechow T, Berishaj M, et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 2006;66(19):9714-9721 (Pubitemid 44623672)
-
(2006)
Cancer Research
, vol.66
, Issue.19
, pp. 9714-9721
-
-
Pedranzini, L.1
Dechow, T.2
Berishaj, M.3
Comenzo, R.4
Zhou, P.5
Azare, J.6
Bornmann, W.7
Bromberg, J.8
-
134
-
-
34548693457
-
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
-
DOI 10.1158/1541-7786.MCR-06-0348
-
Pathak AK, Bhutani M, Nair AS, et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 2007;5(9):943-955 (Pubitemid 47416671)
-
(2007)
Molecular Cancer Research
, vol.5
, Issue.9
, pp. 943-955
-
-
Pathak, A.K.1
Bhutani, M.2
Nair, A.S.3
Kwang, S.A.4
Chakraborty, A.5
Kadara, H.6
Guha, S.7
Sethi, G.8
Aggarwal, B.B.9
-
135
-
-
34249792353
-
Capsaicin is a novel blocker of constitutive and interleukin-6 - Inducible STAT3 activation
-
DOI 10.1158/1078-0432.CCR-06-2575
-
Bhutani M, Pathak AK, Nair AS, et al. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res 2007;13(10):3024-3032 (Pubitemid 46849579)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.10
, pp. 3024-3032
-
-
Bhutani, M.1
Pathak, A.K.2
Nair, A.S.3
Kunnumakkara, A.B.4
Guha, S.5
Sethi, G.6
Aggarwal, B.B.7
-
136
-
-
49249128130
-
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1
-
Ahn KS, Sethi G, Sung B, et al. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res 2008;68(11):4406-4415
-
(2008)
Cancer Res
, vol.68
, Issue.11
, pp. 4406-4415
-
-
Ahn, K.S.1
Sethi, G.2
Sung, B.3
-
137
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
DOI 10.1126/science.296.5573.1655
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296(5573):1655-1657 (Pubitemid 34579158)
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
138
-
-
0034634443
-
Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms
-
DOI 10.1016/S0014-5793(00)02162-1, PII S0014579300021621
-
Balendran A, Hare GR, Kieloch A, et al. Further evidence that 3-phosphoinositide-dependent protein kinase-1(PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett 2000;484(3):217-223 (Pubitemid 30811101)
-
(2000)
FEBS Letters
, vol.484
, Issue.3
, pp. 217-223
-
-
Balendran, A.1
Hare, G.R.2
Kieloch, A.3
Williams, M.R.4
Alessi, D.R.5
-
139
-
-
0034176579
-
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
-
DOI 10.1016/S0960-9822(00)00441-3
-
Williams MR, Arthur JS, Balendran A, et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 2000;10(8):439-448 (Pubitemid 30247331)
-
(2000)
Current Biology
, vol.10
, Issue.8
, pp. 439-448
-
-
Williams, M.R.1
Arthur, J.S.C.2
Balendran, A.3
Van Der Kaay, J.4
Poli, V.5
Cohen, P.6
Alessi, D.R.7
-
140
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
DOI 10.1073/pnas.96.8.4240
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999;96(8):4240-4245 (Pubitemid 29190320)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
141
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
DOI 10.1038/nrc952
-
Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2002;2(12):927-937 (Pubitemid 37328894)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.12
, pp. 927-937
-
-
Hideshima, T.1
Anderson, K.C.2
-
142
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96(6):857-868 (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
143
-
-
0033961280
-
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
-
DOI 10.1128/MCB.20.5.1626-1638.2000
-
Madrid LV, Wang CY, Guttridge DC, et al. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000;20(5):1626-1638 (Pubitemid 30100182)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.5
, pp. 1626-1638
-
-
Madrid, L.V.1
Wang, C.-Y.2
Guttridge, D.C.3
Schottelius, A.J.G.4
Baldwin Jr., A.S.5
Mayo, M.W.6
-
144
-
-
0035379555
-
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38
-
DOI 10.1074/jbc.M101103200
-
Madrid LV, Mayo MW, Reuther JY, et al. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001;276(22):18934-18940 (Pubitemid 37411214)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.22
, pp. 18934-18940
-
-
Madrid, L.V.1
Mayo, M.W.2
Reuther, J.Y.3
Baldwin Jr., A.S.4
-
145
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111(3):293-303
-
(2002)
Cell
, vol.111
, Issue.3
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
146
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2(7):489-501 (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
147
-
-
0037207872
-
Nuclear factor-κB p65 mediates tumor necrosis factor α-induced nuclear translocation of telomerase reverse transcriptase protein
-
Akiyama M, Hideshima T, Hayashi T, et al. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res 2003;63(1):18-21 (Pubitemid 36070412)
-
(2003)
Cancer Research
, vol.63
, Issue.1
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
Tai, Y.-T.4
Mitsiades, C.S.5
Mitsiades, N.6
Chauhan, D.7
Richardson, P.8
Munshi, N.C.9
Anderson, K.C.10
-
148
-
-
0032711250
-
IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
-
Puthier D, Bataille R, Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol 1999;29(12):3945-3950
-
(1999)
Eur J Immunol
, vol.29
, Issue.12
, pp. 3945-3950
-
-
Puthier, D.1
Bataille, R.2
Amiot, M.3
-
149
-
-
0035921689
-
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
-
DOI 10.1038/sj.onc.1204833
-
Hideshima T, Nakamura N, Chauhan D, Anderson KC. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 2001;20(42):5991-6000 (Pubitemid 32955041)
-
(2001)
Oncogene
, vol.20
, Issue.42
, pp. 5991-6000
-
-
Hideshima, T.1
Nakamura, N.2
Chauhan, D.3
Anderson, K.C.4
-
150
-
-
33846887460
-
Perifosine, an oral bioactive novel alkyl-phospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma (MM) cells
-
abstract #250
-
Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkyl-phospholipid, inhibits Akt and induces in vitro and In vivo cytotoxicity in human multiple myeloma (MM) cells [abstract #250]. Blood 2005;106(11):128
-
(2005)
Blood
, vol.106
, Issue.11
, pp. 128
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
-
151
-
-
34548181762
-
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
-
DOI 10.1111/j.1365-2141.2007.06714.x
-
Hideshima T, Catley L, Raje N, et al. Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol 2007;138(6):783-791 (Pubitemid 47313207)
-
(2007)
British Journal of Haematology
, vol.138
, Issue.6
, pp. 783-791
-
-
Hideshima, T.1
Catley, L.2
Raje, N.3
Chauhan, D.4
Podar, K.5
Mitsiades, C.6
Tai, Y.-T.7
Vallet, S.8
Kiziltepe, T.9
Ocio, E.10
Ikeda, H.11
Okawa, Y.12
Hideshima, H.13
Munshi, N.C.14
Yasui, H.15
Richardson, P.G.16
Anderson, K.C.17
-
152
-
-
38949121666
-
Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment
-
DOI 10.1158/1078-0432.CCR-07-1299
-
Huston A, Leleu X, Jia X, et al. Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment. Clin Cancer Res 2008;14(3):865-874 (Pubitemid 351231171)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 865-874
-
-
Huston, A.1
Leleu, X.2
Jia, X.3
Moreau, A.-S.4
Ngo, H.T.5
Runnels, J.6
Anderson, J.7
Alsayed, Y.8
Roccaro, A.9
Vallet, S.10
Hatjiharissi, E.11
Tai, Y.-T.12
Sportelli, P.13
Munshi, N.14
Richardson, P.15
Hideshima, T.16
Roodman, D.G.17
Anderson, K.C.18
Ghobrial, I.M.19
-
153
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L, et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 2002;62(17):5027-5034 (Pubitemid 34984430)
-
(2002)
Cancer Research
, vol.62
, Issue.17
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
Hsu, J.-H.4
Bookstein, R.5
Li, W.6
Lichtenstein, A.7
-
154
-
-
10244229652
-
In vivo anti-tumor effects of the mTOR inhibitor, CCI-779, against human multiple myeloma cells in a xenograft model
-
Frost P, Moatomed F, Hoang B, et al. In vivo anti-tumor effects of the mTOR inhibitor, CCI-779, against human multiple myeloma cells in a xenograft model. Blood 2004
-
(2004)
Blood
-
-
Frost, P.1
Moatomed, F.2
Hoang, B.3
-
155
-
-
10244260355
-
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma
-
DOI 10.1182/blood-2004-06-2281
-
Raje N, Kumar S, Hideshima T, et al. Combination of the mTOR inhibitor Rapamycin and RevlimidTM(CC-5013) has synergistic activity in multiple myeloma. Blood 2004 (Pubitemid 39620173)
-
(2004)
Blood
, vol.104
, Issue.13
, pp. 4188-4193
-
-
Raje, N.1
Kumar, S.2
Hideshima, T.3
Ishitsuka, K.4
Chauhan, D.5
Mitsiades, C.6
Podar, K.7
Le Gouill, S.8
Richardson, P.9
Munshi, N.C.10
Stirling, D.I.11
Antin, J.H.12
Anderson, K.C.13
-
156
-
-
33845348883
-
Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma
-
DOI 10.1158/1078-0432.CCR-06-1331
-
Francis LK, Alsayed Y, Leleu X, et al. Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17- demethoxygeldanamycin has synergistic activity in multiple myeloma. Clin Cancer Res 2006;12(22):6826-6835 (Pubitemid 44876853)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.22
, pp. 6826-6835
-
-
Francis, L.K.1
Alsayed, Y.2
Leleu, X.3
Jia, X.4
Singha, U.K.5
Anderson, J.6
Timm, M.7
Ngo, H.8
Lu, G.9
Huston, A.10
Ehrlich, L.A.11
Dimmock, E.12
Lentzsch, S.13
Hideshima, T.14
Roodman, G.D.15
Anderson, K.C.16
Ghobrial, I.M.17
-
157
-
-
33846914141
-
Targeting PKC in multiple myeloma: In vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
-
DOI 10.1182/blood-2006-08-042747
-
Podar K, Raab MS, Zhang J, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood 2007;109(4):1669-1677 (Pubitemid 46239601)
-
(2007)
Blood
, vol.109
, Issue.4
, pp. 1669-1677
-
-
Podar, K.1
Raab, M.S.2
Zhang, J.3
McMillin, D.4
Breitkreutz, I.5
Tai, Y.-T.6
Lin, B.K.7
Munshi, N.8
Hideshima, T.9
Chauhan, D.10
Anderson, K.C.11
-
158
-
-
35248870218
-
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
-
DOI 10.1517/13543784.16.10.1693
-
Podar K, Raab MS, Chauhan D, Anderson KC. The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. Expert Opin Investig Drugs 2007;16(10):1693-1707 (Pubitemid 350030716)
-
(2007)
Expert Opinion on Investigational Drugs
, vol.16
, Issue.10
, pp. 1693-1707
-
-
Podar, K.1
Raab, M.S.2
Chauhan, D.3
Anderson, K.C.4
-
159
-
-
25844459154
-
NF-κB: Linking inflammation and immunity to cancer development and progression
-
DOI 10.1038/nri1703
-
Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature reviews 2005;5(10):749-759 (Pubitemid 41400849)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.10
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
160
-
-
34547562418
-
Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
-
DOI 10.1016/j.ccr.2007.07.004, PII S1535610807002036
-
Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007;12(2):115-130 (Pubitemid 47199123)
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
Dave, S.11
Hurt, E.M.12
Tan, B.13
Zhao, H.14
Stephens, O.15
Santra, M.16
Williams, D.R.17
Dang, L.18
Barlogie, B.19
Shaughnessy Jr., J.D.20
Kuehl, W.M.21
Staudt, L.M.22
more..
-
161
-
-
34547660308
-
Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma
-
DOI 10.1016/j.ccr.2007.07.003, PII S1535610807002024
-
Keats JJ, Fonseca R, Chesi M, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007;12(2):131-144 (Pubitemid 47208626)
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.-J.6
Van Wier, S.7
Tiedemann, R.8
Shi, C.-X.9
Sebag, M.10
Braggio, E.11
Henry, T.12
Zhu, Y.-X.13
Fogle, H.14
Price-Troska, T.15
Ahmann, G.16
Mancini, C.17
Brents, L.A.18
Kumar, S.19
Greipp, P.20
Dispenzieri, A.21
Bryant, B.22
Mulligan, G.23
Bruhn, L.24
Barrett, M.25
Valdez, R.26
Trent, J.27
Stewart, A.K.28
Carpten, J.29
Bergsagel, P.L.30
more..
-
162
-
-
18544367201
-
NF-κB as a therapeutic target in multiple myeloma
-
DOI 10.1074/jbc.M200360200
-
Hideshima T, Chauhan D, Richardson P, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002;277(19):16639-16647 (Pubitemid 34967682)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.19
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
Munshi, N.7
Dang, L.8
Castro, A.9
Palombella, V.10
Adams, J.11
Anderson, K.C.12
-
163
-
-
0028921477
-
Interleukin-6 in human multiple myeloma
-
Klein B, Zhang XG, Lu ZY, Bataille R. Interleukin-6 in human multiple myeloma. Blood 1995;85(4):863-872
-
(1995)
Blood
, vol.85
, Issue.4
, pp. 863-872
-
-
Klein, B.1
Zhang, X.G.2
Lu, Z.Y.3
Bataille, R.4
-
164
-
-
0029019664
-
Interleukin-6 inhibits apoptosis of malignant plasma cells
-
Lichtenstein A, Tu Y, Fady C, et al. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 1995;162(2):248-255
-
(1995)
Cell Immunol
, vol.162
, Issue.2
, pp. 248-255
-
-
Lichtenstein, A.1
Tu, Y.2
Fady, C.3
-
165
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
DOI 10.1182/blood.V99.12.4525
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002;99(12):4525-4530 (Pubitemid 34627223)
-
(2002)
Blood
, vol.99
, Issue.12
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.C.7
Treon, S.P.8
Anderson, K.C.9
-
166
-
-
9344245148
-
Transforming growth factor β receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
-
DOI 10.1158/1078-0432.CCR-04-0632
-
Hayashi T, Hideshima T, Nguyen AN, et al. Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res 2004;10(22):7540-7546 (Pubitemid 39557515)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.22
, pp. 7540-7546
-
-
Hayashi, T.1
Hideshima, T.2
Nguyen, A.N.3
Munoz, O.4
Podar, K.5
Hamasaki, M.6
Ishitsuka, K.7
Yasui, H.8
Richardson, P.9
Chakravarty, S.10
Murphy, A.11
Chauhan, D.12
Higgins, L.S.13
Anderson, K.C.14
-
167
-
-
10744221197
-
Antitumor Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitors, a Novel Class of Agents, in Multiple Myeloma
-
Hideshima T, Chauhan D, Hayashi T, et al. Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. Cancer Res 2003;63(23):8428-8436 (Pubitemid 37549499)
-
(2003)
Cancer Research
, vol.63
, Issue.23
, pp. 8428-8436
-
-
Hideshima, T.1
Chauhan, D.2
Hayashi, T.3
Podar, K.4
Akiyama, M.5
Mitsiades, C.6
Mitsiades, N.7
Gong, B.8
Bonham, L.9
De Vries, P.10
Munshi, N.11
Richardson, P.G.12
Singer, J.W.13
Anderson, K.C.14
-
168
-
-
20144363221
-
1′-acetoxychavicol acetate is a novel nuclear factor κB inhibitor with significant activity against multiple myeloma in vitro and in vivo
-
DOI 10.1158/0008-5472.CAN-05-0072
-
Ito K, Nakazato T, Xian MJ, et al. 1′-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo. Cancer Res 2005;65(10):4417-4424 (Pubitemid 40775681)
-
(2005)
Cancer Research
, vol.65
, Issue.10
, pp. 4417-4424
-
-
Ito, K.1
Nakazato, T.2
Xian, M.J.3
Yamada, T.4
Hozumi, N.5
Murakami, A.6
Ohigashi, H.7
Ikeda, Y.8
Kizaki, M.9
-
169
-
-
33750283069
-
MLN120B, a novel IκB kinase β inhibitor, blocks multiple myeloma cell growth in vitro and in vivo
-
DOI 10.1158/1078-0432.CCR-05-2501
-
Hideshima T, Neri P, Tassone P, et al. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res 2006;12(19):5887-5894 (Pubitemid 44629622)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.19
, pp. 5887-5894
-
-
Hideshima, T.1
Neri, P.2
Tassone, P.3
Yasui, H.4
Ishitsuka, K.5
Raje, N.6
Chauhan, D.7
Podar, K.8
Mitsiades, C.9
Dang, L.10
Munshi, N.11
Richardson, P.12
Schenkein, D.13
Anderson, K.C.14
-
170
-
-
0037434982
-
Wnt signaling in B-cell neoplasia
-
DOI 10.1038/sj.onc.1206239
-
Qiang YW, Endo Y, Rubin JS, Rudikoff S. Wnt signaling in B-cell neoplasia. Oncogene 2003;22(10):1536-1545 (Pubitemid 36390603)
-
(2003)
Oncogene
, vol.22
, Issue.10
, pp. 1536-1545
-
-
Qiang, Y.-W.1
Endo, Y.2
Rubin, J.S.3
Rudikoff, S.4
-
171
-
-
11144355390
-
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
-
DOI 10.1073/pnas.0305855101
-
Derksen PW, Tjin E, Meijer HP, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci USA 2004;101(16):6122-6127 (Pubitemid 38520538)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.16
, pp. 6122-6127
-
-
Derksen, P.W.B.1
Tjin, E.2
Meijer, H.P.3
Klok, M.D.4
Mac Gillavry, H.D.5
Van Oers, M.H.J.6
Lokhorst, H.M.7
Bloem, A.C.8
Clevers, H.9
Nusse, R.10
Van Der Neut, R.11
Spaargaren, M.12
Pals, S.T.13
-
172
-
-
34250678970
-
Targeting the β-catenin/TCF transcriptional complex in the treatment of multiple myeloma
-
DOI 10.1073/pnas.0610299104
-
Sukhdeo K, Mani M, Zhang Y, et al. Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci USA 2007;104(18):7516-7521 (Pubitemid 47185938)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.18
, pp. 7516-7521
-
-
Sukhdeo, K.1
Mani, M.2
Zhang, Y.3
Dutta, J.4
Yasui, H.5
Rooney, M.D.6
Carrasco, D.E.7
Zheng, M.8
He, H.9
Tai, Y.-T.10
Mitsiades, C.11
Anderson, K.C.12
Carrasco, D.R.13
-
173
-
-
23944524848
-
Wnts induce migration and invasion of myeloma plasma cells
-
DOI 10.1182/blood-2005-01-0049
-
Qiang YW, Walsh K, Yao L, et al. Wnts induce migration and invasion of myeloma plasma cells. Blood 2005;106(5):1786-1793 (Pubitemid 41208595)
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1786-1793
-
-
Qiang, Y.-W.1
Walsh, K.2
Yao, L.3
Kedei, N.4
Blumberg, P.M.5
Rubin, J.S.6
Shaughnessy Jr., J.7
Rudikoff, S.8
-
174
-
-
47649120741
-
Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
-
Qiang YW, Shaughnessy JD Jr, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood 2008;112(2):374-382
-
(2008)
Blood
, vol.112
, Issue.2
, pp. 374-382
-
-
Qiang, Y.W.1
Shaughnessy Jr., J.D.2
Yaccoby, S.3
-
175
-
-
0346363760
-
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
-
DOI 10.1056/NEJMoa030847
-
Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349(26):2483-2494 (Pubitemid 38010074)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.26
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.2
Walker, R.3
Rasmussen, E.4
Ma, Y.5
Barlogie, B.6
Shaughnessy Jr., J.D.7
-
176
-
-
34548008809
-
Production of Wnt inhibitors by myeloma cells: Potential effects on canonical Wnt pathway in the bone microenvironment
-
DOI 10.1158/0008-5472.CAN-06-4666
-
Giuliani N, Morandi F, Tagliaferri S, et al. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res 2007;67(16):7665-7674 (Pubitemid 47281359)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7665-7674
-
-
Giuliani, N.1
Morandi, F.2
Tagliaferri, S.3
Lazzaretti, M.4
Donofrio, G.5
Bonomini, S.6
Sala, R.7
Mangoni, M.8
Rizzoli, V.9
-
177
-
-
6944247322
-
Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications
-
DOI 10.1158/0008-5472.CAN-03-3630
-
Tai YT, Catley LP, Mitsiades CS, et al. Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications. Cancer Res 2004;64(8):2846-2852 (Pubitemid 38500624)
-
(2004)
Cancer Research
, vol.64
, Issue.8
, pp. 2846-2852
-
-
Tai, Y.-T.1
Catley, L.P.2
Mitsiades, C.S.3
Burger, R.4
Podar, K.5
Shringpaure, R.6
Hideshima, T.7
Chauhan, D.8
Hamasaki, M.9
Ishitsuka, K.10
Richardson, P.11
Treon, S.P.12
Munshi, N.C.13
Anderson, K.C.14
-
178
-
-
67649594870
-
Immunomodulatory drug Lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications
-
abstract 5150
-
Tai YT, Catley L, Li XF, et al. Immunomodulatory drug Lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications [abstract 5150]. Blood 2005;106
-
(2005)
Blood
, vol.106
-
-
Tai, Y.T.1
Catley, L.2
Li, X.F.3
-
179
-
-
40949128245
-
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
-
Tai YT, Dillon M, Song W, et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 2007
-
(2007)
Blood
-
-
Tai, Y.T.1
Dillon, M.2
Song, W.3
-
180
-
-
0037443533
-
RANK ligand and osteoprotegerin in myeloma bone disease
-
DOI 10.1182/blood-2002-09-2684
-
Sezer O, Heider U, Zavrski I, et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101(6):2094-2098 (Pubitemid 36302042)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2094-2098
-
-
Sezer, O.1
Heider, U.2
Zavrski, I.3
Kuhne, C.A.4
Hofbauer, L.C.5
-
181
-
-
42749092929
-
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
-
Yao Z, Xing L, Qin C, et al. Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem 2008;283(15):9917-9924
-
(2008)
J Biol Chem
, vol.283
, Issue.15
, pp. 9917-9924
-
-
Yao, Z.1
Xing, L.2
Qin, C.3
-
182
-
-
15444362701
-
2 signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-κB (RANK) ligand/RANK system
-
DOI 10.1210/en.2004-1167
-
Liu XH, Kirschenbaum A, Yao S, Levine AC. Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system. Endocrinology 2005;146(4):1991-1998 (Pubitemid 40396909)
-
(2005)
Endocrinology
, vol.146
, Issue.4
, pp. 1991-1998
-
-
Liu, X.-H.1
Kirschenbaum, A.2
Yao, S.3
Levine, A.C.4
-
183
-
-
0035383761
-
Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
-
Han JH, Choi SJ, Kurihara N, et al. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 2001;97(11):3349-3353
-
(2001)
Blood
, vol.97
, Issue.11
, pp. 3349-3353
-
-
Han, J.H.1
Choi, S.J.2
Kurihara, N.3
-
184
-
-
53049088523
-
CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions
-
Giuliani N, Lisignoli G, Colla S, et al. CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions. Cancer Res 2008;68(16):6840-6850
-
(2008)
Cancer Res
, vol.68
, Issue.16
, pp. 6840-6850
-
-
Giuliani, N.1
Lisignoli, G.2
Colla, S.3
-
185
-
-
4944230728
-
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: A vicious cycle between bone destruction and myeloma expansion
-
DOI 10.1182/blood-2003-11-3839
-
Abe M, Hiura K, Wilde J, et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood 2004;104(8):2484-2491 (Pubitemid 39331851)
-
(2004)
Blood
, vol.104
, Issue.8
, pp. 2484-2491
-
-
Abe, M.1
Hiura, K.2
Wilde, J.3
Shioyasono, A.4
Moriyama, K.5
Hashimoto, T.6
Kido, S.7
Oshima, T.8
Shibata, H.9
Ozaki, S.10
Inoue, D.11
Matsumoto, T.12
-
186
-
-
33644558753
-
Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
-
Yaccoby S, Wezeman MJ, Zangari M, et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91(2):192-199 (Pubitemid 43304138)
-
(2006)
Haematologica
, vol.91
, Issue.2
, pp. 192-199
-
-
Yaccoby, S.1
Wezeman, M.J.2
Zangari, M.3
Walker, R.4
Cottler-Fox, M.5
Gaddy, D.6
Ling, W.7
Saha, R.8
Barlogie, B.9
Tricot, G.10
Epstein, J.11
-
187
-
-
0035664488
-
Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease
-
DOI 10.1172/JCI200113116
-
Choi SJ, Oba Y, Gazitt Y, et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001;108(12):1833-1841 (Pubitemid 34015129)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.12
, pp. 1833-1841
-
-
Choi, S.J.1
Oba, Y.2
Gazitt, Y.3
Alsina, M.4
Cruz, J.5
Anderson, J.6
David Roodman, G.7
-
188
-
-
33947161063
-
Apomine™, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo
-
DOI 10.1002/ijc.22478
-
Edwards CM, Mueller G, Roelofs AJ, et al. Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Int J Cancer 2007;120(8):1657-1663 (Pubitemid 46399350)
-
(2007)
International Journal of Cancer
, vol.120
, Issue.8
, pp. 1657-1663
-
-
Edwards, C.M.1
Mueller, G.2
Roelofs, A.J.3
Chantry, A.4
Perry, M.5
Russell, R.G.G.6
Van Camp, B.7
Guyon-Gellin, Y.8
Niesor, E.J.9
Bentzen, C.L.10
Vanderkerken, K.11
Croucher, P.I.12
-
189
-
-
58049205847
-
The role of Dickkopf-1 in bone development, homeostasis and disease
-
Pinzone JJ, Hall BM, Thudi NK, et al. The role of Dickkopf-1 in bone development, homeostasis and disease. Blood 2008
-
(2008)
Blood
-
-
Pinzone, J.J.1
Hall, B.M.2
Thudi, N.K.3
-
190
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
DOI 10.1182/blood-2005-01-0034
-
Bergsagel PL, Kuehl WM, Zhan F, et al. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005;106(1):296-303 (Pubitemid 40967205)
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy Jr., J.6
-
191
-
-
33645769276
-
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients
-
Carrasco DR, Tonon G, Huang Y, et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 2006;9(4):313-325
-
(2006)
Cancer Cell
, vol.9
, Issue.4
, pp. 313-325
-
-
Carrasco, D.R.1
Tonon, G.2
Huang, Y.3
|