메뉴 건너뛰기




Volumn 14, Issue 1, 2009, Pages 99-127

Emerging therapies for multiple myeloma

Author keywords

Bone marrow microenvironment; Combination therapy; Multiple myeloma

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; 3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; 3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; BELINOSTAT; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CARFILZOMIB; CHIR 258; DEXAMETHASONE; EPOTHILONE D; FLAVOPIRIDOL; GRN 163; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ITF 2357; LENALIDOMIDE; MELPHALAN; MONOCLONAL ANTIBODY; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NEW DRUG; PANOBINOSTAT; PROTEASOME INHIBITOR; ROMIDEPSIN; SALINOSPORAMIDE A; SNDX 275; SU 10091; SU 10991; TELOMESTATIN; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; ANTINEOPLASTIC AGENT;

EID: 65649092058     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728210802676278     Document Type: Review
Times cited : (51)

References (191)
  • 2
    • 42449114035 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111:2962-2972
    • (2008) Blood , vol.111 , pp. 2962-2972
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 3
    • 0014661330 scopus 로고
    • Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens
    • Alexanian R, Haut A, Khan AU, et al. Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. JAMA 1969;208:1680-1685
    • (1969) JAMA , vol.208 , pp. 1680-1685
    • Alexanian, R.1    Haut, A.2    Khan, A.U.3
  • 4
    • 0018668451 scopus 로고
    • The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia
    • Bergsagel DE, Bailey AJ, Langley GR, et al. The chemotherapy on plasma-cell myeloma and the incidence of acute leukemia. N Engl J Med 1979;301:743-748 (Pubitemid 10250478)
    • (1979) New England Journal of Medicine , vol.301 , Issue.14 , pp. 743-748
    • Bergsagel, D.E.1    Bailey, A.J.2    Langley, G.R.3
  • 5
    • 0033864110 scopus 로고    scopus 로고
    • Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: A Finnish Leukaemia Group study
    • DOI 10.1034/j.1600-0609.2000.90218.x
    • Finnish Leukaemia Group. Acute leukaemia and other secondary neoplasms in patients treated with conventional chemotherapy for multiple myeloma: a Finnish Leukaemia Group study. Eur J Haematol 2000;65:123-127 (Pubitemid 30615087)
    • (2000) European Journal of Haematology , vol.65 , Issue.2 , pp. 123-127
    • Olivanen, T.1
  • 6
    • 0020578180 scopus 로고
    • High-dose intravenous melphalan for plasma-cell leukaemia and myeloma
    • McElwain TJ, Powles RL. High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Lancet 1983;2:822-824
    • (1983) Lancet , vol.2 , pp. 822-824
    • McElwain, T.J.1    Powles, R.L.2
  • 7
    • 0022510876 scopus 로고
    • High-dose melphalan with autologous bone marrow transplantation for multiple myeloma
    • Barlogie B, Hall R, Zander A, et al. High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood 1986;67:1298-1301 (Pubitemid 16080597)
    • (1986) Blood , vol.67 , Issue.5 , pp. 1298-1301
    • Barlogie, B.1    Hall, R.2    Zander, A.3
  • 8
    • 0023552805 scopus 로고
    • High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma
    • Barlogie B, Alexanian R, Dicke KA, et al. High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Blood 1987;70:869-872 (Pubitemid 18027425)
    • (1987) Blood , vol.70 , Issue.3 , pp. 869-872
    • Barlogie, B.1    Alexanian, R.2    Dicke, K.A.3    Zagars, G.4    Spitzer, G.5    Jagannath, S.6    Horwitz, L.7
  • 11
    • 14144254245 scopus 로고    scopus 로고
    • Less than half of patients aged 65 years or under with myeloma proceed to transplantation: Results of a two region population-based survey
    • DOI 10.1111/j.1365-2141.2004.05340.x
    • Morris TC, Velangi M, Jackson G, et al. Less than half of patients aged 65 years or under with myeloma proceed to transplantation: results of a two region population-based survey. Br J Haematol 2005;128(4):510-512 (Pubitemid 40283169)
    • (2005) British Journal of Haematology , vol.128 , Issue.4 , pp. 510-512
    • Morris, T.C.M.1    Velangi, M.2    Jackson, G.3    Marks, D.I.4    Ranaghan, L.5
  • 12
    • 0022655622 scopus 로고
    • High-dose glucocorticoid treatment of resistant myeloma
    • Alexanian R, Barlogie B, Dixon D. High-dose glucocorticoid treatment of resistant myeloma. Ann Intern Med 1986;105(1):8-11 (Pubitemid 16097913)
    • (1986) Annals of Internal Medicine , vol.105 , Issue.1 , pp. 8-11
    • Alexanian, R.1    Barlogie, B.2    Dixon, D.3
  • 13
    • 0021322023 scopus 로고
    • Effective treatment of advanced multiple myeloma refractory to alkylating agents
    • Barlogie B, Smith L, Alexanian R. Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984;310(21):1353-1356 (Pubitemid 14149087)
    • (1984) New England Journal of Medicine , vol.310 , Issue.21 , pp. 1353-1356
    • Barlogie, B.1    Smith, L.2    Alexanian, R.3
  • 14
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalidomide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999;341(21):1565-1571
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 15
    • 0035880229 scopus 로고    scopus 로고
    • Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: Identification of prognostic factors in a phase 2 study of 169 patients
    • Barlogie B, Desikan R, Eddlemon P, et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Blood 2001;98(2):492-494
    • (2001) Blood , vol.98 , Issue.2 , pp. 492-494
    • Barlogie, B.1    Desikan, R.2    Eddlemon, P.3
  • 21
    • 0035895104 scopus 로고    scopus 로고
    • Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
    • Moehler TM, Neben K, Benner A, et al. Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy. Blood 2001;98(13):3846-3848
    • (2001) Blood , vol.98 , Issue.13 , pp. 3846-3848
    • Moehler, T.M.1    Neben, K.2    Benner, A.3
  • 24
    • 0003234481 scopus 로고    scopus 로고
    • Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT)
    • Zangari M, Tricot G, Zeldis G, et al. Results of phase I study of CC-5013 for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT). Blood 2001;98;775a
    • (2001) Blood , vol.98
    • Zangari, M.1    Tricot, G.2    Zeldis, G.3
  • 29
    • 34047233904 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients
    • DOI 10.1111/j.1365-2141.2007.06538.x
    • Morgan GJ, Schey SA, Wu P, et al. Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients. Br J Haematol 2007;137(3):268-269 (Pubitemid 46537629)
    • (2007) British Journal of Haematology , vol.137 , Issue.3 , pp. 268-269
    • Morgan, G.J.1    Schey, S.A.2    Wu, P.3    Srikanth, M.4    Phekoo, K.J.5    Jenner, M.6    Davies, F.E.7
  • 30
  • 33
    • 67649582868 scopus 로고    scopus 로고
    • Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma
    • abstract #2717
    • Jagannath J, Barlogie B, Berenson JR, et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma [abstract #2717]. Blood 2007;110(11)
    • (2007) Blood , vol.110 , Issue.11
    • Jagannath, J.1    Barlogie, B.2    Berenson, J.R.3
  • 38
    • 27744489202 scopus 로고    scopus 로고
    • Role of VAD in the initial treatment of multiple myeloma
    • author reply 3674-3675
    • Lane SW, Gill D, Mollee PN, Rajkumar SV. Role of VAD in the initial treatment of multiple myeloma. Blood 2005;106(10):3674M; author reply 3674-3675
    • (2005) Blood , vol.106 , Issue.10
    • Lane, S.W.1    Gill, D.2    Mollee, P.N.3    Rajkumar, S.V.4
  • 44
    • 0019944218 scopus 로고
    • Identical twin marrow transplantation in multiple myeloma
    • Osserman EF, Dire LB, Dire J, et al. Identical twin marrow transplantation in multiple myeloma. Acta Haematol 1982;68(3):215-223
    • (1982) Acta Haematol , vol.68 , Issue.3 , pp. 215-223
    • Osserman, E.F.1    Dire, L.B.2    Dire, J.3
  • 45
    • 0023216770 scopus 로고
    • Bone marrow transplantation in multiple myeloma: Report from the European Cooperative Group for Bone Marrow Transplantation
    • Gahrton G, Tura S, Flesch M, et al. Bone marrow transplantation in multiple myeloma: report from the European Cooperative Group for Bone Marrow Transplantation. Blood 1987;69(4):1262-1264 (Pubitemid 17080954)
    • (1987) Blood , vol.69 , Issue.4 , pp. 1262-1264
    • Gahrton, G.1    Tura, S.2    Flesch, M.3
  • 47
    • 0035883066 scopus 로고    scopus 로고
    • T-cell-depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: Induction of graft-versus-myeloma effect
    • Alyea E, Weller E, Schlossman R, et al. T-cell-depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect. Blood 2001;98(4):934-939
    • (2001) Blood , vol.98 , Issue.4 , pp. 934-939
    • Alyea, E.1    Weller, E.2    Schlossman, R.3
  • 54
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • Weber D, Rankin K, Gavino M, et al. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol 2003;21(1):16-19
    • (2003) J Clin Oncol , vol.21 , Issue.1 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3
  • 55
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the eastern cooperative oncology group
    • DOI 10.1200/JCO.2005.03.0221
    • Rajkumar SV, Blood E, Vesole D, et al. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006;24(3):431-436 (Pubitemid 46630462)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.3 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3    Fonseca, R.4    Greipp, P.R.5
  • 63
    • 54749087249 scopus 로고    scopus 로고
    • Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study
    • abstract 8520
    • Richardson PG, Lonial S, Jakubowiak A, et al. Safety and efficacy of lenalidomide (Len), bortezomib (Bz), and dexamethasone (Dex) in patients (pts) with newly diagnosed multiple myeloma (MM): A phase I/II study [abstract 8520]. J Clin Oncol 2008;26
    • (2008) J Clin Oncol , vol.26
    • Richardson, P.G.1    Lonial, S.2    Jakubowiak, A.3
  • 65
    • 44649149612 scopus 로고    scopus 로고
    • VELCADE/Dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantion (ASCT) in newly diagnosed multiple myeloma (MM): Updated results of the IFM 2005/01 trial
    • abstract #450
    • Harousseau JL, Mathiot C, Attal A, et al. VELCADE/Dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantion (ASCT) in newly diagnosed multiple myeloma (MM): updated results of the IFM 2005/01 trial [abstract #450]. Blood 2007;110(11)
    • (2007) Blood , vol.110 , Issue.11
    • Harousseau, J.L.1    Mathiot, C.2    Attal, A.3
  • 67
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: Updated results of a randomized, controlled trial
    • Palumbo A, Bringhen S, Liberati AM, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized, controlled trial. Blood 2008;112(8):3107-3114
    • (2008) Blood , vol.112 , Issue.8 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.M.3
  • 69
    • 64749104456 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma
    • Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma. Blood 2008
    • (2008) Blood
    • Ludwig, H.1    Hajek, R.2    Tothova, E.3
  • 71
    • 51349103508 scopus 로고    scopus 로고
    • Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: Results of the canadian MM016 trial
    • abstract #3597
    • Bahlis NJ, Song K, Trieu Y, et al. Lenalidomide overcomes poor prognosis conferred by del13q and t(4;14) but not del17p13 in multiple myeloma: results of the canadian MM016 trial [abstract #3597]. Blood 2007;110(11)
    • (2007) Blood , vol.110 , Issue.11
    • Bahlis, N.J.1    Song, K.2    Trieu, Y.3
  • 73
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma. N Engl J Med 2008;359(9):906-917
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 75
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 Clinical Practice Guideline Update on the Role of Bisphosphonates in Multiple Myeloma
    • Kyle RA, Yee GC, Somerfield MR, et al. American Society of Clinical Oncology 2007 Clinical Practice Guideline Update on the Role of Bisphosphonates in Multiple Myeloma. J Clin Oncol 2007;25(17):1-9
    • (2007) J Clin Oncol , vol.25 , Issue.17 , pp. 1-9
    • Kyle, R.A.1    Yee, G.C.2    Somerfield, M.R.3
  • 78
    • 34247859271 scopus 로고    scopus 로고
    • Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma
    • DOI 10.1586/14737140.7.4.551
    • Podar K, Richardson PG, Chauhan D, Anderson KC. Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma. Expert Rev Anticancer Ther 2007;7(4):551-566 (Pubitemid 46690962)
    • (2007) Expert Review of Anticancer Therapy , vol.7 , Issue.4 , pp. 551-566
    • Podar, K.1    Richardson, P.G.2    Chauhan, D.3    Anderson, K.C.4
  • 79
    • 67649579824 scopus 로고    scopus 로고
    • Available from
    • Available from: http://clinicaltrials.gov/
  • 80
    • 67649588244 scopus 로고    scopus 로고
    • Available from
    • Available from: http://www.multiplemyeloma.org/
  • 81
    • 67649618662 scopus 로고    scopus 로고
    • Availbale from
    • Availbale from: http://myeloma.org/
  • 82
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4(6):423-436 (Pubitemid 38745528)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 83
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, et al. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007;7(8):585-598
    • (2007) Nat Rev Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3
  • 86
    • 27244445489 scopus 로고    scopus 로고
    • Molecular pathogenesis and a consequent classification of multiple myeloma
    • DOI 10.1200/JCO.2005.05.021
    • Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005;23(26):6333-6338 (Pubitemid 46218843)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6333-6338
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 87
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • DOI 10.1182/blood-2004-01-0037
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood 2004;104(3):607-618 (Pubitemid 38970551)
    • (2004) Blood , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 88
    • 1942456800 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
    • DOI 10.1182/blood-2003-10-3650
    • Trudel S, Ely S, Farooqi Y, et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 2004;103(9):3521-3528 (Pubitemid 38525687)
    • (2004) Blood , vol.103 , Issue.9 , pp. 3521-3528
    • Trudel, S.1    Ely, S.2    Farooqi, Y.3    Affer, M.4    Robbiani, D.F.5    Chesi, M.6    Bergsagel, P.L.7
  • 89
    • 15944378835 scopus 로고    scopus 로고
    • CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
    • DOI 10.1182/blood-2004-10-3913
    • Trudel S, Li ZH, Wei E, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 2005;105(7):2941-2948 (Pubitemid 40446289)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2941-2948
    • Trudel, S.1    Li, Z.H.2    Wei, E.3    Wiesmann, M.4    Chang, H.5    Chen, C.6    Reece, D.7    Heise, C.8    Stewart, A.K.9
  • 91
    • 0032212243 scopus 로고    scopus 로고
    • The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
    • Chesi M, Nardini E, Lim RS, et al. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 1998;92(9):3025-3034 (Pubitemid 28492306)
    • (1998) Blood , vol.92 , Issue.9 , pp. 3025-3034
    • Chesi, M.1    Nardini, E.2    Lim, R.S.C.3    Smith, K.D.4    Michael Kuehl, W.5    Bergsagel, P.L.6
  • 92
    • 1442285889 scopus 로고    scopus 로고
    • Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
    • DOI 10.1016/S1535-6108(04)00019-4, PII S1535610804000194
    • Hurt EM, Wiestner A, Rosenwald A, et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 2004;5(2):191-199 (Pubitemid 38283804)
    • (2004) Cancer Cell , vol.5 , Issue.2 , pp. 191-199
    • Hurt, E.M.1    Wiestner, A.2    Rosenwald, A.3    Shaffer, A.L.4    Campo, E.5    Grogan, T.6    Bergsagel, P.L.7    Kuehl, W.M.8    Staudt, L.M.9
  • 93
    • 0035892119 scopus 로고    scopus 로고
    • Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
    • Avet-Loiseau H, Gerson F, Magrangeas F, et al. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood 2001;98(10):3082-3086
    • (2001) Blood , vol.98 , Issue.10 , pp. 3082-3086
    • Avet-Loiseau, H.1    Gerson, F.2    Magrangeas, F.3
  • 97
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • DOI 10.1182/blood-2006-04-016055
    • Catley L, Weisberg E, Kiziltepe T, et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006;108(10):3441-3449 (Pubitemid 44776885)
    • (2006) Blood , vol.108 , Issue.10 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3    Tai, Y.-T.4    Hideshima, T.5    Neri, P.6    Tassone, P.7    Atadja, P.8    Chauhan, D.9    Munshi, N.C.10    Anderson, K.C.11
  • 99
    • 34848873093 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage
    • DOI 10.1111/j.1365-2141.2007.06772.x
    • Feng R, Oton A, Mapara MY, et al. The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage. Br J Haematol 2007;139(3):385-397 (Pubitemid 47512171)
    • (2007) British Journal of Haematology , vol.139 , Issue.3 , pp. 385-397
    • Feng, R.1    Oton, A.2    Mapara, M.Y.3    Anderson, G.4    Belani, C.5    Lentzsch, S.6
  • 100
    • 34347375499 scopus 로고    scopus 로고
    • NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
    • DOI 10.1182/blood-2006-03-013128
    • Miller CP, Ban K, Dujka ME, et al. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 2007;110(1):267-277 (Pubitemid 47026844)
    • (2007) Blood , vol.110 , Issue.1 , pp. 267-277
    • Miller, C.P.1    Ban, K.2    Dujka, M.E.3    McConkey, D.J.4    Munsell, M.5    Palladino, M.6    Chandra, J.7
  • 101
    • 2042505684 scopus 로고    scopus 로고
    • Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma
    • DOI 10.1111/j.1365-2141.2004.04882.x
    • Khan SB, Maududi T, Barton K, et al. Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma. Br J Haematol 2004;125(2):156-161 (Pubitemid 38534966)
    • (2004) British Journal of Haematology , vol.125 , Issue.2 , pp. 156-161
    • Khan, S.B.1    Maududi, T.2    Barton, K.3    Ayers, J.4    Alkan, S.5
  • 105
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • DOI 10.1038/ng0797-260
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14) (p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997;16(3):260-264 (Pubitemid 27280209)
    • (1997) Nature Genetics , vol.16 , Issue.3 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3    Schrock, E.4    Ried, T.5    Kuehl, W.M.6    Bergsagel, P.L.7
  • 108
    • 38549132452 scopus 로고    scopus 로고
    • Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance
    • Matsui W, Wang Q, Barber JP, et al. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res 2008;68(1):190-197
    • (2008) Cancer Res , vol.68 , Issue.1 , pp. 190-197
    • Matsui, W.1    Wang, Q.2    Barber, J.P.3
  • 111
    • 0029819604 scopus 로고    scopus 로고
    • Activating mutations of N- And K-ras in multiple myeloma show different clinical associations: Analysis of the Eastern Cooperative Oncology Group phase III trial
    • Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood 1996;88(7):2699-2706 (Pubitemid 26327523)
    • (1996) Blood , vol.88 , Issue.7 , pp. 2699-2706
    • Liu, P.1    Leong, T.2    Quam, L.3    Billadeau, D.4    Kay, N.E.5    Greipp, P.6    Kyle, R.A.7    Oken, M.M.8    Van Ness, B.9
  • 113
    • 33644826253 scopus 로고    scopus 로고
    • RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies
    • Martin P, Santon A, Garcia-Cosio M, Bellas C. RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies. Int J Oncol 2005;27(4):1023-1028
    • (2005) Int J Oncol , vol.27 , Issue.4 , pp. 1023-1028
    • Martin, P.1    Santon, A.2    Garcia-Cosio, M.3    Bellas, C.4
  • 114
    • 0026747866 scopus 로고
    • Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
    • Kato K, Cox AD, Hisaka MM, et al. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA 1992;89(14):6403-6407
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.14 , pp. 6403-6407
    • Kato, K.1    Cox, A.D.2    Hisaka, M.M.3
  • 120
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • DOI 10.1016/0092-8674(89)90438-8
    • Taga T, Hibi M, Hirata Y, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989;58(3):573-581 (Pubitemid 19203542)
    • (1989) Cell , vol.58 , Issue.3 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3    Yamasaki, K.4    Yasukawa, K.5    Matsuda, T.6    Hirano, T.7    Kishimoto, T.8
  • 122
    • 0029052318 scopus 로고
    • Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association
    • Matsuda T, Fukada T, Takahashi-Tezuka M, et al. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association. J Biol Chem 1995;270(19):11037-11039
    • (1995) J Biol Chem , vol.270 , Issue.19 , pp. 11037-11039
    • Matsuda, T.1    Fukada, T.2    Takahashi-Tezuka, M.3
  • 124
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994;264(5155):95-98 (Pubitemid 24144493)
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 126
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
    • Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 1996;87(3):1104-1112 (Pubitemid 26043538)
    • (1996) Blood , vol.87 , Issue.3 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3    Urashima, M.4    Yamamoto, K.-I.5    Libermann, T.A.6    Anderson, K.C.7
  • 127
    • 0027133422 scopus 로고
    • Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
    • Uchiyama H, Barut BA, Mohrbacher AF, et al. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 1993;82(12):3712-3720 (Pubitemid 24006055)
    • (1993) Blood , vol.82 , Issue.12 , pp. 3712-3720
    • Uchiyama, H.1    Barut, B.A.2    Mohrbacher, A.F.3    Chauhan, D.4    Anderson, K.C.5
  • 128
    • 0032428364 scopus 로고    scopus 로고
    • Interleukin-1 in multiple myeloma: Producer cells and their role in the control of IL-6 production
    • DOI 10.1046/j.1365-2141.1998.01101.x
    • Costes V, Portier M, Lu ZY, et al. Interleukin-1 in multiple myeloma: producer cells and their role in the control of IL-6 production. Br J Haematol 1998;103(4):1152-1160 (Pubitemid 29012658)
    • (1998) British Journal of Haematology , vol.103 , Issue.4 , pp. 1152-1160
    • Costes, V.1    Portier, M.2    Lu, Z.-Y.3    Rossi, J.-F.4    Bataille, R.5    Klein, B.6
  • 130
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
    • Gupta D, Treon SP, Shima Y, et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 2001;15(12):1950-1961 (Pubitemid 33115003)
    • (2001) Leukemia , vol.15 , Issue.12 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3    Hideshima, T.4    Podar, K.5    Tai, Y.T.6    Lin, B.7
  • 131
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: Therapeutic applications
    • DOI 10.1038/sj.onc.1204623
    • Hideshima T, Chauhan D, Schlossman R, et al. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001;20(33):4519-4527 (Pubitemid 32772434)
    • (2001) Oncogene , vol.20 , Issue.33 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3    Richardson, P.4    Anderson, K.C.5
  • 136
    • 49249128130 scopus 로고    scopus 로고
    • Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1
    • Ahn KS, Sethi G, Sung B, et al. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res 2008;68(11):4406-4415
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4406-4415
    • Ahn, K.S.1    Sethi, G.2    Sung, B.3
  • 137
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • DOI 10.1126/science.296.5573.1655
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296(5573):1655-1657 (Pubitemid 34579158)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 138
    • 0034634443 scopus 로고    scopus 로고
    • Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms
    • DOI 10.1016/S0014-5793(00)02162-1, PII S0014579300021621
    • Balendran A, Hare GR, Kieloch A, et al. Further evidence that 3-phosphoinositide-dependent protein kinase-1(PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett 2000;484(3):217-223 (Pubitemid 30811101)
    • (2000) FEBS Letters , vol.484 , Issue.3 , pp. 217-223
    • Balendran, A.1    Hare, G.R.2    Kieloch, A.3    Williams, M.R.4    Alessi, D.R.5
  • 139
    • 0034176579 scopus 로고    scopus 로고
    • The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    • DOI 10.1016/S0960-9822(00)00441-3
    • Williams MR, Arthur JS, Balendran A, et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 2000;10(8):439-448 (Pubitemid 30247331)
    • (2000) Current Biology , vol.10 , Issue.8 , pp. 439-448
    • Williams, M.R.1    Arthur, J.S.C.2    Balendran, A.3    Van Der Kaay, J.4    Poli, V.5    Cohen, P.6    Alessi, D.R.7
  • 140
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • DOI 10.1073/pnas.96.8.4240
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999;96(8):4240-4245 (Pubitemid 29190320)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.8 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 141
    • 0036884062 scopus 로고    scopus 로고
    • Molecular mechanisms of novel therapeutic approaches for multiple myeloma
    • DOI 10.1038/nrc952
    • Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2002;2(12):927-937 (Pubitemid 37328894)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.12 , pp. 927-937
    • Hideshima, T.1    Anderson, K.C.2
  • 144
    • 0035379555 scopus 로고    scopus 로고
    • Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38
    • DOI 10.1074/jbc.M101103200
    • Madrid LV, Mayo MW, Reuther JY, et al. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001;276(22):18934-18940 (Pubitemid 37411214)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.22 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin Jr., A.S.4
  • 145
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins. Getting in on the Akt
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111(3):293-303
    • (2002) Cell , vol.111 , Issue.3 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 146
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2(7):489-501 (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 148
    • 0032711250 scopus 로고    scopus 로고
    • IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
    • Puthier D, Bataille R, Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol 1999;29(12):3945-3950
    • (1999) Eur J Immunol , vol.29 , Issue.12 , pp. 3945-3950
    • Puthier, D.1    Bataille, R.2    Amiot, M.3
  • 149
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • DOI 10.1038/sj.onc.1204833
    • Hideshima T, Nakamura N, Chauhan D, Anderson KC. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene 2001;20(42):5991-6000 (Pubitemid 32955041)
    • (2001) Oncogene , vol.20 , Issue.42 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 150
    • 33846887460 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkyl-phospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma (MM) cells
    • abstract #250
    • Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkyl-phospholipid, inhibits Akt and induces in vitro and In vivo cytotoxicity in human multiple myeloma (MM) cells [abstract #250]. Blood 2005;106(11):128
    • (2005) Blood , vol.106 , Issue.11 , pp. 128
    • Hideshima, T.1    Catley, L.2    Yasui, H.3
  • 154
    • 10244229652 scopus 로고    scopus 로고
    • In vivo anti-tumor effects of the mTOR inhibitor, CCI-779, against human multiple myeloma cells in a xenograft model
    • Frost P, Moatomed F, Hoang B, et al. In vivo anti-tumor effects of the mTOR inhibitor, CCI-779, against human multiple myeloma cells in a xenograft model. Blood 2004
    • (2004) Blood
    • Frost, P.1    Moatomed, F.2    Hoang, B.3
  • 158
    • 35248870218 scopus 로고    scopus 로고
    • The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
    • DOI 10.1517/13543784.16.10.1693
    • Podar K, Raab MS, Chauhan D, Anderson KC. The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. Expert Opin Investig Drugs 2007;16(10):1693-1707 (Pubitemid 350030716)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.10 , pp. 1693-1707
    • Podar, K.1    Raab, M.S.2    Chauhan, D.3    Anderson, K.C.4
  • 159
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • DOI 10.1038/nri1703
    • Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature reviews 2005;5(10):749-759 (Pubitemid 41400849)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.10 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 163
    • 0028921477 scopus 로고
    • Interleukin-6 in human multiple myeloma
    • Klein B, Zhang XG, Lu ZY, Bataille R. Interleukin-6 in human multiple myeloma. Blood 1995;85(4):863-872
    • (1995) Blood , vol.85 , Issue.4 , pp. 863-872
    • Klein, B.1    Zhang, X.G.2    Lu, Z.Y.3    Bataille, R.4
  • 164
    • 0029019664 scopus 로고
    • Interleukin-6 inhibits apoptosis of malignant plasma cells
    • Lichtenstein A, Tu Y, Fady C, et al. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 1995;162(2):248-255
    • (1995) Cell Immunol , vol.162 , Issue.2 , pp. 248-255
    • Lichtenstein, A.1    Tu, Y.2    Fady, C.3
  • 168
    • 20144363221 scopus 로고    scopus 로고
    • 1′-acetoxychavicol acetate is a novel nuclear factor κB inhibitor with significant activity against multiple myeloma in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-05-0072
    • Ito K, Nakazato T, Xian MJ, et al. 1′-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo. Cancer Res 2005;65(10):4417-4424 (Pubitemid 40775681)
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4417-4424
    • Ito, K.1    Nakazato, T.2    Xian, M.J.3    Yamada, T.4    Hozumi, N.5    Murakami, A.6    Ohigashi, H.7    Ikeda, Y.8    Kizaki, M.9
  • 170
    • 0037434982 scopus 로고    scopus 로고
    • Wnt signaling in B-cell neoplasia
    • DOI 10.1038/sj.onc.1206239
    • Qiang YW, Endo Y, Rubin JS, Rudikoff S. Wnt signaling in B-cell neoplasia. Oncogene 2003;22(10):1536-1545 (Pubitemid 36390603)
    • (2003) Oncogene , vol.22 , Issue.10 , pp. 1536-1545
    • Qiang, Y.-W.1    Endo, Y.2    Rubin, J.S.3    Rudikoff, S.4
  • 174
    • 47649120741 scopus 로고    scopus 로고
    • Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    • Qiang YW, Shaughnessy JD Jr, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood 2008;112(2):374-382
    • (2008) Blood , vol.112 , Issue.2 , pp. 374-382
    • Qiang, Y.W.1    Shaughnessy Jr., J.D.2    Yaccoby, S.3
  • 178
    • 67649594870 scopus 로고    scopus 로고
    • Immunomodulatory drug Lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications
    • abstract 5150
    • Tai YT, Catley L, Li XF, et al. Immunomodulatory drug Lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications [abstract 5150]. Blood 2005;106
    • (2005) Blood , vol.106
    • Tai, Y.T.1    Catley, L.2    Li, X.F.3
  • 179
    • 40949128245 scopus 로고    scopus 로고
    • Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
    • Tai YT, Dillon M, Song W, et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 2007
    • (2007) Blood
    • Tai, Y.T.1    Dillon, M.2    Song, W.3
  • 180
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • DOI 10.1182/blood-2002-09-2684
    • Sezer O, Heider U, Zavrski I, et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101(6):2094-2098 (Pubitemid 36302042)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3    Kuhne, C.A.4    Hofbauer, L.C.5
  • 181
    • 42749092929 scopus 로고    scopus 로고
    • Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
    • Yao Z, Xing L, Qin C, et al. Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem 2008;283(15):9917-9924
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9917-9924
    • Yao, Z.1    Xing, L.2    Qin, C.3
  • 182
    • 15444362701 scopus 로고    scopus 로고
    • 2 signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-κB (RANK) ligand/RANK system
    • DOI 10.1210/en.2004-1167
    • Liu XH, Kirschenbaum A, Yao S, Levine AC. Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system. Endocrinology 2005;146(4):1991-1998 (Pubitemid 40396909)
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 1991-1998
    • Liu, X.-H.1    Kirschenbaum, A.2    Yao, S.3    Levine, A.C.4
  • 183
    • 0035383761 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
    • Han JH, Choi SJ, Kurihara N, et al. Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 2001;97(11):3349-3353
    • (2001) Blood , vol.97 , Issue.11 , pp. 3349-3353
    • Han, J.H.1    Choi, S.J.2    Kurihara, N.3
  • 184
    • 53049088523 scopus 로고    scopus 로고
    • CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions
    • Giuliani N, Lisignoli G, Colla S, et al. CC-Chemokine ligand 20/macrophage inflammatory protein-3alpha and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions. Cancer Res 2008;68(16):6840-6850
    • (2008) Cancer Res , vol.68 , Issue.16 , pp. 6840-6850
    • Giuliani, N.1    Lisignoli, G.2    Colla, S.3
  • 189
    • 58049205847 scopus 로고    scopus 로고
    • The role of Dickkopf-1 in bone development, homeostasis and disease
    • Pinzone JJ, Hall BM, Thudi NK, et al. The role of Dickkopf-1 in bone development, homeostasis and disease. Blood 2008
    • (2008) Blood
    • Pinzone, J.J.1    Hall, B.M.2    Thudi, N.K.3
  • 190
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
    • DOI 10.1182/blood-2005-01-0034
    • Bergsagel PL, Kuehl WM, Zhan F, et al. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005;106(1):296-303 (Pubitemid 40967205)
    • (2005) Blood , vol.106 , Issue.1 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3    Sawyer, J.4    Barlogie, B.5    Shaughnessy Jr., J.6
  • 191
    • 33645769276 scopus 로고    scopus 로고
    • High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients
    • Carrasco DR, Tonon G, Huang Y, et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 2006;9(4):313-325
    • (2006) Cancer Cell , vol.9 , Issue.4 , pp. 313-325
    • Carrasco, D.R.1    Tonon, G.2    Huang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.